Kartagener syndrome is a rare, ciliopathic, autosomal recessive genetic disorder with an estimated incidence of about 1 case per 32,000 live births. It always causes a triad which is situs inversus,chronic sinusitis and bronchiectasis. We present a case of a 38-year-old male patient complaining of productive cough and hemoptysis since 15 days, headaches since one month and easily fatigability two years ago. He suffered from similar complains during childhood with episodic fever, worsening of symptoms and he was wrongly diagnosed with tuberculosis. After 28 years, he complicated by severe empyema leading to surgical intervention. Laboratory workup was unremarkable except for leukocytosis (>12,000/mm3) and hypoxia, semen analysis showed defective motility (asthenozoospermia) with grade c while other parameters were found normal including sperm count (35 million per milliliter), morphology and volume, chest X-rays and computed tomography (CT) scans were done, and he was diagnosed with Kartagener syndrome. He took medical treatment in the form of antibiotics (Augmantin, 40 mg/kg/day PO), antipyretics (Ibuprofen, 1 tablet PO q8hr), mucolytics (Guaifenesin, 100400 mg PO q4hr), inhaled bronchodilators (Albuterol/ipratropium, nebulizer solution: 3 mL inhaled q6hr) and a regular follow-up is done with chest X-rays. In this case report, we intend to remind physicians by Kartagener syndrome despite being rare because early diagnosis is the key for those patients to avoid complications and to give those patients a better lifestyle, another conclusion is that our case is a fertile male which in uncommon in such syndrome.