Negative Changes Research Articles

Disability in activities of daily living before hospitalisation and clinical outcomes following acute-phase rehabilitation in older individuals with cardiovascular disease

Abstract Background Older individuals with cardiovascular disease (CVD) frequently complicate disability in activities of daily living (ADLs), defined as needing assistance performing ADLs, which is at risk for further functional decline and higher mortality. Although acute-phase physical rehabilitation has been recently highlighted for its effectiveness on functional outcomes in older individuals with CVD, the effectiveness in those with pre-hospitalization ADLs disability is uncertain. Purpose To investigate the association between the ADLs disability before hospitalisation and outcomes after acute-phase rehabilitation, including physical function changes during hospitalisation and clinical events after hospital discharge in older individuals with CVD. Methods We studied 2792 individuals aged ≥65 admitted to a university hospital for CVD treatment and received inpatient physical rehabilitation tailored for each patient. The information on disability in ADLs before admission was obtained through interviews about difficulty performing basic ADLs, including feeding, bathing, toileting, dressing, and ambulating. The primary outcome was the Short Physical Performance Battery (SPPB), measured at the initiation of inpatient rehabilitation as a baseline and at hospital discharge to assess the changes in physical function during hospitalisation. We also investigated the five-year composite events of all-cause death and/or rehospitalisation due to heart failure after discharge. The repeated analysis of covariance adjusted for clinical characteristics was used to examine the change in SPPB between ADLs status. We also analysed the association between SPPB change after acute-phase rehabilitation and incidences of composite events in individuals with or without ADLs disability. Results Individuals with ADLs disability before hospitalisation were observed in 163 (5.8%) patients, who showed older age, higher prevalence of heart failure and comorbidities, and lower SPPB at baseline than those with ADLs independent. Conversely, SPPB was significantly higher at hospital discharge than at baseline, even in patients with pre-hospitalization ADLs disability and without interaction between the ADL status (P=0.091, Figure 1). The negative change in SPPB was observed only in 240 (8.6%), and its rate was higher in individuals with ADLs disability than those without (14.2% vs 7.8%, P=0.007). During the median follow-up of 2.6years, the composite events occurred in 760 patients (27.2%), and the combination of negative change in SPPB with ADLs disability was only associated with higher incidences of composite events against preserved SPPB with ADLs independent as reference (adjusted hazard ratio: 2.57, 95% confidence intervals: 1.11–5.97, Figure 2). Conclusions Acute-phase rehabilitation may contribute to better changes in physical function, which is associated with a lower risk of clinical events in older individuals with CVD and pre-hospitalisation ADLs disability.Figure 2

Lipid changes across menopause status point to increased cardiovascular risk

Abstract Background While women develop cardiovascular disease (CVD) approximately ten years later than men, risk of CVD in women rises precipitously following menopause. The mechanisms underlying this acceleration in CVD risk are not well elucidated, but adverse changes in lipid measures are known to occur during the perimenopause period. Previous investigations have been largely restricted to traditional lipid measures and have not examined changes in lipoprotein particles including lipid subfractions and particle number. Purpose We sought to examine longitudinal changes in lipoprotein particles that occur during the menopause transition. Methods A total of 1305 participants in the Dallas Heart Study with known menopause status underwent measurement of LDL-P, HDL-P, sd-LDL, and ld-HDL by NMR LipoProfile LP4 algorithm (LabCorp, Raleigh Durham, NC, U.S.A.) at 2 examinations (between 7-8 years between DHS studies). We compared longitudinal changes in lipoprotein measures between pre-, peri-, post-menopausal women and men using multivariable adjusted linear regression models. For our analysis peri- is the group that was pre-menopause at DHS I and post-menopause at DHS 2, not to mean the period before menopause. Results There 1346 men (referent group) included in the study with a mean age of 43 ± 9.4 years. There was a total of 1246 women with a mean age of 42 ± 5.6 for peri-group, 54 ± 6.2 for post-group, and 34 ± 3.08 for the pre-group. Of the women 440 (35.3%) were pre-menopausal, 298 (23.9%) were peri-menopausal, and 508 (40.8%) were post-menopausal. Over a median follow-up time of 7 years. All three groups had an increase in LDL-P but the greatest percent change is between peri and post, 18.30 (SE 3.05, P<0.001). When compared to men the post-group has the greatest percent change of HDL-P with a negative change of 4.77 (SE 0.948 P<0.0001). Small-dense LDL had the highest percent change in the peri- group when compared to men with a change of 578.62 (SE 288.45, P<0.045). Large-dense HDL had greatest percent change in the post- group when compared to men with negative change of 37.84 (SE 12.83, P<0.0032). Conclusions We found that menopause is associated with adverse changes in lipoprotein profiles, with the most pronounced changes in LDL-particles and subfractions observed for peri-menopausal women. By contrast, post-menopausal women demonstrated the greatest reductions in HDL-particles and subfractions. Taken together, these changes suggest that menopause is associated with a transition to a more atherogenic lipoprotein profile. Further research is needed to investigate whether these adverse changes in lipoproteins translate to greater CV risk.

Boosting Photoelectrochemical Water Oxidation Performance of Ti–Fe2O3 Photoanode via NH2–MIL–53(FeCo) as a Cocatalyst

α–Fe2O3 is a promising photoanode that can be used for solar‐driven photoelectrochemical (PEC) water splitting. However, due to low carrier separation efficiency and slow water oxidation kinetics, the PEC performance of Ti–Fe2O3 is still severely hindered. Here, a novel inorganic–organic hybrid composite photoanode is prepared by depositing NH2–materials of institute Lavoisier (MIL)–53(FeCo) cocatalyst on the surface of Ti–Fe2O3 using solvothermal method. In the results, it is shown that the Ti–Fe2O3/NH2–MIL–53(FeCo) photoanode has a high photocurrent density (3.0 mA cm−2 at 1.23 V vs reversible hydrogen electrode (RHE), which is 5.1 times that of bare Ti–Fe2O3, and the initial potential of water oxidation also undergoes a negative change of about 100 mV. The separation efficiency of Ti–Fe2O3/NH2–MIL–53(FeCo) is significantly enhanced, and the charge injection efficiency increases from 17.6% to 68% at 1.23 V versus RHE. In the further research, it is suggested that the excellent PEC performance of Ti–Fe2O3/NH2–MIL–53(FeCo) may be attributed to an increase in carrier density, prolonged carrier recombination time, and an increase in exposed reactive sites. In this study, a new understanding for the design of Ti–Fe2O3 photoanodes with superior PEC performance based on metal organic framework modification is provided.

Effect of obstruction ratio rate of change gradients on the deflagration characteristics of H2-Air premixed gases

To investigate the effect of the gradient of obstruction ratio change rate on the H2-Air premixed gas combustion explosion in the semi-confined space, Fluent software is used to simulate the explosion flame, turbulent turning and pressure wave coupling process under the conditions of obstacles with different obstruction ratios change rate. The results indicate that as the obstruction ratio's rate of change increases, flame propagation speed decreases, while pressure peak and pressure change rate increase. The flame front becomes sharper, and a positive change in obstruction ratio more significantly affects flame shape and speed than a negative change. At obstruction ratio change rates of −0.3 and −0.2, the flame front area and peak area reach their maximum values. At a change rate of 0.3, the pressure peak is 232 kPa, and the maximum pressure change is 126 kPa/ms, indicating the explosion intensity reaches its peak.

A koronavírus-járvány társadalmi és gazdasági hatásai a határ menti térségek fejlődésére a magyar–szlovák határrégiók esetében

The Social and Economic Impact of the Coronavirus Pandemic on the Development of Border Regions in the Case of the Hungarian–Slovak Border Regions Borders in a given social context seem to be eternal and unchangeable, but their exact location, their permeability, their functions and the regulations assigned to them are in fact constantly changing according to the ideals of the respective societal eras. The SARS-CoV-2 neo-coronavirus infection, identified in December 2019 as the cause of Covid-19 disease, has become a global pandemic, causing a major health, economic and social crisis. The pandemic had an impact on the single market mechanisms established by the European Union, affecting freedoms—the free movement of services, goods, capital and people—and on almost every aspect of everyday life as it had been until then. In border regions, these effects were magnified. The active socio-economic interactions of the Hungarian–Slovak border regions were interrupted overnight as a result of the border traffic measures, causing significant negative changes and restructuring the functioning of cross-border processes.

Racing toward attaining sustainable development in India: Probing the asymmetric effect of country risk and coal energy

AbstractThe pursuit of a sustainable environment is a common goal for many nations; however, achieving this has become increasingly difficult due to country‐specific risks, often referred to as country risk. Despite its importance, the relationship between country risk and environmental outcomes is still in its early stages of exploration. This study aims to bridge this gap by examining the influence of country risk on India's ecological footprint within an asymmetric empirical framework, while accounting for economic growth and coal energy consumption. Utilizing the nonlinear autoregressive distributed lag (NARDL) estimator, the analysis covers data from 1984 to 2018. The findings reveal that positive changes in economic and financial risk contribute to environmental improvement by significantly reducing the ecological footprint, whereas negative changes in these risks lead to an increase in ecological footprint. Additionally, positive changes in political risk, economic growth, and coal energy usage exacerbate the ecological footprint, while reductions in coal energy use and political risk lead to environmental benefits. Based on these outcomes, policymakers are encouraged to establish a clear risk benchmark and reduce the ecological footprint by fostering economic growth in a sustainable manner. Governments should also prioritize strong support for green technology investments and ensure stability across political, economic, and financial sectors to promote long‐term environmental sustainability.

Sleep, dietary intake and physical activity changes with onset of shift work in intern paramedics

Paramedic work is associated with high staff turn-over, insufficient sleep and adverse health outcomes. Our understanding of the relationship between paramedic work and the health behaviours that may precede adverse health outcomes is limited, as few longitudinal studies have examined health behaviours in workers before they commence on the road work. Such research is needed to inform evidence-based recommendations specifically for new paramedics. The current observational cohort study examined self-reported sleep, dietary intake and physical activity in 21 intern paramedics: 15 female and 6 male (median age: 23.0 years [interquartile range (IQR): 4.0]) from an Australian ambulance service. A subset of participants ( n = 16) provided fasting blood samples for cardiometabolic markers (cholesterol, triglycerides and fasting glucose). Data were collected quarterly (pre-shift work, 3 months, 6 months, 9 months and 12 months post commencement). Linear mixed models showed that the first 12 months of shift work were associated with poorer sleep quality ( p = .036), consumption of fewer kilojoules ( p = .026), reduced saturated fat consumption ( p = .005) and lower sodium ( p = .043) and sugar ( p = .038) intake. There were significant increases in leisure time physical activity ( p = .008). This study shows negative changes in sleep quality and improvements in diet and leisure time physical activity during the first 12 months of paramedic work. Individual differences observed in this study, and ongoing suboptimal dietary intake, highlight a need for larger studies with more participants and a focus on personalised strategies for new recruit paramedics.

Asymmetric impact of climate change on banking system stability in selected sub-Saharan economies

This study is an empirical examination of the asymmetric impact of climate change on banking system stability in selected sub-Saharan economies. The study leverages a quantitative research approach through a panel non-linear ARDL framework and data from 29 selected economies, which spans 1996-2017. Findings from the study reveal that in the long term, partial sums of temperature have an insignificant relationship with banking system stability. Further, partial sums of precipitation are negatively related to banking system stability in the long term. The finding indicates that both positive and negative precipitation do harm banking system stability in the selected sub-Saharan economies. Moreover, we find that partial sums of greenhouse gas emissions had an insignificant relationship with banking system stability. In addition, we conclude that greenhouse gases (positive and negative) do not impair banking system stability in selected sub-Saharan economies in the long term. We surmise from the findings that both positive and negative climate change indexes are harmful to banking system stability. On the short-term asymmetric impact, we discover that partial sums of temperature, precipitation, and climate change index do not harm banking system stability. However, negative greenhouse gas emissions are pernicious to the banking system’s stability in the short term. Conversely, positive greenhouse gas levels were statistically insignificant. The study recommends that central banks and monetary authorities in Sub-Saharan Africa design green banking policies to push the climate change agenda in the banking sector.

Association between land use features and changes in walking patterns from pre-pandemic to post-pandemic: A case study of city of Sydney (2013–2023)

While the impact of the pandemic on active mobility patterns is widely studied in several cities, the underlying characteristics that describe the heterogeneity in changes in active mobility are less understood. This is particularly important for post-pandemic active mobility planning. This study aims to investigate and describe the association between urban population and land-use features, as well as changes in the spatio-temporal patterns of walking from pre-pandemic to post-pandemic through a case study of the city of Sydney, Australia, using 11 years of pedestrian count data from 2013 to 2023. The findings indicate that during the pandemic, the average daily pedestrian traffic in Sydney decreased significantly compared to the pre-pandemic period. However, since experiencing the lowest pedestrian traffic in 2020, activities in the study area have shown signs of partial recovery, with a 51% increase observed in 2023. The observed changes in pedestrian activities are, however, spatially heterogeneous. Modeling results reveal that areas with greater commercial land use, more points of interest (POIs), higher population density, and higher network connectivity experienced a significant negative change in the number of walking trips from the pre-pandemic to the pandemic period. Areas with higher percentages of educational and residential use and with higher personal income experienced smaller changes in pedestrian activities during the pandemic compared to the pre-pandemic period. During the post-pandemic recovery, the influential features remain mostly unchanged; however, the association direction is the opposite.

Exchange rate fluctuations and industrial production in Malaysia: evidence from dynamic simulated ARDL analysis

Contemporary literature argues that the exchange rate serves as an important instrument of industrial policy to boost economic growth. However, it is difficult to design effective exchange rate policies owing to the uncertainty shrouding the outcomes of the exchange rate movement for industrial growth. Therefore, this study uses a dynamic simulated autoregressive distributive lags approach to study the impact of positive and negative changes in the real effective exchange rate on industrial production of Malaysia for the period 1970–2022. We employ an extended production function to study this relationship by incorporating capital, labour and globalisation as additional explanatory variables. The findings suggest that positive (negative) changes in real effective exchange rate are followed by positive (negative) changes in economic growth in the long run. Furthermore, positive changes in capital affect economic growth positively and significantly in both the short and long run. Finally, positive (negative) movement in labour and globalization positively (negatively) and significantly affect industrial production in the long run respectively. Policymakers should depreciate currency to expand industrial production in Malaysia. Moreover, to boost industrial production, short-term loans should be introduced for capital accumulation.

FORCED INTERNAL DISPLACEMENT OF THE UKRAINIAN POPULATION: RISKS RAISED BY WAR

The large-scale war forced millions of Ukrainians to leave their homes in search of safety. The mass displacement of the population led to an increase in the level of uncertainty and raised risks for both individuals and the whole of society. This article aims to assess the scale of internal migration in Ukraine during the war and to investigate the impact of this phenomenon on the quantitative and qualitative characteristics of the labor potential and the possibilities of its use. Our assessment of the number of internally displaced persons (IDPs), and our examination of the state of their adaptation and integration in the new territories of residence are based on administrative data about the registration of citizens as IDPs provided by social services as well as the surveys and research findings by international organizations and domestic sociological institutions. We present an overview of individual challenges and risks raised by the forced displacement of the population, and highlight the specific features of their manifestation. In particular, we single out an increase in the demographic burden, a decrease in the number of people of reproductive age, a reduction in the number of jobs, an increase in the burden on the budget, a drop in labor productivity, a loss or reduction in the income of a large part of the population, a limit of access to quality social services, as well as unemployment, deterioration of the quality of employment, increased social vulnerability, and weakening of social cohesion. Risks increase the probability of negative changes that lead to uncertainty, deterioration of the demographic situation, weakening of the stability of the economy, decline in the level and quality of life of the population, deepening of social inequality, growth of social tension, decline in the consumption capacity of the population, complete or partial loss of social ties and jobs. We offer recommendations regarding priorities and specific measures of the national state policy aimed at avoiding risks and minimizing their possible consequences. The implementation of this policy should be focused on establishing legal, economic, and institutional frameworks for easing tensions in the areas of material security and employment, improving the demographic situation as well as the quality and availability of social services, and improving living conditions.

Impact of periodontal therapy on oral bacterial composition in individuals diagnosed with advanced periodontal disease.

Introduction. Negative changes in the microbial composition have been extensively studied in individuals with periodontal disease.Gap Statement. The changes in the oral microbiota after treating this disease are still unknown.Aim. We sought to elucidate the distinctive traits of salivary microbiota in individuals displaying healthy gums and those with severe periodontitis (SP) and examine the influence of periodontal therapy.Methodology. Periodontal pocket depths were examined to determine disease severity. The presence and quantity of oral Helicobacter pylori (associated with periodontal disease) were determined. Sequencing of 16S ribosomal DNA and bioinformatic analyses were performed to assess oral bacterial compositions in patients.Results. Sequencing analysis of 16S ribosomal DNA revealed a significant reduction in the abundance of operational taxonomic units (OTUs) and Chao1 and Abundance coverage-based estimator(ACE) indices in the oral cavities of individuals with SP compared to those of the healthy controls. However, these parameters showed significant recovery after appropriate treatment severe periodontitis after treatment (TSP). Additionally, the levels of harmful Bacillales and Spirochetes significantly increased, whereas the presence of beneficial Euryarchaeota significantly decreased in the SP group. The TSP group exhibited considerably augmented abundances of Burkholderiaceae and Veillonella, while noteworthy reductions in the pathogenic microbiota (Clostridia, Fusobacteria and Spirochaetes) were noticed compared to those of the SP group. Functionally, these modified OTUs were extensively implicated in 41 metabolic pathways.Conclusion. Our study demonstrates that nonsurgical periodontal therapy can effectively reduce the diversity of the oral microbiota, thereby potentially enhancing the treatment efficacy in patients with periodontal disease.

Electing in the dark? Voting behavior in light of polarization

This paper develops a behavioral public choice model. It provides testable hypothesis to explain voter shifts in European national elections in the last decade. The model comprises three blocs of parties, the government, the opposition and so-called “profiteers”. Retrospective voters evaluate the performance of each bloc. Furthermore, it introduces an exogenous polarizing event that can affect the government’s and the profiteers’ chance to satisfy voters. Moreover, voters are subject to the negativity bias, which means that negative changes in probabilities to satisfy are stronger than positive changes. This framework yields various results on voting behavior under polarization. Most are robust to the introduction of non-voting. The government only profits from polarization iff sufficiently many positively voters are polarized in their favor to outweigh both the negativity bias and the increased competitiveness by profiteers due to polarization. Profiteers, strengthened by polarization, harm the opposition and increase voter turnout. Additionally, a higher negativity bias impairs the government, decreases voter turnout and benefits the opposition and profiteers.

Sugarcane Bagasse Based Adsorbents and their Adsorption Efficacy on Removal of Heavy Metals from Nakuru Industrial Wastewater: Optimization, Kinetic and Thermodynamic Aspects

Currently, researchers are seeking to reduce heavy metal contamination from the environment, using agricultural waste materials like rice husk, groundnuts shells among others. The study focused on the removal of Cu(II), Pb(II), Cd(II), Ni(II), and Cr(III) ions from aqueous solutions and Nakuru industrial wastewater using sugarcane bagasse (NSCB) and valorised bagasse ash (VSCB), as alternative low-cost agricultural waste bio-sorbents. To achieve this goal, sugarcane bagasse was collected from Nzoia sugar industry in western Kenya, while the valorised bagasse was obtained by heating sugarcane bagasse sample in a muffle furnace at 300°C for three hours. Furthermore, batch adsorption studies were performed, and the effects of several factors, i.e. adsorbent particle size, pH, contact time, initial heavy metal ions concentration and temperature were investigated to optimise the removal efficiency of Pb, Cu, Cd, Ni, and Cr. The optimal adsorption conditions were pH of 5.0, adsorbent dosage of 0.1 g and ≤ 150µm particle size, equilibrium time of 60 minutes and at 25 degrees Celcius. The removal kinetics of the metal ions onto both adsorbents fitted well with the pseudo-second-order model. The removal kinetics of the metal ions onto both adsorbents fitted well with the pseudo-second-order model. The adsorption of Pb2+ and Ni2+ onto NSCB fitted better with the Freundlich isotherm model, while Cd2+, Cu2+ and Cr3+ showed better fit for the Langmuir isotherm model. As for VSCB adsorbent, Cr3+ has a better fit with the Langmuir isotherm model whereas Pb2+, Ni2+, Cd2+, and Cu2+ fitted well on the Freundlich isotherm model. Freundlich constant’s (1/n) values and the separation factor (RL) from the Langmuir isotherm model indicate that the metal ions were favourably adsorbed onto the adsorbents. Langmuir isotherm model was used to estimate the maximum adsorption capacities (qmax) for Cu(II), Pb(II), Ni(II), Cd(II), and Cr(III). The negative free energy change (∆G) values revealed that adsorption process of the metal ions onto NSCB and VSCB was spontaneous. Fourier Transform Infrared Spectroscopy (FTIR) was used for characterization studies. Interactions with metal ions caused the frequencies of the active functional groups, –OH, C=O and C=C, on the bio-sorbent surfaces to shift to higher values. Therefore, sugarcane bagasse and valorised bagasse have demonstrated higher potential to remove relatively all selected heavy metals in the industrial wastewater at controlled pH.

Assessment of Nuclear Fusion Reaction Spontaneity via Engineering Thermodynamics.

This work recalls the basic thermodynamics of chemical processes for introducing the evaluation of the nuclear reactions' spontaneity. The application and definition of the thermodynamic state functions of the nuclear processes have been described by focusing on their contribution to the chemical potential. The variation of the nuclear binding potentials involved in a nuclear reaction affects the chemical potential through a modification of the internal energy and of the other state functions. These energy changes are related to the mass defect between reactants and products of the nuclear reaction and are of the order of magnitude of 1 MeV per particle, about six orders of magnitude larger than those of the chemical reactions. In particular, this work assesses the Gibbs free energy change of the fusion reactions by assuming the Qvalue as the nuclear contribution to the chemical potential and by calculating the entropy through the Sackur-Tetrode expression. Then, the role of the entropy in fusion processes was re-examined by demonstrating the previous spontaneity analyses, which assume a perfect gas of DT atoms in the initial state of the fusion reactions, are conservative and lead to assessing more negative ΔG than in the real case (ionized gas). As a final point, this paper examines the thermodynamic spontaneity of exothermic processes with a negative change of entropy and discusses the different thermodynamic spontaneity exhibited by the DT fusion processes when conducted in a controlled or uncontrolled way.

Spindles in WAG/Rij Rats with Absence Epilepsy and Comorbid Depression

WAG/Rij rats are a valid model of absence epilepsy and comorbid depression. We have previously shown that WAG/Rij rats have disturbances in the sleep-wake cycle and changes in the characteristics of sleep spindles. A negative correlation was also found between the number of spike-wave discharges (SWD) and the duration of rapid eye movement (REM) sleep. Clinical evidence suggests that the traditional antidepressants imipramine and fluoxetine are effective in suppressing symptoms of depression, but may have a negative impact on the sleep-wake cycle and comorbid epilepsy in patients. Our previous studies in WAG/Rij rats showed that imipramine, when administered chronically, increases the number of SWDs, while fluoxetine at the same dose reduces their number, although both antidepressants have a pronounced antidepressant effect. Comparison of the effects of the antidepressants imipramine and fluoxetine on the sleep-wake cycle and sleep spindles in WAG/Rij rats remains unstudied. The purpose of this work is to find out: 1) what effects do imipramine and fluoxetine have on the sleep-wake cycle and the characteristics of sleep spindles in WAG/Rij rats and 2) whether there are differences in their effects. To achieve this goal, the characteristics of the sleep-wake cycle and sleep spindles were compared in WAG/Rij rats after chronic administration of antidepressants and saline and in non-epileptic Wistar rats. Administration of imipramine led to a significant decrease in the duration of REM sleep. The administration of imipramine, compared with fluoxetine, also increased the latency of the transition to sleep and the transition to REM sleep. Sleep spindle amplitude was significantly increased by both antidepressants. However, the spectral power density of “slow” and “medium” spindles, which predominate in WAG/Rij rats compared to Wistar rats, was significantly higher after administration of imipramine than fluoxetine. The results suggest that imipramine causes greater negative changes in the sleep-wake cycle and sleep spindles than fluoxetine. Studies in the WAG/Rij rat model indicate that fluoxetine is more preferable antidepressant for the treatment of depressive disorders comorbid with absence epilepsy, since it does not cause a significant deterioration in sleep quality. These results are consistent with clinical data.

Effects of Ovarian Stimulation with Gonadotropins in the Conditions of Chronic Psychosocial Stress on the Quality of Murine Oocyte

Chronic psychosocial stress may negatively affect the female reproductive system. Meanwhile, the effect of ovarian stimulation with gonadotropins during stress on the quality of oocytes remains poorly studied. The purpose of this work was to investigate the effects of chronic psychosocial stress on the quality of murine cumulus-oocyte complexes during natural estrus cycle, as well as during ovarian stimulation with exogenous gonadotropins; the latter is an important part of modern assisted reproductive technologies. The results of the study demonstrate that psychosocial stress does not affect the number of ovulating oocytes, but worsens their quality, i. e. reduces the percentage of mature oocytes. In addition, stressed mice exhibited the increased accumulation of reactive oxygen species in oocytes, which is accompanied by the enhanced rate of apoptosis in cumulus cells. Hormonal stimulation of the ovaries with gonadotropins alleviates the negative changes associated with the psychosocial stress, normalizing the level of reactive oxygen species in oocytes and reducing the rate of apoptosis in cumulus cells.

Pressure Change in a Duct with a Flow of a Homogeneous Gaseous Substance in the Presence of a Point Mass and Momentum Sink of Gas

The flow characteristics of homogeneous gases in complex systems are an important issue in many areas, including underground mines. The flow in mine excavations and ventilation systems is described by known mathematical relationships that could be applied to various cases. In this paper, a flow in a duct with a local sink of mass and momentum for multiple variants of cooperation of a mechanical fan was analyzed. The relationships for the total and static pressure of air in the duct were derived. In the next stage, a calculation example of how the mass flow rate of air, and the total and static pressure of the flowing air will change in the tested sections for the duct with and without a sink, is presented. The derived formulas and calculated values for the considered calculation case allow the verification of the obtained relationships at the measurement station. Analyzing the results of the examples presented in the article, it can be concluded that the total and static pressure at the sink point differ depending on the equation of motion used. In the case of the classic equation, the value of total pressure is lower than the value calculated from the new equation of motion, and the difference between them is about 20 Pa. In the case of static pressure, this difference is about 46 Pa. Qualitative differences in the static pressure distribution at the release location were also demonstrated. Depending on the applied approach, positive or negative changes in the static pressure are noticed. The presented form of the equation of motion made it possible to determine the flow characteristics in the duct with a point mass and momentum sink in the case of the operation with and without a fan.

Justification of the effective sequence of group fitness classes with second mature women (45-55 years old)

This article deals with issues that are aimed at the organization of strength training. First of all, it is necessary to note significant differences between women and men in terms of strength. In women, they are 15-20% lower than in men. Women have a lower tendency to gain muscle mass. This is primarily related to the hormonal background, since the male hormone testosterone is responsible for the growth of muscle mass, and its amount in the body of women is many times smaller than that of men. At the same time, women's ability to display strength indicators of leg muscles is close to men's. Experts in age-related physiology note that at the age of 40-45, reverse processes begin in a woman's body. The main metabolism slows down, the productivity of various organs and systems decreases, the possibility of various pathological processes, chronic diseases, etc. increases. In connection with the decrease in the hormonal background, negative changes are observed in all organs and systems of the body. Blood pressure often rises, a tendency to osteoporosis appears, fat metabolism is disturbed, which often leads to an increase in body fat. There are significant changes in the respiratory system, the vital capacity of the lungs decreases, the mobility of the chest decreases. After 40 years, there is a significant decrease in muscle strength in women. The elasticity of muscles, tendons, and joint performance is lost. At the same time, muscle tone decreases, which leads to negative changes in posture.

Impact of coastal erosion and landscape changes on place attachment and the sense of belongingness: a case study in Oluvil, Sri Lanka

Oluvil is a coastal village on the east coast of Sri Lanka with significant resources of fisheries and agricultural lands. The coastal community of Oluvil has a strong socio-cultural and economic attachment to its natural landscape. The community relies heavily on fishing and agriculture for their economic activities, with the vast coastal lands and rich marine resources providing the main source of livelihood. The haphazard development of the fishery and commercial harbour in 2008 resulted in coastal erosion and related landscape changes. This highly impacted the sensitive coastal belt in the region, resulting in many environmental and social issues. This paper investigates the social impact associated with the related negative environmental changes. The research revealed a significant negative impact on income, livelihood, resources and property due to severe coastal erosion. These economic impacts and landscape changes negatively influenced the cultural identity, social dynamics, social structure and interactions, resulting in the loss of place attachment and the sense of belongingness.