Need For Additional Surgery Research Articles

Risk factors for lymph node metastasis in early gastric cancer without lymphatic invasion after endoscopic submucosal dissection

BackgroundLymphatic invasion (LI) is a potent risk factor for lymph node metastasis (LNM) in early gastric cancer (EGC) after endoscopic submucosal dissection (ESD). However, there are also other risk factors for LNM. Hence, to identify the need for additional surgery in some case of EGC without LI, the present study aimed to identify the risk factors for LNM in patients with EGC without LI. MethodsData from 2284 patients diagnosed with EGC who underwent curative surgery at National Cancer Center in Korea from January 2012 to May 2019 were collected. The clinicopathological characteristics of patients with EGC without LI were compared on the basis of LNM status. ResultsThere were 339 (17.1%) and 1648 (82.9%) patients with and without LI respectively. Among these patients with and without LI, 118 (34.8%) and 91 (5.5%) patients presented with LNM, respectively. In patients with EGC without LI, tumor size larger than 3 cm (OR = 2.12, 95% CI = 1.22–3.68; p = 0.007), submucosal invasion (OR = 4.14, 95% CI = 2.57–6.65; p < 0.001), and undifferentiated histologic type (OR = 2.33, 95% CI = 1.45–3.76; p < 0.001) were significant risk factors for LNM. Rates of LNM in patients meeting absolute, expanded, and beyond expanded criteria without LI were 0%, 1.5% (OR = 3.27, 95% CI = 0.18–59.41; p = 0.423), and 7.3% respectively. When the expanded criteria were divided into four subtypes patients with EGC, without LI within each subtype did not show significant risk of incidence of LNM compared to the absolute criteria. ConclusionsThe current expanded criteria for endoscopic resection (ER) are tolerable in cases without LI, even though minimal risk LNM exists. Therefore, additional surgery may not be needed for patients meeting expanded criteria for ER.

Syndrome-related outcomes following posterior vault distraction osteogenesis.

The most commonly occurring syndromic craniosynostoses are Apert syndrome, Crouzon syndrome, Pfeiffer syndrome, and Saethre-Chotzen syndrome. There is insufficient data regarding postoperative syndrome-related outcomes following the posterior vault distraction osteogenesis (PVDO) procedure, as well as data addressing whether or not additional procedures will be subsequently necessary to comprehensively treat children who undergo PVDO. Thus, the objective of this study is to describe and compare syndrome-related potential complications and outcomes associated with the PVDO procedure. An observational retrospective study was performed on consecutive patients (n=24) with Apert syndrome, Crouzon syndrome, Pfeiffer syndrome, or Saethre-Chotzen syndrome, respectively, who underwent PVDO between 2012 and 2019. Demographic data (patient gender and age when the PVDO procedure was performed), diagnosis, surgery-related data, and outcome data (perioperative and midterm complications and need for additional surgery) were verified. Total relative blood transfusion volumes per kilogram for the patients were as follows: 22.75 ± 9.30 ml for Apert syndrome, 10.73 ± 2.28 ml for Crouzon syndrome (Apert versus Crouzon, p<0.05), 18.53 ± 8.08 ml for Pfeiffer syndrome, and 19.74 ± 9.12 ml for Saethre-Chotzen syndrome. None of the patients required a secondary procedure to alleviate intracranial pressure except for a Saethre-Chotzen patient. PVDO is an effective technique to address elevated intracranial pressure in SC patients that alleviates the need for secondary procedures at midterm follow-up. Apert syndrome patients presented relatively higher total blood transfusion rates than Crouzon syndrome patients who were operated on at a later age and weighed more.

Craniofrontonasal dysplasia: hypertelorism correction in late presenting patients.

Craniofrontonasal dysplasia (CFND) is a rare congenital craniofacial syndrome characterized by single suture synostosis, hypertelorism, other clinical facial features, and abnormalities in the upper extremities. There are only a few studies in the applicable literature that address hypertelorism management for CFND patients and outcomes and complication rates. A retrospective study was performed on consecutive late presenting CFND patients referred to our hospital with substantially completed craniofacial skeleton growth, who underwent hypertelorism correction between 2007 and 2019 following intracranial pressure screening, and who received at least 1 year of follow-up care. None of the patients in this study underwent prior craniofacial surgery. Only those patients with a confirmed mutation of the EFNB1 gene were included in this study. All patients in this study underwent hypertelorism correction by facial bipartition or box osteotomy. A total of ten late presenting CFND patients (all female) were treated at our hospital during the study period. None of the patients presented signs of elevated intracranial pressure. The average patient age at hypertelorism correction was 13.4 ± 7.68 years of age. Major complications, defined as complications requiring a return to the operating room, were limited to infection of the frontal bone, which required partial bone removal, and cerebrospinal fluid (CSF) leak, which was completely resolved by insertion of a lumbar shunt for a 7-day period. The absence of elevated intracranial pressure enables hypertelorism correction in late presenting CFND patients via facial bipartition or box osteotomy without the need for additional operations that provide for cranial expansion.

Recurrent contracted sockets treated with personalized, three-dimensionally printed conformers and buccal grafts.

Purpose:Recurrent contracted sockets are complex situations where previous surgeries have failed, disabling the wear of an ocular prosthesis. A combined method of surgery and long-term fixation using custom-made, three-dimensional (3D) printed conformers is evaluated.Methods:Retrospective case series of nine patients with recurrent excessive socket contraction and inability to wear a prosthesis, caused by chemical burns (n = 3), fireworks (n = 3), trauma (n = 2) and enucleation and radiotherapy at childhood due to optic nerve glioma (n = 1) with three average previous socket surgeries (range 2–6). Treatment consisted of a buccal mucosal graft and personalized 3D-printed conformer designed to be fixated to the periosteum and tarsal plates for minimal 2 months. Primary outcome was the retention of an ocular prosthesis. Secondary outcome was the need for additional surgeries.Results:Outcomes were measured at final follow-up between 7 and 36 months postoperatively (mean 20 months). Eight cases were able to wear an ocular prosthesis after 2 months. Three cases initially treated for only the upper or only the lower fornix needed subsequent surgery for the opposite fornix for functional reasons. Two cases had later surgery for cosmetic improvement of upper eyelid position. Despite pre-existing lid abnormalities (scar, entropion, lash deficiency), cosmetic outcome was judged highly acceptable in six cases because of symmetric contour and volume, and reasonably acceptable in the remaining two.Conclusions:Buccal mucosal transplant fixated with a personalized 3D-designed conformer enables retention of a well-fitted ocular prosthesis in previously failed socket surgeries. Initial treatment of both upper and lower fornices is recommended to avoid subsequent surgeries for functional reasons.

A single institution experience with papillary thyroid cancer: Are outcomes better at comprehensive cancer centers?

IntroductionPapillary thyroid cancer (PTC) is the most common form of thyroid cancer. Although the survival rate is excellent, recurrence is as high as 20%. The mainstay of therapy is thyroidectomy and lymph node dissection based on risk factors. Data from other cancers suggest that surgical outcomes are most optimal at comprehensive cancer centers. We hypothesize that patients with PTC who had their initial operation at a comprehensive cancer center would have a better oncologic outcome. MethodsWe utilized an IRB-approved cancer care registry database of patients with thyroid cancer who were seen at our institution between 2000 and 2018. Patient records were updated with cancer-specific outcomes including recurrence and need for re-intervention. Clinical and surgical outcomes were then compared between patients who had their initial operation at a comprehensive cancer center (CCC group, n = 503) versus those who did not (non-CCC group, n = 72). ResultsMean patient age was 49 ± 16 years and 70% were female. Average tumor size was 1.6 ± 1.6 cm. There was no difference in tumor size, age, gender or race between groups. Pre-operative ultrasound was more frequently performed at the CCC (89%) than at non-CCC’s (51%, p < 0.001). CCC patients were more likely to undergo initial total thyroidectomies compared to non-CCC patients (76% vs. 21%, p < 0.001). Positive surgical margins were more frequently found in patients at non-CCC’s (19%) than at the CCC (9.7%, p = 0.016). Finally, CCC patients had a significantly lower cancer recurrence rate (5.0% vs. 37.5%, p < 0.001). Therefore, the need for additional cancer operations was much greater in patients who had initial thyroid surgery at non-CCC (31.9% vs. 1.4%, p < 0.001). ConclusionsPatients with PTC who have their initial thyroidectomy at non-CCC have higher recurrence rates, higher rates of positive tumor margins on pathology, and increased need for additional operations. These data suggest that patients who have their initial procedure at a CCC for PTC have better long-term outcomes.

One-stop hybrid surgery for treatment of complex Stanford type B aortic dissection.

ObjectivesTo compare the efficacy and prognosis of one-stop hybrid surgery using the elephant trunk procedure for treatment of complex Stanford type B aortic dissection.MethodsWe retrospectively analyzed patients who underwent surgical treatment from January 2014 to July 2019. The patients were divided into those who underwent the elephant trunk procedure (n = 10) and those who underwent one-stop hybrid surgery (n = 10). The cardiopulmonary bypass time, mechanical ventilation time, length of hospital stay, and red blood cell usage were compared between the two groups. All patients’ 3-month postoperative aortic computed tomography angiography (CTA) findings were also reviewed.ResultsThe cardiopulmonary bypass time, mechanical ventilation time, and length of hospital stay were significantly shorter and red blood cell usage was significantly lower in the one-stop hybridization group. The aortic cross-clamp time was not significantly different between the two groups. Aortic CTA review after hybrid surgery showed that the true lumen of the descending aorta was almost completely restored at 3 months.ConclusionOne-stop hybrid surgery effectively alleviated the occlusion of the aortic dissection, prevented the need for additional surgery, and expanded the indications for covered-stent endovascular repair.

Factors Affecting Posterior Glottic Stenosis Surgery Outcomes: Systematic Review and Meta-analysis.

To investigate surgical adjuncts (stents) and previous surgeries on outcomes from posterior glottic stenosis (PGS). PubMED/Medline, CINAHL, EMBASE, and Web of Science were searched for publications on adult patients undergoing surgery for PGS. Decannulation and need for additional surgeries were evaluated as outcomes. Linear mixed-effects (with random effects and fixed effects) models were used for multivariate testing. In total, 516 abstracts were reviewed and 26 articles were considered for systematic review. Of these, 19 articles with 140 pooled patient cases were extracted for meta-analysis. On multivariate meta-analysis analysis accounting for study-specific variation and use of open procedures, prior surgeries were associated with additional surgeries (RR = 3.76 [1.39-3.86], P = .038) and the use of a stent was associated with a lower likelihood of decannulation (RR = 0.42 [0.09-0.98], P = .044). Minimizing repeat surgery is a predictor for avoiding additional future surgeries and use of a stent was correlated with poor outcomes. These 2 findings may assist providers in patient counseling regarding the need for further surgical interventions. Further, this study is the first to compare the efficacy of surgical approaches for the resolution of PGS, and highlights the importance of avoiding repeat procedures and stents for the management of PGS.

External fixation increases complications following surgical treatment of multiple ligament knee injuries.

The purpose of this study was to review post-operative complications after surgical intervention of MLKIs within the first 6 months to be better able to counsel patients before surgical intervention. All patients who underwent surgical reconstruction for a MLKI at one institution from 2009 to 2018 were included in this study. A retrospective review was performed of all patients and post-operative complications were recorded, including motion loss (which included > 10 degree flexion loss or > 3 degree extension loss), hematoma formation, infection, iatrogenic vascular or nerve injury, deep vein thrombosis (DVT), pulmonary embolism (PE), skin lesions, symptomatic hardware, recurrent ligamentous laxity, and need for additional surgery. Knee ligament injuries were classified based on the Schenck Knee Dislocation (KD) Classification. A total of 136 patients were included in this study, 83 with KD I injuries, 40 with KD III injuries, 9 with KD IV injuries, and 4 with KD V injuries. Of these total patients, 48 (35.5%) sustained a post-operative complication: 11 out of 133 (8.3%) from 0 to 1week, 46 out of 132 (34.8%) from 1week to 1month, 28 out of 124 (22.6%) from 1 to 3months, and 26 out of 121 (21.5%) from 3 to 6months. Out of the total complications, 99 (78.5%) occurred at 1week-3months post-operation. Patients who had an external fixator placed at initial injury were more likely to sustain a post-operative complication. The most common complication was motion loss in 39 (28.6%) patients. There was a significant difference in mean number of complications between the KD I and KD III groups, as well as the KD III and KD IV-V groups. There was no significant difference in the overall prevalence of post-operative complications or occurrence of motion loss with KD grade. The main finding of this study was 48 (35.5%) patients sustained a complication after surgical treatment of MLKIs, with 99 (78.5% of all complications) complications occurring at 1week-3months post-operation. Patients who had an external fixator placed at initial injury were more likely to sustain a post-operative complication. The most common post-operative complication was motion loss in 39 (28.6%) patients. The KD grade was not associated with post-operative development of motion loss, but KD III had a significantly greater mean number of complications than KD I or KD IV-V grades. IV.

Revision of failed reverse shoulder arthroplasty to revision reverse shoulder arthroplasty leads to significant clinical and functional improvement

BackgroundReverse shoulder arthroplasty (RSA) is rapidly growing in the United States. As the number of procedures increases, the number of complications and need for additional surgeries correspondingly continues to grow. The purpose of this study was to describe clinical and functional outcomes of revision of RSA to RSA. MethodsA retrospective review of 29 patients from 2 centers who underwent revision surgery following RSA to RSA from 2007 to 2017 was conducted. The reasons for revision were recorded. Clinical outcome measures including shoulder range of motion, American Shoulder and Elbow Surgeons score, Single Assessment Numerical Evaluation score, simple shoulder test and Visual analog scale scores were collected for all patients at an average follow-up of 29 months. Postoperative complications were also recorded. ResultsA total of 29 patients were identified. The average time between index RSA and revision was 2.3 years (30 days – 7 years). Mean follow-up duration for clinical outcome measures was 29.1 months (12-114 months). The most common indication for revision surgery was aseptic loosening (13/29, 44.8%), followed by instability (7/29, 24.1%), fracture (5/29, 17.2%), and infection (4/29, 13.7%). The average Visual analog scale decreased from 7 to 3 (P< .001). American Shoulder and Elbow Surgeons score scores improved from a mean of 30 to 58 (P < .001). Single Assessment Numerical Evaluation score scores improved from 26 to 54 (P < .001), and Simple shoulder test improved from 2 to 6 (P = .001). Range of motion in both forward elevation from 76° to 131° (P < .001) and external rotation from 26 to 42 (P = .001). Complications were seen in 10 of 29 patients (34.5%). ConclusionA failed RSA can be managed with revision RSA with acceptable clinical outcomes although outcome is inferior to primary RSA with a high rate of complications. Level of EvidenceLevel IV; Retrospective Case Series

Efficacy and safety of 5-fluorouracil in infrared monitor guided bleb revision

PurposeInfrared monitor-guided bleb revision (IRGBR), an alternative needling system, visualizes anterior-segment tissues around the bleb not visible during needle revision after trabeculectomy. This study determined the safety and efficiency of 5-fluorouracil (5-FU) as an adjunctive anti-metabolite in IRGBR.MethodsWe retrospectively analyzed 43 consecutive eyes (40 patients; 14 eyes, primary open-angle; 29 eyes, secondary glaucoma) treated with IRGBR for failing filtering blebs. The patients were divided into two groups. The first one had IRGBR without adjunctive 5-FU subconjunctival injection, and the second one had IRGBR with 5-FU. We performed Kaplan-Meier survival analysis using log-rank tests after 2 years of follow-up and Cox proportional hazards regression model to analyze the dependence of the survival time on predictor variables. Two failure criteria were defined as the need for additional surgery for intraocular pressure (IOP) reduction and the IOP at two consecutive follow-up visits based on definition 1, IOP ≧22 mmHg and definition 2, IOP ≧17 mmHg.ResultsThirty eyes (29 cases) underwent IRGBR with subconjunctival 5-FU injection (group A in the second term) and 13 eyes (11 cases) without 5-FU (group B in the first term). The success rates 24 months after IRGBR were 73.3 and 23.1%, respectively, in groups A and B based on the definition 1 failure and 56.7 and 7.7% based on the definition 2 failure. Complications included transient bleb leaks (group A, 3 eyes; group B, none) and choroidal detachment (group A, 1 eye; group B, none). No use of 5-FU and IOPs ≧10 mmHg 1 week after IRGBR were significant risk factors.ConclusionsAdjunctive 5-FU in IRGBR achieved a better success rate for failing trabeculectomy blebs.

A 15-Year Follow-up Retrospective Study on 959 Spine Surgeries: What Can We Learn From Real-world Data?

This was a retrospective study. The aim of this study was to investigate the patient flow and need for additional surgery after first-time lower back surgery. Next, we analyzed the patients who developed chronic low back pain (LBP) and were treated with spinal cord stimulation. LBP has a lifetime prevalence of 84% and imposes a high economic burden. Treatment is focused on preventing chronic pain. Research has shown the efficacy of treatment options. However, less is known about who benefits the most from which therapy and when they should be positioned in the treatment algorithm. In this retrospective study, data of all patients who underwent first-time surgery from 2000 to 2004 were included. After 10-15 years, patients were contacted about their quality of life (QoL) (EuroQoL-5 Dimension) and life and heath perception (EuroQoL Visual Analogue Scale). In all, 959 patients underwent surgery at the lower back area. Follow-up time ranged from 13 to 17 years; 225 patients (23.5%) underwent a second surgery. In total, 20 patients (2.1%) developed chronic neuropathic back pain and received spinal cord stimulation therapy. Ten years postsurgery, 438 (45.7%) patients completed the QoL and LBP questionnaires. The health-related QoL and health situation were significantly lower in patients with multiple surgeries ( P <0.001). The study results indicate that large data sets, with multiple outcome measurements and long-term follow-up are necessary to improve our knowledge and to optimize the therapeutic pathway. In that way, we might learn how to select a patient for the right treatment or treatments at the right moment and shorten the circulation in our health care system.

1170 One-step deflation of bakri intrauterine balloon tamponade is not associated with increased blood loss

Postpartum hemorrhage (PPH) is a leading cause of maternal mortality. Bakri intrauterine balloon tamponade (IBT) for refractory hemorrhage decreases morbidity, need for additional surgery, and blood loss; however, the most effective deflation method is unknown. We aimed to determine if 1-step compared to serial deflation of the IBT is associated with less blood loss after removal. Retrospective cohort study of patients with PPH who received IBT from January 2012 to August 2020 at a single institution. Patients were excluded if the IBT remained in place for fewer than 2 hours. The primary exposure was deflation method: 1-step (removed in 1 pass) or serial (in >1 pass). The primary outcome was estimated blood loss (EBL) from the initiation of IBT deflation to discharge. Secondary outcomes included clinically estimable blood loss (≥200 mL) after IBT deflation, need for additional interventions, postpartum fever and endometritis. 279 patients received an IBT which remained in place for ≥2 hours following PPH. The IBT was deflated in a single pass (1-step) in 112 (40%) and serially in 167 (60%). Baseline characteristics and pre-IBT hemorrhage were similar, except the serial group had less pre-existing hypertension, less labor augmentation with oxytocin, more multiple gestations, and higher EBL prior to IBT placement (Table 1). EBL after starting IBT deflation was greater in the 1-step group (42±294 mL 1-step vs 28±48 mL serial, p <0.001). There was no difference in rate of clinically significant EBL (2.7% 1-step vs 2.4% serial, p = 1.0), including after adjusting for pre-IBT EBL and other baseline characteristics. No difference was seen in need for additional interventions. Rates of postpartum fever (29% vs 32%, p=0.57) and endometritis (11% vs 17%, p=0.18) were not different based on 1-step vs serial deflation, respectively (Table 2). Patients with PPH whose IBT was deflated all at once did not have more post-IBT blood loss compared to those deflated serially, nor was there any difference in rate of need for additional interventions.View Large Image Figure ViewerDownload Hi-res image Download (PPT)

Scleral buckling versus pars plana vitrectomy in simple phakic macula-on retinal detachment: a propensity score-matched, registry-based study

Background/AimsTo assess the anatomical and visual results of uncomplicated phakic macula-on retinal detachment (RD) in patients treated with pars plana vitrectomy (PPV) or scleral buckling (SB).MethodsA retrospective cohort of patients...

Three-Dimensional Presentation of Tumor Histopathology: A Model Using Tongue Squamous Cell Carcinoma.

Medical imaging often presents objects in three-dimensional (3D) form to provide better visual understanding. In contrast, histopathology is typically presented as two-dimensional (2D). Our objective was to present the tumor dimensions in 3D by creating a 3D digital model of it and so demonstrate the location of the tumor and the histological slices within the surgical soft tissue resection specimen. We developed a novel method for modeling a tongue squamous cell carcinoma using commonly available instruments. We established our 3D-modeling method by recognizing and solving challenges that concern the selection of the direction of histological slices. Additional steps to standard handling included scanning the specimen prior to grossing and modeling the carcinoma, which required only a table scanner and modeling software. We present challenges and their solutions in modeling the resection specimen and its histological slices. We introduce a finished 3D model of a soft tissue resection specimen and the actual tumor as well as its histopathological grossing sites in 3D digital and printed form. Our novel method provides steps to create a digital model of soft tissue resection specimen and the tumor within. To our knowledge, this is the first attempt to present histopathological margins of a tongue tumor in 3D form, whereas previously, only 2D has been available. The creation of the 3D model does not call for predetermined grossing directions for the pathologist. In addition, it provides a crucial initiative to enhance oncological management. The method allows a better visual understanding of tumor margins, topography, and orientation. It thus provides a tool for an improved postoperative assessment and aids, for example, in the discussion of the need for additional surgery and adjuvant therapy.

Comparative evaluation of effect of three different crown to implant ratio on marginal bone loss: A systematic review

Partial rehabilitation in the posterior edentulous region remains a challenge due to the anatomical condition present in the area. Excessive pneumatization of the maxillary sinus and accentuated bone crest resorption following teeth extraction cause bone atrophy and may lead to impossibility of inserting standard implants. Constant efforts are aiming at the reduction of the invasiveness of implant surgery. This has led to increase the use of implants with shorter length in the posterior maxilla and mandible region which reduces the need for additional surgical procedure causing less morbidity of the site and faster healing of the region. Does crown to implant ratio has an effect on the marginal bone loss (MBL) around implants in the posterior maxillary and mandibular region? A systematic search was conducted on two databases for the studies published from January 1, 2006, to July 31, 2018. Cross-references were checked. Hand searching was done in the library. Studies were included if they were done among healthy, nonhospitalized individual, and compared for the crown-to-implant ratio and MBL. A total of 143 articles were found through search. Thirteen articles remained after removing duplicates, reading the full text and reviewing abstracts. Thirteen articles were included for the data extraction. Crown-to-implant ratio has no role in the crestal bone loss, but other factors need to be evaluated for its role along with crown-to-implant ratio that can cause the MBL.

Advances in Autologous Breast Reconstruction

Autologous breast reconstruction (ABR) in patients undergoing mastectomy is now routinely performed, and associated with high rates of success and minimal donor site morbidity. Compared to alloplastic techniques, advantages of autologous approaches include the ability to confer a lifelong result without the need for additional surgery, superiority in the setting of radiation therapy, and eliminating the possibility of implant-related complications such as anaplastic large cell lymphoma. Moreover, ABR is associated with superior patient-reported outcomes compared to implant-based reconstruction. This article reviews recent advances in ABR, which have refined existing techniques, broadened the array of donor site options available to reconstructive surgeons, and streamlined the management of patients undergoing these procedures.

Is Labral Size Predictive of Failure with Repair in Hip Arthroscopy? A Review of 571 Cases

The purpose is to assess whether labral size is predictive of labral repair failure or demonstrates association with patient outcomes post-hip arthroscopy. A retrospective chart review was performed for patients undergoing arthroscopic hip labral repair from April 2009 to July 2015. Labral size was measured in 4 quadrants (antero-inferior, antero-superior, posterior-superior, and posterior-inferior). The average size across torn labral segments was assessed for statistical significance with labral repair failure as determined by patient reported outcomes (PROs) and need for additional surgery. Outcomes were evaluated for any continuous correlation as well as significant differences between classes of labral sizes derived from quartile and decile ranges. Included hips were those from patients between the ages 18 and 55 with 2-year postoperative follow up and lateral center edge angles (LCEA) between 25-40°. Exclusion criteria included less than 2 year follow up, Tonnis osteoarthritis grade ≥ 2, coxa profunda or protrosio, previous hip surgeries, pediatric hip conditions such as Perthes and slipped capital femoral epiphysis, avascular necrosis, and certain surgical factors such as labral debridement or reconstruction, and peri-trochanteric or deep gluteal space procedures. A total of 571 hips were included in the study. The mean labral width of involved quadrants was 5.35 ± 1.40 mm. Labral width averages did not show significant difference between those requiring revision versus those not requiring revision (p= .4054). There was no significant correlation between labral width and the change in preoperative and 2-year postoperative iHOT (R2 = 0.05780), mHHS (R2 = 0.19826), or NAHS (R2 = 0.23543) outcome scores. Those with labral sizes in the upper decile of our cohort showed significantly decreased improvement in the iHOT (p= .0287) and NAHS (p= .0490) when compared to the middle 50% of labral sizes. No significant differences in outcome scores were found for the bottom decile, bottom quartile, or upper quartile groups compared to middle 50%. Labral size did not predict clinical outcomes or need for revision in the majority of patients in our cohort. Hypertrophic labrums in the largest 10th percentile, or a size of 7.3 mm or greater, demonstrated lower postoperative outcome scores. This may suggest that patients with extremely large labrums may not improve after arthroscopy to the same degree as those with more normally sized labrums. However, for the majority of patients it is reasonable to suggest differences in labral size should not alter the treatment plan if morphology is otherwise standard. The reported poor outcomes associated with hypoplastic or hypertrophic labra may be due to associated factors rather than labral size alone.

Using Expandable Micro-Motor Bur (EMB) forExtraction of Molar Tooth Root of Dog's UpperJaw

Extraction of a broken tooth root is often a traumatic involvement for both the specialist and the patient. To extract broken roots, generally, invasive approaches as open window surgeries or mucoperiosteal flap and/or removal of buccal bone are performed. Expandable micro-motor bur (EMB) is a practical dental instrument proposed for the removal of broken teeth roots that cannot be extracted by the routine closed methods. The device comprises a micro-motor, spacers, needles, bur base, and a round bur that drills halfway through the root canal, expands to make a spherical cavity around itself, and behaves as an efficient extraction aiding anchor. The utilization of EMB would introduce a new technique in the removal of broken teeth roots in which surgical trauma is minimized and so are post-extraction disorders. The use of EMB would also eliminate surgical invasion to the surrounding tissues, and it would eliminate profound hand forces by the practitioner, consequently reduces stress for both the practitioner and the patient. It would also eliminate high-risk aftermaths of the surgery such as operative morbidity (due to bone loss), maxillary sinus exposure, and probable need for additional surgery which are some of the implications of the conventional open access approaches. We have tested the prototype of EMB on the molar tooth root of a dog in his upper jaw (M1) in the Medical Sciences and Technologies Research Institute of Shahid Beheshti University. No injuries to the buccal bone and surrounding nerves were observed and the root was successfully extracted. Further studies are needed to confirm its effectiveness in clinical cases.

The Clinical Outcome of Laparoscopic Surgery for Endometriosis on Pain, Ovarian Reserve, and Cancer Antigen 125 (CA-125): A Cohort Study.

Background:Endometriosis is an important cause of chronic pain and infertility. Surgery is considered the gold standard for diagnosis and treatment. In this study, we aim to describe the clinical outcomes of women who undergo laparoscopic surgery for endometriosis.Materials and Methods:In this cohort study, a total of 174 women who referred to Farmaniyeh Hospital, Tehran, Iran from August 2015 to December 2017 with surgical diagnoses of endometriosis stages III and IV enrolled. The participants’ demographic, gynaecological, and clinical characteristics were recorded and they were asked to use a numeric rating scale (NRS) to record their severity of pain before and three months after surgery. Blood samples were also taken from the patients before and three months after surgery for measurement of serum levels of anti-Müllerian hormone (AMH) and cancer antigen 125 (CA-125). Data were analysed using SPSS version 21.Results:The patients had a mean age of 34.86 ± 6.47 years, 60.9% were married, and 49.4% were housewives. The primary indication for surgery was pain (68.4%), followed by both pain and infertility in the remainder of patients. Types of endometriotic lesions included endometrioma (19%), deep infiltrating endometriosis (DIE, 3.4%), and both endometrioma and DIE (77.6%). There was a reduction in pain from 6.79 ± 2.19 before surgery to 1.48 ± 1.68 after surgery; serum AMH levels reduced from 2.80 ± 1.86 ng/mL to 1.76 ± 1.40 ng/mL and CA- 125 reduced from 257.06 ± 220.25 U/mL to 23.27 ± 23.25 U/mL (all P<0.001). Of the 21.2% who experienced recurrence, 13.5% underwent additional surgery. The total additional surgery rate was 2.8%. Of the 55 patients with infertility, 78.1% became pregnant after surgery, 54.5% of which was spontaneous.Conclusion:Surgical treatment of endometriosis had a favourable effect on the patients’ pain and inflammation and resolved the patients’ infertility with a minimal need for additional surgery.

190. Osteomyelitis Following Mandibular Reconstruction with Free Fibula Flap: A Cohort Study of an Emerging and Complex Bone and Joint Infection

BackgroundFree fibular flap (FFF) mandible reconstruction is at high risk of complications due to patient comorbidities, microvascular surgery after neck irradiation and intrabuccal exposure. We aimed to describe clinical and microbiological features, management and outcome of osteomyelitis following mandibular reconstruction with FFF.MethodsPatients referred to our reference center for an osteomyelitis following FFF reconstruction of the mandible were included in a retrospective cohort. Microbiology was described based on gold-standard samples. Risk factors for treatment failure (infection persistence or relapse, need for additional surgery for septic reason, infection-related death) were assessed by logistic regression and Kaplan-Meier survival curve analysis.Results48 patients (age, 60.5 [IQR, 52.4–66.6]; 30 males; 62.5%; modified Charlson comorbidity index, 4 [3–5]) were included. Indications for FFF mandible reconstruction were mostly carcinoma (n=27; 56.3%) and osteoradionecrosis (n=12; 25.0%), with 44 (82.9%) previous neck irradiation. FFF osteomyelitis were mostly early (≤ 3 months post-surgery; n=43; 89.6%). Main symptoms were local inflammation (n=28; 59.6%), ununion or sinus tract (n=28; 59.6%), bone or device exposure (n=21; 44.7%), and were associated with radiological signs for infection in 33 (75.0%) cases. Microbiological documentation highlighted Enterobacteriaceae (n=25; 61.0%), Streptococcus spp. (n=22; 53.7%), S. aureus (n=10; 24.4%), anaerobes (n=10, 24.4%), Enterococcus spp. (n=9; 22.0%) and non-fermenting Gram negative bacilli (GNB; n=8; 19.5%). Thirty-nine (81.3%) required surgery, consisting in debridement with implant retention in 25 (64.1%) cases, associated with a 93 (64–128) day course of antibiotherapy. After a follow-up of 18 (11–31) months, 24 (50.0%) treatment failure were observed. An early ID-specialist referral was the only significant predictor of favorable outcome (OR, 0.167; p=0.005). Non-fermenting GNB infections tended to be associated with a higher risk of failure (OR, 8.4; p=0.058).Probability of treatment failure of osteomyelitis following FFF mandible reconstruction according to ID-referral (A), CRP level 2 weeks after surgery (B) and presence of non-fermenting GNB ConclusionOsteomyelitis following mandibular reconstruction with FFF represent difficult-to-treat infections. Our results advocate for a multidisciplinary management, including an early ID-specialist referral.Disclosures All Authors: No reported disclosures