In this study, we examined the dynamics of the perception of “dislike” ties (reputational dislike) among adolescents within the contexts of friendship, perceived popularity, substance use, and Facebook use. Survey data were collected from a longitudinal sample of 238 adolescents from the 11th and 12th grades in one California high school. We estimated stochastic actor-based network dynamic models, using reports of reputational dislike, friendships, and perceived popularity, to identify factors associated with the maintenance and generation reputational dislike ties. The results showed that high-status adolescents and more frequent Facebook users tended to become perceived as or stay disliked by their peers over time. There was a tendency for friendships to promote the creation and maintenance of reputational disliking but not vice versa. Adolescents tended to perceive others as disliked when their friends also perceived them as disliked. There was no evidence that either cigarette smoking or drinking alcohol affected reputational dislike dynamics. This study highlights the important role that the hierarchical peer system, online peer context, and friendships play in driving information diffusion of negative peer relations among adolescents.