Abstract Introduction Psoriasis is a chronic, inflammatory skin disorder affecting millions globally. In low-income countries like Nepal, the economic burden of managing psoriasis is compounded by limited healthcare resources, inadequate access to treatments, and socio-economic constraints. Aim To assess the prevalence and severity of psoriasis in Nepal. To evaluate the direct and indirect economic costs associated with psoriasis management. To identify gaps in healthcare infrastructure and access to treatment. To propose cost-effective strategies to improve psoriasis care and reduce its economic impact. A mixed-methods approach was employed for a year, including:Epidemiological analysis: Reviewed existing literature and health records to estimate psoriasis prevalence and severity in Nepal.Cost analysis: Calculated direct costs (medical expenses, hospital visits, medications) and indirect costs (loss of productivity, absenteeism) through patient surveys and healthcare data.Qualitative interviews: Conducted in-depth interviews with healthcare providers, patients, and policymakers to understand the barriers to effective psoriasis management.Policy review: Analysed national health insurance policies and their effectiveness in addressing psoriasis care. Results Prevalence: Approximately 2–3% of the Nepalese population is affected by psoriasis, with varying degrees of severity. Economic burden: The average annual cost per patient is significant, encompassing medical expenses, travel costs for treatment, and loss of income due to reduced work capacity. Healthcare gaps: Limited availability of dermatologists, high cost of biologic treatment which is not easily available, taking OTC drugs and lack of public awareness are major barriers. Patient impact: Psoriasis patients in Nepal face considerable socio-economic challenges, including stigma, reduced quality of life, and mental health issues. Conclusion The findings indicate that psoriasis imposes a substantial economic burden on both individuals and the healthcare system in Nepal. The lack of specialized care in rural areas and high treatment costs exacerbate this burden. There is an urgent need for integrated healthcare approaches, increased health insurance facility for psoriasis care, and public health initiatives to raise awareness and reduce stigma. Addressing the health economic impact of psoriasis in Nepal requires a multifaceted strategy, including policy reforms, improved access to affordable treatments, and enhanced healthcare infrastructure. By implementing cost-effective and sustainable interventions, it is possible to alleviate the economic burden of psoriasis and improve the quality of life for affected individuals.
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