Negative Mood Induction Research Articles

Evaluating the Mood State Dependence of Automatic Thoughts and Dysfunctional Attitudes in Remitted Versus Never-Depressed Individuals

The cognitive model of depression specifies the role of schema-driven negative processing biases in the onset and maintenance of depression. Research has shown that cognitive reactivity, or the ease with which negative thinking patterns are activated by mild changes in negative mood, is related to relapse and recurrence. The goal of this study was to examine cognitive reactivity following a mood prime in individuals vulnerable to depression. Formerly (n = 28) and never (n = 36) depressed individuals were assessed on two measures of negative cognition, the Automatic Thoughts Questionnaire (ATQ) and Dysfunctional Attitudes Scale (DAS), before and after participating in a sad or neutral mood induction procedure (MIP). The negative mood induction resulted in increased belief in negative automatic thoughts across groups; however, only the formerly depressed participants assigned to this condition demonstrated increased DAS scores. Importantly, individuals who completed the neutral mood induction did not exhibit increases in negative cognition, providing evidence against the possibility that the MIP itself may lead to increases in negative cognition. These findings are discussed in relation to understanding the role of negative cognition and vulnerability to depression.

Experimental evidence that changes in mood cause changes in body dissatisfaction among undergraduate women

Previous research has found concurrent and prospective associations between negative mood and body dissatisfaction; however, only experimental research can establish causal relationships. This study utilized an experimental design to examine the influence of negative mood on body dissatisfaction. Undergraduate women were randomly assigned to an experimental or control condition. Participants in the experimental condition (n=21) completed a negative mood induction procedure. Participants in the control condition (n=24) completed a neutral mood procedure. All participants completed visual analog scales regarding their mood and satisfaction with weight and shape before and after each manipulation. Body dissatisfaction increased following the procedure for experimental but not control participants, suggesting that negative mood caused increased body dissatisfaction. In cultures that idealize thinness, body dissatisfaction may arise from funneling general feelings of dysphoria into more concrete and culturally meaningful negative feelings about the body.

Anomalous functional brain activation following negative mood induction in children with pre-school onset major depression

While major depressive disorder has been shown to be a significant mental health issue for school-age children, recent research indicates that depression can be observed in children as early as the preschool period. Yet, little work has been done to explore the neurobiological factors associated with this early form of depression. Given research suggesting a relation between adult depression and anomalies in emotion-related neural circuitry, the goal of the current study was to elucidate changes in functional activation during negative mood induction and emotion regulation in school-age children with a history of preschool-onset depression. The results suggest that a history of depression during the preschool period is associated with decreased activity in prefrontal cortex during mood induction and regulation. Moreover, the severity of current depressed mood was associated with increased activity in limbic regions, such as the amygdala, particularly in children with a history of depression. Similar to results observed in adult depression, the current findings indicate disruptions in emotion-related neural circuitry associated with preschool-onset depression.

Gender Differences in Smoking Following an Implicit Mood Induction

Smoking is significantly associated with negative affect, which may play an especially important role in the smoking behavior of women. The purpose of this laboratory study was to examine the role of gender in the relationship of negative mood and smoking maintenance for male and female smokers following an implicit mood induction using music. Ninety adult smokers (50% female) completed a laboratory session during which they were randomly assigned to a negative mood induction, a positive mood induction, or a neutral mood condition. Latency to smoke and number of cigarettes smoked were assessed during an ad libitumsmoking period following the mood induction. Female smokers began smoking more quickly following the negative mood induction when compared with males. There were no gender differences in the number of cigarettes smoked or for cravings to smoke by mood condition. This study demonstrated gender differences in the relationship between negative affect and smoking behavior following an implicit and subtle mood manipulation. A better understanding of gender differences in smoking behavior can provide valuable information about mechanisms that maintain smoking behavior and guide treatment development to help adults quit smoking.

A Comparison of Mood‐Dependent Memory in Bipolar Disorder and Normal Controls

Mood-dependent memory was investigated in a sample of 28 individuals, with a diagnosis of bipolar disorder I but not during acute episodes, and 30 non-clinical controls by using the word lists from Wechsler Memory Scale--Third Edition and abstract inkblot recognition. Positive or negative mood induction procedures were used prior to and after the stimuli were presented. After either the same or contrasting high or low mood inductions, participants attempted to recall the word list and performed an inkblot recognition task. Bipolar patients were significantly better at the inkblot recognition in the same mood state, showing mood-dependent memory. No differences were found in the verbal recall task. This study paves the way for further investigation into memory differences of this sort in mood disorders.

Minding the music: Neuroscience, video recording, and the pianist

Research in music education asserts that video review by performers facilitates self-directed learning and transforms performing. Yet, certain videos may be traumatic for musicians to view; those who perceive themselves as failing or experience performance-related failures are prone to feelings of distress and sadness that can negatively affect their music-making and well-being. In this study, the reactions of nine Canadian undergraduate pianists to reviewing themselves regularly on video are examined. The study was designed in two parts: first of all, to track the effects of watching self-referent videos of piano lessons and other performances; second, to highlight student responses to a Recital Review Protocol (RRP). The RRP was designed with instructors and students in mind, incorporating neuroscience strategies to reverse blood flow patterns in areas of the brain responsible for negative mood induction. The results from the first part of the study point to how regular video analysis is able to shift initial negative perceptions and transform practicing and performing. The findings from the second part indicate that more attention needs to be paid to students by instructors immediately after performances.

Mood and Implicit Alcohol Expectancy Processes: Predicting Alcohol Consumption in the Laboratory

Implicit positive alcohol expectancy (PAE) processes are thought to respond phasically to external and internal stimuli-including mood states-and so they may exert powerful proximal influences over drinking behavior. Although social learning theory contends that mood states activate mood-congruent implicit PAEs, which in turn lead to alcohol use, there is a dearth of experimental research examining this mediation model relative to observable drinking. Moreover, an expectancy theory perspective might suggest that, rather than influencing PAEs directly, mood may moderate the association between PAEs and drinking. To test these models, this study examined the role of mood in the association between implicitly measured PAE processes (i.e., latency to endorse PAEs) and immediate alcohol consumption in the laboratory. Gender differences in these processes also were examined. College students (N = 146) were exposed to either a positive, negative, or neutral mood induction procedure, completed a computerized PAE reaction time (RT) task, and subsequently consumed alcohol ad libitum. The mood manipulation had no direct effects on drinking in the laboratory, making the mediation hypothesis irrelevant. Instead, gender and mood condition moderated the association between RT to endorse PAEs and drinking in the laboratory. For males, RT to tension reduction PAEs was a stronger predictor of volume of beer consumed and peak blood alcohol concentration in the context of general arousal (i.e., positive and negative mood) relative to neutral mood. RT to PAEs did not predict drinking in the laboratory for females. The results show that PAE processes are important determinants of immediate drinking behavior in men, suggesting that biased attention to mood-relevant PAEs-as indicated by longer RTs-predicts greater alcohol consumption in the appropriate mood context. The findings also highlight the need to consider gender differences in PAE processes. This study underscores the need for interventions that target automatic cognitive processes related to alcohol use.

Effects of mood and urgency on activation of general and specific alcohol expectancies

We tested the interaction of a mood manipulation with positive and negative urgency on activation of general and specific alcohol expectancies. In Study 1, high negative urgency was associated with increased positive-alcohol IAT scores following a negative mood induction, F(1, 93) = 5.71, p < .01. In Study 2, high positive and negative urgency were associated with faster ETASK reaction times for global positive and tension reduction expectancies. These associations did not differ across mood conditions or expectancy subtypes. Our results suggest that positive and negative urgency are associated with increased activation of general, positive alcohol cognitions, rather than mood-specific subtypes.

Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience

RationaleWe have previously shown that tryptophan depletion enhances punishment but not reward prediction (Cools et al. in Neuropsychopharmacology 33:2291–2299, 2008b). This provided evidence for a valence-specific role of serotonin (which declines under depleted tryptophan) in aversive processing. Recent theoretical (Dayan and Huys in PLoS Comput Biol 4:e4, 2008) and experimental (Crockett et al. in J Neurosci 29:11993–11999, 2009) approaches have, however, further specified this role by showing that serotonin is critical for punishment-induced inhibition.ObjectivesWe sought to examine the role of serotonin in punishment-induced inhibition. We also examined the impact of induced mood on this effect to assess whether effects of tryptophan depletion on affective inhibition are moderated by mood.MethodsHealthy females consumed a balanced amino acid mixture with (N = 20) or without (N = 21) the serotonin precursor tryptophan. Each subject completed either negative or neutral mood induction. All subjects completed the reward and punishment reversal learning task adopted in the previous study.ResultsWe demonstrate a punishment prediction impairment in individuals who consumed tryptophan which was absent in individuals who were depleted of tryptophan. This effect was impervious to mood state.ConclusionsOur results suggest that serotonin promotes the inhibition of responses to punishing outcomes. This may lead to reduced punishment prediction accuracy in the presence of tryptophan and may contribute to resilience to affective disorders. Reduction of serotonin via tryptophan depletion then removes this inhibition. As such, we highlight a mechanism by which reduced serotonin can contribute to disorders of impulsivity and compulsivity as well as disorders of emotion.

Gender differences and the relationships of perceived background stress and psychological distress with cardiovascular responses to laboratory stressors

The primary aim of this study was to evaluate the relationships of perceived background stress and self-reported psychological distress on cardiovascular reactivity during acute laboratory stressors. The Perceived Stress Scale (PSS) was used as the measure of perceived background stress, and the General Health Questionnaire (GHQ) was used as the measure of psychological distress. A secondary aim was to examine whether background stress and psychological distress affected the susceptibility to induction of a negative mood using music. Heart rate (HR) and blood pressure (BP) were measured in 149 female and male college students at rest and during a stressful mental arithmetic (MA) task and a mood induction procedure. Higher scores on the GHQ were associated with lower systolic BP reactivity during the MA task by all participants. Higher scores on the PSS and GHQ were also associated with lower diastolic BP and HR reactivity, but only in females. Thus, higher self-reports of background stress and psychological distress tended to result in blunted reactivity to an acute laboratory challenge. Higher levels of background stress and psychological distress were not associated with greater susceptibility to a negative mood induction. This study adds to the growing literature indicating that potentially negative health outcomes may be associated with diminished cardiovascular reactivity under certain conditions.

The moderating effects of contamination sensitivity on state affect and information processing: Examination of disgust specificity

Although contamination sensitivity has been implicated in several disorders, there is a paucity of research examining the influence of this trait on various outcomes. Accordingly, the present study examined the extent to which individual differences in contamination sensitivity moderated state affect in response to a mood induction and subsequent information processing biases, as assessed by a lexical decision task (LDT). It was hypothesised that the moderating effects of contamination sensitivity would be specific to disgust responding to a negative but not positive mood induction, and to reaction times to disgust and fear compared to happy words on the LDT. The findings were largely consistent with this hypothesis, as contamination sensitivity predicted increased disgust and arousal to the negative mood induction. Contamination sensitivity was also a better predictor of reaction times to disgust and fear words than happy words. However, the moderating effect of contamination sensitivity on reaction times on the LDT was not mediated by its effects on response to the negative mood induction. Implications of these findings for conceptualising the role of contamination sensitivity and its association with disgust in specific disorders are discussed.

Negative mood induction normalizes decision making in male cocaine dependent individuals

Decision making is thought to play a key role in psychostimulant relapse, but very few studies have addressed the issue of how to counteract decision-making deficits in addicted individuals. According to the somatic marker framework, pervasive decision-making problems in addicted individuals may relate to abnormalities in the processing of emotional signals that work to anticipate the prospective outcomes of potential decisions. The present study was conducted to test whether the induction of different emotional states (positive, negative, or drug-related) could either normalize or further impair decision-making performance in male cocaine polysubstance-using individuals (CPSI), as indexed by the Iowa gambling task (IGT). Forty-two CPSI and 65 healthy control individuals (all males) were randomly allocated in four affective conditions using a parallel-group design. Participants in the different conditions performed the IGT during exposure to neutral, positive, negative, or drug-related sets of affective images. The results showed that the CPSI exposed to the negative affective context showed a preference for the risk-averse safe choices of the IGT and had a net performance indistinguishable from that of controls. On the other hand, CPSI exposed to positive, drug-related, and neutral contexts showed the typical pattern of disadvantageous performance in the IGT and performed significantly poorer than controls. The impact of the negative mood induction could not be explained in terms of baseline differences in decision-making skills, personality traits related to sensitivity to reward/punishment, or trait positive/negative affect. We conclude that negative mood induction can normalize decision-making performance in male CPSI, which may have important implications for the treatment of cocaine use-related disorders.

Abnormal Neural Sensitivity to Monetary Gains Versus Losses Among Adolescents at Risk for Depression

Major depressive disorder aggregates within families, although the mechanisms of transfer across generations are not well understood. In light of converging biological and behavioral evidence that depressive symptoms are associated with impaired reward processing, we examined whether adolescent girls with a parental history of depression would also exhibit abnormal reward sensitivity. We performed a negative mood induction and then recorded the feedback negativity, a neural index of reward processing, while individuals completed a gambling task. High-risk adolescents reported greater sadness following the mood induction compared to low-risk adolescents. Among the high-risk group, sadness was strongly associated with a blunted feedback negativity, even after controlling for baseline mood and trait neuroticism. This suggests that high-risk adolescents are more reactive to negative stimuli, which significantly alter neural sensitivity to monetary gains and losses. The feedback negativity might be used to identify information processing abnormalities in high-risk populations prior to the onset of a major depressive episode.

Verhaltensmaße des Kontrollverlustes beim Essen: Bissgröße und Bissgeschwindigkeit

Loss of control (LOC) over eating is a common and psychopathologically relevant experience in childhood. The current study aimed at evaluating bite size and bite velocity as behavioral indicators of LOC eating in an experimental test meal study with a variation of mood. Children with or without LOC eating (N=120, 8-13 years) consumed a parent-child test meal and a child-only meal consisting of snack food, following induction of negative mood. Bite size and bite velocity were determined through behavioral observation, food intake was measured, and sense of LOC and mood were rated. Children with LOC eating did not show greater bite size and bite velocity than children without LOC eating. Bite size of children with LOC eating was increased in negative mood and decreased in neutral mood. Greater bite size and bite velocity predicted greater food intake at test meal and snack eating and greater LOC over eating at snack eating, however, without an intervening influence of negative mood. Bite size was significantly associated with greater body weight of child and parent. Bite size and bite velocity were not significantly associated with eating disorder psychopathology and varying levels of LOC symptoms. The evidence as to whether bite size and bite velocity are suited as behavioral indicators of LOC eating is not clear-cut. Further research on behavioral indicators of childhood LOC eating is warranted.

Does negative mood drive the urge to eat? The contribution of negative mood, exposure to food cues and eating style

The current study investigated whether negative mood alone, or in conjunction with exposure to food cues, influences the urge to eat. Female participants ( N = 160) were allocated to either a negative or neutral mood induction procedure followed by exposure to either a preferred food cue or a non-food cue. Participants reported their urge to eat at baseline, following the mood induction procedure, and following the cue exposure, as well as completing measures of restrained and disinhibited eating. Contrary to prediction, urge to eat decreased following the mood induction procedure for those in the negative mood condition. This was not influenced by eating style (i.e., restrained or disinhibited eaters). Urge to eat subsequently increased following exposure to the food, but not the non-food, cue. This effect was moderated by negative mood and eating style with disinhibited eating being positively associated with urge to eat for those women in the negative mood condition. These findings suggest that negative mood plays a role in the tendency to overeat, but only in the context of personally desirable food cues and for a subgroup of women with a history of disinhibited eating.

Mood and Cue Reactivity among Smokers with a History of Major Depression: The Role of Rumination and Impulsivity

The present study tested the influence of rumination and impulsivity on experimentally induced negative mood among a sample of smokers with a lifetime history of major depression (MDD Hx+). Participants (N = 40) were categorized into four vulnerability groups: nonvulnerable (low rumination, low impulsivity), ruminative (elevated rumination, low impulsivity), impulsive (low rumination, elevated impulsivity), and vulnerable (elevated rumination, elevated impulsivity). Participants were counterbalanced to four experimental conditions, using a combination of a mood induction (negative mood induction vs. control) and smoking cue (in vivo cigarette vs. control cue). Although all participants reported greater anger responses when exposed to the negative mood induction versus control, vulnerable and ruminative smokers reported significantly greater anger responses than impulsive and nonvulnerable smokers [F(9,87) = 2.93, p = .038, Mse = 79.38]. Implications are discussed.

Autonomic nervous system reactivity to positive and negative mood induction: The role of acute psychological responses and frontal electrocortical activity

The differential effects of positive versus negative emotions on autonomic nervous system activity are insufficiently understood. This study examined the role of acute mood responses and central nervous system activity on heart rate variability (HRV) using 5-min event recall tasks (happiness and anger recall) and a 5-min Stroop Color Word Test (SCWT) in 20 healthy individuals (mean age 25±4 years, 55% female). HRV was measured in high frequency (HF) and low frequency (LF) domains, and frontal brain activity using electroencephalography (EEG) in the alpha frequency band in F3 and F4. Happiness Recall resulted in increased LF-HRV (p=0.005) but not HF-HRV (p=0.71). Anger Recall did not change HRV (p-values>0.10). The SCWT produced decreases in HF-HRV (p=0.001) as well as LF-HRV (p=0.001). The magnitude of feeling “happy” during Happiness Recall was positively correlated with ΔHF-HRV (p=0.050), whereas an incongruent mood state (“frustrated”) was associated with smaller ΔHF-HRV (p=0.070). Associations between frontal EEG activation and HRV responses were mostly non-significant, except for increased right frontal activation during Happiness Recall which was associated with a decrease in LF/HF ratio (p=0.009). It is concluded that positive and negative mood induction result in differential HRV responses, which is related to both task valence and the intensity of task-induced emotions.

The Effects of Prior Cognitive Control Task Exposure on Responses to Emotional Tasks in Healthy Participants

Recent advances have been made in the application of cognitive training strategies as interventions for mental disorders. One novel approach, cognitive control training (CCT), uses computer-based exercises to chronically increase prefrontal cortex recruitment. Activation of prefrontal control mechanisms have specifically been identified with attenuation of emotional responses. However, it is unclear whether recruitment of prefrontal resources alone is operative in this regard, or whether prefrontal control is important only in the role of explicit emotion regulation. This study examined whether exposure to cognitive tasks before an emotional challenge attenuated the effects of the emotional challenge. We investigated whether a single training session could alter participants' reactivity to subsequent emotional stimuli on two computer-based tasks as well as affect ratings made during the study. We hypothesized that individuals performing the Cognitive Control (CC) task as compared to those performing the Peripheral Vision (PV) comparison task would (1) report reduced negative affect following the mood induction and the emotion task, and (2) exhibit reduced reactivity (defined by lower affective ratings) to negative stimuli during both the reactivity and recovery phases of the emotion task and (3) show a reduced bias towards threatening information. Fifty-nine healthy participants were randomized to complete CC tasks or PV, underwent a negative mood induction, and then made valence and arousal ratings for IAPS images, and completed an assessment of attentional bias. RESULTS indicated that a single-session of CC did not consistently alter participants' responses to either task. However, performance on the CC tasks was correlated on subsequent ratings of emotional images. While overall these results do not support the idea that affective responding is altered by making healthy volunteers use their prefrontal cortex before the affective task, they are discussed in the context of study design issues and future research directions.

Does Asking Adolescents About Suicidal Ideation Induce Negative Mood State?

Two studies examined the potential for negative mood induction through participating in suicidal ideation questionnaire research. Items immediately preceding mood state measures were hypothesized to influence mood state in a negative or positive direction, depending on their emotional content. Study 1 involved 129 adolescents. Mood state decreased nonsignificantly following items on suicidal-type ideation and significantly improved following a series of positive affect items. Study 2 followed up 71 of the original participants 3 years later using a briefer version of the original questionnaire. Here no significant differences in mood state were found at any measurement point. In both studies, the salience of items preceding the mood measure explained a significant proportion of variance in mood state. We concluded that negative mood induction effects were minimal. Ethical implications are discussed.

Effects of sad mood on autobiographical memory in older adults with and without lifetime depression

The main objective of this study was to determine whether reduced autobiographical memory specificity is also a marker for depression in older adults. To answer this question two experiments and a prospective longitudinal clinical study were executed with the autobiographical memory task (AMT) as measure for memory specificity. The objective of the 1st experimental study was to assess the influence of a negative mood induction versus the effect of multiple testing in a neutral condition in 58 never depressed (ND) elderly. In the 2nd experimental study a negative mood was induced in 63 participants remitted from depression (RD) compared to 60 matched ND controls. All participants were 55 and older. Lastly, the predictive value of the AMT for the course of depressive symptoms was assessed in the RD individuals over a 14-17 months follow-up (FU) period. Performance did not improve with repeated testing, but a trend was found suggesting fatigue. There was no difference between the RD and ND group on baseline AMT. The mood induction had no effect on the AMT regardless of clinical history. Changes in the level of depressive symptoms at the 14-month FU were predicted by residual symptoms at baseline and the number of previous depressive episode, but not by baseline AMT, changes in AMT or mood after mood induction. The results of this study suggest that memory specificity on the AMT may not be a useful marker for vulnerability for clinical depression in older adults.