Negative Interpretation Research Articles

Lupus anticoagulant testing for patients on direct oral anticoagulants

Abstract As use of direct factor Xa inhibitor (direct oral anticoagulant; DOAC) therapy increases, a modified lupus anticoagulant (LAC) testing method was studied to remove interfering DOACs, allowing clinicians to evaluate patients for antiphospholipid syndrome (APS) without altering anticoagulation treatment. We evaluated the use of DOAC-StopTM on our LAC testing panel with two assays: dilute Russell viper venom time (dRVVT), a factor X activator, and Silica Clotting Time (SCT), an intrinsic coagulation pathway activator. The plasma specimens were pretreated with DOAC-STOPTM beads by mixing on a rocking platform for 5 minutes and centrifugation at 5000 rpm for 5 minutes. The treated plasma supernatant was used for each step of the assay including the screen, confirm (addition of phospholipid), 50:50 mix (addition of reagent plasma with coagulation factors) and confirm 50:50 mix. The total ratio (ratio between screen and confirm ratios relative to mean of normal ranges) was calculated and used per the package insert in the positive or negative interpretation of each LAC testing panel. The study included patients with one or more of the following characteristics identified during coagulation sign-out and chart review: no evidence of a LAC (NELAC), evidence of a LAC, and whether on apixaban or rivaroxaban therapy. The effectiveness of DOAC removal was characterized with an apixaban spiking experiment for NELAC and LAC patient specimens which showed no change in LAC testing panel interpretation before and after DOAC-STOPTM treatment. A second experiment with apixaban-spiked NELAC samples demonstrated removal of anti-factor Xa activity upon comparison of pre- and post-treatment with DOAC-STOPTM. Of 10 patients taking rivaroxaban, nine had positive dRVVT interpretations; eight of these specimens changed to negative interpretations after DOAC-STOPTM treatment. For SCT, two positive interpretations remained positive, while two of the remaining eight negatives became positive after treatment. Of nine patients taking apixaban, two had positive dRVVT interpretations, one of which became negative post-treatment. Of the seven negative interpretations, one became positive post-treatment. For SCT, three were positive pre-treatment and seven were negative with no change post-treatment. Providing a LAC testing option for patients on DOACs may be of benefit to patients and clinicians in APS assessment, eliminating the risk of suspending anticoagulation therapy. Our study shows DOAC-STOPTM effectively removes DOAC interference in the majority of patient specimens studied, though LAC testing and interpretation in the setting of a high-complexity patient population on DOAC therapy remains challenging with occasional false positives and false negatives.

Interpretation bias in health anxiety: a systematic review and meta-analysis.

Interpretation bias (i.e. the selective negative interpretation of ambiguous stimuli) may contribute to the development and maintenance of health anxiety. However, the strength of the empirical evidence for this association remains a topic of debate. This study aimed to estimate the association between health anxiety and interpretation bias and to identify potential moderators of this association. Chinese-language databases (CNKI, VIP, and Wanfang), English-language databases (Web of Science, PubMed, PsycINFO, and Scopus), and German-language databases (Psyndex and PubPsych) were searched for relevant studies. There were 36 articles (39 studies) identified by this search (N = 8984), of which 32 articles (34 studies) were included in the meta-analysis (N = 8602). Results revealed a medium overall effect size (g = 0.67). Statistically equivalent effect sizes were observed for patients diagnosed with clinical health anxiety (g = 0.58) and subclinical health anxiety (g = 0.72). The effect sizes for threat stimuli that were health related (g = 0.68) and not health related (g = 0.63) did not differ significantly. The effect size for studies using an offline paradigm (g = 0.75) was significantly higher than that for studies using an online paradigm (g = 0.50). It is concluded that health anxiety is significantly and robustly associated with interpretation bias. These findings are of central importance for the advancement of models and treatment of health anxiety.

The Role of Islam in Peace and Development in Somalia (Continuity and Change)

Since 11 September 2001, Islam has been viewed as a threat to global stability rather than as a potential factor for peacebuilding and development. Therefore, most studies on Islam have been framed around security. Although research on the security threat posed by Islamist extremists is understandable, the main purpose of this study is to explore and give more attention to positive and continued contributions of Islamic faith to Somalia’s history and its current situation. To date, Islam has had an enormous constructive impact on Somali society at different stages of its history. It has strengthened peace capacity and development aspects such as literacy, socio-economic factors, justice, urbanisation, common identity and shared future aspirations, which have risen above clan divisions. In terms of methods, this study employs descriptive and analytical research methodologies. In conclusion, despite the current negative interpretation, activities, and actions attributed to the extremist Islamist groups in Somalia and beyond, Islam, on the other hand, has contributed enormously to civilising Somalis, shaping their common identity, nurturing a culture of peace, and improving social development. As it has been in the past, it maintains the potential to provide for Somalia’s future stability and prosperity.

The nocebo phenomenon in the COVID-19 pandemic: a nocebodemic effect

ABSTRACT Introduction The COVID-19 pandemic had remarkable effects on psychological distress. The main stressors were prolonged quarantine and social isolation, fear of infection and death, stigmatization, infodemic, financial difficulties, and job loss. These negative stressors, which affect mental and physical health, make people more vulnerable to nocebo-related risk behaviors. We aimed to summarize data on nocebo behaviors, such as the negative psychological consequences of the COVID-19 pandemic in terms of how people perceive and interpret medical services and treatments. Areas covered Limited data were found from randomized controlled trials with SARS-CoV-2 vaccines and from surveys on healthy people, healthcare workers, and patients with chronic pain disorders. Expert opinion Studies have shown nocebo effects among participants in SARS-CoV-2 vaccines trials, among patients with chronic pain, and among healthcare workers. These effects were widely amplified during the pandemic era, prefiguring a ‘nocebodemic effect’ to describe the massive negative interpretation of health services and medical treatments. Greater awareness of these findings could reduce the impact of the ‘nocebodemic effect’ and increase public trust in science.

Nathan S. French. A Theocentric Interpretation of :הדעת טוב ורע The Knowledge of Good and Evil as the Knowledge for Administering Reward and Punishment

Nathan S. French. <i>A Theocentric Interpretation of :הדעת טוב ורע The Knowledge of Good and Evil as the Knowledge for Administering Reward and Punishment</i>

Cognitive effort avoidance in veterans with suicide attempt histories

Suicide attempts (SA) are increasing in the United States, especially in veterans. Discovering individual cognitive features of the subset of suicide ideators who attempt suicide is critical. Cognitive theories attribute SA to facile schema-based negative interpretations of environmental events. Over-general autobiographical memory and facile solutions in problem solving tasks in SA survivors suggest that aversion to expending cognitive effort may be a neurobehavioral marker of SA risk. In veterans receiving care for mood disorder, we compared cognitive effort discounting and evidence-gathering in a beads task between veterans with (SAHx+; n = 26) versus without (SAHx-; n = 22) a history of SA. Groups did not differ in depressed mood or in a proxy metric of premorbid intelligence. Compared to SAHx- participants, SAHx+ participants self-reported significantly more severe cognitive problems in most domains, and also eschewed choice to earn higher monetary reward if earning it required a slightly increased working memory (WM) demand relative to an easy WM task. There was no group difference, however, in extent of evidence-gathering before declaring a conclusion in a beads task. These preliminary data suggest that aversion to expenditure of cognitive effort, potentially as a component of cognitive difficulties, may be a marker for SA risk.

PSUN51 Re-Calibrating Aldosterone Assay Interpretations: Immunoassay and Liquid Chromatography-Tandem Mass Spectrometry Measurements Across Multiple Controlled Physiologic Conditions

Abstract Background Clinicians frequently rely on aldosterone thresholds derived from older immunoassays to diagnose primary aldosteronism. However, liquid chromatography tandem mass spectrometry (LC-MS/MS) is in increasingly widespread clinical use and has been reported to yield lower aldosterone concentrations. Given that primary aldosteronism is highly prevalent and morbid, yet rarely diagnosed, incorrect interpretations of aldosterone levels can have significant public health impact. To address the potential for incorrect interpretations across the entire dynamic range of aldosterone physiology, we compared aldosterone measurements using LC-MS/MS and immunoassay under controlled physiologic conditions. Methods Untreated, normotensive, overweight volunteers (n=48) underwent prospective characterization of aldosterone production during four controlled conditions: oral sodium suppression and dietary sodium restriction (to capture the full range of Angiotensin II-mediated aldosterone production) and dexamethasone suppression and cosyntropin stimulation (to capture the full range of ACTH-mediated aldosterone production). Serum aldosterone from each condition (n=188 samples) was measured by both immunoassay and LC-MS/MS. Results Serum aldosterone concentrations by LC-MS/MS and immunoassay had a Pearson correlation of 0.69 (p&amp;lt;0.001), with good agreement (intraclass correlation coefficient 0.76 [95% CI 0.52-0.87]). Overall, aldosterone was 37.2% lower by LC-MS/MS than immunoassay (median 10.5 [IQR 3.8, 21.9] vs. 19.6 [9.5, 28.0] ng/dL; p&amp;lt;0.001) with an average bias of 7.2 (SD 12.0) ng/dL by Bland-Altman analysis. The most notable discrepancy was observed in the clinically discriminatory range below 20 ng/dL: 9.9 [7.1, 13.8] ng/dL by immunoassay corresponded to 5.5 [1.4, 8.9] ng/dL by LC-MS/MS (p&amp;lt;0.001), a median difference of 49.6% [20.6, 75.2%] higher by immunoassay. Following oral sodium suppression testing, the aldosterone-to-renin ratio was 4-fold higher by immunoassay than by LC-MS/MS (27.2 [19.7, 62.4] vs. 6.4 [3.5, 19.1] ng/dL per ng/mL/h; p&amp;lt;0.001). Conclusions Aldosterone measurements are systematically lower by LC-MS/MS than by immunoassay across the entire physiologic spectrum of aldosterone production; this effect was especially pronounced – up to 50-65% lower – when aldosterone levels were less than 20 ng/dL, meaning that clinicians should be careful to verify the assay used and the clinical context before excluding the diagnosis of primary aldosteronism. Our findings highlight the risk for false negative interpretations with increasingly common LC-MS/MS assays, thereby underscoring the urgent need to raise awareness among clinicians that interpretations of circulating aldosterone and aldosterone-to-renin ratio values need to be re-calibrated to include much lower values than previously recommended. Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m.

Lebanon and Syria – the “Siamese twins” of the Levant: a Current Situation

The Syrian Arab and Lebanese Republics are two neighboring states located in the Middle Eastern subregions, traditionally called the Levant. The close neighborhood of both countries led to the preservation of old and the emergence of new common denominators in the socio-economic, socio-political and religious spheres. In modern historiography, there are disagreements regarding the degree of preservation and definition of the nature of today’s relations between the two states. It is about the recognition or non-recognition of the existence of the exceptional character of the modern Syrian-Lebanese relations. At the same time, among researchers who recognize the fact of preserving many common denominators for both countries, the main issue remains the positive or negative interpretation of the mentioned phenomenon.&#x0D; It should be realized that most of the close ties between Syria and Lebanon, which are not determined by the immediate geographical proximity of both countries, are as the result of external interference in the affairs of the subregion. It is about the arbitrary territorial-administrative division carried out by the Ottoman Empire, the artificial idea of “Greater Syria”, which was popularized by a native of Mecca - Faisal bin Hussein al-Hashimi, and French experiments during the mandated period of the history of both countries. As a result of the above-mentioned interventions, reinforced by the geographical factor, there was an established desire of Syria to incorporate the Lebanese Republic into its structure, supported by a part of the population of Lebanon itself. Even after the end of the period of Syrian occupation of Lebanon (1990-2005) as a result of the Cedar Revolution, the danger of the absorbing the country of cedarsby neighbor state has not disappeared. This is indicated by the presence of a wide range of pro-Syrian politicians in the Lebanese ruling circles and the role played by the Lebanese Shiite militia organization Hezbollah in saving the B. al-Assad regime during the ongoing civil war in Syria.

Mediators of negative content and voice-related distress in a diverse sample of clinical and non-clinical voice-hearers.

Negative content in hearing voices (i.e., auditory verbal hallucinations) has been associated with adverse clinical outcomes including voice-related distress. Voice appraisals and responding mindfully to voices are theorized to reduce voice-related distress. This study aimed in examine mediators of the negative content voice-related distress relationship in clinical (those who recently received input from mental health services) and non-clinical voice-hearers. One hundred and twenty-one adults (71.9% female; 35.5% mixed or non-white ethnic background) who hear voices were recruited online and completed self-report measures of negative content of voices, voice-related distress, mindfulness of voices, interpretation of loss of control, thought suppression and intrusion. Clinical voice-hearers had significantly higher levels of negative content, voice-related distress and interpretation of loss of control than non-clinical voice-hearers. A mindful approach to voices and interpretation of loss of control mediated the relationship between negative content and voice-related distress across the whole sample. Thought suppression and intrusion did not mediate the relationship. The results support the use of mindfulness-based psychological intervention to reduce voice-related distress. Further development of valid and reliable measures specifically relating to constructs of voice content, voice-related distress and voice suppression will support further research in this area.

Positive Interpretation Bias Predicts Longitudinal Decreases in Social Anxiety

Theoretical models of social anxiety suggest that distorted interpretation processes contribute to its development and maintenance, although the pathways through which this occurs are not well understood. Therefore, the present longitudinal study sought to determine whether negative interpretation bias, positive interpretation bias, and interpretation inflexibility (the degree to which participants correctly revise initial interpretations) predict changes in social anxiety over time. In an important advance over prior studies, individual differences in working memory capacity (WMC) were accounted for, as WMC is thought to play a crucial role in the generation and maintenance of interpretation biases. Following a baseline assessment of social anxiety, interpretation biases, and WMC, participants completed follow-up assessments of social anxiety both 2 weeks (n = 106) and 4 weeks (n = 96) later. After controlling for baseline social anxiety and WMC, greater positive interpretation bias was found to predict lower social anxiety at both follow-ups. Neither negative interpretation bias nor interpretation inflexibility was significantly associated with follow-up social anxiety. These results provide support for greater positive interpretation bias as a facilitator of decreases in social anxiety and a potential target for clinical intervention.

Threat biases associate with anxiety and depression in physically-abused young people with a history of child labour

Background and objectivesYoung people who have experienced early-life maltreatment preferentially attend to threat and draw more threatening interpretations. In turn, these threat biases may explain elevated risk for lifelong anxiety and/or depression. We investigated whether adolescent labourers with a history of physical abuse showed threat biases relative to non-abused labourers, and whether these threat biases associated with anxiety and depression. Methods100 young people (aged 13–18 years, 64% female) from Nepal rescued from illegal child work were assessed for childhood maltreatment and anxiety and/or depression disorders. Participants completed an emotional visual search task (to measure attention engagement of positive versus negative faces) and an ambiguous scenarios questionnaire (to measure the endorsement of negative versus benign interpretations). ResultsSeventy young people reported a history of physical (and emotional) abuse. They were more likely to meet symptom thresholds for depression, and marginally, for anxiety disorders than non-physically abused participants. Abused and non-abused participants did not differ on attention engagement/disengagement of threat or on interpretational style. Abused participants with anxiety were slower to disengage from negative faces to engage with a positive face than non-anxious abused participants. Abused participants with depression endorsed more negative interpretations of ambiguous situations than those without depression. LimitationsThe cross-sectional design limits our ability to infer whether threat biases reflect risk markers of psychopathology. ConclusionsIf threat biases are shown to confer risk for anxiety and depression in future studies, they could be targeted in mental health prevention programs for these vulnerable young people.

Early Life Maltreatment and Adolescent Interpretations of Ambiguous Social Situations: Investigating Interpersonal Cognitions and Emotional Symptoms

In the general population, negative interpretations of social situations have been associated with risk of developing emotional disorders such as anxiety and depression. Given that childhood maltreatment poses risk for later emotional disorders, this study examined whether interpersonal cognitive style differentiated maltreated adolescents from their non-maltreated peers and correlated with emotional symptoms across each group. Forty-seven maltreated and 28 non-maltreated adolescents were recruited from New South Wales, Australia to complete a battery of questionnaires that assessed interpersonal cognitions and levels of anxiety and depression. Comparable endorsement of threatening interpretations of social situations between maltreated adolescents and their non-maltreated peers across measures was found. Furthermore, an association between anxiety and depressive symptoms and interpretation bias was found within the non-maltreatment group but not the maltreated group. Unlike general population samples, negative cognitions do not associate with emotional symptoms in victims of early maltreatment. More research is needed to investigate the cognitive factors maintaining emotional symptoms in adolescent victims of maltreatment.

The antidepressant effect of cognitive reappraisal training on individuals cognitively vulnerable to depression: Could cognitive bias be modified through the prefrontal-amygdala circuits?

Cognitive reappraisal (CR) is one of the core treatment components of cognitive behavioral therapy (CBT) and is the gold standard treatment for major depressive disorders. Accumulating evidence indicates that cognitive reappraisal could function as a protective factor of cognitive vulnerability to depression. However, the neural mechanism by which CR training reduces cognitive vulnerability to depression is unclear. There is ample evidence that the prefrontal–amygdala circuit is involved in CR. This study proposes a novel cognitive bias model of CR training which hypothesizes that CR training may improve the generation ability of CR with altered prefrontal–amygdala functional activation/connectivity, thus reducing negative cognitive bias (negative attention bias, negative memory bias, negative interpretation bias, and/or negative rumination bias) and alleviating depressive symptoms. This study aims to (1) explore whether there is abnormal CR strategy generation ability in individuals who are cognitively vulnerable to depression; (2) test the hypothesis that CR training alleviates depressive symptoms through the mediators of cognitive bias (interpretation bias and/or rumination bias); (3) explore the neural mechanism by which CR training may enhance the ability of CR strategy generation; and (4) examine the short- and long-term effects of CR training on the reduction in depressive symptoms in individuals who are cognitively vulnerable to depression following intervention and 6 months later. The study is promising, providing theoretical and practical evidence for the early intervention of depression-vulnerable individuals.

On the Typology of the Negative Image of an Anarchist in Graphic Art at the Turn of the XIX-XX centuries.

The subject of the study is the thematic and iconographic directions of the negative interpretation of the image of an anarchist in the printed culture of the turn of the XIX-XX centuries. The object of the study is graphic works published in periodicals of various ideological trends and devoted to the representation of the image of an anarchist. Three main directions of such interpretation are identified and described, namely, the criminal-terrorist, the mentally ill and the immigrant, whose iconographic features are analyzed in the light of socio-political and historical-cultural conditions of each specific context. Among the reviewed publications should be mentioned: L'Assiette au beurre, Le Petit Journal (France), Freie Jugend (Germany), Het Volk (Netherlands), La Obra, El Peludo (Argentina), Star (New Zealand) and The Washington Post (USA). The scientific novelty of the work consists in the fact that for the first time in modern art criticism, the process of forming the negative archetype of an anarchist is considered and analyzed on the basis of its graphic representation. Thus, a methodological basis is being created for studying the types of classification of the anarchist image. The methods used in the work are as follows: source studies, iconographic, artistic and stylistic analysis. The results of the study reveal the specifics of one of the interpretations of the image of an anarchist of the turn of the XIX-XX centuries, which has its roots in both right and left political trends, whose approaches to anarchism are based on socio-legal and medical sciences, among which criminology stands out. The latter, led by Cesare Lombroso, played a primary place in the mythologization, which is still active today, of the image of an anarchist as a carrier of chaos.

Cognitive processes predict worry and anxiety under different stressful situations

Worry, a stream of negative thoughts about the future, is maintained by poor attentional control, and the tendency to attend to negative information (attention bias) and interpret ambiguity negatively (interpretation bias). Memories that integrate negative interpretations (interpretation-memory) may also contribute to worry, but this remains unexplored. We aimed to investigate how these cognitive processes are associated with worry and anxiety cross-sectionally (Phase 1), and then explore which cognitive processes from Phase 1 would predict worry and anxiety during times of high stress, namely prior to examinations (Phase 2), and after the initial onset of the COVID-19 pandemic (Phase 3). Worry, anxiety, and cognitive processes were assessed in an undergraduate sample (N = 64). We found that whilst greater benign interpretation bias and benign interpretation-memory bias were associated with lower levels of concurrent worry and anxiety, only interpretation bias explained unique variance in worry and anxiety. No cognitive predictor significantly explained unique variance in prospective worry and anxiety prior to examinations. In relation to anxiety and worry during the stress of the COVID-19 pandemic, both benign attention bias and benign interpretation-memory bias predicted decreased worry; only benign attention bias predicted decreased anxiety. Findings suggest that cognitive processes can predict changes in worry and anxiety during future stressful contexts.

Just Another Physical Wreck on the Shores of Time

Abstract This article investigates the various ways in which Pentecostals read and interpreted the narrative of the woman whom Jesus healed of an “issue of blood.” It explores the manner in which she and her experience are described and explained by Pentecostals in articles and sermons from the beginning of the movement to the present day. The article attempts to survey and analyze the different interpretations and how they have changed over time. While early pentecostal literature used the narrative as an opportunity to engage in anti-physician rhetoric and to defend the doctrine of healing in the atonement, later literature expanded the interpretation of the woman’s issue beyond physical healing to include other “issues” a person might face. Present throughout the literature is an emphasis on the woman’s faith and her personal agency to bring about the miracle. However, also present are negative interpretations of the woman and her “issue of blood.” Finally, the article looks forward to other possible interpretive strategies.

Now I Always have to Perform Well! Effects of CBT for Social Anxiety Disorder on Negative Interpretations of Positive Social Events

Now I Always have to Perform Well! Effects of CBT for Social Anxiety Disorder on Negative Interpretations of Positive Social Events

Subliminal Training Techniques for Cognitive, Emotional and Behavioural Balance. The role of Emerging Technologies

Traditionally, metacognition &amp; higher mental abilities are thought to be exclusively linked to consciousness. However, a growing number of researchers support the idea that nonconscious processes may hold the keys to higher forms of intelligence. Subliminal messages expose individuals to visual or/and auditory stimuli below the threshold of perception. The current review aims to explore the effectiveness of subliminal cues on fundamental aspects of metacognition such as higher cognitive and emotional meta-abilities, affective and behavioral regulation, and academic achievement. In this context, we search for and classify the existing subliminal training techniques, while evaluating the usability of ICTs such as virtual reality, mobile apps, intelligent tutoring systems, and software in subliminal learning and training. The results of this review revealed that subliminal techniques improve all those aspects that assure metacognitive improvements in terms of self- &amp; emotional regulation, higher mental abilities, and behavioral modification. Subliminal cues lower people's shields and update filtering mechanisms enabling people to focus on positive rather than negative interpretations. Subliminal techniques are under the umbrella of metacognitive strategies, since they can used consciously to increase self-regulation capacity as wells as expand the horizons of consciousness. Subliminal teaching techniques can be used by teachers and parents in general and special education to instill higher-level needs &amp; motives, accelerate students’ performance and unfold students’ existing but underdeveloped abilities. Therapists can also utilize these methods to help patients with phobia, anxiety and depression to overcome fear. Subliminal techniques can be also used as a strategy by leaders, mentors, and employees to build trust, inspire and provide humanity with innovative ideas. ICTs provide the ideal environment for implementing subliminal training. However, more research is needed.

The Relations of Attention to and Clarity of Feelings With Facial Affect Perception.

Attention to emotions and emotional clarity are core dimensions of individual differences in emotion awareness. Findings from prior research based on self-report indicate that attention to and recognition of one’s own emotions are related to attention to and recognition of other people’s emotions. In the present experimental study, we examined the relations of attention to and clarity of emotions with the efficiency of facial affect perception. Moreover, it was explored whether attention to and clarity of emotions are linked to negative interpretations of facial expressions. A perception of facial expressions (PFE) task based on schematic faces with neutral, ambiguous, or unambiguous emotional expressions and a gender decision task were administered to healthy individuals along with measures of emotion awareness, state and trait anxiety, depression, and verbal intelligence. Participants had to decide how much the faces express six basic affects. Evaluative ratings and decision latencies were analyzed. Attention to feelings was negatively correlated with evaluative decision latency, whereas clarity of feelings was not related to decision latency in the PFE task. Attention to feelings was positively correlated with the perception of negative affects in ambiguous faces. Attention to feelings and emotional clarity were not related to gender decision latency. According to our results, dispositional attention to feelings goes along with an enhanced efficiency of facial affect perception. Habitually paying attention to one’s own emotions may facilitate processing of external emotional information. Preliminary evidence was obtained suggesting a relationship of dispositional attention to feelings with negative interpretations of facial expressions.

Yevgeny Fomich Molevich: patterns of progressive evolution of his life path in the 1960s–70s

Professor of the Department of Sociology and Cultural Studies of Samara University Evgeniy Fomich Molevich reached 91 years on the 25th of April 2022. Anniversary events and publications regarding this famous scientist have shown that for the modern youth he remains an example and a man of progress. Nevertheless, the origins of his progressive thinking and the foundation of all his modern concepts of society development were laid in the distant 1960s and 1970s. This period of Molevich work as a philosopher is undeservedly overshadowed by the following discoveries of Molevich as a sociologist, although it is obvious that these are interrelated roles of this amazing person. This article examines the period of formation of Y.F. Molevich as an independent researcher. Moreover, additional attention is paid to his creative path as an employee of the Ural State University and the beginning of his working period at Samara University. The contribution of E.F. Molevich is examined and analyzed within the scope of his correcting interpretation of the philosophical law negation of negation and the concept development referring to the natures dialectical evolution. Both concepts will have been applied in the further established sociological theory.