Negative Emotional Information Research Articles

Habenula: Recently recognized functions and potential clinical relevance.

The habenula (Hb) (from the Latin, little rein) is a phylogenetically old structure located in the dorsomedial portion of the thalamus and is an important link between the forebrain and brainstem monoaminergic nuclei. The Hb includes 2 subdivisions—lateral and medial—which differ in their neurochemical characteristics and connectivity. The lateral Hb receives inputs from the cerebral cortex, lateral hypothalamus, and globus pallidus (GP) and exerts an inhibitory modulation both on dopaminergic neurons of the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) and on serotonergic neurons of the median and dorsal raphe nuclei. This inhibitory effect is primarily mediated by γ-aminobutyric acid (GABA)ergic neurons located in the rostromedial tegmental nucleus (RMTg). The medial Hb receives its main inputs from the medial septum and projects to the interpeduncular nucleus (IPN), which in turn controls the activity of monoaminergic brainstem nuclei. Via all these connections, the Hb has a major role in emotional regulation of behavior. For example, the lateral Hb processes negative emotional state information (including disappointment, punishment, and pain) and inhibits the SNc/VTA neurons involved in learning and motivation. Both the lateral Hb and the medial Hb may also participate in sleep regulation, pain modulation, and the mechanism of drug addiction. Neuroimaging studies allow identification of the Hb and its main connections in humans, and showed its activation in response to negative emotions or pain. The increasing interest in the physiology of the Hb and its involvement in neurologic and psychiatric disease is reflected by a large number of recent reviews.1–9

Age-related differences in attention and memory toward emotional stimuli.

From the perspectives of time perception and motivation, socioemotional selectivity theory (SST) postulates that in comparison with younger adults, older adults tend to prefer positive stimuli and avoid negative stimuli. Currently the cross-cultural consistency of this positivity effect (PE) is still not clear. While empirical evidence for Western populations is accumulating, the validation of the PE in Asians is still rare. The current study compared 28 younger and 24 older Chinese adults in the processing of emotional information. Eye-tracking and recognition data of participants in processing pictures with positive, negative, or neutral emotional information sampled from the International Affection Picture System were collected. The results showed less negative bias for emotional attention in older adults than in younger adults, whereas for emotional recognition, only younger adults showed a negative bias while older adults showed no bias between negative and positive emotional information. Overall, compared with younger adults, emotional processing was more positive in older adults. It was concluded that Chinese older adults show a PE.

Appetitive and aversive information coding in the primate dorsal raphé nucleus.

Serotonin is known to play a key role in the regulation of emotional behavior. There have been conflicting hypotheses about whether the central serotonergic system is involved in positive or negative emotional information processing. To reveal whether and how such opposing information processing can be achieved by single neurons in the dorsal raphé nucleus (DRN), the major source of serotonin in the forebrain, we recorded the activity of DRN neurons while monkeys were conditioned in a Pavlovian procedure with two distinct contexts: an appetitive block where a reward was available; and an aversive one where an airpuff was delivered. We found that single DRN neurons were involved in several aspects of both appetitive and aversive information processing. First, more than half of the recorded DRN neurons discriminated between appetitive and aversive contexts by tonic changes in their activity. In the appetitive context, they then kept track of the expected reward value indicated by the conditioned stimuli. Some of them also encoded an error between the obtained and expected values. In the aversive context, the same neurons maintained tonic modulation in their activity throughout the block. However, modulation of their responses to aversive task events depending on airpuff probability was less common. Together, these results indicate that single DRN neurons encode both appetitive and aversive information, but over differing time scales: relatively shorter for appetitive, and longer for aversive. Such temporally distinct processes of value coding in the DRN may provide the neural basis of emotional information processing in different contexts.

Processing of Emotional Information in Major Depressive Disorder: Toward a Dimensional Understanding

Several decades of research converge on the formulation that individuals diagnosed with major depressive disorder (MDD) exhibit negative biases in their processing of emotional information. It is becoming increasingly clear, however, that traditional between-group comparisons have obscured the substantial heterogeneity of cognitive and affective dysfunction that is associated with depressive symptomatology. In this article, we review the findings of research examining attention to and memory for negative emotional information using a more dimensional perspective on depression. Specifically, we explore studies that assess cognitive biases along a continuum of depressive symptom severity and consider the influence of co-occurring dimensions of functioning, in particular the severity of anxiety symptoms. Finally, we identify critical empirical questions and issues in this growing literature.

Napping and the selective consolidation of negative aspects of scenes.

After information is encoded into memory, it undergoes an offline period of consolidation that occurs optimally during sleep. The consolidation process not only solidifies memories, but also selectively preserves aspects of experience that are emotionally salient and relevant for future use. Here, we provide evidence that an afternoon nap is sufficient to trigger preferential memory for emotional information contained in complex scenes. Selective memory for negative emotional information was enhanced after a nap compared with wakefulness in 2 control conditions designed to carefully address interference and time-of-day confounds. Although prior evidence has connected negative emotional memory formation to REM sleep physiology, we found that non-REM delta activity and the amount of slow wave sleep (SWS) in the nap were robustly related to the selective consolidation of negative information. These findings suggest that the mechanisms underlying memory consolidation benefits associated with napping and nighttime sleep are not always the same. Finally, we provide preliminary evidence that the magnitude of the emotional memory benefit conferred by sleep is equivalent following a nap and a full night of sleep, suggesting that selective emotional remembering can be economically achieved by taking a nap.

Biomarkers reflecting the effects of deep brain stimulation on cognitive control

s / Brain Stimulation 8 (2015) 360e377 375 NoGo visual discrimination task with threat-related emotional distractors. During the task, stimulation was switched ON and OFF every few minutes. Repeated Measures Analysis of Variance was carried out for RTs and Go N2-P3 ERP amplitude with Stimulation (ON, OFF) and Emotion (neutral, threat) as within subjects factors. ANT-DBS was associated with enhanced right parietal Go N2-P3 amplitude and increased reaction time in the context of emotional distractors. Threat related distractors increased attention related parietal N2-P3 amplitude and prolonged response speed during ANT-DBS. In summary, stimulating ANT increased attention allocation to negative emotional information. Enhanced attention allocation to negative emotional information, i.e. negativity bias, is linked with depression. The current results show promise for objective behavioral and electrophysiological biomarkers reflecting mood related stimulation effects. Such biomarkers for objective assessment of the stimulation effects on affective functions have major clinical significance with DBS used for treating depression as well as depressive symptoms reported as side effects of ANT-DBS.

Negative emotional stimuli enhance vestibular processing.

Recent studies have shown that vestibular stimulation can influence affective processes. In the present study, we examined whether emotional information can also modulate vestibular perception. Participants performed a vestibular discrimination task on a motion platform while viewing emotional pictures. Six different picture categories were taken from the International Affective Picture System: mutilation, threat, snakes, neutral objects, sports, and erotic pictures. Using a Bayesian hierarchical approach, we were able to show that vestibular discrimination improved when participants viewed emotionally negative pictures (mutilation, threat, snake) when compared to neutral/positive objects. We conclude that some of the mechanisms involved in the processing of vestibular information are also sensitive to emotional content. Emotional information signals importance and mobilizes the body for action. In case of danger, a successful motor response requires precise vestibular processing. Therefore, negative emotional information improves processing of vestibular information.

Cognitive vulnerability and implicit emotional processing: imbalance in frontolimbic brain areas?

It has been proposed that the neural basis for cognitive vulnerability to depression involves an imbalance in frontolimbic activity during the processing of cues with a negative affective value. Although the question is central to cognitive theory, whether this association is amplified by diagnosis of an affective disorder or recent life stress has not been investigated. A composite cognitive vulnerability score based on questionnaire assessment was used to predict neural responses to negative emotional stimuli in N = 112 participants. Potential moderating effects of psychiatric diagnosis and negative life events were examined. Main and interaction effects were tested against a threshold of p < .05, family-wise error (FWE) corrected at the cluster level, and the results were small-volume corrected in regions of interest. Cognitive vulnerability predicted higher activation of superior parietal areas (p(FWE) < .01) for negative than for positive faces. The association was significantly stronger in healthy participants. For negative versus control stimuli, cognitive vulnerability predicted higher ventrolateral prefrontal and subgenual anterior cingulate activation (p(FWE) < .05) to equal extents in both groups. We found no evidence for an association with amygdala activation. Life events did not moderate the findings. We concluded that cognitive vulnerability was associated with higher activation of frontoparietal areas during an implicit emotional task. These higher levels of activation may potentially reflect increased effort being required to ignore irrelevant negative emotional information in vulnerable populations.

Amygdala response to negative stimuli predicts PTSD symptom onset following a terrorist attack.

Individuals with posttraumatic stress disorder (PTSD) exhibit heightened amygdala reactivity and atypical activation patterns in the medial prefrontal cortex (mPFC) in response to negative emotional information. It is unknown whether these aspects of neural function are risk factors for PTSD or consequences of either trauma exposure or onset of the disorder. We had a unique opportunity to investigate this issue following the terrorist attacks at the 2013 Boston Marathon and the ensuing manhunt and shelter in place order. We examined associations of neural function measured prior to the attack with PTSD symptom onset related to these events. A sample of 15 adolescents (mean age = 16.5 years) who previously participated in a neuroimaging study completed a survey assessing posttraumatic symptoms related to the terrorist attack. We examined blood oxygen level dependent (BOLD) response to viewing and actively down-regulating emotional responses to negative stimuli in regions previously associated with PTSD, including the amygdala, hippocampus, and mPFC, as prospective predictors of posttraumatic symptom onset. Increased BOLD signal to negative emotional stimuli in the left amygdala was strongly associated with posttraumatic symptoms following the attack. Reduced bilateral hippocampal activation during effortful attempts to down-regulate emotional responses to negative stimuli was also associated with greater posttraumatic symptoms. Associations of amygdala reactivity with posttraumatic symptoms were robust to controls for pre-existing depression, anxiety, and PTSD symptoms and prior exposure to violence. Amygdala reactivity to negative emotional information might represent a neurobiological marker of vulnerability to traumatic stress and, potentially, a risk factor for PTSD.

Visual search and emotion: how children with autism spectrum disorders scan emotional scenes.

This study assessed visual search abilities, tested through the flicker task, in children diagnosed with autism spectrum disorders (ASDs). Twenty-two children diagnosed with ASD and 22 matched typically developing (TD) children were told to detect changes in objects of central interest or objects of marginal interest (MI) embedded in either emotion-laden (positive or negative) or neutral real-world pictures. The results showed that emotion-laden pictures equally interfered with performance of both ASD and TD children, slowing down reaction times compared with neutral pictures. Children with ASD were faster than TD children, particularly in detecting changes in MI objects, the most difficult condition. However, their performance was less accurate than performance of TD children just when the pictures were negative. These findings suggest that children with ASD have better visual search abilities than TD children only when the search is particularly difficult and requires strong serial search strategies. The emotional-social impairment that is usually considered as a typical feature of ASD seems to be limited to processing of negative emotional information.

Cognitive-Processing Biases in Individuals High on Perceived Criticism

A considerable literature now shows that perceived criticism (PC) predicts clinical outcomes transdiagnostically. Recent work has begun to identify potential mechanisms underlying PC’s connection to clinical outcomes. For example, anomalies have been found in neural processing when individuals who rate their key relatives as highly critical listen to criticism. To explore whether high-PC individuals are also characterized by other processing abnormalities, we examined cognitive processing in a sample of community participants ( N = 76) high or low on PC. We measured the executive control of attention when these two groups of individuals processed emotional information and interpreted acoustically presented ambiguous words. High-PC individuals showed impaired executive control of negative emotional information relative to low-PC individuals. They also made more negative interpretations of ambiguous words. These findings indicate that PC is associated with underlying vulnerabilities that may predispose individuals to develop psychopathology.

Interpersonal Self-Support and Attentional Disengagement from Emotional Faces

Prior studies have shown that interpersonal self-support is related to emotional symptoms. The present study explored the relationship between interpersonal self-support and attentional disengagement from emotional faces. A spatial cueing task was administrated to 21 high and 24 low interpersonal self-support Chinese undergraduate students to assess difficulty in shifting away from emotional faces. The Sidak corrected multiple pairwise tests revealed that the low interpersonal self-support group had greater response latencies on negative faces than neutral faces or positive faces in the invalid cues condition, F(2, 41) = 5.68, p < .01, η2 = .22. In addition, in the invalid cues condition, the low interpersonal self-support group responded more slowly than the high interpersonal self-support group to negative faces, F(1, 42) = 7.63, p < .01, η2 = .15, the 95% confidence interval for difference of reaction time from 16.30 to 104.70. The results support our hypotheses that low interpersonal self-support is related to difficulty disengaging from negative emotional information and suggest that interpersonal self-support may refer to emotional dispositions, especially negative emotional dispositions.

Lateral prefrontal cortex activity during cognitive control of emotion predicts response to social stress in schizophrenia.

LPFC dysfunction is a well-established neural impairment in schizophrenia and is associated with worse symptoms. However, how LPFC activation influences symptoms is unclear. Previous findings in healthy individuals demonstrate that lateral prefrontal cortex (LPFC) activation during cognitive control of emotional information predicts mood and behavior in response to interpersonal conflict, thus impairments in these processes may contribute to symptom exacerbation in schizophrenia. We investigated whether schizophrenia participants show LPFC deficits during cognitive control of emotional information, and whether these LPFC deficits prospectively predict changes in mood and symptoms following real-world interpersonal conflict. During fMRI, 23 individuals with schizophrenia or schizoaffective disorder and 24 healthy controls completed the Multi-Source Interference Task superimposed on neutral and negative pictures. Afterwards, schizophrenia participants completed a 21-day online daily-diary in which they rated the extent to which they experienced mood and schizophrenia-spectrum symptoms, as well as the occurrence and response to interpersonal conflict. Schizophrenia participants had lower dorsal LPFC activity (BA9) during cognitive control of task-irrelevant negative emotional information. Within schizophrenia participants, DLPFC activity during cognitive control of emotional information predicted changes in positive and negative mood on days following highly distressing interpersonal conflicts. Results have implications for understanding the specific role of LPFC in response to social stress in schizophrenia, and suggest that treatments targeting LPFC-mediated cognitive control of emotion could promote adaptive response to social stress in schizophrenia.

Brains of Optimistic Older Adults Respond Less to Fearful Faces

The authors examined the neural correlates of emotion processing and how they relate to individual differences in optimism among older adults. Brain response during processing of fearful faces was measured by functional magnetic resonance imaging in 16 older adults and was correlated with level of optimism. Greater optimism was associated with reduced activation in the fusiform gyrus and frontal regions, which may reflect decreased salience of negative emotional information or better emotion regulation among optimistic individuals. Relationships persisted after taking into account cortical thickness, amygdala volume, and resting perfusion. Findings have potential implications for the promotion of successful aging.

Selective attention to emotional pictures as a function of gambling motives in problem and nonproblem gamblers.

Problem gambling may reflect a maladaptive means of fulfilling specific affect-regulation motives, such as enhancing positive affect or coping with negative affect. Research with clinical populations indicates that disorders with prominent affective symptoms are characterized by attentional biases for symptom-congruent information. Thus, we assessed whether problem gamblers with enhancement motives for gambling would demonstrate attentional biases for positive emotional information, relative to other types of emotional information, and problem gamblers with coping motives for gambling would demonstrate attentional biases for negative emotional information, compared with other types of emotional information. In addition, we expected motive-congruent biases to be stronger in problem gamblers than nonproblem gamblers. To test these hypotheses, problem and nonproblem gamblers received an emotional orienting task in which neutral, negative, and positive pictorial cues appeared to one side of the computer screen, followed by target words in cued or uncued locations. In a look-away condition, participants had to shift attention away from pictures to respond to predominantly uncued targets, whereas in a look-toward condition, they had to orient to pictures to categorize predominantly cued targets. The results revealed motive-congruent orienting biases and disengagement lags for emotional pictures in problem gamblers. The link between motives and affective biases was less apparent in nonproblem gamblers. Results suggest that attentional measures may provide a useful complement to the subjective methodologies that are typically employed in studying problem gamblers.

Angry expressions strengthen the encoding and maintenance of face identity representations in visual working memory

Visual working memory (WM) for face identities is enhanced when faces express negative versus positive emotion. To determine the stage at which emotion exerts its influence on memory for person information, we isolated expression (angry/happy) to the encoding phase (Experiment 1; neutral test faces) or retrieval phase (Experiment 2; neutral study faces). WM was only enhanced by anger when expression was present at encoding, suggesting that retrieval mechanisms are not influenced by emotional expression. To examine whether emotional information is discarded on completion of encoding or sustained in WM, in Experiment 3 an emotional word categorisation task was inserted into the maintenance interval. Emotional congruence between word and face supported memory for angry but not for happy faces, suggesting that negative emotional information is preferentially sustained during WM maintenance. Our findings demonstrate that negative expressions exert sustained and beneficial effects on WM for faces that extend beyond encoding.

“Disorganized in time”: Impact of bottom-up and top-down negative emotion generation on memory formation among healthy and traumatized adolescents

“Travelling in time,” a central feature of episodic memory is severely affected among individuals with Post Traumatic Stress Disorder (PTSD) with two opposite effects: vivid traumatic memories are unorganized in temporality (bottom-up processes), non-traumatic personal memories tend to lack spatio-temporal details and false recognitions occur more frequently that in the general population (top-down processes). To test the effect of these two types of processes (i.e. bottom-up and top-down) on emotional memory, we conducted two studies in healthy and traumatized adolescents, a period of life in which vulnerability to emotion is particularly high. Using negative and neutral images selected from the international affective picture system (IAPS), stimuli were divided into perceptual images (emotion generated by perceptual details) and conceptual images (emotion generated by the general meaning of the material). Both categories of stimuli were then used, along with neutral pictures, in a memory task with two phases (encoding and recognition). In both populations, we reported a differential effect of the emotional material on encoding and recognition. Negative perceptual scenes induced an attentional capture effect during encoding and enhanced the recollective distinctiveness. Conversely, the encoding of conceptual scenes was similar to neutral ones, but the conceptual relatedness induced false memories at retrieval. However, among individuals with PTSD, two subgroups of patients were identified. The first subgroup processed the scenes faster than controls, except for the perceptual scenes, and obtained similar performances to controls in the recognition task. The second subgroup group desmonstrated an attentional deficit in the encoding task with no benefit from the distinctiveness associated with negative perceptual scenes on memory performances. These findings provide a new perspective on how negative emotional information may have opposite influences on memory in normal and traumatized individuals. It also gives clues to understand how intrusive memories and overgeneralization takes place in PTSD.

Oxytocin and social pretreatment have similar effects on processing of negative emotional faces in healthy adult males

Oxytocin has been shown to affect several aspects of human social cognition, including facial emotion processing. There is also evidence that social stimuli (such as eye-contact) can effectively modulate endogenous oxytocin levels. In the present study we directly tested whether intranasal oxytocin administration and pre-treatment with social stimuli had similar effects on face processing at the behavioral level. Subjects (N = 52 healthy adult males) were presented with a set of faces with expressions of different valence (negative, neutral, positive) following different types of pretreatment (oxytocin—OT or placebo—PL and social interaction—Soc or no social interaction—NSoc, N = 13 in each) and were asked to rate all faces for perceived emotion and trustworthiness. On the next day subjects' recognition memory was tested on a set of neutral faces and additionally they had to again rate each face for trustworthiness and emotion. Subjects in both the OT and the Soc pretreatment group (as compared to the PL and to the NSoc groups) gave higher emotion and trustworthiness scores for faces with negative emotional expression. Moreover, 24 h later, subjects in the OT and Soc groups (unlike in control groups) gave lower trustworthiness scores for previously negative faces, than for faces previously seen as emotionally neutral or positive. In sum these results provide the first direct evidence of the similar effects of intranasal oxytocin administration and social stimulation on the perception of negative facial emotions as well as on the delayed recall of negative emotional information.

Are there sex differences in ERPs related to processing empathy-evoking pictures?

ObjectiveThis study aimed to investigate sex differences in the temporal dynamics of experiencing empathy by using electrophysiological measurements. MethodsTwenty-five females and 27 males viewed 414 pictures of the International affective picture system varying in emotional valence (positive, negative and neutral) and presence of humans (human and scenes). EEG event related potentials (ERPs) were obtained and correlations were computed with self-reported empathy. ResultsCompared to males, females showed increased anterior N2 and parietal LPP amplitudes to humans contrasted with scenes (independent of emotional valence) and to negative contrasted with neutral emotions (independent of human presence). Independent of sex the N1 and anterior N2 were specifically increased for positive human emotions and the parietal LPP for negative human emotions. Across sexes, the N2 and LPP human emotion effects and LPP human effects were associated with self-reported affective empathy, but not with cognitive empathy. ConclusionsThis study provides electrophysiological evidence that women prioritize the processing of socially relevant and negative emotional information, but that women did not show enhanced brain potentials to pictures with positive or negative emotions in humans.

Elevated Affective Lability and Poor Response Inhibition: An Investigation based on Emotional and Non-Emotional Go/No-Go Tasks

The aim of the current study was to test the association between affective lability and the magnitude of response inhibition deficits using four different versions of go/no-go tasks that were composed of (a) affective faces, (b) affective words, (c) neutral faces, or (d) neutral words, with an undergraduate sample that displayed a wide range of emotional instability and impulsivity (N = 45). We hypothesized that heightened affective lability would be significantly associated with deficits in response inhibition, particularly in the context of emotional go/no-go tasks that presented salient and potent emotional materials. Overall findings showed that the magnitude of difficulty in inhibiting potent but irrelevant stimuli on emotional go/no-go tasks was significantly associated with heightened affective lability (characterized by unstable shifts between elated and depressed moods) after taking into consideration the contribution of negative affect and impulsiveness. In contrast, non-emotional go/no-go performance did not significantly predict affective lability. Further, depression-elation mood shifts were significantly associated with greater difficulty in inhibiting irrelevant positive rather than negative emotional information. This line of research may help improve our understanding on the nature of poor inhibitory control associated with conditions characterized by emotional dysregulation.