Negative Reinforcement Research Articles

Impulsivity, mental health state and emotion regulation modulate alcohol and marijuana use in a sample of Argentinean citizens

Impulsivity and substance-related outcomes share a complex relationship, as various facets of impulsivity exhibit distinct associations with different drug-related outcomes. This study examines the associations between frequency and quantity of alcohol and marijuana use with impulsivity traits, psychological distress, and the utilization of emotion regulation strategies. A survey asked Argentinian citizens (n = 1507, 356 men) about frequency and quantity of alcohol or marijuana use on each day of a typical week, as well as anxiety, stress, and depression symptoms (DASS-21), impulsivity-like traits (UPPS-P), and emotion regulation strategies (ERQ). The 2-month prevalence of alcohol or marijuana use was 80.1%, and 27.2%, respectively. Premeditation was significantly (p < 0.05) and negatively associated with both frequency and quantity of alcohol consumed, whereas negative and positive urgency were positively and significantly (p < 0.05) associated with quantity of alcohol or marijuana use, respectively. Greater depression symptoms predicted greater quantity of alcohol use, whereas lower emotional suppression or lower cognitive reappraisal were significantly (p < 0.05) associated with a greater frequency of alcohol or marijuana use. Sensation seeking was significantly (p < 0.05) and positively associated with frequency of marijuana use. Individuals with higher levels of impulsivity-like traits, higher levels of depression, or lower use of emotional regulation abilities appeared to be at a higher risk of alcohol or marijuana use. In this sample, the use of alcohol (though not marijuana) seems to fit a negative reinforcement pathway. The study suggests that individuals with risk factors for drug misuse could benefit from interventions aimed at enhancing emotion regulation.

Strategy Analysis of Health Care Products Advertising for the Aged: Optimization Suggestions Based on Appeal Presentation and Advertising Elements

With the increase in the elderly population, the advertising strategy of healthcare products for older people needs to be systematically analyzed and optimized. Through literature review, this study adopted the advertisements targeting the elderly of three famous Chinese health products brands as cases, analyzing the typical strategies of current advertising practices based on the expression of appeals including rational and perceptual appealing and advertising elements related to social power, then offering suggestions on needs, advertising content and media mix. The results showed that as the basis of perceptual appeal, rational appealing contained product information and health problems. Product information focused on communication at the core benefit level, while the description of health problems promoted purchasing behavior through negative reinforcement. Perceptual appeal mostly adopted the framing of family affection with the appeal objects were simultaneously the elderly and their children. Advertising elements were related to legitimate, reward, and referent power, corresponding to the use of uniform image, incentive enticement and upward social comparison related to the idealized self-image of the elderly. Recommendations involved broadening the appealing technique corresponding to alternative types and higher levels of needs, attempting heuristics including humor and celebrity endorsements, and considering social media-related touching points. This study provided mechanism clarification and theoretical support for health communication and advertising practice.

Two subtypes of compulsive sexual behavior disorder.

Models explaining addictive behaviors such as the Interaction of Person-Affect-Cognition-Execution (I-PACE) model emphasize the importance of reinforcement mechanisms for developing and maintaining these behaviors, including compulsive sexual behavior disorder (CSBD) as well as personal characteristics as vulnerability factors. This study aimed to determine whether there are CSBD subtypes distinguished by reinforcement sensitivity. We hypothesize that one subtype is sensitive to positive reinforcement (C+subtype) and one is sensitive to negative reinforcement (Ȼ-subtype). We calculated a cluster analysis with data from 62 patients with CSBD and tested differences between the identified clusters by t-test. The sample consisted only of men. Cluster variables were: the sensitivity to the Behavioral Inhibition and Approach System (BIS/BAS), the severity of depressive symptoms (BDI-II), the severity of Trait Anxiety (STAI-T), Sexual Sensation Seeking (SSSS), Thrill- and Adventure-Seeking (SSS-V subscale), Disinhibition (SSS-V subscale), Experience Seeking (SSS-V subscale), and Boredom Susceptibility (SSS-V subscale). Between-cluster differences were analyzed for Trait Sexual Motivation (TSMQ) and Sexual Compulsivity (SCS). The results showed a two-cluster solution with cluster 1 representing patients sensitive to negative reinforcement (Ȼ-subtype) and cluster 2 representing patients sensitive to positive reinforcement (C+subtype). No significant difference in symptom severity of Sexual Compulsivity between clusters was found. Cluster 2 showed higher Importance of Sex and a higher motivation to seek sexual encounters than cluster 2. We found a two-cluster solution regarding reinforcement sensitivity in patients with CSBD. This may have clinical implications regarding individual therapy by focusing on the underlying maintenance mechanisms.

Neuroinflammation drives sex-dependent effects on pain and negative affect in a murine model of repeated mild traumatic brain injury.

The Center for Disease Control and Prevention estimates that 75% of reported cases of traumatic brain injury (TBI) are mild, where chronic pain and depression are 2 of the most common symptoms. In this study, we used a murine model of repeated mild TBI to characterize the associated pain hypersensitivity and affective-like behavior and to what extent microglial reactivity contributes to these behavioral phenotypes. Male and female C57BL/6J mice underwent sham or repeated mild traumatic brain injury (rmTBI) and were tested for up to 9 weeks postinjury, where an anti-inflammatory/neuroprotective drug (minocycline) was introduced at 5 weeks postinjury in the drinking water. Repeated mild traumatic brain injury mice developed cold nociceptive hypersensitivity and negative affective states, as well as increased locomotor activity and risk-taking behavior. Minocycline reversed negative affect and pain hypersensitivities in male but not female mice. Repeated mild traumatic brain injury also produced an increase in microglial and brain-derived neurotropic factor mRNA transcripts in limbic structures known to be involved in nociception and affect, but many of these changes were sex dependent. Finally, we show that the antiepileptic drug, gabapentin, produced negative reinforcement in male rmTBI mice that was prevented by minocycline treatment, whereas rmTBI female mice showed a place aversion to gabapentin. Collectively, pain hypersensitivity, increased tonic-aversive pain components, and negative affective states were evident in both male and female rmTBI mice, but suppression of microglial reactivity was only sufficient to reverse behavioral changes in male mice. Neuroinflammation in limbic structures seems to be a contributing factor in behavioral changes resulting from rmTBI.

Rapid appearance of negative emotion during oral fentanyl self-administration in male and female rats.

Opioid use disorder has become an epidemic in the United States, fuelled by the widespread availability of fentanyl, which produces rapid and intense euphoria followed by severe withdrawal and emotional distress. We developed a new preclinical model of fentanyl seeking in outbred male and female rats using volitional oral self-administration (SA) that can be readily applied in labs without intravascular access. Using a traditional two-lever operant procedure, rats learned to take oral fentanyl vigorously, escalated intake across sessions, and readily reinstated responding to conditioned cues after extinction. Oral SA also revealed individual and sex differences that are essential to studying substance use risk propensity. During a behavioural economics task, rats displayed inelastic demand curves and maintained stable intake across a wide range of fentanyl concentrations. Oral SA was also neatly patterned, with distinct 'loading' and 'maintenance' phases of responding within each session. Using our software DeepSqueak, we analysed ultrasonic vocalizations (USVs), which are innate expressions of current emotional state in rats. Rats produced 50 kHz USVs during loading then shifted quickly to 22 kHz calls despite ongoing maintenance of oral fentanyl taking, reflecting a transition to negative reinforcement. Using fibre photometry, we found that the lateral habenula differentially processed drug cues and drug consumption depending on affective state, with potentiated modulation by drug cues and consumption during the negative affective maintenance phase. Together, these results indicate a rapid progression from positive to negative reinforcement occurs even within an active drug taking session, revealing a within-session opponent process.

Elevated hair cortisol and decreased hair testosterone indicates chronic disruption of the HPA/HPG axis and is reflective of poor welfare in Rhesus Macaques used as performing (dancing) monkeys in Pakistan

Throughout South and South East Asia it is common to see native monkeys being used in public entertainment as Dancing Monkeys (DM). In Pakistan, native rhesus macaques are captured from the wild during infancy and trained using negative reinforcement methods to perform for public entertainment. This study aimed to quantify and compare physiological stress in 50 DM with 77 controls from an outdoor harem- housed colony of captive rhesus macaques, and to assess whether certain behavioural indices observed in DM were reflective of physiological state. DM had significantly higher hair cortisol concentrations (t(77.358)=−2.8099CI(−0.519,−0.088), p<0.01, d= 0.531) and lower hair testosterone concentrations (t(66.6)=4.917, 95CI(0.474, 1.1108), p<0.0001, d=1.16) compared to the controls. Linear modelling indicated that hair cortisol was positively associated with fear and ectoparasite load, and negatively associated with ectoparasite presence. Hair testosterone was negatively associated with aggression and body welfare and positively associated with abnormal behaviour. The results were assessed relative to semi-structured trainer interviews to better understand observed negative physiological and behavioural markers indicating stress and hence poor welfare. Overall, the results exemplify the merit of using a two-fold biobehavioural approach for assessing welfare and indicate that DM are under chronic physiological stress which is associated with negative behavioural outcomes.

Altered reinforcement learning in Narcolepsy type I and other central disorders of hypersomnolence

Cognitive impairments are described in central disorders of hypersomnolence (CDH), but studies remain very limited and largely focused on narcolepsy type 1 (NT1). The precise nature and origin of these cognitive impairments is poorly understood. Specifically, impaired decision making under ambiguity has been reported in NT1 and suggested to be caused by dysregulation of the direct projections of hypocretin neurons to the dopamine network. However, the decision-making tasks used previously embed different cognitive functions that are difficult to isolate.This study aims to test reinforcement learning in participants with NT1 and with other (non-hypocretin deficient) CDH in a task known to directly depend on the dopamine system. Participants with NT1 (N = 27), other CDH (N = 34, including narcolepsy type 2 and idiopathic hypersomnia, matched with NT1 participants for sleepiness severity), and healthy participants (N = 34) took part in the study.Results showed that all groups had normal and similar positive reinforcement learning, a pattern not suggestive of dopamine deficiency. However, both participants with NT1 and other CDH had decreased learning abilities to avoid losses. This decreased negative reinforcement learning in participants with CDH was associated with the alteration of vigilance.This study provides new insights into the nature of decision making impairment in people with CDH and suggests that these alterations could be minimized by restoring adequate vigilance.

Event-level positive and negative reinforcement risk factors for alcohol use: Moderation by individual-level alcohol consequences and post-traumatic stress disorder symptom severity.

The multistage model of drug addiction posits that risk processes contributing to alcohol use change as individuals develop alcohol use disorders. However, few studies have tested this theory outside of the lab or at the event level. We assessed whether event-level associations between positive reinforcement (e.g., positive affect, sociability expectancies) and negative reinforcement risk factors (e.g., negative affect, tension reduction expectancies) and same-/next-day alcohol consumption varied as a function of an individual's level of alcohol consequences. Given elevated alcohol use consequences among individuals with post-traumatic stress disorder (PTSD) and disruptions in reward processing that affect this population, we also tested whether these processes differed based on the presence and severity of PTSD. We used data from a 30-day ecological momentary assessment study with 174 undergraduate women who regularly engaged in heavy episodic drinking. A majority (78%) of the sample had experienced sexual assault and 44% had current PTSD. Analyses used Bayesian multilevel structural equation modeling with diffuse (non-informative) priors. We used markov chain monte carlo (MCMC) algorithms to generate a series of 10,000 random draws from the multivariate posterior distribution of our sample for each model. Results partially supported the multistage model. Event-level negative reinforcement risk factors only predicted more alcohol consumption among individuals who experienced more alcohol consequences. Findings for positive reinforcement risk factors were partially consistent with hypotheses. Overall, findings appear to operate similarly across PTSD symptom severity. Results suggest that interventions for heavy episodic drinking could benefit from attending to an individual's level of alcohol consequences. For example, preventive interventions for individuals who tend to experience few consequences may benefit more from addressing positive reinforcement risk factors, while treatment interventions for those who experience more consequences may benefit from attending to both positive and negative reinforcement.

Is elastic fantastic? The impact of elastic inserts on rein tension

Sustainable and ethical equitation requires clear signals and timely pressure-release. This study aimed to determine the effect of elastic inserts in reins on the tension applied for normal riding and a walk-to-halt transition, and the ability to release rein tension. Thirty female, regular riders, age 22 ± 3.87 years, participated in this study. The Centaur Rein Tension Gauge™▲ was fixed to a solid structure, and reins with elastic insert (elastic) or standard leather (rigid) were attached. Both measured 20 mm x 6 mm x 1500 mm and weighed 350 g. Rein tensions (N) were measured for left and right hands, both rein types when taking up a normal riding contact and executing a walk-to-halt transition using a cross-over design. Significantly lower tensions were exerted with elastic reins (3.33 ± 1.97N) than with rigid reins (5.83 ± 1.17N; F1,16 = 5.54; P < 0.05) in the normal riding contact condition, whilst higher tensions were evident with elastic reins (21.3 ± 6.19N) than rigid reins (15.8 ± 4.4N) in the walk-to-halt transition. The time (s) for rein tension return to zero following complete release from 25N was significantly greater, and less consistent, with elastic reins (t58 = 5.63; P < 0.001; 3.85 ± 3.22 seconds) than with rigid reins (0.53 ± 0.27 seconds). Although elastic inserts in reins result in less tension during general riding, they may be detrimental to the effective application of negative reinforcement and the ability to accurately reward required responses during training.

Dual Electronic and Combustible Cigarette Use: Understanding the Relation of Cannabis Use with E-Cigarette Outcomes

Background: E-cigarette use is on the rise and many who use e-cigarettes also smoke combustible cigarettes. Dual use (i.e., use of both electronic and combustible cigarettes) is associated with greater rates of cannabis use and cannabis use among individuals who engage in dual use is related to more severe ecigarette-related problems. Yet, no known studies have tested whether cannabis use is related to more severe e-cigarette problems via negative affect and the expectation that e-cigarettes can help manage negative affect. Objectives: The current study tested this hypothesis among 400 adults who endorsed dual use, 33% of whom endorsed current (past three month) cannabis use. Results: Results indicated that participants with cannabis use reported more anxiety, depression, e-cigarette problems, and the following e-cigarette use expectancies: negative consequences, negative reinforcement, and weight concerns. Multiple mediator models found that the relation between cannabis use status and e-cigarette problem severity was mediated by anxiety (but not depression) and by negative reinforcement and weight concerns (but not negative consequences) expectancies. Serial mediator models indicated that the relation between cannabis use and e-cigarette problems occurred via the serial effects of anxiety and negative reinforcement (but not weight concerns) expectancies. Conclusions: These results highlight several clinical correlates of cannabis use among adults who smoke combustible and e-cigarettes, and suggest that anxiety and the expectation that e-cigarettes may help manage such negative emotions play important roles in e-cigarette-related problems among these individuals.

The Role of Auditory and Visual Cues in the Perception of Mandarin Emotional Speech in Male Drug Addicts

Evidence from previous neurological studies has revealed that drugs can cause severe damage to the human brain structure, leading to significant cognitive disorders in emotion processing, such as psychotic-like symptoms (e.g., speech illusion: reporting positive/negative responses when hearing white noise) and negative reinforcement. Due to these emotion processing disorders, drug addicts may experience difficulties in emotion recognition and speech illusion, which are essential for interpersonal communication and a healthy life experience. However, previous research has yielded divergent results regarding whether drug addicts are more attracted to negative stimuli or positive stimuli. Additionally, little attention has been paid to the speech illusion experienced by drug addicts. Therefore, the current study aimed to investigate the effect of drugs on patterns of emotion recognition through two basic channels: auditory (speech) and visual (facial expression), as well as the speech illusions of drug addicts. The current study conducted a perceptual experiment in which 52 stimuli of four emotions (happy, angry, sad, and neutral) in three modalities (auditory, visual, auditory + visual [congruent & incongruent]) were presented to address Question 1 regarding the multi-modal emotional speech perception of drug addicts. Additionally, 26 stimuli of white noise and speech of three emotions in two noise conditions were presented to investigate Question 2 concerning the speech illusion of drug addicts. A total of thirty-five male drug addicts (25 heroin addicts and 10 ketamine addicts) and thirty-five male healthy controls were recruited for the perception experiment. The results, with heroin and ketamine addicts as examples, revealed that drug addicts exhibited lower accuracies in multi-modal emotional speech perception and relied more on visual cues for emotion recognition, especially when auditory and visual inputs were incongruent. Furthermore, both heroin and ketamine addicts showed a higher incidence of emotional responses when only exposed to white noise, suggesting the presence of psychotic-like symptoms (i.e., speech illusion) in drug addicts. Our results preliminarily indicate a disorder or deficit in multi-modal emotional speech processing among drug addicts, and the use of visual cues (e.g., facial expressions) may be recommended to improve their interpretation of emotional expressions. Moreover, the speech illusions experienced by drug addicts warrant greater attention and awareness. This paper not only fills the research gap in understanding multi-modal emotion processing and speech illusion in drug addicts but also contributes to a deeper understanding of the effects of drugs on human behavior and provides insights for the theoretical foundations of detoxification and speech rehabilitation for drug addicts.

Experimental analysis of voice volume for children with autism spectrum disorder

AbstractInappropriate prosodic production, or features of speech, is an often observed but rarely treated communication skill deficit in individuals with autism. Expanding on previous literature, we conducted a functional analysis (FA) on the voice volume responses (VVRs) of two children with autism spectrum disorder utilizing similar procedures to those of Edgerton and Wine. Then, we evaluated the efficacy of visual feedback from an app and a function‐based treatment to decrease loud VVRs and increase appropriate VVRs. Results of the FA indicated loud VVRs were maintained by social negative reinforcement for one participant and by both social negative and automatic reinforcement for another. For one participant, the intervention decreased the use of loud VVRs and increased appropriate VVRs. For the other participant, the results of the intervention were inconclusive. Implications of conducting functional analyses and behavioral interventions to treat inappropriate voice volume are discussed.

PENGARUH REINFORCEMENT TERHADAP KEDISIPLINAN BELAJAR SISWA DI SMP NEGERI 05 BALIKPAPAN

This paper argues about the relationship between reinforcement and learning discipline of State Junior High School (SMPN) 5 Balikpapan students. As for the background in this research is the importance of reinforcement in the sense of positive or negative reinforcement in the process of creating student learning discipline. The problems discussed in this thesis can be formulated in the form of questions, namely how is reinforcement At SMP Negeri 5 Balikpapan, how is student learning discipline at SMP Negeri 5 Balikpapan, and is there a relationship between reinforcement. Based on the results of the research analyzed, it shows that the reinforcement given by the teachers of SMP Negeri 5 Balikpapan is in the very high category with a frequency of 55. 56%. The remaining 5. 56% are in the high category, 5. 56% are in the medium category, 1. 85% are in the low category. Meanwhile, the level of learning discipline of SMP 5 Balikpapan students is in the high category with a frequency of 7. 41. The remaining 5.56% is in the very high category, 3.70% is in the medium category and 3.70% is in the low category. Because the frequency results obtained at all levels are almost the same, it can be concluded that the learning discipline of SMP 05 Balikpapan students is in the high category. The results of the hypothesis test show that there is no relationship between reinforcement and student discipline at SMP Negeri 5 Balikpapan with a product moment correlation coefficient (r) of 0.606 in the interpretation table of correlation data, which is at a level between 0. 600-0. 800 the correlation is in the high category. The table value of the correlation coefficient for 5% is 0.666 and at a significance level of 1% is 0. 789. With the r count r table. Thus, it is concluded that there is no correlation between reinforcement and student discipline at SMP Negeri 05 Balikpapan.

Anxiety-related constructs and smoking outcome expectancies among Latinx smokers.

Hispanic/Latinx (hereafter Latinx) smokers in the United States (US) experience unique smoking cessation-related challenges. Smoking outcome expectancies (i.e., positive and negative beliefs about the consequences of smoking behavior) have been linked to the maintenance of smoking and comorbidity with negative emotional states such as anxiety among Latinx smokers. However, past work has not characterized rates of probable anxiety disorder and elevated levels of anxiety sensitivity among English-speaking daily Latinx smokers from the United States or concurrently evaluated the explanatory relevance of anxiety symptoms and anxiety sensitivity for negative and positive smoking outcome expectancies. The present investigation sought to (a) determine the base rate of probable anxiety disorder and elevated anxiety sensitivity and (b) explore the unique roles of anxiety symptoms and anxiety sensitivity in relation to negative and positive smoking outcome expectancies. Participants included 338 English-speaking Latinx adult daily cigarette smokers from the United States (Mage = 35.53 years; SD = 8.65; age range 18-61; 37.3% female). Findings revealed high rates of probable anxiety disorder (50.9%) and elevated anxiety sensitivity (73.4%) among English-speaking Latinx smokers from the United States. Anxiety sensitivity, but not anxiety symptoms or disorders, was significantly related to negative consequences, negative reinforcement, positive reinforcement, and appetite/weight control smoking outcome expectancies. Overall, anxiety experiences were common among Latinx smokers, and anxiety sensitivity was a relatively more consistent and robust predictor of negative and positive outcome expectancies relative to anxiety symptoms and probable anxiety disorder. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Modeling the value-based decision to consume alcohol in response to emotional experiences.

Evidence for negative reinforcement of alcohol use is mixed; one possible explanation for this is that people make value-based decisions whether to regulate their emotions via alcohol or an alternative, and only drink-to-cope when alcohol's reinforcing value is larger than that of available alternatives. If this is the case, immediately following a negative emotional event, the value for alcohol should increase primarily in heavy drinkers, whereas in light drinkers, alternative ways of coping should be valued. We conducted a preregistered online experiment (N = 200) with a mixed design (between: heavy vs. light drinker; within: negative/neutral/positive mood induction). In each of three experimental sessions, participants first provided value ratings for a set of alcohol and food stimuli. Second, they were subjected to a mood induction. Third, they made forced choices between either two alcohol or food stimuli. We then applied a drift-diffusion model to these data and tested whether alcohol- and food-related decision-making parameters are differentially affected following the mood inductions in heavy and light drinkers. In preregistered analyses, we found that heavy drinkers did not value alcohol more but valued food less after the negative mood induction. Exploratory analyses uncovered that both heavy- and light-drinking participants valued alcohol more following the negative mood induction if they reported high alcohol craving at the start of the session. Collectively, these results provide some evidence for the idea that drinking-to-cope might be a value-based decision-making process. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

The role of habit in maintaining binge/purge behaviors: An ecological momentary assessment study.

Individuals with eating disorders transdiagnostically engage in binge eating (BE) and/or purging, despite life-threatening consequences. Little is known about factors that contribute to the persistence of these behaviors. This study explored whether habitual control over binge/purge (B/P) spectrum behaviors contributes to symptom persistence and whether negative reinforcement via reductions in negative affect is less influential in maintaining B/P behaviors that are under habitual control and are persistent. Women with BE and/or purging (N = 81) completed self-report measures assessing habit strength of BE and purging. Then, they completed a 14-day ecological momentary assessment (EMA) protocol during which they completed measures of negative affect, BE, and purging multiple times per day. Habitual control over purging was associated with a greater frequency of purging during the EMA period. However, habitual control over BE was not associated with the severity of loss of control eating or the frequency of BE episodes. Habitual control did not moderate temporal relations between negative affect and B/P behaviors during the EMA period. However, exploratory analyses revealed that individuals with a longer duration of BE and greater habitual control over BE showed a less pronounced reduction in negative affect following BE. Overall, these findings suggest that purging may be maintained by habitual stimulus-response learning. In addition, they support the possibility that reduction in negative affect may play a less prominent role in maintaining BE that is habitual and persistent. This study investigated whether habit contributes to the persistence of symptoms in women with binge/purge spectrum behaviors and whether negative reinforcement via reductions in negative affect is less influential in maintaining binge/purge behaviors that are under habitual control. The findings suggest that purging may be maintained through habit. This supports the potential utility of habit reversal interventions to decrease habitual purging.

The GlyT1-inhibitor Org 24598 facilitates the alcohol deprivation abolishing and dopamine elevating effects of bupropion + varenicline in rats

Alcohol Use Disorder (AUD) is a relapsing brain disorder that involves perturbations of brain dopamine (DA) systems, and combined treatment with varenicline + bupropion produces additive effects on accumbal DA output and abolishes the alcohol deprivation effect (ADE) in rats. Also, direct and indirect glycine receptor (GlyR) agonists raise basal DA, attenuate alcohol-induced DA release in the nucleus Accumbens (nAc) and reduce alcohol consumption in rats. This study in rats examines whether the GlyT1-inhibitor Org 24598, an indirect GlyR agonist, enhances the ADE-reducing and DA elevating action of the combined administration of varenicline + bupropion in lower doses than previously applied. Effects on voluntary alcohol consumption, the ADE and extracellular levels of glycine and DA in nAc were examined following treatment with Org 24598 6 and 9 mg/kg i.p., bupropion 3.75 mg/kg i.p. and varenicline 1.5 mg/kg s.c., in monotherapy or combined, using a two-bottle, free-choice alcohol consumption paradigm with an ADE paradigm, and in vivo microdialysis in male Wistar rats. Notably, all treatment regimens appeared to abolish the ADE but only the effect produced by the triple combination (Org24598 + varenicline + bupropion) was significant compared to vehicle. Hence, addition of Org 24598 may enhance the ADE-reducing action of varenicline + bupropion and appears to allow for a dose reduction of bupropion. Treatment with Org 24598 raised accumbal glycine levels but did not significantly alter DA output in monotherapy. Varenicline + bupropion produced a substantial elevation in accumbal DA output that was slightly enhanced following addition of Org 24598. Conceivably, the blockade of the ADE is achieved by the triple combination enhancing accumbal DA transmission in complementary ways, thereby alleviating a hypothesized hypodopaminergia and negative reinforcement to drink. Ultimately, combining an indirect or direct GlyR agonist with varenicline + bupropion may constitute a new pharmacological treatment principle for AUD, although further refinement in dosing and evaluation of other glycinergic compounds are warranted.

The development of compulsive coping behavior depends on dorsolateral striatum dopamine-dependent mechanisms

Humans greatly differ in how they cope with stress, a natural behavior learnt through negative reinforcement. Some individuals engage in displacement activities, others in exercise or comfort eating, and others still in alcohol use. Across species, adjunctive behaviors, such as polydipsic drinking, are used as a form of displacement activity that reduces stress. Some individuals, in particular those that use alcohol to self-medicate, tend to lose control over such coping behaviors, which become excessive and compulsive. However, the psychological and neural mechanisms underlying this individual vulnerability have not been elucidated. Here we tested the hypothesis that the development of compulsive adjunctive behaviors stems from the functional engagement of the dorsolateral striatum (DLS) dopamine-dependent habit system after a prolonged history of adjunctive responding. We measured in longitudinal studies in male Sprague Dawley rats the sensitivity of early established vs compulsive polydipsic water or alcohol drinking to a bilateral infusion into the anterior DLS (aDLS) of the dopamine receptor antagonist α-flupentixol. While most rats acquired a polydipsic drinking response with water, others only did so with alcohol. Whether drinking water or alcohol, the acquisition of this coping response was insensitive to aDLS dopamine receptor blockade. In contrast, after prolonged experience, adjunctive drinking became dependent on aDLS dopamine at a time when it was compulsive in vulnerable individuals. These data suggest that habits may develop out of negative reinforcement and that the engagement of their underlying striatal system is necessary for the manifestation of compulsive adjunctive behaviors.

Do Cops Still Care? A Phenomenological Exploration of Narcotics (De)Criminalization and Officer Discretion in Southern California

&lt;i&gt;The purpose of this transcendental phenomenological study was to explore how law enforcement officers in Los Angeles County described their lived experiences of engaging in discretionary enforcement behaviors when policing narcotics crimes. Rational choice theory was utilized as the theoretical lens for the study. Convenience sampling was used to recruit 15 active law enforcement officers in Los Angeles County. Data were collected through open-ended surveys, semi-structured interviews, and reflexive memos. The data were coded utilizing thematic analysis with the assistance of NVivo 12 Plus. Three primary themes were evident from the data: (1)&amp;nbsp;positive reinforcement-motivators, (2) justifications for reduced narcotics enforcement, and (3) methods of reduced enforcement. Findings revealed law enforcement officers, much like offenders’ criminal behaviors in rational choice theory, can be dissuaded from discretionary enforcement behaviors with adequate negative reinforcement. Implications of the study’s findings, limitations, and recommendations for future research are discussed. &lt;/i&gt;

Activación conductual para dejar de fumar en universitarios mediante videoconferencia: estudio piloto

Introduction: tobacco use is a public health problem in the world. In Mexico, prevalence rates are higher in young adults. There are different reasons for smoking or quitting in a college environment, but they all overlap since most include positive affect induction and reduction of negative affect, which accounts for positive and negative reinforcement processes in smoking behavior. Behavioral Activation (BA) was originally proposed in the treatment of depression through the reinforcement of incompatible behaviors. Promising results have been reported recently in the use of substances and modification of affective states. Objective: to evaluate the effectiveness of a Behavioral Activation intervention to Smoking cessation (BA-S) in the consumption pattern. Method: BA-S was applied by videoconference to 15 college students, with a single-case design with replication; the effect size was calculated using the non-overlap of all pairs (NAP). Results: The BA-S was effective for smoking cessation and reducing consumption patterns. The effect size ranged between 91.10% and 100%; nine students quit smoking and six reduced their consumption. Discussion and conclusions: BA-S decreased the pattern of tobacco consumption and modified the affective states; these results should be taken with caution due to the limited number of participants. It is suggested to continue with the application of the intervention through videoconference since it is a viable alternative in this population.