Neoplastic Thyroid Lesions Research Articles

Fine needle aspiration of thyroid nodules: three years' experience.

To overcome the difficulties arising in the management of cold nodules of the thyroid--many are unnecessarily resected because of the risk of malignancy--fine needle aspiration cytology was used in the assessment of thyroid lesions in 113 patients. Aspirates were categorised into three groups as follows: group (i), consistent with simple goitre or cyst; group (ii), suspicious of underlying cellular lesion or tumour; group (iii), malignant. Resections for simple goitre were reduced from eight of 14 (40%) to two of 42 (3%) over three years, and the yield of neoplastic lesions coming to surgery as a result of aspiration increased from two of 12 (16%) to nine of 14 (69%) over the same period. It is concluded that fine needle aspiration cytology is an effective means of discriminating between simple and neoplastic thyroid lesions. This permits more appropriate patient management and a beneficial saving of resections for simple goitre. False negative diagnoses (two cases) in our series are of more concern than false positive results, but can be minimised by careful attention to sampling and cytological detail.

Dose-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low dose 3'-methyl-4-dimethylaminoazobenzene promotion.

Dietary administration of 0.1, 0.05, or 0.025% 2‐amino‐3‐methylimidazo[4,5‐f]quinoline (IQ) for two weeks combined with partial hepatectomy at the end of the first week and followed by long‐term treatment with phenobarbital (PB) or 3′‐methyl‐4‐dimethylaminoazobenzene (3′‐MeDAB) from week 3 to week 86 resulted in dose‐dependent development of liver and thyroid neoplastic and preneoplastic lesions. Quantitation of glutathione S‐transferase placental form (GST‐P)‐positive hepatocellular focal populations revealed a significant correlation of IQ concentration with lesion area, with a yield approximately equal to that generated by a similar dose of 2‐acetylaminofluorene. The fact that IQ was less toxic therefore allowed greater yields of hepatocellular carcinomas to be induced. The development of thyroid tumors initiated by the IQ treatment was significantly enhanced by the administration of PB, whereas Zymbal gland tumors induced by IQ did not show any correlation with either PB or 3′‐Me‐DAB treatment.