A series of amide derivatives containing the 1,3,4-thiadiazole moiety has been recently synthesized and tested against Meloidogyne incognita (Kofold & White) Chitwood (nematode) and Xanthomonas oryzae pv. oryzae (Ishiyama) Swings, van den Mooter, Vauterin, Hoste, Gillis, Mew & Kersters (rice bacteria). We have now reported the quantitative structure-activity relationship (QSAR) modeling of these biological activities, as well as docking studies to understand the action mechanisms of these compounds. Novel agrochemical candidates were proposed based on an interplay of the substituents which most affect the biological data. The reliable and predictive models obtained from multivariate image analysis applied to QSAR (nematocidal: r 2 = 0.750 and r 2 pred = 0.751; antibacterial: r 2 = 0.650 and r 2 pred = 0.668) were employed to estimate the biological activities of the proposed compounds. At least two chemical candidates for each endpoint exhibited promising agrochemical performance, as the substituents R 1 = CF 3 or 2,4-diCl, R 2 = CH 2 CH 2 Cl or CH 2 CH 2 Br, and X = SO 2 demonstrated a synergistic effect on the nematocidal and antibacterial activities. The promising outcomes were supported by docking studies against the acetylcholinesterase (for M. incognita ) and β-ketoacyl-acyl carrier protein synthase (for Xoo ) enzymes. • MIA-QSAR was used to model nematocidal and antibacterial activities. • Docking studies interpreted and validated the QSAR findings. • Promising agrochemicals were proposed using the models built.