Negative Side Research Articles

Health Risk Associated with Conventional Skin Lighteners and Female Civil Servants’ Comprehension of Skin Lightening Ingredient Information in Anambra State

Skin-lightening products have been in use for many years to lighten skin colour. However, these products contain chemicals that can alter the skin's chemical structure and inhibit the production of melanin. Therefore, users of these products need to understand the ingredients and the potential health risks associated with their use. A study was conducted to assess the health risks associated with conventional skin-lightening products and to determine how well female civil servants understood the ingredient information on the product packaging. The study aimed to determine how many women read the ingredient information on these products, how many understood the information, and how many were aware of the health risks associated with their use. The study was conducted as a survey of 348 civil servants from 21 Ministries in Anambra State using an online sample size calculator. The study was anchored on the Individual Difference theory and selective perception media effect. The survey found that a significant number of female civil servants in Anambra state do not read the ingredient information on skin-lightening products. It was also discovered that the majority of female civil servants in Anambra State do not comprehend the product ingredient information because of its technical nature. Despite this, the study found that most women were aware of the health risks associated with the use of these products. The study concluded that female civil servants in Anambra State were aware of the ingredient information composition on skin-lightening products, but did not read it, making it difficult for them to understand and interpret the information. However, most of these women were still aware of the health risks associated with the use of skin-lightening products but still used them because of the benefits they claimed to have experienced. The study recommended that manufacturers and brand designers should simplify the technical language used to describe the product ingredients to make it easier for users to understand. Additionally, regulatory agencies like NAFDAC and SON should ensure that manufacturers produce skin products that do not contain harmful chemicals like hydroquinone, corticosteroids, and mercury. If these chemicals are used, users should be informed of the negative side effects.

Weekly information communication technology availability demand and family experiences in dual‐earner couples: A perspective from the spillover–crossover model

AbstractThe prevalence of information communication technology (ICT) enables employees to conveniently communicate with coworkers and clients regardless of time and place. However, recent studies have revealed a negative side of ICT use, especially its capacity to invade the family domain. This study was developed based on the spillover–crossover model (SCM) to test how ICT availability demand shapes employees' family experiences and how this demand crosses over to spouses. A total of 961 cases nested in 101 dual‐earner couples were collected using a 10‐week experience sampling method. Multilevel structural equation modelling revealed that (1) employees' work interference with family (WIF) mediated the indirect impact of employees' ICT availability demand on their family satisfaction and family undermining; (2) employees' WIF mediated the indirect impact of employees' ICT availability demand on their spouses' family satisfaction and family undermining; and (3) employees' ICT control buffered these two indirect relationships by which employees' ICT availability demand impacted their own and their spouses' family satisfaction and family undermining. This research elaborates on the spillover and crossover process through which ICT availability demand shapes family experience, thus contributing to the literature on ICT availability demand and the SCM.

Minimizing Negative Side Effects in Cooperative Multi-Agent Systems using Distributed Coordination

Autonomous agents operating in real-world environments frequently encounter undesirable outcomes or negative side effects (NSEs) when working collaboratively alongside other agents. Even when agents can execute their primary task optimally when operating in isolation, their training may not account for potential negative interactions that arise in the presence of other agents. We frame the challenge of minimizing NSEs as a lexicographic decentralized Markov decision process in which we assume independence of rewards and transitions with respect to the primary assigned tasks, but recognize that addressing negative side effects creates a form of dependence among the agents. We present a lexicographic Q-learning approach to mitigate the NSEs using human feedback models while maintaining near-optimality with respect to the assigned tasks---up to some given slack. Our empirical evaluation across two domains demonstrates that our collaborative approach effectively mitigates NSEs, outperforming non-collaborative methods.

Natural variant of Rht27, a dwarfing gene, enhances yield potential in wheat.

Discovery of Rht27, a dwarf gene in wheat, showed potential in enhancing grain yield by reducing plant height. Plant height plays a crucial role in crop architecture and grain yield, and semi-dwarf Reduced Height (Rht) alleles contribute to lodging resistance and were important in "Green Revolution." However, the use of these alleles is associated with some negative side effects in some environments, such as reduced coleoptile length, low nitrogen use efficiency, and reduced yield. Therefore, novel dwarf gene resources are needed to pave an alternative route to overcome these side effects. In this study, a super-dwarf mutant rht27 was obtained by the mutagenesis of G1812 (Triticum urartu, the progenitor of the A sub-genome of common wheat). Genetic analysis revealed that the dwarf phenotype was regulated by a single recessive genetic factor. The candidate region for Rht27 was narrowed to a 1.55Mb region on chromosome 3, within which we found two potential candidate genes that showed polymorphisms between the mutant and non-mutagenized G1812. Furthermore, the natural variants and elite haplotypes of the two candidates were investigated in a natural population of common wheat. The results showed that the natural variants affect grain yield components, and the dwarf haplotypes show the potential in improving agronomic traits and grain yield. Although the mutation in Rht27 results in severe dwarf phenotype in T. urartu, the natural variants in common wheat showed desirable phenotype, which suggests that Rht27 has the potential to improve wheat yield by utilizing its weak allelic mutation or fine-tuning its expression level.

Tamarix aphylla derived metabolites ameliorate indomethacin-induced gastric ulcers in rats by modulating the MAPK signaling pathway, alleviating oxidative stress and inflammation: In vivo study supported by pharmacological network analysis.

Nature has proven to be a treasure resource of bioactive metabolites. In this regard, Tamarix aphylla (F. Tamaricaceae) leaves crude extract was investigated for its gastroprotective effect against indomethacin-induced damage to the gastric mucosa. Additionally, phytochemical investigation of the methanolic extract afforded eight flavonoids' derivatives (1-8). On pharmacology networking study, the isolated compounds identified 123 unique targets where only 45 targets were related to peptic ulcer conditions, these 45 targets include 11 targets specifically correlate to gastric ulcer. The protein-protein interaction defined the PTGS2 gene as one of the highly interacted genes and the complete pharmacology network defined the PTGS2 gene as the most represented gene. The top KEGG signaling pathways according to fold enrichment analysis was the EGFR tyrosine kinase inhibitor resistance pathway. As a result, these findings highlighted the significance of using T. aphylla leaves crude extract as an anti-gastric ulcer candidate, which provides a safer option to chemical antisecretory medicines, which are infamous for their negative side effects. Our findings have illuminated the potent anti-inflammatory and antioxidant effects of T. aphylla, which are likely mediated by suppressing IL-1β, IL-6, TNF-α, and MAPK signaling pathways, without compromising gastric acidity.

Problem Penggunaan AI (Artificial Intelligence) dalam Bidang Pendidikan

Artificial intelligence (AI) has become an increasingly important research subject in various fields, including education. In the educational context, the use of AI promises a fundamental transformation in the way we teach and learn. However, despite AI's enormous potential to improve the efficiency and effectiveness of education, there are a number of challenges that need to be overcome. The purpose of this research is to provide readers with the view that apart from the many positive sides of AI, there are also negative sides. This research focuses on the negative side of using AI in the education sector. The method used is library research. However, if managed wisely, the use of AI in education can provide significant benefits. For example, AI can be used to personalize learning, enabling teaching tailored to each student's individual needs. Additionally, AI can help in automated grading, freeing up teachers' time to focus on direct interactions with students. By considering existing challenges and exploiting the opportunities offered by AI, education can make significant progress in improving its quality and accessibility. Therefore, further research and development is needed to overcome technical and ethical obstacles to the application of AI in education, while ensuring that its benefits are widespread and non-discriminatory.

Social Media in the Management of Obesity and Diabetes: An Underutilised Population Educational Tool.

Obesity and diabetes are two of the most common chronic medical conditions encountered, putting an ever-increasing strain on healthcare systems worldwide. Social media meanwhile has taken the world by storm over the last 2 decades, providing a way to distribute information instantly and on a vast scale at the click of a button. The use of social media to aid in the management of obesity and diabetes though is an underutilised tool, with the potential to help in educating and supporting these patients in numerous ways both now and in the future, on a grand scale. The caveat to this, however, is the negative side of social media, which can include the spread of disinformation and bullying. In this commentary, we discuss the methodology and wide scale of positive and negative effects of social media across the management of obesity and diabetes, as well as the possible methods we can use this to our advantage in the medical profession to help our patients going forward.

Development of biocomposite films incorporated with the extract from pitcher associated bacteria for the postharvest protection from fungi.

Pythium aphanidermatum is known to cause diseases likedamping-off, root rot, stem rot and fruit rot in a wide range of plants. Eventhough many chemical methods have been demonstrated to have the potential to manage these diseases, their benefits are being offset equally by the negative side effects. Therefore, the control of Pythium spp. using natural antifungal agents is of immense significance due to its environmental safety. Here, the plant associated microorganisms with antifungal metabolites have significant promises to be explored both as sustainable biocontrol agents and also as active constituents of antifungal materials. Antimicrobial packaging films prepared using such components can have significant applications to meet the requirements to prevent postharvest loss of agricultural produce by inhibiting the fungal growth. Eventhough there are reports on the development of antimicrobial packaging films for such applications, the use of bacterial extracts with antifungal activity for the same is least investigated. Hence, the present study demonstrates the development of biocomposite films prepared using polyvinyl alcohol (PVA) incorporated with the extracts prepared from bacterial isolates (Serratia sp. NhPB1, Kocuria sp. NhPB49, and Pantoea dispersa NhPB54) previously isolated from the pitcher plant. Here, the individual films were prepared by incorporating 1mL of bacterial extract in 40mL of 3% PVA solution and the developed films were then subjected to antifungal activity screening against P. aphanidermatum. The antifungal activity analysis of the films prepared with the incorporation of extracts from Serratia sp. NhPB1, Kocuria sp. NhPB49, and Pantoea dispersa NhPB54 showed remarkable activity against the tested pathogen. The application of biocomposite films on Solanum lycopersicum and Capsicum annuum fruits for its protection from P. aphanidermatum by dip coating method further indicates the promises of developed biocomposite films for active packaging applications.

Measuring the Influence of Side Effect Expectations, Beliefs, and Incident Side Effects on the Risk for Drug Discontinuation Among Individuals Starting New Medications, a Cross-sectional Study.

To measure the impact of beliefs, expectations, side effects, and their combined effects on the risk for medication nonpersistence. Using a cross-sectional design, individuals from Saskatchewan, Canada who started a new antihypertensive, cholesterol-lowering, or antihyperglycemic medication were surveyed about risk factors for nonpersistence including: (a) beliefs measured by a composite score of three questions asking about the threat of the condition, importance of the drug, and harm of the drug; (b) incident side effects attributed to treatment; and (c) expectations for side effects before starting treatment. Descriptive statistics and logistic regression models were used to quantify the influence of these risk factors on the outcome of nonpersistence. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Among 3,029 respondents, 5.8% (n=177) reported nonpersistence within four months after starting the new drug. After adjustment for numerous covariates representing sociodemographics, health-care providers, medication experiences and beliefs, both negative beliefs (OR: 7.26, 95%CI: 4.98-10.59) and incident side effects (OR: 8.00, 95%CI: 5.49-11.68) were associated with the highest odds of nonpersistence with no evidence of interaction. In contrast, expectations for side effects before starting treatment exhibited an important interaction with incident side effects following treatment initiation. Among respondents with incident side effects (n=741, 24.5%), the risk for early nonpersistence was 11.5% if they indicated an expectation for side effects before starting the medication compared to 23.6% if they did not (adjusted OR: 0.38, 95%CI: 0.25-0.60). Expectations for side effects may be a previously unrecognized but important marker of the probability to persist with treatment. A high percentage of new medication users appeared unprepared for the possibility of side effects from their new medication making them less resilient if side effects occur.

Orthostatic Hypotension and Antihypertensive Treatment in Lung Transplant Recipients: A Cross-Sectional Study.

Lung transplant is the ultimate treatment of many end-stage lung diseases. Calcineurin inhibitors, crucial in immunosuppression for lung transplant recipients, are linked to secondary hypertension, necessitating antihypertensive treatment. In addition, lung transplant recipients frequently experience orthostatic hypotension, occasionally stemming from autonomic dysfunction, but also commonly attributed as a negative side effect of antihypertensive treatment. Our study aimed to evaluate the frequency of orthostatic blood pressure irregularities and investigate the involvement of antihypertensive treatment as a potential risk factor in the occurrence among lung transplant recipients. Fifty-six consecutive lung transplant recipients, both inpatient and outpatient, at the University Hospital Zurich (Switzerland) were monitored from 1999 to 2013. Transplant recipients underwent a Schellong test (an active standing test). Our evaluation encompassed their initial traits, such as the existence of supine hypertension. We computed the odds ratio for the comparison of the likelihood of experiencing orthostatic hypotension while using a minimum of 1 type of antihypertensive medication versus absence of antihypertensive drugs. Of the lung transplant recipients, 25% showed a positive Schellong test. Within this group, 64% had supine hypertension, and 29% displayed symptoms of orthostatic hypotension. Among the patients, 71% were using at least 1 type of antihypertensive medication. The odds ratio for showing orthostatic hypotension while taking at least 1 type of antihypertensive drug versus the absence of antihypertensive medications was 1.64 (95% exact CI, 0.39-6.90) with P = .50. This finding remained consistent regardless of age, sex, inpatient or outpatient status, and the duration since transplant. Orthostatic blood pressure dysregulation is prevalent among lung transplant recipients, frequently without noticeable symptoms. In our cohort, the use of antihypertensive medications did not elevate the risk of orthostatic hypotension.

Advanced PamGene Coregulator Interactome Analysis of PPARgamma Reveals that Diet Influences Regulatory Protein Interactions and Signaling Mechanisms

Studies show a strong correlation with type 2 diabetes mellitus (T2DM) in obese patients developing congestive heart failure (CHF) with rosiglitazone treatment. Rosiglitazone, a thiazolidinedione, treats T2DM by improving insulin resistance. Its use has been halted due to a subset of patients developing CHF through unknown mechanisms. Rosiglitazone targets PPARγ, a nuclear receptor highly expressed in adipose tissue and, to a lesser extent, in cardiac tissue. An important mechanism of PPARγ regulation is through coregulators that can alter transcriptional activity through protein-protein interaction to drive PPARγ toward specific pathways. We hypothesized coregulator interaction with PPARγ may regulate its activity differently in adiposity, inducing CHF through adipose-derived peripheral signaling. To address this, we fed 8-week-old C57BL/6 mice a normal chow (NCD) or high-fat (HFD) diet for 16 weeks. Mice were then injected with rosiglitazone every 48 hours for 4 weeks. In NCD and HFD Rosi mice, we found significantly increased heart weights (p-value<0.05) and various weight changes in five adipose depots. To understand the roles of the PPARγ coregulator interactome in adiposity, we used our state-of-the-art PamGene PamStation Nuclear Hormone Receptor chip to measure the interaction of PPARγ with 155 coregulators in five adipose depots and the liver. In adipose depots increasing in weight due to Rosi treatment, such as retroperitoneal white adipose tissue (WAT) and mesenteric WAT, more coregulators associated with the PPARγ complex. Conversely, depots that did not change in weight with Rosi treatment, such as epididymal WAT and inguinal WAT, showed a reduction of coregulators leaving the PPARγ complex, indicating differential PPARγ regulation. Our data suggests that the coregulator interactome of PPARγ in adipose depots represents potential therapeutic targets, and understanding how PPARγ regulation is different in adiposity is crucial to understanding the negative side effects of rosiglitazone treatment. R01DK121797 (T.D.H.) R01DA058933 (T.D.H.). This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Higher Education Students' Perceptions and Attitudes about Using ChatGPT in Oman: A Case Study of OCMT

This study aims to determine the role of ChatGPT as a virtual assistant for the students in higher education institutions in the Sultanate of Oman to enhance learning, foster their skill growth and improve their productivity. It also aims to identify how the students at Oman College of Management and Technology (OCMT) can use ChatGPT in an effective way, the advantages of using it, and the challenges that prevent it from being used in education, from their point of view, keeping in mind the ethical considerations that arise in the process. Some consider it as a support for the process of developing education, while others see it as a threat that affects its future. On the positive side, ChatGPT helps improve education, while on the negative side, it raises several concerns about fraud and plagiarism. Since the results of the survey showed that many students at Oman College of Management and Technology tend to use AI applications in their studies, the problem of this study emerged in the researchers' desire to explore the degree of students' use of ChatGPT, the advantages of using it, the obstacles, challenges and ethical considerations that may affect its integration in education.

Higher Education Students' Perceptions and Attitudes about Using ChatGPT in Oman: A Case Study of OCMT

This study aims to determine the role of ChatGPT as a virtual assistant for the students in higher education institutions in the Sultanate of Oman to enhance learning, foster their skill growth and improve their productivity. It also aims to identify how the students at Oman College of Management and Technology (OCMT) can use ChatGPT in an effective way, the advantages of using it, and the challenges that prevent it from being used in education, from their point of view, keeping in mind the ethical considerations that arise in the process. Some consider it as a support for the process of developing education, while others see it as a threat that affects its future. On the positive side, ChatGPT helps improve education, while on the negative side, it raises several concerns about fraud and plagiarism. Since the results of the survey showed that many students at Oman College of Management and Technology tend to use AI applications in their studies, the problem of this study emerged in the researchers' desire to explore the degree of students' use of ChatGPT, the advantages of using it, the obstacles, challenges and ethical considerations that may affect its integration in education.

Hyperhomocysteinemia Transcriptionally Regulates Expression of a Set of Ion Channels in Brain and Heart Tissues in Mice

The alterations of ion channel gene expressions in brain and heart tissues in HHcy have not been previously reported. We investigated the mRNA expression levels in brain and heart tissues of the HHcy mice compared to the control mice to characterize distinct expression of 36 ion channels. C57BL/6 J. mice were divided into two groups of 15 animals each: (1) control group and (2) HHcy group. The HHcy was induced by methionine administiration. The mRNA levels of ion channels were analyzed using qRT-PCR. TUNEL staining and MDA assay were used for verification of the negative side effects of HHcy in heart and brain tissues. RT-PCR revealed the upregulation of Hcn4, Trpc3, Trpm2 and the downregulation of Abbc8, Cacna1b, Cacna1c, Cacna1e, Cacna1h, Hcn1, Kcnc3, Kcnh7, Kcnj8, Trpc4, Trpc5, Trpc6, Trpm3, Trpm4, Trpv4, Trpv6 in brain tissues of the HHcy group compared to the control. The upregulation of ion channel expressions in heart tissues were not detected, but we found only the downregulation of Accn1, Accn2, Accn3, Hcn1, Kcnc4 and Trpv6 ion channels. Apoptozis and MDA level were significantly increased in brain and heart tissues of the HHcy group compared to the control. Brain tissues compared to heart tissues exhibit a very considerable and diverse ion channel gene expression pattern in mice with HHcy than control. Clarifying the roles of ion channels in HHcy could shed light on the development of novel therapeutic strategies and ultimately improve HHcy side effects.

Nanoparticle-functionalized acrylic bone cement for local therapeutic delivery to spine metastases

Aim: Polymethylmethacrylate bone cement is often used to reconstruct critical-sized defects generated by the surgical resection of spinal metastases. Residual tumor cells after a resection can drive recurrence and destabilization. Doxorubicin (DOX) is a common chemotherapeutic drug with unwanted side-effects when administered systemically. Mesoporous silica nanoparticles (NPs) are gaining attention for targeted drug delivery to bypass the negative side effects associated with systemic drug administration. An NP-functionalized cement was developed for the local release of DOX and its ability to suppress cancer cells was tested. Methods: DOX was loaded onto NPs which were then mixed into the cement. Static contact angles were measured. Drug release profiles were obtained over a period of 4 weeks. Cement constructs were incubated with two-dimensional (2D) cultures of human bone-marrow derived mesenchymal stem cells and human osteoblasts, as well as 2D and three-dimensional (3D) cultures of breast and prostate cancer cell lines. Cell metabolic activity and viability were evaluated. Cell migration and spheroid growth of cancer cell lines were assessed in collagen-coated spheroid cultures. Results: NPs were homogenously dispersed and did not alter the mechanical strength nor the wettability of the cement. A sustained DOX release profile was achieved with the addition of NPs to the bone cement. The release profile of DOX from NP cement may be modified by varying the amount of the drug loaded onto the NPs and the proportion of NPs in the cement. Cancer cells treated with the cement constructs showed a dose- and time-dependent inhibition, with minimal toxicity against healthy cells. Cancer cell migration and spheroid growth were impaired in 3D culture. Conclusions: NPs were shown to be essential for sustained DOX release from bone cement. DOX-loaded NP cement can inhibit cancer cells and impair their migration, with strong potential for in vivo translation studies.

Impact of conflict evolution and geostrategy on national resilience of a nation

National resilience is the ability of a nation to maintain the survival of its country and state. Various factors, including conflict evolution and geostrategy, influence national resilience. The evolution of conflict and geostrategy can positively or negatively impact national resilience. On the positive side, the evolution of conflict and geostrategy can encourage increased national resilience. This can happen if the evolution of conflict and geostrategy encourages increased national awareness, social cohesion and national defense capabilities. On the negative side, the evolution of conflict and geostrategy can threaten national security. This can happen if the evolution of conflict and geostrategy leads to national disintegration, political destabilization, and increased national security threats.

"Everything is kind of the same except my mind is with me": exploring cannabis substitution in a sample of adults in early recovery from an opioid or stimulant addiction.

Recovery from addiction is frequently equated with abstinence. However, some individuals who resolve an addiction continue to use substances, including via substitution (i.e., increased use of one substance after eliminating/ reducing another). Substitution may play a distinct role during early recovery (≤ 1 year), as this period is marked by dramatic change and adjustment. Cannabis is one of the most used substances and is legal for medical and recreational use in an increasing number of states. Consequently, cannabis an increasingly accessible substitute for substances, like fentanyl, heroin, cocaine and methamphetamine, with higher risk profiles (e.g., associated with risk for withdrawal, overdose, and incarceration). Fourteen participants reported that they had resolved a primary opioid or stimulant addiction and subsequently increased their cannabis use within the previous 12 months. Using grounded theory, the interviewer explored their experiences of cannabis use during early recovery. Data were analyzed in three stages: line by line coding for all text related to cannabis use and recovery, focused coding, and axial coding to generate a theory about recovery with cannabis substitution. The motivational model of substance use provided sensitizing concepts. The final sample included eight men and six women ranging in age from 20 to 50 years old. Three participants resolved an addiction to methamphetamine and the remaining 11, an addiction to opioids. Participants explained that cannabis was appealing because of its less harmful profile (e.g., no overdose risk, safe supply, few side effects). Participants' primary motives for cannabis use included mitigation of psychiatric symptoms, withdrawal/ cravings, and boredom. While cannabis was effective toward these ends, participants also reported some negative side effects (e.g., decreased productivity, social anxiety). All participants described typical benefits of recovery (e.g., improved self-concept, better relationships) while continuing to use cannabis. Their experiences with and beliefs about substitution suggest it can be an effective strategy for some individuals during early recovery. Cannabis use may benefit some adults who are reducing their opioid or stimulant use, especially during early recovery. The addiction field's focus on abstinence has limited our knowledge about non-abstinent recovery. Longitudinal studies are needed to understand the nature of substitution and its impact on recovery over time.

Dynamic relationship between workplace friendship and knowledge-sharing behavior: formation, development and decline

PurposeThe purpose of this study is to empirically examine the cause–effect relationships between workplace friendship and knowledge-sharing behavior, from a static perspective. Furthermore, it investigates the bi-directional relationship between the increase in both workplace friendship and knowledge-sharing behavior over same time periods, and also endeavors to identify whether there is a significant negative lagged effect of the increase in both workplace friendship on knowledge-sharing behavior, and vice versa, across time from a dynamic perspective.Design/methodology/approachThe study conducts a three-wave questionnaire survey to test the research model. A latent change score approach was used to test the direct relationship between changes in workplace friendship and changes in knowledge-sharing behavior.FindingsThe findings reveal that knowledge-sharing behavior fosters workplace friendship and workplace friendship promotes the emergence of knowledge-sharing behavior. An increase in workplace friendship promotes an increase in knowledge-sharing behavior over same time periods. However, an increase in workplace friendship will lead to a lagged decrease of knowledge-sharing behavior across time, and vice versa.Research limitations/implicationsThe time interval in this study is a little short to capture the full changes in workplace friendship. Some important control factors and mediating mechanisms are not included in the research model.Practical implicationsThis study guides managers to focus on various motivators to better strengthen workplace friendship and knowledge-sharing behavior and to consider and effectively respond to the negative side of workplace friendship and knowledge-sharing behavior across time.Originality/valueThis study emphasizes the predictivity of one important interaction patterns, namely, knowledge-sharing behavior on friendship at the workplace, from a static perspective. This study also shows the benefits of an increase in workplace friendship for the development of knowledge-sharing behavior in the same time period. Furthermore, the study presents a counterintuitive finding when taking the lag effect into consideration in exploring the relationship between changes both in workplace friendship and knowledge-sharing behavior, and identifies a negative side of both when viewed over longer periods.

Effect of smartphone addiction on compulsive app downloading tendency: protective factors for generation Z consumers

Purpose This study aims to focus on how smartphone addiction impacts young consumer behavior related to mobile technology (i.e. the compulsive app downloading tendency). After a thorough literature review and following the risk and protective factors framework, this study explores factors that could mitigate its effects (resilience, family harmony, perceived social support and social capital). Design/methodology/approach The study used the covariance-based structural equation modeling approach to analyze data collected from 275 Generation Z (Gen Z) smartphone users in Spain. Findings Results suggest that resilience is a critical factor in preventing smartphone addiction, and smartphone addiction boosts the compulsive app downloading tendency, a relevant downside for younger Gen Z consumers. Originality/value Through the lens of the risk and protective factors framework, this study focuses on protective factors to prevent smartphone addiction and its negative side effects on app consumption. It also offers evidence of younger consumers’ vulnerability to smartphone addiction, not because of the device itself but because of app-consumption-related behaviors.

Knowledge, attitude, and practice of insulin among diabetic patients and pharmacists in Egypt: “cross-sectional observational study”

BackgroundDiabetes recently has been identified as a growing epidemic. Although insulin’s vital role in both types of diabetes, it is considered one of the harmful medications if used incorrectly. In Egypt, effective usage of insulin remains a challenge due to insufficient knowledge of insulin and diabetes management, leading to errors in insulin therapy. As pharmacists are experts in pharmacological knowledge, they are uniquely situated to assess adherence to treatment regimens, the effect of drug therapy, or potential alterations in drug therapy to meet patient goals. To provide effective patient education and counseling, community pharmacists in Egypt should be efficiently knowledgeable about diabetes and insulin.ObjectiveTo identify the knowledge, attitude, and practice of pharmacists and patients about insulin. To identify pharmacists’ educational preparedness and confidence in counseling diabetic patients.MethodsA descriptive, cross-sectional study was conducted with two knowledge, attitude, and practice surveys. This study was carried out from September 2016 to February 2023. Face-to-face interviews were conducted with patients, and a paper-based questionnaire was administered to pharmacists. The two questionnaires were adapted from previous studies.ResultsA total of 492 patients and 465 pharmacists participated in this study. The mean knowledge score of correct answers among patients and pharmacists was 10.67 ± 1.9 and 15 ± 3.6. Most of the patients and pharmacists had a positive attitude regarding insulin’s role in improving health and to better control blood glucose. On the negative side, around half of the patients reported that they believe that regular use of insulin leads to addiction, while only 14.5% of the pharmacists believed that insulin could cause addiction. Self-confidence scores for pharmacists differed statistically with sex, years of experience, and pharmacist’s direct exposure to diabetic patients.ConclusionsThis study uncovers considerable deficiencies in patients’ and pharmacists’ knowledge about insulin therapy. This study also strongly recommends higher education and a more structured pharmacist training schedule.