Nerve Center Research Articles

Hypoxanthine Produces Rapid Antidepressant Effects by Suppressing Inflammation in Serum and Hippocampus.

The occurrence and development of depression are closely related to disorders of the brain and peripheral substances. Abnormal metabolites in the blood affect the signal regulation function of the nerve center, which is one of the key factors for depression episodes. This study was focused on metabolites in serum and the mechanism of its antidepressant in the hippocampus. In the present study, serum metabolites in patients with depression were screened by metabolomic techniques. Various depressive mouse models and behavioral tests were used to assess its antidepressant effects. The expressions of inflammatory signaling were detected by using Western blot, ELISA, and immunofluorescence. We found that the metabolite hypoxanthine in the serum of patients with depression was significantly reduced, and the same result was also found in two mouse models of depression such as chronic unpredictable mild stress (CUMS) and social defeat stress (SD). By administering different doses of hypoxanthine (5, 10, 15 mg/kg), we found that only 15 mg/kg was able to significantly reduce the latency and increase food consumption in the novelty suppressed-feeding test (NSF), which was also able to reverse the depressive phenotypes of mice in the CUMS model after a single administration at 2 h later. Hypoxanthine obviously reduced the expressions of inflammation in serum and downregulated the expressions of MAPK and NLRP3-related pathways in the hippocampus in CUMS mice. Moreover, hypoxanthine also suppressed the activations of glial cells including GFAP and IBA-1 in hippocampal CA1, CA3, and dentate gyrus (DG). To sum up, hypoxanthine exerted antidepressant effect relying on the inhibition of peripheral and hippocampal inflammations by regulating MAPK, NLRP3-related pathways, and glial cells. This was the first time that we have found a disordered metabolite in patients with depression and further systematically demonstrated its efficacy and potential mechanism of antidepressants, providing new ideas for antidepressant drug development.

AI-Driven FlightOps: Revolutionizing Airline Operations Control with Predictive Analytics and NLP

Abstract: Flight operations control centers (OCCs) are the nerve centers of airline operations, tasked with managing a wide range of activities such as flight scheduling, crew assignments, maintenance coordination, and dealing with disruptions. While traditional approaches have relied heavily on human decision-making and manual analysis of operational data, the increasing complexity of modern airline operations demands more efficient solutions. This paper presents FlightOps AI, a cutting-edge AIpowered system that integrates advanced natural language processing (NLP), deep neural networks (DNNs), reinforcement learning (RL), and computer vision to provide OCC staff with actionable insights and predictive capabilities. The system processes massive amounts of structured and unstructured data in real time, enabling smarter decision-making and automation of routine tasks. By adopting these technologies, FlightOps AI transforms the operational landscape, optimizing airline performance while minimizing human errors

Factors Related to Family Attitudes in Helping Patients Adapt to Meet Basic Needs and Prevention of Post-Stroke Depression

Stroke is the leading cause of disability and death. One of the major problems faced by individuals who have a stroke is physical disability and depression. Strokes often interfere with the ability to move, speak, and perform daily activities. It can lead to dependence on others for self-care. The study aimed to find out the relationship between gender, education, experience, knowledge, and family attitudes in helping patients adapt to meet basic needs and prevent post-stroke depression at the Indrasari Rengat Hospital. The design of the research was a cross-sectional survey with a sample of 54 respondents in the nerve center and intensive care room of the Indrasari Rengat hospital unit from May 4 to August 9, 2023.A data collection tool using a questionnaire that contains questions about adaptation in the fulfillment of basic needs and prevention of post-stroke depression, as well as statements of family attitudes toward meeting basic needs and post-stroke prevention. The data analysis in this study is descriptive analysis and bivariate analysis with a chi-square test. The results show that there is a meaningful relationship between gender, experience, knowledge, and family attitudes in helping patients adapt to meet basic needs and prevent post-stroke depression. Family attitudes toward helping stroke patients adapt and prevent post-stroke depression are generally positive.

Adrien Rist (1841–1923), membre de la Société mdico-psychologique (1881) et fondateur d’une maison de santé privée à Versailles : « La Châtaigneraie » (1889) (Partie II)

A member of artistic, literary and scientific associations including the Société médico-psychologique (1881), A. Rist opened a private psychiatric clinic in Versailles in the years 1890–1891 called: La Châtaigneraie. This establishment will open its doors shortly before those of the old people's home (1892); they will complete the establishment opened in 1858: the civil hospital. In addition to his work as physician director of La Châtaigneraie, he was a medical expert at the court of Versailles. While practicing in Switzerland, he taught forensic medicine at the Law School of Lausanne. For example, A. Rist assessed Marie Christmann, a spiritualist masseuse, known as “the witch of Versailles”, who was denounced for the illegal practice of medicine and the mummified body of a woman was found in her house or Fernand-Théodore Charlatte, known as “the satyr of Saint-Cloud”, who simulated madness. Being an alienist was not without risk. He was threatened with death by an insane Arthur-Désiré Ferger who had twice escaped from the asylum; inspectors were assigned to protect him. A. Rist was a doctor fighting against alcohol abuse; the head office of the Versailles section of the French Anti-Alcohol Union was located at his home 11 rue des Deux Moulins. The National League against Alcoholism has founded “rooms of the soldier” in different cities of France (Cherbourg and Le Havre). A. Rist had one such room located at 29 rue de Béthune (Versailles). Author of “La philosophie naturelle intégrale les rudiments des sciences exacts” (1904), A. Rist shows us his pronounced taste for mathematics which inclined him more towards the physical sciences and their speculative aspect than towards biology, a discipline of observation and experimentation. In this second part, A. Rist appears to be a man of conviction and opinion. He was Dreyfusard and Republican. He was among the signatories of the “Appel à l’Union” (1899) like his friend Gabriel Monod (1844–1912), a member of the Institute. This founding document aimed to calm the political situation in the middle of the Dreyfus affair in order to save the parliamentary republican regime then in place. He does not hesitate to take up the pen to oppose Ferdinand Brunetière (1849–1906); director of the Revue des Deux Mondes, he was an antidreyfusard but not an antisemite. The latter had declared war on the scientific spirit and on Science which was not the point of view of A. Rist. In a national daily newpapers, he expressed his opposition to the reform of secondary education; this was a measure which had been advocated by the Minister of Public Instruction: Léon Bourgeois (1851–1925). At the end of the 19th century, A. Rist made a political commitment having being elected member of the municipal council of Versailles (1896–1900); he joined the Democratic Republican Alliance party (1901). During his career, A. Rist did not communicate or publish very much. In addition to his imposing work on “La philosophie naturelle intégrale”, we find among his works an article on phrenology published in the Dictionnaire de Dechambre, which he considered to be a science lacking a scientific basis; a case of idiopathic anorexia, which he said was a mental illness caused by a direct attack on the nerve center that regulates the need to eat; a case of forensic expertise on an anarchist sentenced to prison because he was not fit for internment. He was also supposed to publish a second volume of his natural philosophy, but it never saw the light of day. He died in November 1923, “La Châtaigneraie” closed its doors.

Utilisation of Coir Fiber as Reinforcement in M20 Concrete Mix

Sustainability is a wide accepted concept in modern construction scenario. Even though the construction industry is revolutionizing in a significant manner in terms of both equipment and materials used, the cost of construction has skyrocketed along with the deteriorative impact on environment. This resulted in the adoption of a more balanced approach with the environment as its nerve centre to create a better world to live in. This has led to the adoption of a natural fiber like Coconut for the strength enhancement in concrete. Concrete needs to be reinforced in order to improve its engineering qualities. Coconut fibers were employed for this study since they are widely accessible and come in big numbers. The study includes a comparison of the qualities of regular concrete and concrete reinforced with coconut fiber based on laboratory experimentation. Concrete with different fiber contents was evaluated with conventional concrete or prestressed concrete and different strengths parameters such as bending, compression and tensile strength of coconut fiber of length 25, 50, and 75 mm were added with proportions (0.5%, 1%, 1.5% and 2%) of total weight of the volume of concrete coconut fibre is carried out. The various strength aspects analysed are the flexural, compressive and tensile strength of the coconut fibre reinforced concrete.

Hearing, balance, and imaging assessment in adolescent Menière's disease: A retrospective analysis.

To retrospectively analyze clinical features in adolescent Menière's disease (MD). The medical records of adolescents with MD (11-17 years old) from May 2014 to March 2023 in Shandong Provincial ENT Hospital were retrospectively analyzed, including clinical features, a battery of auditory and vestibular function tests, sensory organization test, and imaging assessments. Patients with recurrent vertigo of childhood (RVC) were as controls. Compared with RVC, adolescent MD showed higher pure tone average threshold (p < .001), lower speech discrimination score (p = .014), and lower otoacoustic emission pass rates (p = .005). Adolescents with MD exhibited significant reduction in equilibrium score (Conditions 1, 5, and 6; p1 = .035; p5 = .033; p6 = .003), composite sensory score (p = .014), and vestibular sensory score (p = .029). Adolescents with bilateral MD exhibited worse performance in equilibrium score and strategy score compared to adolescents with unilateral MD. For the affected ear, the more severe endolymphatic hydrops detected by gadolinium-enhanced magnetic resonance imaging, the higher the auditory brainstem response threshold (r = .850, p = .007), and the lower the otoacoustic emission pass rate (r = -.976, p < .001). Adolescent MD has similar vestibular information inputs with that of RVC, but the ability for the nerve center to use these clues to maintain balance is worse in adolescents with MD. There were potential differences in vestibular weights in adolescents with unilateral and bilateral MD, also potential effects on vision and proprioception. Level 4.

Reseña de «Estados mórbidos. Desgaste corporal en la vida contemporánea»

Estados Mórbidos. Desgaste Corporal en la Vida Contemporánea (Morbid States. Corporal Wear and Tear in Contemporary Life) is a feminist ethnography on the Central Sensitization Syndrome (CSS) −a disruption of nerve centres which causes chronic diseases such as fibromyalgia and chronic-fatigue. Méndez de la Brena takes distance from the hegemonic medical approach, and embraces an anthropological and a gender perspective to investigate the handling of the diseases and unravels new forms of resistance. The book can be briefly defined as a necro-political analysis of the disease in its material existence and of the production of knowledge and practices of resistance of women in a neoliberal context.

Smart Unary Multilevel Marketing

The "Raksham" project stands as a cutting-edge Unilevel Marketing platform meticulously engineered to promote and distribute Raksham Ayurvedic health-conscious products. Harnessing a sophisticated amalgamation of HTML, CSS, JavaScript, MySQL, and PHP technologies, Raksham orchestrates a seamless and intuitive interface for interactions between distributors and end-users, redefining the paradigm of online marketing and sales. The Admin Portal emerges as the nerve center of Raksham, furnishing distributors with an array of powerful tools and features to streamline their operations. These include dynamic dashboards that furnish real-time insights into team performance, robust profile management capabilities, streamlined package enrollment processes, agile payment systems for seamless financial transactions, and sophisticated team management functionalities. These tools empower distributors to monitor their business performance meticulously, manage their teams effectively, and orchestrate secure and efficient financial transactions with ease. On the end-user front, Raksham presents a captivating and user-centric interface designed to enhance the shopping experience and foster customer engagement. Through features like intuitive messenger services facilitating seamless communication between users and distributors, comprehensive product catalogs showcasing the diverse range of Raksham products, and streamlined order tracking mechanisms, Raksham ensures that end-users can navigate the platform effortlessly, make informed purchasing decisions, and track their orders with convenience. The strategic integration of these features within Raksham's technological infrastructure not only augments operational efficiencies for distributors but also enhances user satisfaction and engagement among end-users. By leveraging state-of-the-art technologies and a user-centric design philosophy, Raksham solidifies its position as a formidable contender in the realm of Ayurvedic health-conscious products, poised to revolutionize the landscape of online marketing and sales in this domain. Keywords: The Advertising, Business ,Social , Network Service, Internet, Data Mining, Website

Changes in Perceived Emotions in Facial Paralysis Patients After Depressor Anguli Oris Excision.

Depressor anguli oris (DAO) excision can improve clinician-graded, objective, and patient-reported smile outcomes in patients with nonflaccid facial paralysis (NFFP). However, no prior research has studied changes in perceived emotions after surgery. This study quantifies changes in perceived emotions with smiling after DAO excision in the largest case series presented to date. Prospectively collected data from patients with NFFP who underwent DAO excision at a tertiary care facial nerve center were reviewed. Patient-reported, clinician-graded, and objective smile metrics were compared before and after surgery. Videos of faces at rest and while smiling were analyzed by artificial intelligence-derived facial expression analysis software to quantify perceived emotions. Sixty-eight patients underwent isolated DAO excision between August 2021 and August 2023. Patients conveyed significantly more perceived happiness with smile and at rest after surgery (p < 0.001 and p = 0.012, respectively). DAO excision improved oral commissure excursion (p < 0.001), dental show (p < 0.001), and smile angle (p < 0.001) symmetry. Patients reported significant improvements in smiling and social function after surgery. This study demonstrates DAO excision increases perceived happiness conveyed by patients with NFFP while smiling and at rest. It confirms improved objective, clinician-graded, and patient-reported smile outcomes after surgery. 4 Laryngoscope, 134:4028-4035, 2024.

Reflections on the Construction of Strategic Performance Management System in Chinese Manufacturing Enterprises

In the surge of global economic integration, China's manufacturing industry is poised at the forefront of a transformational upgrade. Beyond the hum of production lines, the vital pulse lies within the robust rhythm of Strategic Performance Management Systems (SPMS). Yet, studies indicate that despite China's manufacturing sector advancing towards "intelligent manufacturing" and innovation, there are numerous areas within strategic performance management systems that urgently demand enhancement. In the coming years, for China's manufacturing industry to secure higher value positioning within the global supply chain and assert dominance in niche markets, it must seize the nerve center of strategic performance management. Confronted with a series of challenges including slowing growth, rising costs, and tightening environmental regulations, manufacturing enterprises urgently need to construct an efficient and precise performance management system. However, in reality, many enterprises still exhibit a weak strategic execution, lacking a systematic performance orientation and employee incentive mechanisms, often resulting in a disconnect between strategic objectives and performance management. The factors affecting the effective implementation of strategic performance management within enterprises are intricate. Internal factors primarily encompass the rigidity of corporate culture, bottlenecks in leadership style and employee engagement, as well as hindrances in information sharing and communication mechanisms. External factors involve the volatility of market environments, unclear policy directions, and intensifying international competition. The formulation of a comprehensive performance management system undoubtedly holds profound significance for optimizing resource allocation, reinforcing core competitiveness, and enhancing strategic responsiveness.

Research on the Spatial Network Structure of Tourist Flows in Hangzhou Based on BERT-BiLSTM-CRF

Tourist flows, crucial information within online travelogues, reveal the interactive relationships between different tourist destinations and serve as the nerve center and link of the tourism system. This study takes Hangzhou, China, as a case to investigate the spatial network structure of its tourist flows. Firstly, a BERT-BiLSTM-CRF model and pan-attraction database are built to extract tourist attractions from online travelogues and create the tourist flow matrix. Then, this study uses social network analysis (SNA) to examine the structure of the tourist flow network from a county-level perspective. Additionally, GIS spatial analysis methods are applied to analyze the evolution of the tourist gravity center and standard deviation ellipse (SDE) of the network. The results reveal that the identification performances of the tourist flow extraction model this study proposed are significantly better than those of previous mainstream models, with an F1 value of 0.8752. Furthermore, the tourist flow network in Hangzhou displays a relatively sparse and unbalanced distribution, forming a “Core–Semi-Periphery–Periphery” structure. Lastly, from 2020 to 2022, the network’s gravity center experienced a shift towards the southwest, paralleled by an initial expansion and subsequent contraction of the SDE in the same southwest direction. These findings provide valuable insights into the spatial network structure of tourism in Hangzhou and can serve as a reference for policymakers to promote the “all-for-one” tourism.

Effect of Intelligent Health Education Based on Health Belief Model on Patients With Kinesophobia After Surgical Treatment of Cervical Spondylosis

To explore the application effect of intelligent health education based on the health belief model on patients with postoperative kinesophobia after surgical treatment of cervical spondylosis. A prospective cohort study was conducted with patients who underwent anterior cervical discectomy, decompression, and fusion surgery with a single central nerve and spine center, and who had postoperative kinesophobia, ie, fear of movement. The patients made voluntary decisions concerning whether they would receive the intervention of intelligent health education. The patients were divided into a control group and an intelligent education group and the intervention started on the second day after the surgery. The intelligent education group received intelligent education starting from the second day after surgery through a WeChat widget that used the health belief model as the theoretical framework. The intelligent health education program was designed according to the concept of patient problems, needs, guidance, practice, and feedbacks. It incorporated four modules, including knowledge, intelligent exercise, overcoming obstacles, and sharing and interaction. It had such functions as reminders, fun exercise, shadowing exercise, monitoring, and documentation. Health education for the control group also started on the second day after surgery and was conducted by a method of brochures of pictures and text and WeChat group reminder messages. The participants were surveyed before discharge and 3 months after their surgery. The primary outcome measure compared between the two groups was the degree of kinesophobia. Secondary outcome measures included differences in adherence to functional exercise (Functional Exercise Adherence Scale), pain level (Visual Analogue Scale score), degree of cervical functional impairment (Cervical Disability Index), and quality of life (primarily assessed by the Quality of Life Short Form 12 [SF-12] scale for psychological and physiological health scores). A total of 112 patients were enrolled and 108 patients completed follow-up. Eventually, there were 53 cases in the intelligent education group and 55 cases in the control group. None of the patients experienced any sports-related injuries. There was no statistically significant difference in the primary and secondary outcome measures between the two groups at the time of discharge. At the 3-month follow-up after the surgery, the level of kinesophobia in the intelligent education group (25.72±3.90) was lower than that in the control group (29.67±6.16), and the difference between the two groups was statistically significant (P<0.05). In the intelligent education group, the degree of pain (expressed in the median [25th percentile, 75th percentile]) was lower than that of the control group (0 [0, 0] vs. 1 [1, 2], P<0.05), the functional exercise adherence was better than that of the control group (63.87±7.26 vs. 57.73±8.07, P<0.05), the psychological health was better than that of the control group (40.78±3.98 vs. 47.78±1.84, P<0.05), and the physical health was better than that of the control group (43.16±4.41 vs. 46.30±3.80, P<0.05), with all the differences being statistically significant. There was no statistically significant difference in the degree of cervical functional impairment between the two groups (1 [1, 2] vs. 3 [2, 7], P>0.05). Intelligent health education based on the health belief model can help reduce the degree of kinesophobia in patients with postoperative kinesophobia after surgical treatment of cervical spondylosis and improve patient prognosis.

Smart Billing Software

The set of solutions offered by the Business Operation Support System revolves around Smart Billing Software. Because billing is the nerve centre of the company, it oversees all the important data, including product catalogues, customers, rates, taxes, financial accounting, invoices, payments, debit and credit notes, dual ledgers, support for multiple currencies, and more. You can manage any business operation involving metered charges, recurring charges, event-based charges, and ad-hoc charges with the help of Smart Billing Software's engine, which offers unparalleled flexibility in setting up any kind of product, product packages, user-defined rating structures, tax rules, and more. With Smart Billing Software, any service model and offering can be easily integrated into a single platform. It is compatible with both pre-paid and post-paid payment systems. Due to its open API foundation, Smart Billing Software is highly compatible with other BOSS products, allowing for the construction of comprehensive solutions. Smart Billing is a pre-integrated component of Xsinfosol Solutions and is one of the BOSS solutions offered by Xsinfosol.

Change in Thrombin Time in Epiphysectomized Animals With Simultaneous Dereception of the Olfactory Bulb

Despite a comprehensive study of the neuro-reflex and humoral-hormonal mechanism of regulation of the functional blood coagulation system, the role of the epiphysis in the mechanism of regulation of hemostasis is still not fully understood. It has been established that the epiphysis is one of the main transducers that transmit light information to the neurohormonal regulation of functional systems and determine their chronophysiological features. The olfactory tract coming out of the olfactory bulb consists of several bundles that are directed to different parts of the forebrain: the anterior olfactory nucleus, olfactory tubercle, preperiform cortex and part of the nuclei of the amygdala complex. The molecules of the odorous substance come into contact with the mucous membrane of the nasal passages, interact with specialized proteins embedded in the receptor membrane, as a result of which a receptor potential is generated in the receptor, and then impulse activity. The excitation transmitted along the fiber of the olfactory nerve enters the olfactory bulb, the primary nerve center of the olfactory analyzer.

Moving from a Textual to Visual Medium: Transposition of Ruskin Bond’s The Blue Umbrella to the Cinematic Canvas

Intertextuality, which emphasizes the interaction of various works of art, is associated with adaptation studies. According to comparative literature scholar James Naremore, modern life's nerve center is remaking. Additionally, based on the interpretation of the original source material, remaking brings out ideological and aesthetic beliefs. According to the intertextuality school of thought, the novel always comes before the movie, but a consumer is more likely to see the movie first. However, the novel and the movie complement one another visually and aesthetically due to the components they contain. The study attempts to explore how Vishal Bharadwaj's adaptation of Ruskin Bond's novella The Blue Umbrella differs from the original and how they stay connected. The paper will try to find aspects of film and literature that are not easily changeable while considering the convergence of these two art forms.

Effects and mechanisms of acupuncture analgesia mediated by afferent nerves in acupoint microenvironments.

In the past few decades, the use of acupuncture analgesia in clinical practice has increased worldwide. This is due to its various benefits, including natural alleviation of pain without causing various adverse effects associated with non-steroidal anti-inflammatory drugs (NSAID) and opioids. The acupoint represents the initial site of acupuncture stimulation, where diverse types of nerve fibers located at the acupoint hold significant roles in the generation and transmission of acupuncture-related information. In this study, we analyzed the patterns and mechanisms of acupuncture analgesic mediated by acupoint afferent fibers, and found that acupuncture stimulates acupoints which rapidly and directly induces activation of high-density primary afferent fibers under the acupoints, including myelinated A fibers and unmyelinated C fibers. During acupuncture stimulation at the muscle layer, the analgesic effects can be induced by stimulation of A fiber threshold intensity. At the skin layer, the analgesic effects can only be produced by stimulation of C fiber threshold intensity. Electroacupuncture (EA) activates A fibers, while manual acupuncture (MA) activates both A and C fibers. Furthermore, acupuncture alters acupoint microenvironments, which positively modulates afferent fibers, enhancing the transmission of analgesic signals. In addition to local activation and conduction at acupoints, nerve fibers mediate the transmission of acupuncture information to pain centers. In the spinal cord, acupuncture activates neurons by inducing afferent fiber depolarization, modulating pain gating, inhibiting long-term potentiation (LTP) of the spinal dorsal horn and wide dynamic range (WDR) neuronal activities. At higher nerve centers, acupuncture inhibits neuronal activation in pain-related brain regions. In summary, acupuncture inhibits pain signal transmission at peripheral and central systems by activating different patterns of afferent fibers located on various layers of acupoints. This study provides ideas for enhancing the precise application and clinical translation of acupuncture.

Analysis of the impact of financial market development on China's national economy

Finance serves as the nerve center in the modern economic model, connecting various modern economic sectors and reflecting the development status of each modern economic sector. In the past 20 years, the international situation has been turbulent, and international economic development and recovery are also full of instability. The global interest rate hike frenzy led by the Federal Reserve has also added more risks to the stability of the financial environment. Currently, China is at a critical node in the transformation of its economic structure from growth to quality. The economic development structure also reflects the shift from a real-based economy to a virtual economy. The unbalanced characteristics of the transformation, in which the flow of financial capital can adjust the focus of the structure of economic development, and at the same time reflect the scope of benefits of economic development dividends, what role finance plays in the growth of China's national economy will be based on statistics Analyze and conduct research.

1808 QIP to improve the board round process on a general geriatric medicine ward

Abstract Introduction Effective board rounds improve the patient’s experience and reduce the risks associated with a prolonged hospital stay. Ward C54 at Queen’s Medical Centre is a 30-bedded ward dedicated to the provision of care for older, frail (CFS ≥ 6) patients. Board round on C54 was unstructured and could take over an hour. The project team set out to reduce the duration of board round, improve the quality of information handed over and improve staff satisfaction with board round. Method Pre- and post-intervention data on the daily duration of board round were collected by the junior doctors on the ward. PDSA methodology was then used to test the following interventions: 1. Nerve centre updated daily by the junior doctor responsible for that bay 2. Junior doctors to present information using 4Q approach 3. Staff nurse in each bay highlighting any issues for that bay. Pre- and post-intervention surveys were also distributed to staff working on C54. Results The duration of board round was reduced from an average of 52 minutes to an average of 38 minutes post-intervention. Over 90% of survey respondents believed the board round to be more efficient and over 80% were either satisfied or very satisfied with board round duration. Conclusions The findings have shown it is possible to improve the duration of and staff satisfaction with board round by giving MDT members a framework to help structure handover of written and verbal information. Future considerations include providing teaching sessions to staff on the board round process.

Analisis Perkembangan Fisik Motorik Anak Melalui Kegiatan Bermain

Real work education (KKN) is an education in the form of community service. In this service, students apply the theories they have after studying for several semesters into a real form of community service. In this service, students carry out several activities that develop children's physical motor skills. Physical development is the growth or changes experienced in a person's body which are clearly visible from changes in the shape and size of a person's body. Motor development is controlling the development of body movements through coordinated activity of muscles, nerves and nerve centers. Therefore, a child's physical motoric development is a process that the child goes through regarding the growth and development that occurs in the child. The aim of this research is to find out the extent of children's physical motor development through real work lecture activities.

Mechanism and Evidence of the Impact of Foreign Investment on Foreign Trade in Jiangsu Province

Since the modernization initiatives and opening up of China, the trajectory of national economic and social development has surged forward. Highlighted in the report of the Twentieth Party Congress, through a more proactive opening-up strategy, China has orchestrated a dynamic framework of international engagement on a broader scale, spanning diverse sectors, and with increased profundity. Notably, the ascendancy of China's foreign trade has been monumental, with the trade volume skyrocketing to 39.1 trillion yuan in 2021, a staggering increment from the turn of the millennium. Jiangsu Province, a pinnacle of export-driven economic prowess in China, benefits from its strategic placement in the eastern coastal belt, leveraging both its geographical advantage and rich resources. Serving as the nerve center of the Yangtze River Delta, Jiangsu is also a crucial nexus in the "One Belt, One Road" initiative, bridging regions such as Beijing, Tianjin, and Hebei. Propelled by the collaborative spirit of the "Belt and Road" nations, the infrastructural evolution of the Jiangsu Pilot Free Trade Zone has seen exponential growth, bolstering Jiangsu's outward-focused economy. As such, a meticulous examination of foreign investment trends in Jiangsu can illuminate invaluable insights for shaping the foreign economic stratagem of the province. This, in turn, can act as a catalyst to refine China's FDI blueprint and champion a paradigm of sustainable excellence in development.