The purpose of this study was to clarify the effects of psychological and physiological measures of body sites and sex on the perception of different frequencies and speeds of airflow. In this study, we administered various airflow stimuli, which were produced by an airflow-generating device developed in a previous study, to 20 participants (10 men and 10 women) on the back of the hand, palm, cheek, and back of the neck in a room with the temperature set to 20 °C and humidity to 65%. We found the following: 1) Higher airflow speeds were associated with a greater decline in cutaneous temperature, higher coldness scores, and more negative preference scores. While a higher amplitude and frequency of sine wave signal (FSS) was associated with higher coldness scores, a higher level of temperature decline (delta-T) accompanying a higher FSS did not influence the preference score. 2) Women tended to give higher coldness scores and more positive preference scores, and men tended to give lower coldness scores and more negative preference scores. 3) Coldness scores were highest for the back of the hand, followed in order by the palm, cheek, and the back of the neck. Preference scores were most negative for the cheek, followed in order by the back of the neck, back of the hand, and palm (only among men). 4) Coldness scores were higher for body sites associated with a low two-point discrimination threshold, while preference scores were lower for body sites associated with larger pressure sensitivity thresholds. Relevance to industryThe above outcomes (1–4) are relevant for industries involved in the development of comfortable life spaces, including the electronics industry, for developing air-conditioning systems; the entertainment industry, for using air as a new medium of entertainment; and the lifestyle industry, for providing new standards of life to humans.