Mines result in land use and land cover (LULC) change due to degradation of natural resources and establishment of new infrastructure for ore extraction and beneficiation. The present study was carried out to, with objectives, (1) characterize LULC change (from 1975 to 2017) in Khetri copper mine region, (2) spatial distribution of pollution indices and (3) spectral response of elemental concentration of soil and groundwater using Landstat and ASTER satellite data. The study was designed to fulfil the objectives and for the same NDVI values were calculated for LULC classification and generated maps were analyzed for landscape pattern. Spatial distribution of pollution indices calculated using geochemical data of soil and groundwater was plotted to understand the impact of contamination on landscape pattern. The correlation of spectral response of Landstat bands with heavy metals concentration was plotted to assess their possible use in quantification of heavy metals. Results show constant increase in settlements, mines and open area while vegetation cover has decreased. Landscape and class level metrics (number of patch, patch density, aggregation index and landscape shape index) indicate increase in the fragmentation of landscape in recent years. Shannon’s Evenness Index indicates increase in uniformity in landscape and it is attributed to loss of vegetation and agriculture patches. Pollution indices, Pollution Load Index for soil is high near the overburden materials and Index of Environmental Risk (IER) and Contamination Index for ground water is high near abandoned mines. Spectral bands 5 and 6 (SWIR 1) show significant negative correlation, and 9 (Cirrus) shows significant positive correlation with metal concentration in soil and water suggesting the possible use of remote sensing in assessment of metal concentration at ground level. Thus, it can be concluded that mines significantly influence the landscape pattern and remote sensing could be used for the assessment and predication of heavy metal contamination at broader scale in a cost-effective way.