For the past two decades, there has been increasing emphasis in science education to facilitate learning of the nature of science (National Research Council, 1996; Osborne et al., 2003). The issues that fall under the domain of nature of science are wide ranging, and while there is some disagreement about the importance of various natureofscience issues, recent science education literature demonstrates that some issues are regarded as more fundamental or core to student understanding of science (Lederman et al., 2002; McComas, 2005a). These nature-of-science core tenets include such things as (McComas, 2005b): * Science demands and relies on empirical evidence. * Knowledge production in science shares common methods and shared habits of mind, norms, logical thinking and methods (such as careful observation and data recording, truthfulness in reporting, etc.). --Experiments are not the only route to knowledge. --Science uses both inductive reasoning and hypothetico-deductive testing. --However, there is no one step-wise scientific method by which all science is done. * Laws and theories are related but distinct kinds of scientific knowledge. * Science has a creative component. * Scientific knowledge is tentative, durable and self correcting (meaning that science cannot prove anything but scientific conclusions are still valuable and long-lasting because of the way in which they are developed). * Science has a subjective component (theory-laden character). * There are historical, cultural, and social influences on the practice of science. * Science and technology impact each other, but are not the same. * Science and its methods cannot answer all questions. Episodes from the history of science are particularly useful for helping students understand the nature of science, and at least partially for this reason, stakeholders have often advocated using the history of science in science teaching to promote student understanding of one or more of these core ideas. Though the development of NOS core tenets has been an important step in establishing targeted benchmarks for NOS instruction, teachers need examples that they can use instrumentally in the classroom to give students meaningful contexts from which they can interpret the relevance of NOS issues. At the same time, it is important that teachers who are receptive to the use of HOS be knowledgeable of how to interpret other HOS episodes in light of their potential worth for teaching NOS. The following is an example of this instrumental approach in using the history of genetics on heterozygote protection in sickle-cell anemia to help students to connect to multiple NOS tenets. The case is followed by a brief discussion about practical considerations for adopting this approach with other episodes from the HOS. Sickle-Cell Anemia & Heterozygote Protection Sickle-cell anemia is a recessive genetic disease that affects the proper function of the human red blood cell. Persons who possess two defective copies of the gene that codes for a portion of the hemoglobin molecule produce red blood cells that become sickled in shape when they are exposed to low oxygen levels, as is commonly found in the venous system. Persons who suffer from the disease experience extreme shortness of breath and pain known as sickle crises, and the disease has both short--and long-term potential negative consequences for the normal functioning of the cardiovascular system. The genetics of the disease are frequently used in introductory biology textbooks to illustrate the concept of heterozygote protection (e.g., Cain et al., 2000). The underlying idea is that heterozygotes (carriers) of the disease are afforded a measure of protection against malaria. There are certain areas of the world where people face near continual exposure to the mosquito that often carries the parasitic agent of malaria, Plasmodium falciparum (http://evolution. …
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