Abstract Aim : Evaluate value ER, PR and HER2 status as independent prognostic factor of local recurrence after breast conserving surgery Methods and materials: The retrospective study of 537 breast cancer patients stage I,II,III which were combined treated in Institute Oncology, Vilnius University in 2005-2006.was made The surgery treatment was used as primarily selection criteria, the data on vital status of all patients was summarized by December, 2008. The median follow-up time was 33 month. Pts age was from 29 years to 76 years. Premenopausal pts (<50 years) - 181 pts, postmenopausal – 356 pts. All pts underwent Breast conserving surgery, irradiation and chemohormono therapy. Distribution of pts according pathological tumor size "pT" was pT0 - 5 pts (1,0%), pT1 - 312 pts (58,1%), pT2 - 208 pts (38,7%), pT3 - 12 pts (2,2%). Distribution of pts according to nodal status "pN" was: "N0" - 333 pts (62,1%), "N1"- 172 pts (32%), "N2" - 30 pts (5,8%), "N3" - 2 pts (0,3%). Distribution of pts according differentiation degree "G" was “G1"- 100 (18,6%), "G2"- 266 (49,7%), "G3" - 171 (31,7%). Pts distribution according ER receptors positive tumors was ER strong (score >=10) - 166 pts (30,9%), medium (score 6-9) - 146 pts (27,2%), week (scrore <=5) - 72 pts (13,4%), no reaction - 148 pts (27,6%). Pts distribution according PR receptors positive tumors was PR strong (score >=10) - 141 pts (26,6%), medium (score 6-9) - 125 pts (23,3%), week (scrore <=5) - 84 pts (15,6%), no reaction - 182 pts (33,9%). Pts distribution according HER2 receptors (3+) - 117 pts (21,8%), HER2 receptors (2+) - 116 pts (21,8%), HER2 receptors (1+) - 188 pts (35,0%), HER2 receptors no reaction - 110 pts (20,5%).Results: Local recurrence rate was calculated according Nelson-Aalen cumulative hazard estimate (analysis time 4 years) and was equal to 8 %.Local recurrence rate according ER-, PR-, HER2 0 vs ER+, PR+, HER2 3+ was equal to 14% vs 4,5%.In 63,5% of all local recurrence ER, PR were negative “0 “,in 40.9% of all local recurrences HER2 was positive (3+) Conclusion: According to our preliminary results ER, PR and HER2 status are independent prognostic factor of local recurrence after breast. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 6047.