There is a growing recognition that the post-rifting phase of basin evolution is far from being tectonically quiescent, as it can involve episodic uplift. However, the dynamic mechanisms responsible for this phenomenon remain a subject of controversy, particularly for intra-plate basins situated distant from active plate boundaries. Accurately determining the timing and magnitude of uplift is essential for elucidating the driving model behind these processes. In this study, we document the thermal history of the Doseo basin within the West and Central Africa Rift System (WCARS) using a combination of apatite fission track analysis and vitrinite reflectance data. Our findings reveal a period of accelerated exhumation during the late Eocene to Miocene epoch (∼45-20 Ma), characterized by kilometer-scale uplift, which corresponds to the formation of angular unconformities, folds, and fault-related anticlines. This specific time interval appears to be critical for the Cenozoic petroleum system, coinciding with the peak maturation of source rocks and the simultaneous formation of compressional traps. When integrated with the seismic data and previously published thermochronological data, our research reveals two significant cooling and uplift events in WCARS: a Santonian extrusion event and a late Eocene exhumation event. Both of these events have the potential to impact the entire tectonic plate, and Tethys realm. Furthermore, this two-stage exhumation event aligns closely with the timing of the Africa-Europe convergence collision. Consequently, we come to conclude that far-field lateral compression emerges as the dominant driving mechanism for intra-plate uplift, outweighing the influence of the mantle model.