The article is devoted to the problem of natural science education of pedagogical university students in the context of the transition of fundamental science to a new paradigm. The article substantiates the key role of natural science education in the formation of the worldview of humanities students and the scientific style of thinking. The article presents the main provisions of the post-non-classical worldview, highlights the main differences between the non-classical and post-non-classical paradigms, and characterizes the stages of students mastering the basics of the post-non-classical paradigm. The authors put forward pedagogical conditions for the natural science education of students – future teachers in the context of a change in the fundamental scientific paradigm: the selection of the content of the studied material and bringing it into line with the conclusions of post-non-classical science, and a cultural approach that allows you to see all education through the prism of the concept of culture, all branches of which are interconnected. In the course of work on the topic, theoretical research methods (theoretical analysis of literature and generalization of pedagogical experience) and empirical methods (observation, questioning and conversation).