Map Network Research Articles

From Private to Public: The Movement of Pahari Paintings from Royal Collections to the Chandigarh Museum in Post-Independence India

The Government Museum and Art Gallery of Chandigarh was established to fill a cultural vacuum in post-partition Punjab. It received the seed of its collection from Lahore and the rest was amassed by M. S. Randhawa (1909–1986), an Indian Civil Service officer with a love for painting that at the time was identified as “Kangra” for its style and association with the eponymous region and kingdom. In the 1950s, he spent considerable time traveling in the western Himalayas, tracking down paintings and acquiring them for the museum. The many volumes of correspondence that he later bequeathed to the museum reveal how collections of early modern Pahari paintings were rapidly dispersing to form new collections elsewhere. Through the lens of the bureaucrat-collector Randhawa, this article sheds light on the complex history of collecting in mid-twentieth-century South Asia. In tracing the movement of paintings from private royal collections to a public government museum, the article approaches provenance as biography with the goal to contribute to collective efforts of mapping networks that connect collections and collectors.

Risk prediction of computer investment database information management system based on machine learning algorithms

In recent years, with the continuous development of the financial market, the risk prediction of computer investment database information management systems (IMS) has high practical value. At present, there are risk issues in the information management system, which may cause drawbacks to investment data processing. To address these issues, this article used Machine Learning (ML) algorithms to analyze the risk prediction of computer investment database IMS. This article introduced and utilized typical Self-Organizing Map (SOM) and Artificial Neural Network (ANN) combination algorithms, regression algorithms, and Gradient Boosting Decision Tree (GBDT) algorithms to compare and analyze the prediction accuracy of these three algorithms. This article found that the GBDT algorithm has the highest prediction accuracy. Through a large amount of experimental data, it has been proven that the average testing accuracy using regression algorithms was 3.5% higher than that using neural network algorithms. It was found that the average test accuracy using the GBDT algorithm was 7.2% higher than the average test accuracy using the regression algorithm. The study also explores the combination of physiological and behavioral data collected by wearable devices to provide more comprehensive risk assessment and decision support, which provides an important reference for the optimization of enterprise risk management. Through this innovative data source integration, this paper provides a new perspective for the application and development of machine learning algorithms in computer investment database IMS.

Effects of the long-term rice expansion on ecosystem carbon budget in the typical agricultural area of Northeast China

Extensive rice expansion in northeast China has significantly altered land use and land cover (LULC) changes. However, the impact of long-term rice expansion on regional carbon budget dynamics remains unclear. A major obstacle in addressing this gap is the absence of agricultural LULC information with high spatiotemporal resolution. Here, we selected the Sanjiang Plain experienced dramatic rice expansion as the study area, presenting a framework that integrates high-resolution crop distribution data with a process-based model to quantify the impact of rice expansion on regional carbon budgets. Specifically, we employed a robust deep-learning network for crop mapping based on Landsat data, to reconstruct the spatiotemporal dynamics of rice expansion from 1985 to 2020. We then incorporated these long-term crop maps into the Denitrification-Decomposition (DNDC) model, to explore the effects of rice expansion on the regional carbon budget over this period. Analysis results showed that the rice planting area expanded by 708.64 km2/yr, resulting in more than a tenfold increase over the past 36 years. Spatially, rice planting expanded from the southwest to the northeast and from the interior to the exterior. This expansion has resulted in approximately 275 Mt. of CO2 and 6.92 Mt. of CH4 greenhouse gas emissions, altering the dynamics of the regional carbon budget and shifting the ecosystem from a carbon sink to a carbon source since 2016. Although the long-term expansion of rice increased soil respiration and CH4 emissions, it also enhanced soil carbon sequestration through agricultural management practices. These findings greatly enhance our understanding of the ecosystem carbon cycle's response to long-term agricultural LULC changes, providing more accurate data support and scientific evidence for developing low-carbon agricultural policies.

A Comprehensive Analysis of Network Scanning and Security Assessment Tool

An essential component of any network pen testing effort is network reconnaissance. Gaining additional knowledge about the target's network will help us understand its infrastructure as well as any potential attack routes and exploits that could expose vulnerabilities. By employing both passive and active reconnaissance methods and tools, an attacker can possess substantial volumes of data with a reduced likelihood of being discovered. NMAP, short for Network Mapper, is a widely recognized and powerful open-source network scanning and security assessment tool. This research study analyzes NMAP, including its background, features, usage, and impact on network security. The research also explores the ethical issues of employing NMAP and suggests strategies to avoid such hazards.

Evolution of climate-smart agriculture research: A science mapping exploration and network analysis

Abstract The integrated approach of bibliometric mapping and literature review was adopted to critically examine the evolution of climate-smart agriculture (CSA) research climate from 2012 to 2023 using publications data recovered from the Elsevier Scopus database. The publication trends, stakeholder profiles, social networks, and thematic area analysis on CSA research were examined. Findings revealed that the publication trends on CSA research revealed an incremental pattern from 2012 to 2023. Stakeholder profile analysis identified numerous authors, affiliations, and countries actively engaged in CSA research. The most prolific researcher is Mangi L. Jat, whereas Wageningen University & Research is the most prolific affiliation. Finally, the United States is the most prolific nation. Stakeholder’s productivity was ascribed to a combination of factors ranging from access to research funding to collaborations. The most active funder of CSA research is CGIAR (Consortium of International Agricultural Research Centres), which has funded 52 publications, gained 1,529 citations, and an h-index of 20. The CGIAR has greatly supported the works of highly prolific authors such as Mangi L. Jat, Hanuman S. Jat, and Suresh K. Kakraliya. Social network analysis revealed strong, active, and extensive links, particularly between nations such as the US, India, Kenya, and Ethiopia. The cluster and thematic area analyses of the CSA research landscape revealed three areas, namely, Climate-Resilient Agricultural Adoption, Climate-Responsive Agricultural Practices, and Integrated Food Systems, which are the current focus of stakeholders in the field. Overall, the study showed that CSA is a broad and interdisciplinary topic with a significant impact on the social, economic, and environmental aspects of humanity and societies across the globe.

Modeling inter-modal incongruous sentiment expressions for multi-modal sarcasm detection

Multi-modal sarcasm detection (MSD) presents a formidable and intricate endeavor. Despite strides made by extant models, two principal hurdles persist: Firstly, prevailing methodologies merely address superficial disparities between textual inputs and associated images, neglecting nuanced inter-modal combinations. Secondly, satirical instances frequently involve intricate emotional expressions, highlighting the imperative of leveraging emotional cues across modalities to discern satirical nuances. Accordingly, this research proposes the utilization of a deep graph convolutional network that integrates cross-modal mapping information to effectively identify significant incongruent sentiment expressions across various modalities for the purpose of multi-modal sarcasm detection. Specifically, we first design a cross-modal mapping network, which obtains the interaction information between these two modalities by mapping text feature vectors and image feature vectors two by two to compensate for the lack of multi-modal data in the fusion process. Additionally, we employ external knowledge of ANPS as a bridge to construct cross-correlation graphs through highly correlated satirical cues and their connection weights between image and text modalities. Afterward, the GCN architecture with retrieval-based attentional mechanisms will effectively capture satirical cues. The experiments conducted on two publicly available datasets demonstrate a significant enhancement in the performance of our method when compared to numerous contemporary models.

Анализ транспортной доступности населенных пунктов Республики Мордовия с использованием геоинформационных технологий

The study is devoted to the analysis of transport accessibility of the settlements in the Republic of Mordovia, which is proposed by the authors as one of the indicators for assessing the level of the transport system development. Methods of spatial analysis and graph theory are used to create a transport network model. The selection of graph elements includes settlements in Mordovia with a population of 2 000 people or more, as well as all sections of highways that provide the shortest paths between them. The measure of distance is used as impedance. The article discusses the usability of geographic and potential accessibility, as well as the detour index to detect problematic elements of the transport network, and compares the indicators using the ranking and classification methods. Using web mapping services and network analysis tools in GIS, the selected indicators were calculated and a series of maps were created to display them, using natural breaks classification method and graduated symbols as a method of cartographic representation. During the study, it was found that some of the shortest paths between the considered settlements of the Republic of Mordovia pass through the Nizhny Novgorod Oblast, which indicates that the regional transport network goes beyond the borders of the federal subject. The problem of artificial barriers within one country at the level of municipal districts and federal subjects has been identified. The possibility of creating a project to improve transport accessibility of the region is being considered, and arguments in favor of the construction of missing direct connections between settlements of the Republic of Mordovia are given. The target indicators and limiting factors for improving the transport accessibility of settlements in the region are identified. The possibilities of further research using the obtained results for a comprehensive analysis of the regional transport system are considered.

Multi-layer graph attention neural networks for accurate drug-target interaction mapping

In the crucial process of drug discovery and repurposing, precise prediction of drug-target interactions (DTIs) is paramount. This study introduces a novel DTI prediction approach—Multi-Layer Graph Attention Neural Network (MLGANN), through a groundbreaking computational framework that effectively harnesses multi-source information to enhance prediction accuracy. MLGANN not only strides forward in constructing a multi-layer DTI network by capturing both direct interactions between drugs and targets as well as their multi-level information but also amalgamates Graph Convolutional Networks (GCN) with a self-attention mechanism to comprehensively integrate diverse data sources. This method exhibited significant performance surpassing existing approaches in comparative experiments, underscoring its immense potential in elevating the efficiency and accuracy of DTI predictions. More importantly, this study accentuates the significance of considering multi-source data information and network heterogeneity in the drug discovery process, offering new perspectives and tools for future pharmaceutical research.

Loneliness and Social Isolation: qualitative study among youth in vulnerable situations

Abstract Background Loneliness and social isolation are increasing among young people, particularly those in vulnerable NEET (Not in Education, Employment or Training) situations, potentially leading to poor health and well-being outcomes. We aim to explore these challenges from the perspective of NEET youngsters and link workers who support them in co-creating individual action plans for their social and economic integration. Methods Data were collected through in-depth and semi-structured interviews with 15 young people in NEET situations, aged 18-34, and 7 link workers from several social organisations in rural and urban areas in Portugal. The young participants were selected based on their age, educational level, mental health needs, and urban/rural regions. Thematic analysis was used to analyse the interviews. Results The results showed a convergence between the perspectives of young people and link workers on the factors that influence social isolation and loneliness, including social and emotional skill deficits, excessive use of social media platforms, and mental health problems. Young people reported to being heavily involved in social media platforms, which often did not translate into meaningful relationships in real life. Youngsters also highlighted the lack of local support and community resources in rural areas. Link workers identified specific challenges young migrants face in community integration, including language barriers (for the youth with a migrant origin) and lack of familiarity with local resources. Conclusions This study highlights social media platforms, mental health and social and emotional skill deficits as main factors contributing to the social isolation and loneliness of young people in a NEET situation. This emphasizes the importance of integrated proximity-based interventions that incorporate community resource mapping and local support networks, including mental health support services, and promote multi-sector collaboration. Key messages • Social media platforms, mental health needs, and social and emotional skill deficits drive social isolation in NEET youth, stressing integrated, community-focused interventions. • Proximity-based strategies with community mapping and mental health support enhance NEET youths’ social integration, urging cross-sector collaboration.

High-resolution population mapping based on SDGSAT-1 glimmer imagery and deep learning: a case study of the Guangdong-Hong Kong-Marco Greater Bay Area

ABSTRACT Accurate population mapping is crucial for disaster management, urban planning, etc. However, current methods using nighttime light (NTL) and gridded population datasets are limited by low spatial resolution and insufficient training data for complex models such as deep learning. These models do not adequately utilize spatial information in population mapping. To address these limitations, this study proposes a high-resolution population mapping method using the Sustainable Development Goals Science Satellite 1 (SDGSAT-1) glimmer imager data and deep learning. The method includes a sample generation strategy with multiple regression and multilevel screening to provide sufficient, high-quality samples for deep learning. A Fine Population mapping network (FinePop-net) is also developed to train regression models using image samples, capturing multi-scale features for model training. When applied to the Guangdong-Hong Kong-Macao Greater Bay Area with 40-meter resolution SDGSAT 1 glimmer imagery, the method significantly reduced the average absolute error and root-mean-square error by 9.35% and 11.44%, respectively, compared with those of the pixel-level learning methods. It also outperformed other population spatialization datasets and NTL data by over 30% and 10%, respectively, in terms of error reduction. The results highlight the method’s effectiveness and the value of SDGSAT-1 glimmer imagery for fine population spatialization.

Transcriptome analyses of shell color and egg production traits between the uteruses of blue-green eggshell chickens and Hy-Line brown layers

Blue-green eggs exhibit unique shell color; however, compared to commercial layers, blue-green eggshell chickens have lower egg production and lack uniform shell colors. Aiming to confirm the molecular mechanisms that affect shell color and egg production, this study collected the uteruses of 12 blue-green eggshell chickens (BG group) and six Hy-Line layers (Brown group), which had significantly different shell color indexes (SCI) and egg numbers at 300 days of age (EN300). Transcriptome sequencing and comparative analyses were subsequently performed. BG hens were divided into two groups for comparative analysis (BGblue vs. BGgreen and BGlow vs. BGhigh, respectively), based on the differences in SCI and EN300, respectively. The result of weighted gene co-expression network (WGCNA) analysis showed that the sequenced and mapped 16,785 genes were clustered into 18 modules, among which six modules with a total of 4270 genes were highly correlated with SCI and EN300 traits. Five hundred and eleven differentially expressed genes (DEGs) belonged to the six key modules. Through KEGG mapping, GO enrichment, and Cytoscape network analysis, nine Hub genes were tightly associated with SCI and EN300. The up-regulated genes were CCR2, CCR8, CD40LG, IL18RAP, INHBA, and P2RY13, while the down-regulated genes were ABCA13, ADCY2, and GRM1. Co-analyses with the results of comparisons between the BG subgroups revealed that the expression of solute carrier (SLC) proteins and ABC transporters were highly related to eggshell color, while cytokine-cytokine receptor interactions and neuroactive ligand-receptor interactions were key pathways affecting egg production. The expression of extracellular cytokines and membrane receptors were significantly up-regulated in low-yield chickens. The candidate DEGs and pathways found in the study will assist in clarifying the molecular mechanisms affecting shell color and egg production, and improve the breeding of blue-green eggshell chickens.

Impact of multiplexing noise on multilayer networks of bistable maps

We explore numerically the complex dynamics of multilayer networks (consisting of three and one hundred layers) of cubic maps in the presence of noise-modulated interlayer coupling (multiplexing noise). The coupling strength is defined by independent discrete-time sources of color Gaussian noise. Uncoupled layers can demonstrate different complex structures, such as double-well chimeras, coherent and spatially incoherent regimes. Regions of partial synchronization of these structures are identified in the presence of multiplexing noise. We elucidate how synchronization of a three-layer network depends on the initially observed structures in the layers and construct synchronization regions in the plane of multiplexing noise parameters “noise spectrum width – noise intensity”. It is shown that in a hundred-layer network, clusters of synchronized layers can be formed at certain optimal values of multiplexing noise parameters. The performed numerical studies confidently indicate that the spatial dynamics of multilayer networks can be controlled by varying multiplexing noise parameters.

Leveraging Digital Twins and Intrusion Detection Systems for Enhanced Security in IoT-Based Smart City Infrastructures

In this research, we investigate the integration of an Intrusion Detection System (IDS) with a Digital Twin (DT) to enhance the cybersecurity of physical devices in cyber–physical systems. Using Eclipse Ditto as the DT platform and Snort as the IDS, we developed a near-realistic test environment that included a Raspberry Pi as the physical device and a Kali Linux virtual machine to perform common cyberattacks such as Hping3 flood attacks and NMAP reconnaissance scans. The results demonstrated that the IDS effectively detected Hping3-based flood attacks but showed limitations in identifying NMAP scans, suggesting areas for IDS configuration improvements. Furthermore, the study uncovered significant system resource impacts, including high Central Processing Unit (CPU) usage during SYN and ACK flood attacks and persistent memory usage after Network Mapper (NMAP) scans, highlighting the need for enhanced recovery mechanisms. This research presents a novel approach by coupling a Digital Twin with an IDS, enabling real-time monitoring and providing a dual perspective on both system performance and security. The integration offers a holistic method for identifying vulnerabilities and understanding resource impacts during cyberattacks. The work contributes new insights into the use of Digital Twins for cybersecurity and paves the way for further research into automated defense mechanisms, real-world validation of the proposed model, and the incorporation of additional attack scenarios. The results suggest that this combined approach holds significant promise for enhancing the security and resilience of IoT devices and other cyber–physical systems.

Analysis of evolutionary paths and application scenarios of InSAR in geohazard research

AbstractWith the deterioration of the world environment and intense human activities, geohazards show a frequent occurrence, and InSAR, with its all-weather, all-day, and penetrating nature, rapidly develops into an essential means of earth monitoring. In this paper, using Citespace knowledge graph analysis software, we combed the CNKI core database from 2004 to 2023 and the literature about InSAR in geohazards. The evolution path was analyzed through the spatiotemporal evolution mapping and keyword co-occurrence network parsing, and the research trends and hotspots were predicted. The research results show that firstly, the application of InSAR in geohazards has experienced three classic stages: emerging development, early identification, and synergistic monitoring; secondly, the research topics were clustered into three main spatial and temporal evolution paths, which were “geohazard,” “phase disentanglement”, and “genetic algorithm”; thirdly, future perspectives of InSAR-based technology for geohazard monitoring mainly include as “efficient and intelligent monitoring” and “digital multidimensional monitoring”.

Application of Seismic Attribute Clustering Method Based on PCA-SOM in Identification of Paleochannels

Abstract Paleochannels are crucial reservoir types in continental oil and gas fields. The P oil layer in the Sanzhao Depression of the Songliao Basin is a typical example of river-controlled delta-phase deposition. The underwater diversion channel is highly developed and serves as the primary unit of the oil and gas reservoir. The stacking of the river channel creates a complex relationship. Identifying river channels has always been a challenging aspect of predicting sweet spot reservoirs due to the thinness of the sand, fault cutting, seismic acquisition and processing noise, low-resolution constraints, and other factors. This paper proposes a method for identifying river channels by combining principal component analysis (PCA) and self-organised mapping network (SOM) with seismic attribute clustering. The aim is to address the issue of difficult identification of paleochannels. The seismic attribute set, which contains multiple types of attributes, is first dimensionality reduced using principal component analysis. Then, a few principal components that can characterise the attribute set are extracted and used as inputs to the self-organising map (SOM). This reduces the dimensionality of the training sample set and simplifies the network structure. The self-organising neural network structure is designed based on the input sample features. Training is then carried out, and the network weights are updated. Attribute clustering is performed to obtain the river identification results. The effectiveness of this method for paleochannel recognition is verified by the clear morphology of the recognised paleochannels in the Songliao Basin, their conformity to geological understanding, and their matching with drilling information.

Localization and Network Connectivity of Lesions Causing Limb Ataxia in Patients With Stroke.

Ataxia is primarily considered to originate from the cerebellum. However, it can manifest without obvious cerebellar damage, such as in anterior circulation stroke, leaving the mechanisms of ataxia unclear. The aim of this study was to investigate whether stroke lesions causing limb ataxia localize to a common brain network. In this prospective cohort study, adult patients with new-onset stroke with visible lesions on CT or MRI from Turku University Hospital, Finland, were clinically examined (1) after their stroke while still admitted to the hospital (baseline) and (2) 4 months later (follow-up) to assess limb ataxia. Lesion locations and their functional connectivity, computed using openly available data from 1,000 healthy volunteers from the Brain Genome Superstruct Project, were compared voxel-by-voxel across the whole brain between patients with and without ataxia, using voxel-based lesion-symptom mapping and lesion network mapping. The findings were confirmed in an independent stroke patient cohort with identical clinical assessments. One hundred ninety-seven patients (mean age 67.2 years, 39%female) were included in this study. At baseline, 35 patients (68.3 years, 34%female) had and 162 (67.0 years, 40%female) did not have new-onset acute limb ataxia. At follow-up, additional 4 patients had developed late-onset limb ataxia, totalling to 39 patients (68.6 years, 36%female) with limb ataxia at any point. One hundred eighteen patients (66.2 years, 40%female) did not have ataxia at any point (n = 40 with missing follow-up data). Lesions in 54% of the patients with acute limb ataxia were located outside the cerebellum and cerebellar peduncles, and we did not find an association between specific lesion locations and ataxia. Lesions causing acute limb ataxia, however, were connected to a common network centered on the intermediate zone cerebellum and cerebellar peduncles (lesion connectivity in patients with vs without acute limb ataxia, pFWE < 0.05). The results were similar when comparing patients with and without ataxia at any point, and when excluding lesions in the cerebellum and cerebellar peduncles (pFWE < 0.05). The findings were confirmed in the independent stroke dataset (n = 96), demonstrating an OR of 2.27 (95% CI 1.32-3.91) for limb ataxia per standard deviation increase in limb ataxia network damage score. Lesions causing limb ataxia occur in heterogeneous locations but localize to a common brain network.

Mapping connectivity and network alterations in youth depression by functional brain imaging

Mapping connectivity and network alterations in youth depression by functional brain imaging

Super-resolution water body mapping with a feature collaborative CNN model by fusing Sentinel-1 and Sentinel-2 images

Mapping water bodies from remotely sensed imagery is crucial for understanding hydrological and biogeochemical processes. The identification of water extent is mainly dependent on optical and synthetic aperture radar (SAR) images. However, the use of remote sensing for water body mapping is often undermined by the mixed pixel dilemma inherent to traditional hard classification approaches. At the same time, the presence of clouds in optical imagery and speckle noise in SAR imagery, coupled with the difficulty in differentiating between water-like surfaces and actual water bodies, significantly compromise the accuracy of water body identification. This paper proposes a DEEP feature collaborative convolutional neural network (CNN) for Water Super-Resolution Mapping based on Optical and SAR images (DeepOSWSRM), which collaboratively leverages Sentinel-1 and Sentinel-2 imagery to address the challenges of missing data and mixed pixels. The Sentinel-1 image provides complementary water distribution information for the cloudy areas of the Sentinel-2 image, while the Sentinel-2 image enhances the perception capabilities for small water bodies in the Sentinel-1 image. Using PlanetScope imagery as the true reference data, the effectiveness of the proposed method was assessed through two experimental scenarios: one utilizing synthetic coarse-resolution imagery degraded from Sentinel-1 and Sentinel-2 data and another using actual Sentinel-1 and Sentinel-2 data, encompassing both simulated and real cloud conditions. A comparative analysis was conducted against three state-of-the-art CNN-based water mapping methods and two CNN SRM methods. The findings demonstrate that the proposed DeepOSWSRM method successfully produces accurate, fine-resolution water body maps, with its performance mainly benefiting from the fusion of SAR and optical images.

DMMGNet: A discrimination mapping and memory bank mean guidance-based network for high-performance few-shot industrial anomaly detection

For deep learning-based industrial anomaly detection, it is still challenging to get adequate images for model training and achieve cold start for cross-product migration, restricting their practical application in real industrial production. Herein, an innovative few-shot anomaly detection network DMMGNet based on discrimination mapping and memory bank mean guidance strategies are demonstrated, which is trained by a new two-branch data augmentation technique. By separating the features stored in memory bank from the features used for training, the two-branch data augmentation method can significantly improve the robustness of few-shot model training and reduce the redundance of memory bank. In the elaborately designed discrimination mapping module, new negative samples are generated by adding dynamic Gaussian noise to normal samples along the channel dimension in feature space to solve the problem of sample imbalance. Meanwhile, the discrimination mapping module also helps to map the feature distribution of positive samples to the target domain more efficiently and reduce the deviation of feature domain, conducive to a more precise separation of positive and negative samples. In addition, a novel mean guidance approach with an optimized loss function is developed to guide the positive sample feature mapping by specifying the local feature space center to form a clear feature domain contour and enhance the detection accuracy. The multiple experimental results validate that our DMMGNet outperforms the most advanced anomaly detection counterparts on image-level AUROC, showing an increase by 0.3–3 % on both MVTec AD and MPDD benchmarks under several few-shot scenarios.

Using a Dual-Disease Target Mapping Network Pharmacology Approach, Verbascoside Ameliorates Osteoporosis by Activating Estrogen Signaling to Alleviate Oxidative Stress.

Verbascoside, a compound classified as a phenylethanol glycoside in Dihuang, has been the subject of modern pharmacological investigations. These studies have revealed its noteworthy antioxidant, anti-inflammatory, memory-enhancing, neuroprotective, antitumor, and various other pharmacological properties. While verbascoside exhibits favorable antioxidant effects, its precise mechanism of action in ameliorating osteoporosis through the treatment of oxidative stress remains unclear. This study employed CCK8, ALP, ELISA, and ROS staining techniques to examine the osteoporotic effects of verbascoside on zebrafish and MC3T3-E1 cells. Additionally, this study aimed to investigate the molecular mechanism by which verbascoside improves osteoporosis by mitigating oxidative stress. To identify the common targets of verbascoside in relation to oxidative stress and osteoporosis, network pharmacology and molecular dynamics simulation were employed. The construction of the verbascoside - oxidative stress - osteoporosis - potential target gene network aimed to identify the core targets, while the mechanism of action was elucidated through KEGG analysis, and the accuracy was confirmed by assessing the mRNA expression of the targets. In vivo experiments demonstrated that verbascoside exhibited therapeutic effects on osteoporosis and reduced ROS production in zebrafish. In vitro experiments further revealed that verbascoside enhanced the proliferation and differentiation of MC3T3-E1 cells, thereby improving the oxidative stress status of osteoblasts. Thirteen core targets and estrogen signaling pathways were identified through the application of network pharmacology. The pivotal role of the estrogen signaling pathway in facilitating the ability of verbascoside to mitigate oxidative stressinduced osteoporosis was substantiated by the modulation of target protein mRNA expression. The findings underscore the considerable therapeutic potential of verbascoside in ameliorating osteoporosis through the alleviation of oxidative stress, thus establishing it as a promising compound for the treatment of this condition.