Lunar orbit dynamics and transfers at low altitudes are subject to considerable perturbations related to the gravitational harmonics associated with the irregular lunar mass distribution. This research proposes the combination of two techniques applied to low-thrust lunar orbit transfers, i.e. (i) the variable-time-domain neighboring optimal guidance (VTD-NOG), and (ii) a proportional-derivative attitude control algorithm based on rotation matrices (PD-RM). VTD-NOG belongs to the class of feedback implicit guidance approaches, aimed at maintaining the spacecraft sufficiently close to the reference trajectory. This is an optimal path that satisfies the second-order sufficient conditions for optimality. A fundamental original feature of VTD-NOG is the use of a normalized time scale, with the favorable consequence that the gain matrices remain finite for the entire time of flight. VTD-NOG identifies the trajectory corrections by assuming the thrust direction as the control input. Because the thrust direction is fixed with respect to the spacecraft, VTD-NOG generates the desired orientation pursued by the attitude control system. A proportional-derivative approach using rotation matrices (PD-RM) is employed in order to drive the actual spacecraft orientation toward the desired one. Reaction wheels are considered as the actuators that perform attitude control. Extensive Monte Carlo simulations are performed, in the presence of nonnominal flight conditions related to (i) lunar gravitational harmonics, (ii) gravitational pull of the Earth and the Sun as third bodies, (iii) unpredictable propulsive fluctuations, and (iv) errors on initial attitude. The numerical results unequivocally demonstrate that the joint use of VTD-NOG and PD-RM control represents an accurate and effective methodology for guidance and control of low-thrust lunar orbit transfers.