Neem seed kernels were used in feeds either raw or autoclaved for 10, 20 and 30 min and each soaked in water (1:2; wt/vol.) for 24 hours. The four-neem kernel portions were ground and incorporated into standard basal diet at 150 and 225 g/kg, respectively, as substitutes for groundnut cake (GNC). The nine experimental diets were fed to 270 cockerel chicks (30/diet) for 49 days to evaluate haematology, weight changes and organ weight in response to the supplements. At 150 g/kg, autoclaved neem kernels supported weight gain and food efficiency as GNC; higher level of heat-treated and both levels of raw neem kernels depressed (P0.05) on the economic traits. Autoclaving improved (P