It is generally recognized that the cortical collecting duct plays a major role in the fine control of renal sodium excretion, and thus in the regulation of extracellular fluid volume. Several lines of evidence point to the cortical collecting duct as a possible site of kinin action on sodium transport. First, both kallikrein1-3 and kininogen4 have been localized to the collecting duct system. Second, high-affinity binding sites for bradykinin have recently been localized to the cortical and outer medullary collecting ducts5. Third, kinins have a marked inhibitory effect on vasopressin-stimulated water permeability in the isolated, perfused cortical collecting duct of the rabbit. First part of our studies is to investigate whether bradykinin directly affects net sodium transport in the cortical collecting duct of the rat using the isolated, perfused tubule technique.KeywordsSodium TransportDistal NephronNeutral EndopeptidaseElectrolyte TransportCortical Collect DuctThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.