Net Advantage Research Articles

Development of a nomogram for predicting postoperative recurrence of cervical intraepithelial neoplasia using immunohistochemical and clinical parameters

ABSTRACT Background We aimed to develop a nomogram to predict abnormal follow-up results of co-testing for cytology and human papillomavirus (HPV) in cervical intraepithelial neoplasia (CIN) patients after conization. Research design and methods Two hundred sixty-three patients initially diagnosed as CIN2+ were recruited. Data on immunohistochemical (IHC) staining scores, along with demographic and clinical information were collected. Using least absolute shrinkage and selection operator (LASSO) regression analysis, variables were identified for inclusion. A predict model and nomogram were developed through multi-factor logistic regression. The goodness-of-fit test was applied across different cohorts to construct the calibration curve of the model, and the predictive effect was evaluated by the receiver operating characteristic curve. Decision curve analysis was performed to determine the net benefit. Results Five predictor variables, including protein expression score, vaginal infection, HPV coinfection, and cone height were screened and plotted as a nomogram. The calibration curves showed a good fit. The area under the curve of the model was 0.835 for the training cohort and 0.728 for the internal test cohort. The decision curve analysis indicated that the nomogram provides significant net advantages for clinical use. Conclusion A practical nomogram predict model was developed to predict abnormal follow-up outcomes in CINs after conization.

Efficacy and safety of ticagrelor monotherapy following a brief DAPT vs. prolonged 12-month DAPT in ACS patients post-PCI: a meta-analysis of RCTs.

As per current guidelines, acute coronary syndrome (ACS) patients who undergo percutaneous coronary intervention (PCI) should be started on dual antiplatelet therapy (DAPT) for a period of 12months. To assess the efficacy and safety of brief DAPT (up to 3months) succeeded by ticagrelor monotherapy compared with a 12-month DAPT in ACS patients following PCI. We systematically searched Cochrane, Embase, and PubMed to find relevant randomized clinical trials. Examined outcomes included the incidence of major adverse cerebrovascular and cardiovascular events (MACCE), bleeding events, and the composite incidence of net adverse clinical events (NACE). Our primary analysis included 21,927 ACS patients from six RCTs. Our pooled results indicate that following PCI in individuals with ACS, brief DAPT followed by ticagrelor did not increase the risk of MACCE (OR 0.92, 95% CI 0.79-1.07) but significantly reduced the risk of minor or major bleeding (OR 0.52, 95% CI 0.44-0.62) and NACE (OR 0.71, 95% CI 0.59-0.86) compared with a long-term DAPT within a follow-up of 12months. Brief DAPT followed by ticagrelor monotherapy is superior to a 12-month DAPT in offering a net clinical advantage in ACS patients following PCI.

Analysis of the spatial mismatch pattern of net carbon in agriculture and its influencing factors

Agricultural production has dual functions as a carbon emitter and sink, and fully exploiting the carbon sink function of agriculture is highly valuable for ensuring carbon neutrality. The layout of net carbon in agriculture shows an imbalance, i.e., underscaling in areas with a net carbon advantage or overscaling in areas with a net carbon disadvantage, which restricts the fulfillment of agricultural carbon sinks. Clarifying the global pattern of net carbon imbalances in agriculture and their drivers is highly important for improving the overall net carbon. In this regard, this paper focuses on the global net carbon in agriculture in 155 countries and regions, and a spatial mismatch index of net carbon in agriculture (MNCA) is constructed based on the relative difference between net carbon and cultivated land. Spatial autocorrelation analysis and the standard deviation ellipse are used to reflect its spatiotemporal evolution pattern. In addition, through geographically weighted regression, we explored the effects of agricultural structure, agricultural economic development, the scale of labor and cultivated land and organized the mismatches into carbon and area effects. The results show that (1) global agricultural production represents net carbon emissions, while developing countries represent net carbon sinks, and there is a mismatch of net agricultural carbon in most regions; (2) the MNCA is characterized by low-low clustering in North America, Asia and Europe, with its center of gravity falling in western Africa and migrating northeastward; and (3) the main factors influencing the MNCA are the agricultural structure and economic level. Underscaling in areas with a net carbon advantage is a major problem. To increase the global agricultural carbon sink capacity, we suggest that North America, South Asia and other regions strictly implement agricultural emission reduction policies and that Central America, South America and Africa tentatively upgrade agricultural technology and their economies to alleviate farmland pressure through transnational cooperation. In this paper, the global net carbon imbalance in agriculture is identified and the overall implementation path of increasing carbon sinks is explored to provide a reference for achieving carbon neutrality. SynopsisThis study reports a global mismatch in net carbon in agriculture and identifies the wasted carbon sink advantage of developing countries as the root problem.

Age and mean platelet volume-based nomogram for predicting the therapeutic efficacy of metoprolol in Chinese pediatric patients with vasovagal syncope.

Vasovagal syncope (VVS) is the most common type of orthostatic intolerance in children. We investigated whether platelet-related factors related to treatment efficacy in children suffering from VVS treated with metoprolol. Metoprolol-treated VVS patients were recruited. The median duration of therapy was threemonths. Patients were followed and divided into two groups, treament-effective group and treatment-ineffective group. Logistic and least absolute shrinkage selection operator regressions were used to examine treatment outcome variables. Receiver-operating characteristic (ROC) curves, precision-recall (PR) curves, calibration plots, and decision curve analyses were used to evaluate the nomogram model. Among the 72 patients who complete the follow-up, treatment-effective group and treatment-ineffective group included 42 (58.3%) and 30 (41.7%) cases, respectively. The patients in the treatment-effective group exhibited higher mean platelet volume (MPV) [(11.0 ± 1.0) fl vs. (9.8 ± 1.0) fl, P < 0.01] and platelet distribution width [12.7% (12.3%, 14.3%) vs. 11.3% (10.2%, 12.2%), P < 0.01]than those in the treatment-ineffective group. The sex ratio was significantly different (P = 0.046). A fit model comprising age [odds ratio (OR) = 0.766, 95% confidence interval (CI) = 0.594-0.987] and MPV (OR = 5.613, 95% CI = 2.297-13.711) might predict therapeutic efficacy. The area under the curve of the ROC and PR curves was computed to be 0.85 and 0.9, respectively. The P value of the Hosmer-Lemeshow test was 0.27. The decision curve analysis confirmed that managing children with VVS based on the predictive model led to a net advantage ranging from 0.01 to 0.58. The nomogram is convenient for clinical applications. A novel nomogram based on age and MPV can predict the therapeutic benefits of metoprolol in children with VVS.

Does ESG advantage promote total factor productivity (TFP)? Empirical evidence from China’s listed enterprises

ABSTRACT The question of whether enterprises are incentivized to improve their environment, society, and governance(ESG)performance is uncertain since scholars have long debated whether or not ESG directly benefits the enterprise. In this study, this research question is addressed by investigating the potential effect on productivity of the net advantage yielded by corporations taking specific ESG behaviours. Using panel data of A-share listed companies spanning from 2010 to 2022, this paper draws multiple research findings. Firstly, the fundamental result of this study shows that the corporate ESG advantages significantly enhance the relevant total factor productivity(TFP). This means that firms have a willingness to adopt behaviours to achieve net ESG advantages due to the productivity gains. Secondly, the heterogeneous analysis indicates that ESG advantages improve TFP for large, state-owned enterprises(SOEs),labour-intensive corporations, and non-mature corporations. Thirdly, in terms of the influential mechanism, ESG advantages improve TFP by enhancing labour expenses and reducing agency costs within the enterprise while assisting enterprises in overcoming external environment uncertainty. The findings illuminate that China’s enterprises are interested in achieving ESG advantages since this enables firms to improve productivity and achieve high-quality development. Simultaneously, this offers novel perspectives for investors to assess ESG performance.

Comparative analysis in selecting best irrigation method to maximize tomato yield from various irrigation approaches in water scarce regions

It is now essential for farmers to evaluate and compare different irrigation scheduling strategies in order to operate their irrigation systems in accordance with their resources and achievements. For tomato crops, a rigorous comparison was made between the yield of soil moisture and irrigation scheduling systems based on evapotranspiration. The experimental setup used a randomized complete block design (RCBD) with three replications, with water requirements of 100%, 75%, and 50%. Using a ReplogleBos-Clemmens (RBC) flume with an input rate of 1.62 l/s, water was applied to the furrows. The total applied amount in the Soil Moisture (SM) and Evapotranspiration (ET) based methods was 229.1 mm, and 280 mm, respectively. The collected data were assessed using ANOVA at a 5% significance level. For every technique, yield values, yield attributes, and agronomic traits were computed. The result indicates that there is no appreciable variation among the factors. The net yield advantage was highest at 75% SM and lowest at 25% SM. Furthermore, compared to the ET-based approach, it was demonstrated that the SM-based method conserved approximately 18.2% of irrigation water. As a result, when producing crops that require a lot of water, like tomatoes, in areas with limited water resources, SM-based irrigation scheduling is preferable to ET-based irrigation scheduling.

Net survival of men with localized prostate cancer after LDR brachytherapy

OBJECTIVESTo compare survival of patients who received LDR prostate brachytherapy relative to that of peers in the general population of England, UK. PATIENTS AND METHODSNet survival was estimated for 2472 cases treated between 2002 and 2016 using population-based analysis guidelines. Life tables adjusted for social deprivation in England from the Office for National Statistics were used to match patients by affluence based on their postcode. RESULTSThe median (range) age at time of brachytherapy was 66 (55–84) years, 84% resided in Southeast England, 51% under an index of deprivation quintile 5 (most affluent), 55% were clinical stage T1 and the remainder T2. Death from any cause occurred in 270 patients at a median (range) of 7 (1–17) years postimplant.Five and 10-year estimates (95% CI) of overall survival were 96% (95–97) and 90% (89–92), and net survival 103% (102–104) and 109% (107–110) respectively. The net survival remained above 100% in all age-at-treatment and clinical stage groups. CONCLUSIONNet survival above 100% indicates patients survive longer than the matched general population. The study shows for the first time the net survival of patients treated with a radical therapy for localized prostate cancer in England. The impact of treatment choice on the long-term net survival advantage requires further investigation.

Creation of the HIV-1 antisense gene asp coincided with the emergence of the pandemic group M and is associated with faster disease progression.

Despite being first identified more than three decades ago, the antisense gene asp of HIV-1 remains an enigma. asp is present uniquely in pandemic (group M) HIV-1 strains, and it is absent in all non-pandemic (out-of-M) HIV-1 strains and virtually all non-human primate lentiviruses. This suggests that the creation of asp may have contributed to HIV-1 fitness or worldwide spread. It also raises the question of which evolutionary processes were at play in the creation of asp. Here, we show that HIV-1 genomes containing an intact asp gene are associated with faster HIV-1 disease progression. Furthermore, we demonstrate that the creation of a full-length asp gene occurred via the evolution of codon usage in env overlapping asp on the opposite strand. This involved differential use of synonymous codons or conservative amino acid substitution in env that eliminated internal stop codons in asp, and redistribution of synonymous codons in env that minimized the likelihood of new premature stops arising in asp. Nevertheless, the creation of a full-length asp gene reduced the genetic diversity of env. The Luria-Delbruck fluctuation test suggests that the interrupted asp open reading frame (ORF) is the progenitor of the intact ORF, rather than a descendant under random genetic drift. Therefore, the existence of group-M isolates with a truncated asp ORF indicates an incomplete transition process. For the first time, our study links the presence of a full-length asp ORF to faster disease progression, thus warranting further investigation into the cellular processes and molecular mechanisms through which the ASP protein impacts HIV-1 replication, transmission, and pathogenesis.IMPORTANCEOverlapping genes engage in a tug-of-war, constraining each other's evolution. The creation of a new gene overlapping an existing one comes at an evolutionary cost. Thus, its conservation must be advantageous, or it will be lost, especially if the pre-existing gene is essential for the viability of the virus or cell. We found that the creation and conservation of the HIV-1 antisense gene asp occurred through differential use of synonymous codons or conservative amino acid substitutions within the overlapping gene, env. This process did not involve amino acid changes in ENV that benefited its function, but rather it constrained the evolution of ENV. Nonetheless, the creation of asp brought a net selective advantage to HIV-1 because asp is conserved especially among high-prevalence strains. The association between the presence of an intact asp gene and faster HIV-1 disease progression supports that conclusion and warrants further investigation.

Men's Migration and Women's Health in Rural Sub-Saharan Africa: The Role of Migration's Economic Returns and Spousal Communication

In this study, we investigate the association between men's labor migration and changes in their non-migrating wives’ self-rated health (SRH) over time using longitudinal data from rural Mozambique. In addition to comparing wives of non-migrants and wives of migrants, we account for variation in the economic impact of migration and in migrants’ phone communication with their spouses. We find that migrants’ wives are significantly less likely to report low SRH, compared to non-migrants’ wives, net of other factors. However, this net advantage is concentrated among migrants’ wives who receive frequent remittances and who report that their households’ conditions have improved thanks to husband's migration. We also find that women who engage in frequent phone communication with their migrant husbands have decreased likelihoods of low SRH, compared to migrants’ wives who do not communicate with their husbands during their migration and to women married to non-migrants, regardless of other characteristics. We interpret these findings within the context of multifaceted gendered implications of men's migration for left-behind women's health and wellbeing.

Development of a Novel Nomogram to Predict Major Adverse Cardiac Events in Patients with Chronic Total Occlusion.

Objectives: To create a nomogram using single photon emission computed tomography (SPECT) myocardial perfusion imaging and 18F-FDG positron emissions tomography (PET) gated myocardial metabolism imaging to forecast major adverse cardiovascular events (MACE) in chronic total occlusion (CTO) patients treated with optimal medical therapy (OMT). Methods: A total of 257 patients who received OMT between January 2016 and December 2021 were included in this retrospective study. Patients were randomly divided into development (n=179) and validation (n=78) cohorts. A thorough evaluation was conducted, encompassing clinical features and imaging analysis, which involved assessing myocardial perfusion and metabolism. Independent risk factors were identified using least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analyses. Calibration curves and decision curve analysis (DCA) were used to evaluate the clinical usefulness. Results: In the development cohort, 53 patients (29.6%) experienced MACE out of 179 patients, while in the validation cohort, MACE occurred in 23 (29.5%) patients out of 78. The PET-left ventricular end-systolic volume (P-ESV) (HR 1.01; 95% CI 1.003-1.017; p=0.003), hibernating myocardium / total perfusion defect (HM/TPD) (HR 1.053; 95% CI 1.038-1.069; p<0.001), PET-left ventricular ejection fraction (P-LVEF) (HR 0.862; 95% CI 0.788-0.943; p=0.001), and left anterior descending branch (LAD) (HR 2.303; 95% CI 1.086-4.884; p=0.03) were significantly associated with MACE and were used to develop the nomogram. The nomogram demonstrated excellent discrimination with C-indexes of 0.931 and 0.911 in the development and validation cohorts. DCA determined that the model exhibited a considerably superior net advantage in predicting MACE. Conclusion: A new nomogram integrating clinical factors and imaging features was created to predict the risk of MACE in patients with CTO.

Variable Selection for Sparse Logistic Regression with Grouped Variables

We present a new penalized method for estimation in sparse logistic regression models with a group structure. Group sparsity implies that we should consider the Group Lasso penalty. In contrast to penalized log-likelihood estimation, our method can be viewed as a penalized weighted score function method. Under some mild conditions, we provide non-asymptotic oracle inequalities promoting the group sparsity of predictors. A modified block coordinate descent algorithm based on a weighted score function is also employed. The net advantage of our algorithm over existing Group Lasso-type procedures is that the tuning parameter can be pre-specified. The simulations show that this algorithm is considerably faster and more stable than competing methods. Finally, we illustrate our methodology with two real data sets.

THE COMPARISON OF GOOGLE BARD AND CHATGPT USE IN FINANCIAL MARKETS

The main purpose of this study is to investigate the advantages and disadvantages of using ChatGPT and Google Bard in finance. As a method, academic studies and researches done so far were examined. In this direction, the advantages and disadvantages of both methods were tried to be presented in tables. As a result of the study, it was observed that special abilities can be attributed to both artificial intelligence systems, and when compared, it was found that the net advantage would be better understood over time. Because artificial intelligence systems are fed by the feedback of users. However, it has been observed that while ChatGPT works effectively in data analysis and rapid decision making, it may have limitations when it comes to freedom from emotion and bias. Google Bard, on the other hand, has been stated to be effective in risk management and portfolio optimization with its advanced forecasting and analysis capabilities. However, it is common opinion that the use of up-to-date and accurate data is important in both systems and that the factors will affect the performance of the methods.

Molecular surveillance of insecticide resistance in Phlebotomus argentipes targeted by indoor residual spraying for visceral leishmaniasis elimination in India.

Molecular surveillance of resistance is an increasingly important part of vector borne disease control programmes that utilise insecticides. The visceral leishmaniasis (VL) elimination programme in India uses indoor residual spraying (IRS) with the pyrethroid, alpha-cypermethrin to control Phlebotomus argentipes the vector of Leishmania donovani, the causative agent of VL. Prior long-term use of DDT may have selected for knockdown resistance (kdr) mutants (1014F and S) at the shared DDT and pyrethroid target site, which are common in India and can also cause pyrethroid cross-resistance. We monitored the frequency of these marker mutations over five years from 2017-2021 in sentinel sites in eight districts of north-eastern India covered by IRS. Frequencies varied markedly among the districts, though finer scale variation, among villages within districts, was limited. A pronounced and highly significant increase in resistance-associated genotypes occurred between 2017 and 2018, but with relative stability thereafter, and some reversion toward more susceptible genotypes in 2021. Analyses linked IRS with mutant frequencies suggesting an advantage to more resistant genotypes, especially when pyrethroid was under-sprayed in IRS. However, this advantage did not translate into sustained allele frequency changes over the study period, potentially because of a relatively greater net advantage under field conditions for a wild-type/mutant genotype than projected from laboratory studies and/or high costs of the most resistant genotype. Further work is required to improve calibration of each 1014 genotype with resistance, preferably using operationally relevant measures. The lack of change in resistance mechanism over the span of the study period, coupled with available bioassay data suggesting susceptibility, suggests that resistance has yet to emerge despite intensive IRS. Nevertheless, the advantage of resistance-associated genotypes with IRS and under spraying, suggest that measures to continue monitoring and improvement of spray quality are vital, and consideration of future alternatives to pyrethroids for IRS would be advisable.

The Influence of User Trust and Experience On User Satisfaction Of E-Commerce Applications During Transactions in Mini Markets Using Delon and McLean Method

In order to increase net advantages for users of e-commerce applications in minimarkets, this research attempts to quantify the degree and influence of experience and trust on user pleasure. This research employs a quantitative methodology. Direct observations of e-commerce applications, literature reviews, and the online distribution of Google Forms-assisted questionnaires to application users via social media were the methods used to collect data. Both statistical and demographic analysis were used to analyze the data for this study. Users of e-commerce applications make up the study's population. Purposive sampling was the method employed for sampling. With a total of 180 samples, the non-probability sampling approach makes use of the PLS-SEM theory. The majority of respondents expressed high levels of satisfaction with the e-commerce application in minimarkets, according to the data processing results. Because perceived utilitarian's path coefficient and t-test values are below the threshold, the analysis of the aspects of user experience represented by perceived hedonic and perceived utilitarian shows that perceived hedonic has a significant effect on user satisfaction while perceived utilitarian does not. The user happiness variable is significantly impacted by the trust variable. Perceived hedonic value, trust, and ease of use are factors that significantly impact customer satisfaction with e-commerce applications in minimarkets.

Development and Validation of a Nomogram Model for the Risk of Cardiac Death in Patients Treated with Chemotherapy for Esophageal Cancer.

The primary cause of mortality in esophageal cancer survivors is cardiac death. Early identification of cardiac mortality risk during chemotherapy for esophageal cancer is crucial for improving the prognosis. We developed and validated a nomogram model to identify patients with high cardiac mortality risk after chemotherapy for esophageal cancer for early screening and clinical decision-making. We randomly allocated37,994 patients with chemotherapy-treated esophageal cancer into two groups using a 7:3 split ratio: model training (n = 26,598) and validation (n = 11,396). 5- and 10-year survival rates were used as endpoints for model training and validation. Decision curve analysis and the consistency index (C-index) were used to evaluate the model's net clinical advantage. Model performance was evaluated using receiver operating characteristic curves and computing the area under the curve (AUC). Kaplan-Meier survival analysis based on the prognostic index was performed. Patient risk was stratified according to the death probability. Age, surgery, sex, and year were most closely related to cardiac death and used to plot the nomograms. The C-index for the training and validation datasets were 0.669 and 0.698, respectively, indicating the nomogram's net clinical advantage in predicting cardiac death risk at 5 and 10years. The 5- and 10-year AUCs were 0.753 and 0.772 for the training dataset and 0.778 and 0.789 for the validation dataset, respectively. The accuracy of the model in predicting cardiac death risk was moderate. This nomogram can identify patients at risk of cardiac death after chemotherapy for esophageal cancer at an early stage.

Knowledge Management System Evaluation Using DeLone McLean Model: A Case Study of IT Service Desk Bank XYZ

Bank XYZ is one of the biggest banks in Indonesia. It has IT Service Desk function under Information Technology Division that specifically handles complaints or problems related to IT. Knowledge management in IT service desk can help to increase the availability of information and knowledge for the IT service desk team who must provide explanations to users. IT Service Desk of Bank XYZ has built knowledge management system using open-source platform since 2017. It is called SDKPedia which was developed inhouse by IT Service Desk team and never been evaluated since it was built. The objective of this study is to evaluate SDKPedia as knowledge management system used in IT Service Desk Bank XYZ. Evaluation was carried out based on Delone and McLean assessment criteria. Survey is distributed to IT Service Desk worker and 31 valid feedback is used in this study. To determine the indications that have a substantial impact and result in a net advantage for SDKPedia, the PLS-SEM algorithm is utilized. Service quality is the only exogen latent variable that affected intension of use. While the other two exogen latent variable are system quality and information quality, did not have significant impact for intention to use or user satisfaction. Considering the findings of this study, several improvements can be made by the IT Service Desk manager to make the quality of SDKPedia better. The points that need more attention are information quality and system quality.

Study of the Multimodal Freight Transport Sector in Romania: Analysis of the External and Internal Environment

The paper studies the current situation of the multimodal freight transport sector in Romania, using the analysis of its external and internal environment. The goal is to find out what are the pluses and minuses of this sector and what strategies must be adopted so that the targets set by the European Green Deal can be reached. This EU strategy emphasizes that, in order to reduce pollution, emphasis must be placed on multimodal transport, with an emphasis on rail transport. Thus, the general external environment is defined by the following factors: demographic, economic, technological, ecological, etc. While the labor force crisis in the road transport of goods deepens, and the average age of the staff in the railway sector is getting higher, the policy of the EU and, implicitly, of the EU member states stimulates multimodal transport, in order to reduce CO2 emissions. The Porter model shows that, despite the forces acting in a negative direction, the multimodal freight transport market is attractive. At the same time, from the strategic group belong both multinational corporations and enterprises with domestic capital, which underlines the attractiveness of the market. Thus, it is necessary to apply the strategy that involves a reduction of costs, but not by decreasing the quality of the services offered. On the other hand, the SWOT analysis indicates that multimodal freight transport in Romania is in the ideal/maximum situation. Therefore, it is necessary to apply an aggressive strategy. Thus a net competitive advantage will be ensured. The strategy consists in stimulating rail freight transport, which will contribute to reducing pollution.

Vaccination Intention Following Receipt of Vaccine Information Through Interactive Simulation vs Text Among COVID-19 Vaccine–Hesitant Adults During the Omicron Wave in Germany

In this cross-sectional study, vaccine-hesitant adults presented with an interactive risk ratio simulation were more likely to show positive change in COVID-19 vaccination intention and benefit-to-harm assessment than those presented with a conventional text-based information format. These findings suggest that the interactive risk communication format can be an important tool in addressing vaccination hesitancy and fostering public trust. Cross-sectional study conducted online with 1255 COVID-19 vaccine-hesitant adult residents of Germany in April and May 2022, surveyed using a probability-based internet panel maintained by respondi, a research and analytics firm. Participants were randomized to 1 of 2 presentations on the benefits and adverse events associated with vaccination. Participants were randomized to a text-based description vs an interactive simulation presenting age-adjusted absolute risks of infection, hospitalization, ICU admission, and death after exposure to coronavirus in vaccinated vs unvaccinated individuals relative to the possible adverse effects as well as additional (population-level) benefits of COVID-19 vaccination. Hesitancy toward COVID-19 vaccination is a major factor in stagnating uptake rates and in the risk of health care systems becoming overwhelmed. Absolute change in respondents' COVID-19 vaccination intention category and benefit-to-harm assessment category. To compare an interactive risk ratio simulation (intervention) with a conventional text-based risk information format (control) and analyze change in participants' COVID-19 vaccination intention and benefit-to-harm assessment. Participants were 1255 COVID-19 vaccine-hesitant residents of Germany (660 women [52.6%]; mean [SD] age, 43.6 [13.5] years). A total of 651 participants received a text-based description, and 604 participants received an interactive simulation. Relative to the text-based format, the simulation was associated with greater likelihood of positive change in vaccination intentions (19.5% vs 15.3%, respectively; absolute difference, 4.2%; adjusted odds ratio [aOR], 1.45; 95% CI, 1.07-1.96; P = .01) and benefit-to-harm assessments (32.6% vs 18.0%; absolute difference, 14.6%; aOR, 2.14; 95% CI, 1.64-2.80; P < .001). Both formats were also associated with some negative change. However, the net advantage (positive - negative change) of the interactive simulation over the text-based format was 5.3 percentage points for vaccination intention (9.8% vs 4.5%) and 18.3 percentage points for benefit-to-harm assessment (25.3% vs 7.0%). Positive change in vaccination intention (but not in benefit-to-harm assessment) was associated with some demographic characteristics and attitudes to COVID-19 vaccination; negative changes were not.

Dispozițiile testamentare de desemnare a moștenitorului și legatarului (analiză de drept comparat)

"This inquiry deals with a classical question of European succession law, if a testamentary disposition appointing a beneficiary is to be taken as a designation of a universal legal successor (testamentary heir) or merely a legatee (successor in respect of a single item of property). Wills prepared without the employment of a succession law specialist often contain designations of heir in respect of a single piece of property (heredis institutio ex re certa), which raises the question of the legal status of such a testamentary beneficiary (heir or legatee). Following the German and Italian models, the new succession law contained in the Moldovan Civil Code applies the test of the practical intent of the testator (mens testantis): whether he or she intended the beneficiary to merely receive a net financial advantage (i.e. institution of legatee) or to replace the testator in all of his or her legal positions (i.e. institution of heir)."

Effect of liquid splattering on thermal performance of jets and sprays over plain and pillared surfaces

A comparative study of liquid jet and spray is explored over plain and pillared copper surfaces with coolant flow (water) ranging over 3000 < Re < 10500, and heat fluxes up to the critical heat flux limit. Liquid jets and sprays are hydrodynamically characterized using high-speed videography and the phase-Doppler particle analyzer system. The interaction of liquid jets and sprays with the respective metallic substrates is experimentally investigated and strong liquid splattering is observed over the pillared surfaces at higher coolant flow rates. The resulting splattering mass fraction is measured over a range of coolant flow rates and radial positions of the nozzle. Subsequently, the effect of splattering on heat transfer performance is compared for various heat flux conditions by measuring the steady-state surface temperature. Heat transfer coefficient is found to be a strong function of coolant flow rate, operating heat flux conditions, and splattered mass fraction. Significant differences are not seen in these quantities between the liquid jet and spray for a plain surface. However, spray cooling clearly shows superior heat transfer enhancement over a liquid jet for a pillared surface where the critical heat flux limit is significantly delayed. The apparent advantages of heat transfer performance enhancement with patterning of surfaces are not always guaranteed, and the design consideration must address the coolant interaction with it to ensure a net advantage, which may get diminished due to liquid splattering induced by the interaction of the coolant with the patterned surface.