Neoplastic Mass Research Articles

Comparison of clinicopathological and preoperative computed tomography findings of sinonasal masses

Background and objectives: Computerized tomography (CT) scan with contrast can delineate soft tissue pathologies and is now the first choice in diagnosing sinonasal malignancy and inflammatory lesions. The present study compared the diagnostic nasal endoscopy (DNE) and CT scan to diagnose cases presented with sinonasal mass. Materials and methods: This was a descriptive study conducted on patients with sinonasal masses attending at Government TD Medical College, Alappuzha, Kerala from 1/1/2014 to 30/6/2015. Each patient was examined by diagnostic nasal endoscopy and had undergone preoperative CT scan. Histopathological examination of the specimens was carried out and compared with the findings of DNE and CT scan. Results: A total of 72 cases were enrolled in the study. Age group was from 13-85 years with a male to female ratio of 1.3:1. Nasal obstruction was the commonest symptom. Among the 72 cases, 59 belonged to the non-neoplastic group and 13 to the neoplastic group. Sinonasal polyps (65.3%) formed the majority of the non-neoplastic lesions. Vascular lesions (6.9%) were the commonest benign neoplastic mass and malignancy was seen in 6.9% of cases. Diagnosis by DNE and CT scan was same except in 3 cases. Histopathology and radiological scan result correlated well except in 3 cases. Conclusion: Histopathology still remains the gold standard in the diagnosis of sinonasal masses. Clinical, CT scan and histopathology diagnoses were complementary with each other. However, CT scan is indispensible in studying the anatomical variants and providing the route map prior to and during endoscopic sinus surgeries. IMC J Med Sci 2022; 16(1): 008 *Correspondence: Santhi Thankappan Pillai, Department of Otorhinolaryngology, Government TD Medical College, Vandanam, Alappuzha, Kerala 688005, India. Email: sttpillai@gmail.com

Immunophenotyping of intraepithelial lymphocytes in canine chronic enteropathy and intestinal T-cell lymphoma using endoscopic samples.

Human enteropathy-associated T-cell lymphoma (EATL) is considered to be derived from intraepithelial lymphocytes (IELs); however, the origin of canine intestinal T-cell lymphoma (ITCL) remains unclear. Histological, immunohistochemical, and clonality examinations were performed using endoscopically collected canine duodenum samples of mucosal lesions of chronic enteropathy (CE; 73 cases) and ITCL without transmural neoplastic mass lesions (64 cases). Histopathological examinations revealed the intraepithelial accumulation of lymphocytes (called "intraepithelial lymphocytosis") in 54/73 CE cases (74%) and the epitheliotropism of neoplastic lymphocytes in 63/64 ITCL cases (98%). Immunohistochemically, IELs in CE with intraepithelial lymphocytosis (IEL+CE) were diffusely immunopositive for CD3, with scattered immunopositivity for CD5, CD8, CD20, and granzyme B (GRB). The percentage of CD8+ in CD3+ IELs was significantly lower in IEL+CE than in CE without intraepithelial lymphocytosis (IEL-CE). Double-labeling immunohistochemistry revealed a high percentage of GRB expression in CD8- IEL among IEL+CE. Among 64 ITCL cases, CD3 was immunopositive in 64 (100%), CD5 in 22 (34%), CD8 in 8 (13%), CD20 in 12 (19%), CD30 in 13 (20%), and GRB in 49 (77%). In CD3+ cells, Ki67 immunopositivity was highest in ITCL, intermediate in IEL+CE, and lower in IEL-CE. A clonal TCR gene rearrangement was detected in 1/19 IEL-CE cases (5%), 15/54 IEL+CE (28%), and 38/58 ITCL (66%). These results indicate that the immunophenotype of canine ITCL (CD8-GRB+) is similar to that of the increased IELs in CE. The high proliferative activity and clonality of T cells in IEL+CE suggest that canine ITCL originates from these IELs, similar to human EATL.

OC03.06: Origin of acoustic shadowing as a discriminatory tool in determining the nature of neoplastic adnexal masses

Acoustic shadowing is considered a predictor of benignity in adnexal masses but may also be seen in malignant ones. We aimed to investigate whether the origin of the shadow can help determine the nature of a mass. This was a retrospective multicentre study of neoplastic adnexal masses with known histopathology, which showed acoustic shadowing on preoperative sonography. Two examiners reviewed the images and video clips, and reached consensus. The study included 100 adnexal masses with 25 different histopathologic diagnoses. More than 80% of the masses with shadowing from cystic contents (e.g. dermoid) or solid tissue because of inherent structural features (e.g. fibroma) were benign. When shadowing from solid areas arose in calcific foci (e.g. immature teratoma) or along fibrovascular tissue (e.g. serous carcinoma), 80-90% were malignant. Shadows from the margins of locules, or intracystic septae imaged perpendicularly or obliquely appeared non-informative. There was one case of shadowing from calcific foci in the walls of a mucinous cystadenoma (figure 1). Acoustic shadowing in an adnexal mass can have different connotations depending on the structure causing the attenuation. Of particular importance are shadows along the fibrovascular structures in solid tissue, which may result in malignant masses being erroneously classified as ‘likely benign’. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

A RARE CASE OF MATURE CYSTIC TERATOMA OF THE URINARY BLADDER

Introduction: Mature cystic teratomas or dermoid cysts are benign “tumors” which arise from more than one germ cell layer. These occur most commonly in the ovaries. Urinary bladder is an extremely rare site. Only few cases of urinary bladder dermoid cysts have been documented in the literature. Case report: We present a rare case in which a 29-year-old female patient presented with hematuria, passage of hairs in urine and painful micturition. Urinary bladder dermoid cyst along with vesicular calculus was diagnosed on imaging and cystoscopy and conrmed after surgery by histopathological examination. Conclusion: Bladder dermoids mimic bladder calculus and neoplastic mass lesion both clinically and radiologically. Correct diagnosis can be achieved by multimodality imaging, cystoscopy and conrmed on histopathology.

The Value of Contrast-Enhanced Ultrasound (CEUS) in Differentiating Testicular Masses: A Systematic Review and Meta-Analysis

Ultrasound (US) still represents the mainstay of scrotal imaging. However, contrast-enhanced ultrasound (CEUS) is a relatively novel, but increasingly utilized diagnostic modality. In consequence, we performed a systematic review (SR) and pooled meta-analysis to investigate the diagnostic performance of CEUS in the evaluation of testicular masses (TM). A SR up to June 2021 was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The diagnostic performance of CEUS was evaluated basing on two different endpoints: neoplastic vs. non-neoplastic and malignant vs. benign TM. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) from eligible studies were pooled and summary receiver operating characteristic (SROC) curves were constructed for each endpoint. Overall, six qualified studies were deemed suitable for this meta-analysis. Diagnostic performance of CEUS showed an accuracy of 0.96 in detecting neoplastic masses (sensitivity of 0.89, PPV of 0.85, specificity of 0.62, and NPV of 0.69) and an accuracy of 0.96 in detecting malignant masses (sensitivity of 0.86, PPV of 0.73, specificity of 0.87, and NPV of 0.91). Taken together, CEUS may represent a promising minimally invasive diagnostic tool for characterization of TM, since it allows clinicians to identify neoplastic lesions and exclude malignant tumor.

The many faces of neurofibromatosis type 1 in the pediatric brain

Background Neurofibromatosis type 1 (NF1) is the most common neurocutaneous syndrome. It is diagnosed based on a group of clinical criteria that were established by the National Institute of Health in 1988, yet, NF1 remains a challenging disorder to diagnose, mainly in the pediatric-age group. Aim The purpose of this study was to highlight the different MRI findings encountered in the brain of NF1 pediatric patients in order to evaluate if some of these findings can be added to the diagnostic criteria of NF1 and to assess the role of MR spectroscopy in differentiating non-neoplastic from tumefactive neoplastic lesions. Patients and methods This study was a single-center retrospective review of available brain MRIs from 40 children with NF1 in the period from June 2018 to January 2020. MRI examinations were done on a 1.5-Tesla MRI scanner. Magnetic resonance spectroscopy (MRS) was done in selected cases to differentiate foci of abnormal signal intensity (FASI) from neoplastic tumefactive lesions and assess the grade of such neoplastic masses. Results The studied group included 23 females (57.5%) and 17 males (42.5%) with mean age of 7.4±4.4 years. The findings encountered in MRI included FASI in all 40 patients (100%), brain neoplastic lesions in 24 patients (52.5%),18 of which were optic pathway gliomas and six were nonoptic gliomas, while five patients (12.5%) showed thickened corpus callosum. MRS was significantly different in tumefactive neoplastic lesions from FASI with elevated choline and reduced N-acetyl aspartate (NAA) in the former. Choline/creatine, NAA/choline, and NAA/creatine ratios were 3.7±0.93, 0.20±0.17, and 0.37±0.06, respectively, in neoplastic lesions compared with 0.74±0.13, 1.5±0.18, and 1.5±0.13, respectively, in FASI. Conclusion Pediatric neuroradiologists should be familiar with the different pathologies encountered within the brain of NF1 patients, not just obvious optic pathway gliomas, but more importantly the underlooked FASI. We recommend that these FASI should be included in the diagnostic criteria for NF1. MRS is also recommended to differentiate questionable tumefactive neoplastic lesions from FASI.

Accuracy of MRI in the Differential Diagnosis of Wilms Tumor

Background & Objective: Renal tumors are a common finding in diagnostic imaging; these lesions usually are solid or cystic, benign or malignant, and the correct diagnosis may be difficult. The current study aims at to determine the diagnostic accuracy of magnetic resonance imaging for the diagnosis of Wilms tumor taking histopathology as gold standard. Methodology: This cross-sectional study was carried at the Department of Radiology, The Children’s Hospital & Institute of Child Health Lahore over 6 months from March 2019 to September 2019. The study involved 125 children of both genders aged between 2 years to 14 years presenting with a neoplastic mass in the retroperitoneum on ultrasound abdomen during initial workup. These children were assessed on MRI for the diagnosis of Wilms tumor. Later the diagnosis was confirmed on histopathology which was taken as gold standard and the diagnosis of MRI was judged accordingly as true/false and positive/negative. A written informed consent was obtained from every patient. Results: The mean age of the children was 5.8±3.9 years having a male predominance with male to female ratio of 1.8:1. Wilms tumor was suspected in 13 (10.4%) children on MRI. The diagnosis of Wilms tumor was confirmed in 13 (10.4%) children on histopathology. MRI was found to be 76.9% sensitive, 97.3% specific and 95.2% accurate with positive and negative predictive values of 76.9% and 97.3% respectively. Conclusion: In the present study, MRI was found to be 95.2% accurate in the differential diagnosis of Wilms tumor in children presenting with retroperitoneal mass which along with its non-invasive and radiation free nature advocates the preferred use of MRI in the diagnostic evaluation of such children in future oncologic practice. Keywords: Retroperitoneal Tumor, Wilms Tumor, MRI, Diagnostic Accuracy

First reported case of a histiocytic sarcoma in an Armenian hamster (Cricetulus migratorius).

A 14-month-old male Armenian hamster (Cricetulus migratorius) presented with a spontaneous, subcutaneous, firm mass (4.0 × 2.0 × 1.5 cm) on the ventral neck extending towards the cheek pouch causing multifocal small oral ulcerations. This animal was immunized subcutaneously on the dorsal neck for the development of monoclonal antibodies seven months before presentation. The animal was euthanized and necropsy was performed. Histopathology of the mass showed a well demarcated, multilobulated, unencapsulated, highly cellular, neoplastic mass composed of spindle cells arranged in interlacing streams and bundles, with a moderate amount of fibrovascular stroma. The neoplastic cells exhibited indistinct cell borders and a moderate to large amount of eosinophilic, fibrillar cytoplasm, marked anisocytosis and anisokaryosis, binucleated and multinucleated cells, and high mitotic rate. Based on the histomorphologic features of the mass, and the presence of renal tubular hyaline globules and myeloid hyperplasia in the bone marrow, a diagnosis of histiocytic sarcoma was made. The presumptive diagnosis was confirmed by immunohistochemistry, upon which the neoplastic cells showed strong immunoreactivity for the histiocytic cell markers Iba1 and CD11b. Histiocytic sarcomas have been reported in Syrian (Mesocricetus auratus) and Siberian dwarf (Phodopus sungorus) hamsters but, to our knowledge, the current report represents the first case of histiocytic sarcoma described in an Armenian hamster. It is plausible to consider the animal's experimental immunization history and the development of the histiocytic sarcoma to be related. An association between adjuvanted vaccines and soft-tissue sarcomas has been described in cats and referred to as feline injection-site sarcomas.

Metastatic gastric adenocarcinoma associated with hypertrophic gastropathy resembling Ménétrier's disease in an adult Labrador Retriever dog

We describe a case of hypertrophic gastropathy (Ménétrier’s like disease) with metastatic gastric adenocarcinoma in a seven-year-old intact female Labrador Retriever dog. The animal suddenly presented with emesis and died. Gross lesions included a marked diffuse thickening of the gastric mucosa and an ulcerated transmural neoplastic mass in the gastric body. Gastric body and fundus were affected by foveolar hyperplasia with loss of chief and parietal cells replaced by mucous cells and marked dilatation of gastric glands. An area of gastric adenocarcinoma with submucosal lymphatic vessels invasion was also present and metastases were observed in the gastric lymph nodes, small intestine, pancreas, lung and liver. Due to its similarity with other gastric proliferative disorders, including this condition in the list of differentials is a necessary step in the diagnostic investigation of canine gastropathies.

Unusual cause of urinary retention in a child: inflammatory pseudotumor of the urinary bladder

BackgroundUrinary bladder masses are uncommon in the pediatric age group and pose a diagnostic challenge, often necessitating histopathological differentiation and confirmation. An unusual mimic of neoplastic bladder mass is inflammatory pseudotumor, and timely identification and diagnosis of which prevents undue patient stress and radical treatment.Case presentationWe present a case of a 7-year-old female child who presented with hematuria, and a urinary bladder mass was detected on ultrasound which was further characterized by magnetic resonance imaging (MRI) and diagnosed as an inflammatory pseudotumor (IPT) on histopathology.ConclusionsThis case report describes the imaging features of IPT along with a list of differential diagnoses emphasizing the need for radiologists to be aware of this surprising and rare entity.

The Histopathological Analysis of 122 Cases of Ovarian Lesions

Aim: To outline various histopathological types of ovarian cysts received in our teaching hospital along with their prevalence and mode of presentation and to assess the proportion of physiologic versus pathological cysts and benign versus malignant ovarian cysts. Duration of study: From Jan 2019 to March 2021. Methods: Histopathology Department of Bakhtawar Amin Medical & Dental College & Hospital, Multan. A retrospective review of 122 ovarian lesions including physiological/functional cysts, pathological non neoplastic cysts as well as benign, borderline and malignant neoplasm. Histopathology reports of all ovarian specimens were reviewed and counted. Details like age, marital status, parity, presenting complaints, procedure opted, laterality, size, gross and microscopic details and final histological diagnosis etc were recorded. H&E stained slides of all cases were reviewed. In difficult suspicious cases, immunohistochemistry was also carried out. Percentage and proportions were calculated for all the variables. Relevant tables and charts were computed. Results: A total of 122 ovarian specimens with some lesion were segregated in histopathology department of Bakhtawar Amin Hospital from 117 patients with 5 patients having bilateral lesions. The mean age was 33.2 years (ranging from 13-71 years). Most ladies presented between 25-45 years of age. Out of these 117 patients, 18 ladies were unmarried. Out of the 99 married, 12 were nulliparous. Sixty four ladies (54.7%) found to have cysts/neoplasm in right sided ovary, forty eight (41%) presented with left sided ovarian involvement and 5 (4.3 %) presented with bilateral ovarian lesions. Conclusion: Non neoplastic ovarian cysts are more frequent as compared to neoplastic masses. Histopathological diagnosis is mandatory for final confirmatory diagnosis. Keywords: Ovarian lesions, reproductive cells, cyst

LIQUID NITROGEN CRYOSURGERY FOR CUTANEOUS AND OCULAR NEOPLASMS IN KOI (CYPRINUS CARPIO) AND GOLDFISH (CARASSIUS AURATUS): EIGHT CASES (2018-2019).

Cryosurgery, also known as cryotherapy and cryoablation, is a promising surgical technique that employs highly localized freezing to destroy damaged and diseased tissue, including benign and malignant neoplasms. This procedure has been reported in the treatment of chromatophoromas, fibromas, and peripheral nerve sheath tumors in piscine patients. This study presents eight clinical cases of cryosurgery on cyprinid pet fish for a wide array of neoplastic masses, including chromatophoromas, squamous cell carcinoma, and sarcomas that were diagnosed by histopathology. Surgical excision of external masses, liquid nitrogen cryotherapy, injectable medications (meloxicam and danofloxacin), and topical medical-grade honey were applied to the patients after biopsy sampling. Five out of seven cutaneous cases and two out of three ocular cases had complete resolution without recurrence for at least three months posttreatment. Treatment was unsuccessful for two of the cutaneous cases in which the cutaneous masses were extremely invasive, resulting in severe ulceration and deep invasion into the coelomic cavity. One of the ocular cases involved a corneal mass that did not change in size and had no complications after treatments, suggesting that the treatment might be useful in limiting growth. The effectiveness of cryotherapy appears to correlate with the tumor type, as well as the stage and progression of tumor invasion.

Detecting Imaging For Neoplastic Liver Masses in Hepatic Patients Who Received Direct Acting Antiviral Drugs

Background: Hepatocellular carcinoma makes up 75%-85% of all primary liver cancers and is the fourth most common cause of cancer related death worldwide. The aim of this study was to screen for hepatocellular carcinoma in hepatic patients who received direct acting antiviral drugs using different imaging modalities. Methods: This was a cross sectional study included 50 patients who were hepatic and received Direct Acting Antiviral '' DAA'' and were carried out at radiology department in Elobour Hospital for Health Insurance after obtaining written informed consent from all patients. Results: There were 31(62%) male, 19(38%) female, the mean age 52.28 years old with range (39-65), 35(70%) urban, 15(30%) rural. There were (70%) with duration of illness ≤ 5 years, (30%) with > 5 years, (100%) with DAA, (90%) easy to treat, (10%) difficult to treat. There were 35(70%) with average liver, 14(28%) with shrunken liver, 1(2%) with enlarged liver, 13(26%) with Bright pattern, 34(68%) with cirrhotic, 3(6%) with coarse bright, the mean P.V diameter 14.68(± 2.51 SD) with range (9-17).There were (100%) with Single focal lesion in RT lobe, the mean size 4.47with range (3.6-5.6), (33.3%) Isochoric, (33.3%) with Hypo echoic, (33.3%) with Hyper echoic, (66.7%) with malignancy. There were 3(100%) with typical CT enhancement, 1(33.3%) with P.V thrombosis. There was no one with Affection on liver vascular, no one with intrahepatic biliary radicles, no one with L.N in porta hepatis. Conclusion: Based on our findings, we recommend for close imaging evaluations after DAA in cirrhotic patients.

Role of Contrast Enhanced Cardiac MRI in Differentiation between Cardiac Masses

Background: Cardiac tumors, either benign or malignant, are rare. Malignant tumors have a poorer prognosis than benign tumors; however both are associated with significant morbidity in cases of delayed management. The goal of this study is to evaluate the diagnostic value of Cardiac MRI in tissue characterization of cardiac masses. Methods: we interpreted and analyzed separately the imaging data of 27 patients who met the inclusion criteria and performed CMR at MRI unit in National Heart Institute in Giza. Results: CMR has not only the ability to differentiate between benign and malignant lesions but also has the ability to differentiate between different types of benign tumors in most of cases by determination the location of the cardiac mass, its mobility, presence of pedicles and the variable MR signal intensity in different pre and post contrast sequences. In contrast to the malignant lesions, CMR shows a difficulty in the differentiation between different types of malignant lesions and usually needs histopathological correlation. However CMR shows a great value in determining the extent of the malignant lesions that is needed before planning the therapeutic management. Conclusion: CMR has a great role in evaluation of the cardiac masses by its powerful assessment of the anatomical and soft tissue characterization of the masses as well as their functional impact and so it allows the differentiation between neoplastic and non-neoplastic masses as well as between malignant and benign masses that is necessary in pre-therapeutic planning without the need of the unnecessary invasive biopsy.

Nonpituitary neoplastic mass lesions of the sellar region: Hematologic malignancies – A 16-year single-centre experience

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Rabdomiossarcoma botrióide na vesícula urinária de um American Pitbull Terrier

O rabdomiossarcoma botrióide é uma variante do rabdomiossarcoma embrionário e tem origem nas células musculares estriadas, ou precursores destas células, por isso podem se iniciar em partes do corpo com ausência de músculo estriado, como o trato urogenital. Geralmente, os cães acometidos são jovens até dois anos e as massas neoplásicas têm aspecto de cacho de uva. O objetivo do presente relato foi descrever um caso de rabdomiossarcoma botrióide em um cão, American Pittbull Terrier, de 16 meses que apresentou uma massa no interior da vesícula urinária, posteriormente diagnosticada através de exame histopatológico e imunoistoquímico. A massa era multilobulada, firme, rósea a vermelha com áreas multifocais de necrose e estava aderida na mucosa da região mais cranial da vesícula urinária emitindo ramificações disseminadas em direção ao trígono vesical. Microscopicamente, a neoplasia é constituída por duas populações celulares entremeadas a uma matriz mixóide, uma composta por células pequenas e redondas, com citoplasma escasso e núcleo basofílico hipercorado e a outra por células alongadas, com citoplasma eosinofílico e núcleo paracentral, ambas as populações celulares possuíam pleomorfismo moderado e 2 figuras de mitose por campo (400 x). Densidade celular aumentada foi observada abaixo do epitélio vesical. A combinação de exames complementares foi conclusiva para o diagnóstico da neoplasia.

Tumor Dormancy: Implications for Invasion and Metastasis.

Tumor dormancy refers to a critical stage of cancer development when tumor cells are present, but cancer does not progress. It includes both the concept of cellular dormancy, indicating the reversible switch of a cancer cell to a quiescent state, and that of tumor mass dormancy, indicating the presence of neoplastic masses that have reached cell population equilibrium via balanced growth/apoptosis rates. Tumor dormancy provides the conceptual framework, potentially explaining a major challenge in clinical oncology, tumor recurrence, which may occur years after cancer diagnosis. The mechanisms by which tumors are kept dormant, and what triggers their reawakening, are fundamental questions in cancer biology. It seems that a plethora of intracellular pathways and extracellular factors are involved in this process, rewiring the cells to plastically alter their metabolic and proliferative status. This phenomenon is highly dynamic in space and time. Mechanistic insights into both cellular and tumor dormancy have provided the rationale for targeting this otherwise stable period of cancer development, in order to prevent recurrence and maximize therapeutic benefit.

Papilloma and granulomatous tumors of the oral cavity mucosa of sheep in Mosul area

This study was undertaken to investigate the prevalence of papilloma virus and granulomatous reaction which occur naturally in sheep in Mosul area, Iraq. These lesion were diagnosed in 10 cases out of a total 325(3%) examined cases, papilloma percentage was 1.23% and granulomatous infection percentage was 1.84% .The gross and microscopic features of papilloma showed a red tissue nodule hanging from the inner surface (mucosa) of the lower lip .Microscopically, the mass was formed from multiple papillary protrusions of fibrous connective tissue with marked increase in the number and size of inflammatory cell . The macro and micro examination of granulomatous reaction showed a subcutaneous and neoplastic mass of tissue which were connected to the jaw bone at the level of seventh and eighth cheek teeth and upon opening the skin .A white mass was observed while the microscopic exam showed the presence of a severe fibrous reaction in the form of inflammation and neoplasm granuloma. Finally, this research determined the type of papilloma and granulomatous reaction in local sheep and their prevalence rates, with accurate description of gross and microscopic lesions.

Not Just Uterine Adenocarcinoma—Neoplastic and Non-Neoplastic Masses in Domestic Pet Rabbits (Oryctolagus cuniculus): A Review

With increasing numbers of pet rabbits living out their natural lifespan, rabbit oncology is stepping more and more into the limelight. On the other hand, rabbit tumors are less covered in recent editions of textbooks of veterinary pathology than before. We present 1238 cases with neoplastic and non-neoplastic masses in rabbit tissue, submitted from 2008 to 2019, supplemented by a review of the literature on neoplasms in rabbits. Cutaneous masses comprised 47% of submissions. Trichoblastoma was by far the most common skin neoplasm, and nodular suppurative panniculitis was the second most frequent skin nodule in this series. Epithelial as well as mesenchymal cutaneous neoplasms can be virally induced in rabbits (eg, Shope papilloma, myxomatosis) but were infrequent in the current cases. Mammary neoplasms comprised 21% of submitted masses and 94% of these had histologic features of malignancy. Tumors of the female reproductive tract were responsible for 9% of biopsies and were predominantly uterine adenocarcinoma. Polypoid proliferation of rectal mucosa was the most common lesion in the alimentary tract. A broad spectrum of other neoplasms was described, including sarcomas at vaccination sites and ocular posttraumatic sarcomas, comparable to lesions described in cats.

Role of Magnetic Resonance Imaging in Evaluation of Neonatal and Pediatric Adnexal Masses

Ovarian masses are most commonly observed in adults; they rarely occur in children. The majority of the ovarian masses encountered in children or patients of pre- menarchal age are non-neoplastic lesions. The clinical signs and symptoms of ovarian masses are usually non-specific. Early management may be necessary to preserve fertility. Gynecological malignant conditions constitute approximately 3% of all types of cancer in children. Ovarian tumors in children account for only 1% of childhood malignancies. However, the true incidence of malignant ovarian tumors in the pediatric population is unknown. is to study the role of magenetic resonace (MR) imaging in evaluation of neoplastic and non-neoplastic masses arising from uterine adnexa in neonates and pediatric age groups. During a period of 12 months (from December 2017 to December 2018), 100 consecutive patients (age range, 1–14 years; mean age, 8.8 years) with different clinical presentations were enrolled in this study. There was a highly significant reduction in the overall sexual satisfaction after hysterectomy (p < 0.001). On the basis of the findings, the study concludes that MRI is good modality for differentiation of benign and malignant adnexal masses. Certain imaging features and the degree of enhancement on MRI images are helpful in differentiating adnexal masses. Thus, imaging findings may contribute incremental value to clinical parameters in providing prognostic information, consequently improving the quality of the data used in therapeutic planning