Robotic and manned exploration of the Moon is the next target in Solar System exploration. The availability of in situ resources such as water ice, iron oxides, helium-3, and rare earth elements, combined with permanently sunlit areas, provides the opportunity for the first settlement, either human or robotic, on the Moon. We used several selection criteria (abundance of water ice, the slope of terrain, usable energy sources, communications, and base expandability) to identify a suitable area for a future base in the southern polar crater Sverdrup-Henson. Due to the higher abundance of water ice, we found that the Sverdrup-Henson site is better suited to host a base than the nearby craters de Gerlache and Shackleton. The crater floor is partly in permanent shadow and exhibits numerous signatures of water ice. Since water ice is essential for rocket fuel production and human survival, its presence is necessary for a first settlement. Sverdrup-Henson has a flat floor ideal for building and safe traversing, is accessible from the surrounding intercrater plains, and has nearby locations suitable for communications and solar power production. Thus, the Sverdrup-Henson site holds great potential for future missions. We propose further exploration of this area through in situ measurements to better constrain available resources.