The Jiangsu Coast (JC), China, is an area susceptible to the impact of tropical cyclones (TCs). However, due to the lack of available on-site observation data, nearshore sedimentary dynamic processes under the impact of TCs have not been fully explored. This study developed a 3D wave–current–sediment numerical model for the JC based on the Finite Volume Community Ocean Model (FVCOM) to investigate sediment dynamic responses to TCs under various scenarios, including different tracks, intensities of TCs and tidal conditions. The validation results demonstrated the model’s satisfactory performance. According to the simulation results, typhoons can significantly impact the hydrodynamics and sediment dynamics. During Typhoon Lekima in 2019, strong southeasterly winds substantially increased the current velocity, bottom stress, wave height, and suspended sediment concentration (SSC). Three typical landfall-type typhoons, with prevailing southeasterly winds, brought significant sediment flux from southeast to northwest along the coast, while the typhoon that moved northward in the Yellow Sea induced a relatively small sediment flux from north to south. Typhoons could also induce stripe-like erosion and deposition, which is closely related to seafloor topography, resulting in seabed thickness variations of up to ±0.3 m. Additionally, strengthening typhoon wind fields can lead to increased sediment flux and seabed morphological changes. Typhoon Winnie, particularly at spring tide, had a greater impact on sediment dynamics compared to other landfall typhoons. Numerical simulations showed that the typhoon-induced net sediment flux within the spring tidal cycle could increase by 80% to 100% compared to the neap tidal cycle, indicating the significant influence of tidal conditions on sediment transport during TC events.