Understanding the dynamics of vegetation system change is often limited by relatively brief data sequences and the shortage of comparable analyses of variation over longer periods. In this study, GIMMS NDVI and MODIS NDVI datasets were integrated to establish a consistent NDVI time series from 1982 to 2012 on vegetation of the Tibetan Plateau in China. The spatiotemporal patterns of change in seasonal NDVI and their linkage with climatic variables were analyzed at regional and pixel scales over 14 periods ranging from 18 to 31 years and beginning in 1982. On a regional scale, positive trends of growing season and seasonal NDVI were observed during the 14 periods, and the increases were statistically significant for growing season NDVI during all periods, and for summer and autumn NDVI during only the last four and the last two periods, respectively. The rates of NDVI increase in growing season and spring significantly decreased over the 14 periods. NDVI rates slightly decrease in summer and significantly increase in autumn. At a pixel scale, areas with significant greening or significant browning significantly increased over the 14 periods during the growth season and during all seasons except spring, in which the proportion of vegetated area with greening rapidly decreased. Temperature was the primary climatic driver for the observed vegetation changes during multiple periods while precipitation and sunshine duration had significant impacts on vegetation growth only in limited parts of the study area or during spring. Vegetation growth response to climate change varied across seasons and regions. Trend analysis during the multiple nested time series provides a better understanding of NDVI dynamics and may help to forecast future changes. Spring NDVI is likely to continue decreasing, autumn NDVI will continue increasing, and the magnitude of the NDVI increase during growing season will decline in the future.