Negative Features Research Articles

BDNF-TrkB Signaling Pathway in Spinal Cord Injury: Insights and Implications.

Spinal cord injury (SCI) is a neurodegenerative disorder that has critical impact on patient's life expectance and life span, and this disorder also leads to negative socioeconomic features. SCI is defined as a firm collision to the spinal cord which leads to the fracture and the dislocation of vertebrae. The current available treatment is surgery. However, it cannot fully treat SCI, and many consequences remain after the surgery. Accordingly, finding new therapeutics is critical. BDNF-TrkB signaling is a vital signaling in neuronal differentiation, survival, overgrowth, synaptic plasticity, etc. Hence, many studies evaluate its impact on various neurodegenerative disorders. There are several studies evaluating this signaling in SCI, and they show promising outcomes. It was shown that various exercises, chemical interventions, etc. had significant positive impact on SCI by affecting BDNF-TrkB signaling pathway. This study aims to accumulate and evaluate these data and inspect whether this signaling is effective or not.

Electronic transport properties of tetracene molecular junctions formed with different metallic electrodes

Density functional theory in combination with non-equilibrium Green’s function is employed to study the electron transport properties of tetracene-based molecular junctions formed with silver, gold, copper and platinum electrodes. The physical origin of the IV curves is discussed by analyzing their density of states, molecular projected self-consistent Hamiltonian, transmission spectra, conductance trends and HOMO-LUMO gap at different operating voltages. The results indicate that till a low bias voltage of 1.4 V, the tetracene molecule shows metallic behavior with silver and copper electrodes while semi-metallic and non-metallic nature with gold and platinum electrodes respectively is observed. The zero bias conductance is found to be greatest for Ag followed by Cu and Au with the least in Pt. Furthermore, it is worth mentioning that negative differential resistance feature is observed in molecular junctions with all the electrodes except Pt, with the highest peak-to-valley current ratio of 1.283 found in Ag-Tetracene-Ag molecular junction.

Symbolic Signs of the Eye Concept in English Language View of the World

The article deals with the symbolic meanings and cultural meanings associated with the concept “eye” in the English linguistic picture of the world. On the basis of a comprehensive analysis of lexicographic sources, phraseology, paremi, artistic discourse and corpus data a wide range of symbolic features of this concept is revealed. To achieve the purpose of the article a number of methods were used: linguocultural, paremiological, linguistic and linguistic-stylistic analysis, as well as the analysis of artistic discourse. It is established that the concept "eye" in English linguoculture symbolizes a “window” for comprehending the inner world of a person and reflects ideas about soul, emotions, personal qualities. At the same time, eyes are metaphorically associated with perception, aesthetic pleasure, inspiration, insight, but also greed, sinfulness, threat and cruel retribution. The revealed richness and ambivalence of symbolic meanings are explained by the cultural significance of the concept “eye” in the English tradition, its deep roots in Christianity, paganism, folklore, literature and art. The symbolism of eyes represents the national values of the English — the search for truth, love of beauty, thirst for knowledge, but also negative features that require attention. It is concluded that the concept “eye” is one of the main codes of English linguoculture, embodying the originality of the national worldview through metaphorical conceptualization of the most important “window” for cognition of reality.

Drug addiction and acquired immune deficiency syndrome

It is inevitable today, speaking of AIDS, not to reopen a series of social, health and ethical-moral issues that we know as negative features of the current models of advanced society. The problem of drug use and abuse together with the radical changes that have taken place in sexual mores in recent decades make this pathology, today still without a precise therapeutic solution, the sounding board of issues that strain the social balances of modern Western societies.

Negative features of sporadic amyotrophic lateral sclerosis: Motor neurons of Onuf's nucleus survive in ADAR2-conditional knockout mice

Patients with amyotrophic lateral sclerosis (ALS) do not develop oculomotor disturbances and vesicorectal dysfunction until end-stage disease owing to the survival of certain motor neurons (MNs), including oculomotor neurons and MNs within Onuf's nucleus. In sporadic ALS, adenosine deaminase acting on RNA 2 (ADAR2)-mediated editing of GluA2 mRNA at the Q/R site is compromised in lower MNs. We previously developed genetically modified mice with a conditional knockout of ADAR2 in cholinergic neurons (ADAR2flox/flox/VAChT-Cre, Fast; AR2). These mice displayed slow and progressive lower motor neuron death with TAR DNA-binding protein 43 (TDP-43) pathology, attributable to insufficient editing at the GluA2 Q/R site due to ADAR2 deficiency. MN death was more common in fast-fatigable MNs owing to differential vulnerability under conditions of ADAR2 deficiency. Although facial and hypoglossal nerves were impaired in AR2 mice, cell death did not occur within the oculomotor nerve nucleus, as observed in patients with sporadic ALS. Since the basis for avoiding cystorectal damage in ALS is unknown, we compared the features of Onuf's nucleus MNs in 12-month-old AR2 mice with those in age-matched wild-type mice. Although the number of MNs was not significantly lower in AR2 mice, the neurons exhibited a shrunken morphology and TDP-43 pathology. Onuf's nucleus MNs could survive in an ADAR2-deficient state and mainly included fast fatigue-resistant (FR) and slow (S) MNs. In summary, FR and S MNs show increased resilience to ADAR2 deficiency, potentially participating in an important neuronal death avoidance mechanism in ALS.

Performance Improvement of an MR-Damper-Based Vibration-Reduction System with Energy Harvesting at Sprung Mass Changes

The present paper is concerned with a magnetorheological (MR)-damper-based vibration-reduction system with energy harvesting capability considering sprung mass changes. The system represents a mechanical harmonic oscillator with electrical coupling, set in motion by kinematic excitation. The authors examine the system performance in the case when the MR damper control coil (damper control coil) is powered directly by the alternating current resulting from the voltage generated in an electromagnetic harvester in the assumed frequency range of sine excitation. Such a system is able to attenuate vibration in the near-resonance frequency range when the current in the damper control coil increases; however, its drawback is vibration amplification at higher frequencies. To eliminate this negative feature, it is proposed to connect shunt capacitors in parallel with the damper control coil. Then, the system can be tested experimentally in terms of current in the damper control coil, sprung mass, and the capacity of shunt capacitors in order to evaluate system performance according to the assumed performance index. The obtained results demonstrate significant improvement in system performance at higher frequencies of excitation.

Doing and belonging: A photo-elicitation study on place attachment of older adults living in depopulated rural areas

ABSTRACT Background The relationship between doing and belonging is rooted in individuals’ engagement in meaningful occupations, which contributes to their sense of connectedness. The meaningfulness of occupation relates closely to the context in which it is performed. However, despite its importance, context is often overlooked and underexplored. Aim To explore how older adults living in depopulated rural areas depict positive and negative features of their neighbourhoods and how belonging was connected to doing and participation. Methods We utilised data from photo-elicited interviews with 7 men and 10 women, aged 68 to 88 years, from depopulated rural areas in southern Sweden. Data were analysed using Rowles’ place attachment framework with a thematic analysis. Results The participants expressed how belonging was connected to doing by depicting resources in the area, how community was created through interaction, the importance of past actions for present belonging, how they acted on pride and feelings of obligation, as well as how they experienced challenges for doing and belonging. Discussion Our study revealed a reciprocal relationship of doing and belonging. Specifically, doing strengthened participants’ belonging, while feelings of belonging resulted in loyalty and motivated supportive community actions. Importantly, participants’ actions were more driven by a collective interest in community welfare than personal gain. Conclusions This study contributes to occupational science by knowing how doing supports belonging and vice versa. Furthermore, our study showed that belonging can serve as a catalyst for older adults to engage in their community, which likely reduces the risk of social exclusion.

Enhanced neuroprotective effect of verapamil-loaded hyaluronic acid modified carbon quantum dots in an in-vitro model of amyloid-induced Alzheimer's disease

This study aims to investigate the molecular mechanisms and the neuroprotective effect of hyaluronic acid modified verapamil-loaded carbon quantum dots (VRH-loaded HA-CQDs) against an in-vitro Alzheimer's disease model induced by amyloid beta (Aβ) in SH-SY5Y and Neuro 2a neuroblastoma cells. Briefly, different HA-CQDs were prepared using hydrothermal method and optimized by Box-Behnken design to maximize quantum yield and minimize particle size. Serum stable negatively charged VRH-loaded HA-CQDs was successfully prepared by admixing the optimized HA-CQDs and VRH with association efficiency and loading capacity of 81.25 ± 3.65 % and 5.11 ± 0.81 %, respectively. Cells were pretreated with VRH solution or loaded-HA-CQDs followed by exposure to Aβ. Compared to the control group, amyloidosis led to reduction in cellular proliferation, mitochondrial membrane potential, expression of cytochrome P450, cytochrome c oxidase, CREB-regulated transcriptional coactivator 3, and mitotic index, along with marked increase in reactive oxygen species (ROS) and inflammatory cytokines. Pretreatment with VRH, either free or loaded HA-CQDs, enhanced cell survival, mitochondrial membrane potential, mitotic index, and gene expression. It also reduced inflammation and ROS. However, VRH-loaded HA-CQDs exhibited superior effectiveness in the measured parameters. These findings suggest that VRH-loaded HA-CQDs have enhanced therapeutic potential compared to free VRH in mitigating amyloidosis negative features.

Data-driven prediction on critical mechanical properties of engineered cementitious composites based on machine learning

The present study introduces a novel approach utilizing machine learning techniques to predict the crucial mechanical properties of engineered cementitious composites (ECCs), spanning from typical to exceptionally high strength levels. These properties, including compressive strength, flexural strength, tensile strength, and tensile strain capacity, can not only be predicted but also precisely estimated. The investigation encompassed a meticulous compilation and examination of 1532 datasets sourced from pertinent research. Four machine learning algorithms, linear regression (LR), K nearest neighbors (KNN), random forest (RF), and extreme gradient boosting (XGB), were used to establish the prediction model of ECC mechanical properties and determine the optimal model. The optimal model was utilized to employ SHapley Additive exPlanations (SHAP) for scrutinizing feature importance and conducting an in-depth parametric analysis. Subsequently, a comprehensive control strategy was devised for ECC mechanical properties. This strategy can provide actionable guidance for ECC design, equipping engineers and professionals in civil engineering and material science to make informed decisions throughout their design endeavors. The results show that the RF model demonstrated the highest prediction accuracy for compressive strength and flexural strength, with R2 values of 0.92 and 0.91 on the test set. The XGB model outperformed in predicting tensile strength and tensile strain capacity, with R2 values of 0.87 and 0.80 on the test set, respectively. The prediction of tensile strain capacity was the least accurate. Meanwhile, the MAE of the tensile strain capacity was a mere 0.84%, smaller than the variability (1.77%) of the test results in previous research. Compressive strength and tensile strength demonstrated high sensitivity to variations in both water-cement ratio (W) and water reducer (WR). In contrast, flexural strength exhibited high sensitivity solely to changes in W. Conversely, the sensitivity of tensile strain capacity to input features was moderate and consistent. The mechanical attributes of ECC emerged from the combined effects of multiple positive and negative features. Notably, WR exerted the most significant influence on compressive strength among all features, whereas polyethylene (PE) fiber emerged as the primary driver affecting flexural strength, tensile strength, and tensile strain capacity.

ADVANTAGES AND DISADVANTAGES OF DIGITAL EDUCATION IN THE CONTEXT OF TEACHING DISCIPLINES FROM THE POINT OF VIEW OF THE PHILOSOPHY OF EDUCATION

The article represents the author’s first step in researching the futuristic aspect of future pedagogy and the education system from the standpoint of philosophy and social and pedagogical, medical and psychological sciences. The article is devoted to analytical research and comparative analysis of digital education in China, Lithuania and Ukraine. The positive and negative features of digital education were investigated using the comparative method. It has been proven that modernity without taking into account the knowledge of past methods of technical means of learning will not be complete even in the era of digitalization. The significance of the human component in pedagogy, which cannot be replaced by any artificial intelligence, is substantiated.

MANAGEMENT OF INNOVATIVE DEVELOPMENT OF ENTERPRISES IN THE SMART ECONOMY

In the contemporary economic landscape, the concept of a smart economy has emerged as a critical framework for fostering innovation and enhancing the competitiveness of enterprises. This article explores the management of innovative development within enterprises operating in the smart economy, characterized by the integration of digital technologies, intelligent systems, and data-driven decision-making processes. Through a comprehensive examination of existing literature and a mixed-methods research approach, this study analyzes the strategies, tools, and practices essential for enterprises to thrive in a continuously evolving digital environment. The article provides a comparative analysis of domestic and foreign research, highlighting the practical focus of Ukrainian scholars on implementing innovative technologies and managing processes, contrasted with the theoretical perspectives of international researchers on competitive strategies and open innovation. A detailed comparison between the development of the smart economy in Ukraine and Europe is presented, showcasing key metrics, achievements, and challenges. Furthermore, the discussion addresses the positive and negative features of the smart economy, such as enhanced efficiency and productivity, innovation and competitiveness, and issues like digital divide and cybersecurity concerns. The study offers recommendations for improving the mechanisms of managing smart economy development, emphasizing investments in digital infrastructure, promoting digital literacy, fostering public-private partnerships, and ensuring inclusive access. Finally, the article proposes an adaptive mechanism for managing innovative development, incorporating external environment analysis, organizational flexibility, human capital investment, open innovation, and advanced information technology solutions. These insights and recommendations aim to guide enterprises in effectively harnessing innovation to achieve sustainable success in the smart economy.

ИСПОЛЬЗОВАНИЕ МЕДИАННОЙ ФИЛЬТРАЦИИ ДЛЯ ПОВЫШЕНИЯ КАЧЕСТВА ИЗМЕРЕНИЙ УЛЬТРАЗВУКОВЫМИ ДАТЧИКАМИ РАССТОЯНИЯ

An option has been considered to improve the quality of range measurements by ultrasonic sensors through the use of median filtering. This approach allows us to eliminate the negative feature of ultra-sonic sensors, which is that due to the characteristics of the environment in which the distance is measured, the sensor periodically determines this distance incorrectly. From a metrological point of view, this means that in a series of distance measurements, measurement results often appear that differ sharply from the rest in this series

GASP: A Pan-Specific Predictor of Family 1 Glycosyltransferase Acceptor Specificity Enabled by a Pipeline for Substrate Feature Generation and Large-Scale Experimental Screening.

Glycosylation represents a major chemical challenge; while it is one of the most common reactions in Nature, conventional chemistry struggles with stereochemistry, regioselectivity, and solubility issues. In contrast, family 1 glycosyltransferase (GT1) enzymes can glycosylate virtually any given nucleophilic group with perfect control over stereochemistry and regioselectivity. However, the appropriate catalyst for a given reaction needs to be identified among the tens of thousands of available sequences. Here, we present the glycosyltransferase acceptor specificity predictor (GASP) model, a data-driven approach to the identification of reactive GT1:acceptor pairs. We trained a random forest-based acceptor predictor on literature data and validated it on independent in-house generated data on 1001 GT1:acceptor pairs, obtaining an AUROC of 0.79 and a balanced accuracy of 72%. The performance was stable even in the case of completely new GT1s and acceptors not present in the training data set, highlighting the pan-specificity of GASP. Moreover, the model is capable of parsing all known GT1 sequences, as well as all chemicals, the latter through a pipeline for the generation of 153 chemical features for a given molecule taking the CID or SMILES as input (freely available at https://github.com/degnbol/GASP). To investigate the power of GASP, the model prediction probability scores were compared to GT1 substrate conversion yields from a newly published data set, with the top 50% of GASP predictions corresponding to reactions with >50% synthetic yields. The model was also tested in two comparative case studies: glycosylation of the antihelminth drug niclosamide and the plant defensive compound DIBOA. In the first study, the model achieved an 83% hit rate, outperforming a hit rate of 53% from a random selection assay. In the second case study, the hit rate of GASP was 50%, and while being lower than the hit rate of 83% using expert-selected enzymes, it provides a reasonable performance for the cases when an expert opinion is unavailable. The hierarchal importance of the generated chemical features was investigated by negative feature selection, revealing properties related to cyclization and atom hybridization status to be the most important characteristics for accurate prediction. Our study provides a GT1:acceptor predictor which can be trained on other data sets enabled by the automated feature generation pipelines. We also release the new in-house generated data set used for testing of GASP to facilitate the future development of GT1 activity predictors and their robust benchmarking.

Flexor Tendon Continuity and Negative X-ray: The "Combo" Negative Features in Finger Subamputation.

Background: The subamputation of fingers with vascular compromise presents a surgical challenge. Although tissue continuity may be considered a favourable prognostic element, in our experience, we noticed that there is not always a direct correlation between soft tissue involvement, radiographic appearance and final outcome. Methods: We included, in our study, all cases of vascular pedicle injury in which finger salvage was attempted with microsurgical revascularisation. Exclusion criteria were: integrity of both vascular pedicles, pedicle lesion without global circulatory compromise and patients treated immediately with amputation. Results: Between May 2018 and July 2023, 27 male patients with finger subamputation injuries were treated at our institution. In 11 cases of injured fingers, the only intact tissue was the flexor digitorum profundus (FDP) or flexor pollicis longus (FPL). Our global failure rate was 49%; whereas, in the subgroup of the 11 cases with continuity of the FDP or FPL, the failure rate rose to 73% and when the fingers showed flexor tendon integrity and radiographs demonstrated minimal bone damage, revascularisation failure was observed in all cases (100%). Conclusions: The results of the study show that subamputations with devascularisation, clinically presented with the combination of flexor tendon as the only element of tissue continuity and dislocation or minimal bone/articular injury, have a worse prognosis because of their trauma mechanism. We propose to add them to the Kay-Adani Classification as a subset of the poorest prognostic injuries group (III), to help surgeons to make decisions about the management of subamputation finger injuries.

Homologous recombination proficient subtypes of high-grade serous ovarian cancer: treatment options for a poor prognosis group.

Approximately 50% of tubo-ovarian high-grade serous carcinomas (HGSCs) have functional homologous recombination-mediated (HR) DNA repair, so-called HR-proficient tumors, which are often associated with primary platinum resistance (relapse within six months after completion of first-line therapy), minimal benefit from poly(ADP-ribose) polymerase (PARP) inhibitors, and shorter survival. HR-proficient tumors comprise multiple molecular subtypes including cases with CCNE1 amplification, AKT2 amplification or CDK12 alteration, and are often characterized as "cold" tumors with fewer infiltrating lymphocytes and decreased expression of PD-1/PD-L1. Several new treatment approaches aim to manipulate these negative prognostic features and render HR-proficient tumors more susceptible to treatment. Alterations in multiple different molecules and pathways in the DNA damage response are driving new drug development to target HR-proficient cancer cells, such as inhibitors of the CDK or P13K/AKT pathways, as well as ATR inhibitors. Treatment combinations with chemotherapy or PARP inhibitors and agents targeting DNA replication stress have shown promising preclinical and clinical results. New approaches in immunotherapy are also being explored, including vaccines or antibody drug conjugates. Many approaches are still in the early stages of development and further clinical trials will determine their clinical relevance. There is a need to include HR-proficient tumors in ovarian cancer trials and to analyze them in a more targeted manner to provide further evidence for their specific therapy, as this will be crucial in improving the overall prognosis of HGSC and ovarian cancer in general.

Explainable feature selection and ensemble classification via feature polarity

Feature selection aims to choose the most relevant features from the dataset that can enhance the performance and efficiency of machine learning models. Although feature selection has been studied for many years, most existing methods focus on accuracy and efficiency while neglecting the interpretability of selected features. Therefore, inspired by the “Yin-Yang” philosophy, we introduce the concept of feature polarity for the first time and divide the features into positive and negative features. For example, by analyzing a patient's symptoms (features), we can obtain two sets of features to explain whether the patient has the flu. Positive features help us determine if the patient has the flu, while negative features can help us rule out the possibility of the flu. We introduce the PN (Positive and Negative) coefficient to measure the polarity of candidate features and develop a novel and explainable feature selection method based on feature polarity. Furthermore, we propose an ensemble classification framework that leverages both positive and negative features for each class to improve classification performance. Extensive experiments demonstrate the effectiveness of the PN coefficient compared to other information measurements. Moreover, our proposed classification framework performs excellently compared to some state-of-the-art feature selection methods.

Coherence of socio-cultural processes in the Eurasian space

The study of the evolution of the Eurasian socio-cultural space allows us to reflect the positive and negative aspects and features of the transformation of socio-culture. The aim of the study is to analyze the influence of coherence on the evolution of the Eurasian socio-cultural space, to identify models of sociocultural variability in the context of globalization. The synthesis of a systemic and socio-cultural approach makes it possible to explore the trends of socio-cultural transformation more deeply. It is shown that in the process of evolution of the socio-cultural space of Eurasia, multidirectional lines of development are formed. The socio-cultural system is losing its stability, which leads to disintegration, the formation of new structures that initiate instability and conflict. The emerging models of socioculture reflect the multidirectional trends of integration and differentiation, fixing the problem of preserving local socio cultural originality and identity, maintaining traditional socio-cultural standards. Coherence acts as a system of communication and dialogue of sociocultures, actualizing the perception and recognition of values, interaction, and integration of subcultures. Structures are being developed that are more resistant to innovations and more actively adapt to new conditions. In the process of interaction, a socio-cultural environment is crystallized with a pronounced dominance of the innovative layer in socioculture, rejection of traditions. On the other hand, the need to preserve traditional culture and sociality is determined in local communities. In conditions of modification of the socio-cultural environment, the principle of coherence contributes to the definition of culture and sociality as a local integrated experience, transformed from generation to generation. Coherence serves as a kind of basis for the concept of fixing, integrating historical, traditional, functional, information relations, communications, contributing to the adoption and institution of innovations in conjunction with traditional values. The emerging models of the socio-cultural space reflect the processes of transformation of the life system and lifestyle of local communities, determining the transition from the paradigm of sustainable traditional development to the paradigm of innovative transformations, while preserving traditional values to the utmost.

Understanding marital stability through work–family experiences in proximal and distal contexts: Comparing United States and Japan

AbstractObjectiveGuided by Gottman's framework of marital stability and the ecological theories, the present study aims to understand the relationships between work–family spillover and marital stability within two levels of context—the relational and social cultural contexts.BackgroundThe relational context of marriage is manifested by spousal relationships—spousal support and strain, which would moderate the relationship between work–family spillover and marital stability. Identified relationships also unfold within sociocultural contexts.MethodThis study uses data from the Midlife in the United States 2 (MIDUS 2) and Midlife in Japan (MIDJA) projects to explore these dynamics. The current study involved 500 Japanese and 1,800 American participants who were married and employed at the time of data collection.ResultsResults from multigroup path models revealed cultural differences. The relational context—spousal support and strain—played moderating roles in the associations between work–family spillover and marital stability in both countries. However, distinct sociocultural patterns emerged as spousal strain showed a stronger association among Japanese participants, whereas spousal support was more prominent among Americans in relation to marital stability.ConclusionThe results support Gottman's contention that positive and negative features of marriage are related to marital stability directly and indirectly by shaping the impacts of work–family spillover and sociocultural expectations of work and family.ImplicationsPractitioners and organizations should recognize the role of spouses in addressing the negative effects of work–family spillover in marriage, as well as incorporating clients' or employees' cultural backgrounds when addressing marital concerns.

Similarity judgements: the comparison of normative predictions and subjective evaluations - A study of the ratio model of similarity in social context.

This study examines the consistency between subjective similarity evaluations and the theoretical predictions derived from Tversky's ratio model of similarity, alongside the impact of additional positive and negative features on perceived similarity to ideal and bad politicians. Using a sample of 120 participants, we assessed the similarity of eight candidate profiles to an ideal and bad politician, varying in positive and negative features. Participants' subjective evaluations were compared with theoretical predictions derived from Tversky's ratio model. The analysis focused on how candidate and referent valence influenced observed versus theoretical similarity. Subjective similarity judgments deviated systematically from theoretical predictions, especially for positively featured candidates, indicating a negativity effect. Additional positive features decreased the perceived similarity of favorable candidates to an ideal politician, while additional negative features did not significantly affect similarity judgments of unfavorable candidates. Our findings underscore a significant disparity between subjective and objective similarity judgments, notably for favorable candidates. While the ratio model performs well for unfavorable candidates, its applicability diminishes for favorable ones, emphasizing the role of feature valence in decision-making. Further research on feature valence is crucial for a comprehensive understanding across contexts.

Abstract PO5-02-12: Comparison of survival outcomes according to axillary ultrasonography findings and cytology results in early-stage breast cancer patients

Abstract Purpose: Axillary lymph node dissection and sentinel lymph node biopsy are associated with increased risk of post-surgical complications including lymphedema and recent trials have raised questions about the therapeutic benefit of axillary operation in early-stage breast cancer patients. While treatment options for lymph nodes with negative findings on axillary ultrasonography (AUS) or positive findings on fine needle aspiration biopsy (FNAB) are evident, data regarding lymph nodes that are suspicious on AUS but negative by FNAB are limited. Thus, we aimed to compare clinicopathological characteristics of AUS positive and FNAB negative patients with those of AUS negative or FNAB positive patients. Materials and Methods: Medical records of patients who underwent breast cancer surgery between January 2010 and December 2017 were reviewed. Patients were grouped into the following three groups: (a) negative findings on AUS, (b) suspicious findings on AUS but negative on FNAB, (c) and FNAB positive. A total of 4,506 patients were included for analysis, with 3,771 patients with no suspicious lymph nodes on AUS, 557 patients who had suspicious AUS findings but were negative on FNAB, and 178 patients with positive findings on both AUS and FNAB. Primary endpoints were disease free survival (DFS) and recurrence free survival (RFS), and secondary endpoint was overall survival (OS). Results: At a median follow-up period of 92 months, DFS and RFS was significantly higher in the AUS negative group compared to the other two groups (10-year-DFS: 91.6% vs 87.5% vs 75.7%, 10-year-RFS: 95.0% vs 89.9% vs 77.1%, p < 0.001). In terms of OS, AUS negative group and the AUS positive and FNAB negative group did not show statistically significant survival difference (10-year-OS: 94.5% vs 92.8%, p = 0.061), while the FNAB positive group showed significantly lower survival rates (10-year-OS: 81.8%, p < 0.001). Multivariable analysis revealed that not AUS positive and FANB negative but positive FNAB was significantly associated with poor RFS. Moreover, hormone receptor (HR) positive and HER2 negative subtype showed poor DFS and RFS in subgroup analysis. Conclusion: Early breast cancer patients with suspicious findings on AUS but negative FNAB results had similar OS but inferior DFS and RFS compared to those with negative features on AUS, especially in HR(+)HER2(-) subtype. While further prospective trials are warranted to determine whether additional treatment is necessary, close surveillance is recommended for this subgroup of patients. Figure1. Overall survial and Disease free survival according to axillay US and FNAB status Table1. patients' characteristics Table2. prognostic factors for overall survival and disease free survival related to axillary US and FNAB status Citation Format: Suk Jun Lee. Comparison of survival outcomes according to axillary ultrasonography findings and cytology results in early-stage breast cancer patients [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-02-12.