Neoplasms In Japan Research Articles

Mechanism of action of diet as a carcinogen

Stomach cancer in the United States has decreased over the last 50 years. It is still a major type of neoplasm in Japan, Eastern and Northern Europe, and parts of Latin America. Current concepts suggest that the reduction of gastric cancer in the U. S. stems from an increased consumption of foods with vitamin C on a year round basis, which is shown to antagonize the formation of putative gastric carcinogens. Risk factors for large bowel, breast, and prostate cancer are totally different from those for gastric cancer and thus are amenable to independent controls, with the goal of ultimately reducing the risk and preventing these major cancers in man. Current research aims to identify the nature of the mutagenic materials obtained during the frying of protein-containing foods. This process may be involved in the generation of carcinogens for cancer of the colon, breast, and prostate. Cancer of the colon is subject to somewhat different controlling elements than cancer of the breast because of the nature of the cell kinetics governing these tissues. Thus, the mechanism of action of diet involves lifestyle. The type, quality, and mode of cooking of food, particularly, play important roles in the etiology of the main human cancers in the gastrointestinal tract and the endocrine-sensitive organs.

Cohort analysis of death from malignant neoplasms in Japan.

(1) Cohort analyses were made of the total and partial death rate for malignant neoplasms in both sexes.(2) The cohort phenomenon was shown in the transition of the total death rate induced by malignant neoplasms in both sexes. The age-specific death rate curve forms a line similar to the rectilinear pattern seen in the middle age groups and above.(3) Decreasing cohort phenomena were seen in the uterine and stomach cancer analyses. Both forms of cancer are now on the decrease.(4) Increasing cohort phenomena were demonstrated in the lung and pancreas cancer analyses for both sexes. The rate of increase has nearly reached zero, and the age-specific death rate curves are approximately straight lines.(5) A two-phase cohort phenomenon was observed in the liver cancer analysis for females.(6) The transition of the death rate for leukemia showed cohort phenomena for both sexes. However, a final age-specific death rate curve is being reached, and the nature of this disease has changed.(7) The transition of the death rates for malignant neoplasms according to site can be classified as with and without cohort phenomena. Those that showed cohort phenomena can be classified into four types.a) The simple decreasing cohort phenomenonb) The two-phase cohort phenomenonc) The increasing cohort phenomenon that produces an age-specific death rate curve with a rectilinear pattern.d) The increasing cohort phenomenon in all age groups.(8) Suggestions for health control and related etiology were made in relation to the cohort phenomenon shown in malignant neoplasms.

Mechanism of action of diet as a carcinogen

Stomach cancer in the U.S. has decreased over the last 50 years. It is still a major type of neoplasm in Japan, Eastern and Northern Europe and parts of Latin America. Current concepts suggest that the reduction of gastric cancer in the U.S. stems from an increased consumption of foods with Vitamin C on a year round basis which is shown to antagonize the formation of putative gastric carcinogens.