Natural Tannin Research Articles

New Technology of Rumen-Protected Bypass Lysine Encapsulated in Lipid Matrix of Beeswax and Carnauba Wax and Natural Tannin Blended for Ruminant Diets

Tannins are compounds present in forage plants that, in small quantities in the diet of ruminants, produce protein complexes that promote passage through the rumen and use in the intestine. This study tested the hypothesis that beeswax (BW) and carnauba wax (CW) lipid matrices are effective encapsulants for creating bypass lysine (Lys) for ruminants, with tannin extracted from the Mimosa tenuiflora hay source enhancing material protection. Microencapsulated systems were made using the fusion–emulsification technique with a 2:1 shell-to-core ratio and four tannin levels (0%, 1%, 2%; 3%). The following eight treatments were tested: BWLys0%, BWLys1%, BWLys2%, BWLys3%, CWLys0%, CWLys1%, CWLys2%, and CWLys3%. Tannin inclusion improved microencapsulation yield and efficiency. CWLys3% had the highest microencapsulation efficiency and retained Lys. Lysine in BW and CW matrices showed higher thermal stability than in its free form. Material retention was greater in BW than CW. Rumen pH and temperature remained unaffected, indicating that BW and CW as the shell and tannin as the adjuvant are efficient encapsulants for Lys bypass production. The formulation CWLys3% is recommended as it is more efficient in protecting the lysin amino acid from rumen degradation.

Enhanced antibacterial effect of natural tannin stabilized silver nano particles against human pathogens: A target toward FtsZ proteins

BackgroundTannins are the polyphenolic group of plant compounds having strong antimicrobial potential. Research on human pathogens using silver nanoparticles for antimicrobial purposes has opened up new possibilities in nanomedicine. ObjectiveThe present study was concerned with combining the effectiveness of the two by the green synthesis of silver nanoparticles with plant tannin. MethodsSynthesis of silver nanoparticles was done based on the tannin content of the selected plants. Characterization of the synthesized nanoparticles has been performed through UV–VIS, FTIR spectroscopy, Zeta potential, XRD analysis and FEGSEM imaging. The antibacterial potentiality of the nanoparticles was checked against two most susceptible bacteria Staphylococcus epidermidis and Salmonella typhi. ResultsAmong the studied plants, Phyllanthus emblica showed highest tannin content and best bactericidal properties. The nanoparticles synthesized with P. emblica showed the highest zone of inhibition against the studied bacteria. An in-silico comparative molecular docking study of the bioactive compounds from the selected plants was performed against the FtsZ protein of S. epidermidis and YfdX protein of S. typhi. Three compounds namely Isocorilagin,1(β), 6-di-o-galloylglucose and Hamamelitannin appeared as the best inhibitors of the said proteins and among them, Isocorilagin, a natural tannin showed the best docking score of -10.2 Kcal/mol with FtsZ protein. Further molecular dynamics simulation studies of the FtsZ protein-Isocorilagin complex support its stability indicating Isocorilagin as the natural inhibitor of the pathogenic bacterial protein FtsZ. ConclusionThese results concluded that synthesis of nanoparticles with plant tannin is a cost effective green approach and the synthesised nanoparticles appear as efficient antimicrobial agent.

The Impact of Cashew Nut (Anacardium occidentale) Testa Tannin Feeding Ratio on the Chemical and Mechanical Characteristics of Leather Tanned from Cowhide, Goatskin and Sheepskin

In recent years, there has been a growing interest in exploring natural alternatives to synthetic tannins, driven by concerns over sustainability and environmental impact. Natural tannins offer several advantages, including biodegradability, renewability, and lower environmental impact compared to synthetic chemicals. Among the natural tannins under investigation, cashew nut testa tannin has emerged as a promising candidate due to its abundance, renewability, and potential benefits in leather tanning applications. This research investigated the impact of varying feeding ratios of cashew nut testa tannin on the chemical and mechanical characteristics of leather tanned from cowhide, goatskin, and sheepskin. The objective was to determine how different concentrations of cashew nut testa tannin influence the quality and performance of the leather. Leather samples were prepared using different feeding ratios of cashew nut testa tannin and subjected to a series of chemical and mechanical tests. The results indicated that the absorption of tannin and the resultant chemical stability varied with the type of hide or skin, with each exhibiting unique optimal ratios for tannin uptake. Higher tannin ratios generally improved the tensile and tear strength of the leather across all types, with significant enhancements noted in goatskin and sheepskin. However, an increase in tannin ratio reduced the flexibility of cowhide, while goatskin and sheepskin maintained adequate flexibility. The study demonstrates that cashew nut testa tannin is an effective and sustainable tanning agent, capable of producing quality leather. The findings suggest that the leather industry can utilize cashew nut testa tannin to enhance leather properties, with potential customization of tannin feeding ratios to meet specific performance requirements. Further research is recommended to explore long-term durability and economic viability on a commercial scale. This study contributes to the development of eco-friendly tanning practices and provides insights into optimizing the use of cashew nut testa tannin for various types of leather.

Natural Tannin Layers for the Corrosion Protection of Steel in Contact with Water-Based Media

Natural Tannin Layers for the Corrosion Protection of Steel in Contact with Water-Based Media

Handling-friendly, waterproof, and mildew-resistant all-bio-based soybean protein adhesives with high-bonding performance via bio-inspired hydrophobic-enhanced crosslinking network

Eco-friendly and formaldehyde-free soybean protein adhesives are highly attractive to the wood-based panel industry but typically suffer from low water-resistant bonding strength, high viscosity, and susceptibility to mildew. Inspired by adaptive hydrophobic and hydrophilic interactions of mussel foot proteins, herein, a high-performance and versatile all-bio-based adhesive (STF) was synthesized through employing bio-derived furfural and natural tannic acid to assist soybean protein in developing a biomimetic physical/chemical cross-linking network. The collaboration of the hydrophobic furan ring and the hydrophilic catecholic moiety endowed the as-prepared STF adhesives with exceptional water-resistant bonding strength, easy-coating performance, and mildew resistance. Compared to the original soybean protein, the optimal STF demonstrated dry and wet shear strengths of up to 2.52 MPa and 1.71 MPa, respectively, representing an increase of 65.8 % and 263.8 %. Notably, the aged bonding strength of STF surpassed that of previously reported soybean protein-based adhesives with a value as high as 1.19 MPa. The viscosity of the STF decreased by ≈ 98.1 % compared to the unmodified adhesive. Additionally, the STF exhibited excellent mildew resistance (no mildew for 7 days) and storage stability (> 72 h). Combined with life cycle assessment, the biomimetic STF adhesive holds great potential for large-scale production of environment-friendly wood panels.

Production and Characterization of Natural Tannin-Degrading Aspergillus strains

Among the different types of agrowastes, tannin biomass also contributes to significant amount. The tannin rich biomass can be exploited as the most economic substrate for the production of industrially important enzyme Tannase. Tannases are hydrolases which find applications in different industries such as leather, food, feed, beverage and pharmaceutical industry. Tannases are gaining importance as industrially-important biocatalyst. The present study focuses on the isolation of natural tannin degrading fungal strains including their characterization. Among the fifty fungal cultures isolated from soil samples, eleven tannase producing isolates were selected by qualitative screening. The selected isolates were cultivated by liquid surface fermentation for quantitative estimation of extracellular tannase activity. On the basis of quantitative screening, two isolates Aspergillus niger and Aspergillus flavus were identified as efficient tannase producers. To study natural tannin degradation efficiency of the isolates, different tannin rich agro-residues were tested as carbon source in the production medium for tannase production as well as substrate for the enzyme. Both isolates utilized natural tannins appreciably, producing significant tannase yield. Gauva leaves and ber leaves proved to be the best carbon source for Aspergillus niger and Aspergillus flavus respectively. The optimum incubation period for maximum tannin utilization was found to be 72 hrs for Aspergillus niger and 96 hrs for Aspergillus flavus. In conclusion, both fungal isolates exhibited potential for tannin biomass utilization and conversion to various valuable industrial products.

Tannic acid-poloxamer self-assembled nanoparticles for advanced atherosclerosis therapy by regulation of macrophage polarization.

Atherosclerosis (AS) is a significant contributor to cardiovascular events. Advanced AS is particularly concerning, as it leads to the formation of high-risk vulnerable plaques. Current treatments for AS focus on antithrombotic and lipid-lowering interventions, which are effective in treating early-stage AS. Recent studies have shown that macrophage polarization plays a crucial role in the development of AS. This study presents a new biomedical application of natural tannic acid as an anti-inflammatory nanoplatform for advanced AS. Tannic acid-poloxamer nanoparticles (TPNP) are fabricated through self-assembly of tannic acid (TA) and poloxamer. TPNP has the potential to provide effective treatment for advanced AS. According to in vitro studies, TPNP has been found to suppress the inflammatory response in lipopolysaccharide-stimulated macrophages by scavenging reactive oxygen species (ROS), downregulating the expression levels of inflammatory cytokines (such as interleukin-10 and tumor necrosis factor-α) and regulating polarization of macrophages. In vivo studies further reveal that TPNP can retard the development of advanced atherosclerotic plaques by reducing ROS production and promoting M2 macrophage polarization in the aorta of ApoE-/- mice. Overall, these findings suggest that TPNP could be used to develop natural multifunctional nanoplatforms for molecular therapy of AS and other inflammation-related diseases.

The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2.

The Coronavirus Disease 2019 (COVID-19) pandemic continues to infect people worldwide. While the vaccinated population has been increasing, the rising breakthrough infection persists in the vaccinated population. For living with the virus, the dietary guidelines to prevent virus infection are worthy of and timely to develop further. Tannic acid has been demonstrated to be an effective inhibitor of coronavirus and is under clinical trial. Here we found that two other members of the tannins family, oligomeric proanthocyanidins (OPCs) and punicalagin, are also potent inhibitors against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with different mechanisms. OPCs and punicalagin showed inhibitory activity against omicron variants of SARS-CoV-2 infection. The water extractant of the grape seed was rich in OPCs and also exhibited the strongest inhibitory activities for viral entry of wild-type and other variants in vitro. Moreover, we evaluated the inhibitory activity of grape seed extractants (GSE) supplementation against SARS-CoV-2 viral entry in vivo and observed that serum samples from the healthy human subjects had suppressive activity against different variants of SARS-CoV-2 Vpp infection after taking GSE capsules. Our results suggest that natural tannins acted as potent inhibitors against SARS-CoV-2 infection, and GSE supplementation could serve as healthy food for infection prevention.

Effects of Increasing Levels of Total Tannins on Intake, Digestibility, and Balance of Nitrogen, Water, and Energy in Hair Lambs.

This study aims to evaluate the effects of increasing tannin levels from Mimosa tenuiflora hay on the intake, digestibility, and balance of nitrogen (N), water, and energy in hair lambs. Thirty-two Santa Ines lambs, at an average age of 150 days and body weight of 26.75 ± 2.29 kg, were randomly assigned to four treatments in a completely randomized design. The treatments consisted of four diets: a control diet, tannin-free, and three diets with increasing levels of total tannin, 26.2, 52.4, and 78.6 g tannin/kg dry matter (DM). Including the total tannins in the lambs' diet led to a quadratic increase in the intake of nutrients, N-retention (g/day), water intake, water absorption and retention, energy intake, and energy excretion in feces and gases. However, the digestibility of crude protein, neutral and acid detergent fibers, and total carbohydrates decreased. It was observed that there is a correlation between the variable nutrient digestibility and N-ingested and the N-absorbed, N-urinary, and N-retained. However, the N-excreted in feces did not correlate with any of the variables studied. It is recommended to include 33 g/kg DM of total natural tannins from Mimosa tenuiflora hay in the diet of hair lambs, as it improves intake, energy balance, dietary N, and body water composition while reducing the excretion of N-urinary and gas emissions to the environment.

Dietary supplementation of natural tannin relieved intestinal injury and oxidative stress in piglets challenged with enterotoxigenic Escherichia coli

Dietary supplementation of natural tannin relieved intestinal injury and oxidative stress in piglets challenged with enterotoxigenic Escherichia coli

Molecular networking-assisted systematical profiling and the in vivo neuroprotective effect of ellagitannins from the Melastoma dodecandrum Lour

BackgroundEllagitannins (ETs) are a major classification of natural tannins, with relatively large and complex structures. ETs from medicinal plants are focused increasingly due to urolithins, a kind of intestinal metabolite of ETs, which showed promising anti-Alzheimer's disease (AD) effects. Melastoma dodecandrum (MD), a widely used traditional Chinese medicine is rich in ETs, but their chemistry and potential neuroprotective effects have not been investigated. PurposeThis study aimed to identify the chemical composition of ETs in the crude extract of MD and to investigate their neuroprotective effects in vivo. MethodsUPLC-QTOF-MS-based molecular networking (MN) and structural characterization were applied to targeted profiling of the MD-ETs. Animal behavior experiments, including the novel object recognition test (NOR), open field test (OFT), and Morris water maze test (MWM), were conducted to assess the memory improvement effects of MD-ETs in AD model mice. ResultsA total of 70 ETs, ranging from monomers to tetramers, were tracked and characterized in the MD extract using MN-guided targeted profiling, with 59 of them reported for the first time in this species. MD-ETs significantly improved memory impairment in AD mice, as indicated by decreased escape latency, increased number of crossings and target quadrant distance in MWM, increased rearing number in OFT, and increased preference index in NOR. ConclusionThis study systematically characterized the composition and structural features of ETs in MD using targeted LC-MS profiling, expanding the chemical information of ETs in MD. Furthermore, the results demonstrate that MD-ETs have significant effects on improving impaired memory in AD mice, suggesting their potential as alternative natural medicines for the treatment of neurodegenerative diseases.

Synthesis of NiO nanoparticles for gas sensor application

A green combustion technique assisted by freshly extracted tea (Camellia sinensis /natural tannic acid) was adopted to synthesize NiO nanoparticles. Further research into the physicochemical properties of the NiO nanoparticles was conducted after heating them to 350℃. The average particle size of NiO nanoparticles in their as-prepared state was found to be 18.4 nm, while the average particle size of NiO nanoparticles in their heat-treated condition was found to be 28.7 nm. The scanning electron microscope (SEM) and transmission electron microscope (TEM) were used to record NiO nanoparticles' external morphology, particle shape, and particle size. It was discovered that the NiO nanoparticles had a spherical shape with an average particle size of 23.5 nm for the samples created as is and 34.8 nm for the heated samples. The performance assessment of the petrol sensor was carried out using a number of testing techniques and a variety of gases. NiO nanoparticles outperformed all other testing gases when it came to how effectively the sensor responded to ethanol gas. NiO nanoparticles are interesting materials for use in gas sensor applications, as evidenced by their response-recovery time.

Synthesis, analysis and characterization of camellia sinensis mediated synthesis of NiO nanoparticles for ethanol gas sensor applications

A green combustion technique assisted by freshly extracted tea (Camellia sinensis /natural tannic acid) was adopted to synthesize NiO nanoparticles. Further research into the physicochemical properties of the NiO nanoparticles was conducted after heating them to 350 ℃. The average particle size of NiO nanoparticles in their as-prepared state was found to be 18.4 nm, while the average particle size of NiO nanoparticles in their heat-treated condition was found to be 28.7 nm. The scanning electron microscope (SEM) and transmission electron microscope (TEM) were used to record NiO nanoparticles' external morphology, particle shape, and particle size. It was discovered that the NiO nanoparticles had a spherical shape with an average particle size of 26 nm for the samples created as is and 35 nm for the heated samples. The performance assessment of the petrol sensor was carried out using a number of testing techniques and a variety of gases. NiO nanoparticles outperformed all other testing gases when it came to how effectively the sensor responded to ethanol gas. NiO nanoparticles are interesting materials for use in gas sensor applications, as evidenced by their response-recovery time.

Mussel-inspired preparation of dispersible mica nanosheets for waterborne epoxy coatings with reinforced anticorrosive performance

Mica is a low-cost, naturally layered material with superior insulation, high-temperature resistance, acid and alkali resistance, but the preparation of its nanosheets on a large scale and their compatibility with resin are still to be solved. In this work, hydroxyl-functionalized mica nanosheets (MNs) were prepared by the introduction of plasma treatment with a yield of 6.695 %. Inspired by mussels, natural tannic acid (TA) was chosen to modify MNs via the interaction of catechol groups with OH to prepare functionalized MNs (MNs@TA). Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) proved the successful preparation of TA-modified MNs. The obtained MNs@TA exhibited good dispersion in solvent and waterborne epoxy (WEP) coating, enhancing the compatibility with WEP resin. In addition, the MNs@TA/WEP composite coatings were used on Q235 carbon steel, and their corrosion protection performance and mechanism were investigated by electrochemical impedance spectroscopy (EIS), ultra-depth three-dimensional microscope, and energy dispersive spectrometer (EDS). The results illustrated that the incorporation of 0.5 wt% MNs@TA significantly improved the anticorrosive performance of the WEP coating via enhanced barrier properties.

The effects of diets incorporating natural source of tannins on laying hens’ production performances and physical parameters of eggs

Abstract This study aimed to evaluate the effects of natural tannins in laying hens’ diets on production parameters and the alterations of eggs’ physical properties during storage time and temperature. A six weeks experiment was carried out on 168 Lohmann Brown laying hens, 51 weeks of age, accommodated within digestibility cages, structured on 3 levels. The dietary basic structure was the same for all 3 tested groups. The difference between the experimental and control groups was established by the type of plant additive added E1 (0.5% chestnut flour) vs. E2 (0.5% bark oak). At the end of the experiment, 36 eggs/group were collected to evaluate internal and external quality parameters of eggs during storage. These eggs were divided into two parts: 18 eggs/group were kept at room temperature (22°C) and 18 eggs/group were kept in the refrigerator (4°C) for 42 days and analysed to determine shelf time. The results obtained showed that the physical parameters of eggs laid by hens fed with diets supplemented with natural source of tannins (chestnut powder and oak bark) were improved in terms of Haugh Units, yolk colour and eggshell thickness, but only in refrigeration storage conditions.

Functionalized Natural Tannins For Preparation of a novel non-isocyanate polyurea-based adhesive

In recent years, the shortcomings of products bonded with adhesives of conventional resins (e.g. urea-formaldehyde, phenol-formaldehyde, melamine-based) have raised concerns as people have become more environmentally conscious while fossil resources are in short supply. This has prompted researchers to develop a new generation of adhesives derived from natural renewable biomass resources, with excellent properties and no or limited contamination. In this study, a novel epoxidized tannin-based non-isocyanate polyurea adhesive was prepared from natural tannin after functionalization with epichlorhydrin. The structure, molecular weight, and thermal degradation behavior of this resin adhesive synthesized in this way, were investigated using FT-IR, ESI-MS, GPC, and TGA, respectively. The mechanical properties and water resistance of the produced plywood were evaluated. It was found that the adhesive possess ideal bonding strength and excellent water resistance, and the prepared plywood can have potential application prospects under harsh conditions.

Polyphenol based hybrid nano-aggregates modified collagen fibers of biological valve leaflets to achieve enhanced mechanical, anticoagulation and anti-calcification properties

Glutaraldehyde (Glut)-crosslinked porcine pericardium and bovine pericardium are mainly consisted of collagen and widely used for the preparation of heterogenous bioprosthetic heart valves (BHV), which play an important role in the replacement therapy of severe valvular heart disease, while their durability is limited by degeneration due to calcification, thrombus, endothelialization difficulty and prosthetic valve endocarditis. Herein, we develop a novel BHV, namely, TPly-BP, based on natural tannic acid and polylysine to improve the durability of Glut crosslinked bovine pericardium (Glut-BP). Impressively, tannic acid and polylysine could form nanoaggregates via multiple hydrogen bonds and covalent bonds, and the introduction of nanoaggregates not only improved the mechanical properties and collagen stability but also endowed TPly-BP with good biocompatibility and hemocompatibility. Compared to Glut-BP, TPly-BP showed significantly reduced cytotoxicity, improved endothelial cell adhesion, a low hemolysis ratio and obviously reduced platelet adhesion. Importantly, TPly-BP exhibited great antibacterial and in vivo anti-calcification ability, which was expected to improve the in vivo durability of BHVs. These results suggested that TPly-BP would be a potential candidate for BHV.Graphical abstract

Comparing carriers as a support media of white-rot fungi in natural tannins removal

• The growth of white-rot fungi was tested on polyethylene carriers containing cellulose; • Basidiomycetes could cover fully the carriers with the highest cellulose percentage; • B. adusta could grow up to 60% of carrier surface in not-sterile conditions; • B. adusta growth was associated with 25±4% Quebracho tannin sCOD removal; • B. adusta and A. tubingensis could grow together and remove Quebracho sCOD up to 15±4% In the last decades, White-rot Fungi bioremediation potential has been widely investigated, providing remarkable results toward several recalcitrant molecules. However, full-scale applications based on fungi are not employed yet and little is known about their optimal operating conditions, such as i) their ability to grow without sterile conditions, ii) co-substrate requirements and iii) the accurate carrier design for fungal growth. In this study, several batch tests were performed as preliminary steps to evaluate the possible design of a pilot-scale reactor based on fungal biomass to be operated under not-sterile conditions in the removal of Quebracho natural tannin. The tests were performed to verify fungal affinity, including Basidiomycetes and Ascomycetes for innovative cellulose-containing carriers compared to commonly employed PolyUrethane Foam Cubes. In particular, four fungi, including three Basidiomycetes White-rot Fungi, Bjerkandera adusta, Phanerochaete chrysosporium and Tyromyces chioneus and the Ascomycota strain Aspergillus tubingensis , were employed. As a first step, fungi were tested to evaluate their ability to attach and grow onto 12 types of innovative carriers made by High-Density PolyEthylene and containing cellulose in different percentages. Other tests were performed without sterile conditions. In particular, fungal abilities i) to attach and grow onto two different types of support, including cellulose-containing carrier and polyurethane foam cubes and ii) to biotransform recalcitrant molecules (Quebracho natural tannin) iii) to grow and operate synergistically in a consortium of two fungi, were evaluated. The main parameters evaluated were soluble Chemical Oxygen Demand (sCOD) reduction and dry weight increase. Basidiomycetes showed high affinity for cellulose-containing carrierswith the highest cellulose percentage (7%) achieving full colonization and 60% coverage, in sterile conditions and not- sterile conditions, respectively. These results were associated with a Quebracho sCOD removal of 25±4%, without sterility. When combined, the two selected strains, Bjerkandera adusta and Aspergillus tubingensis were able to grow on carriers and to remove up to 15±4% of tannins recalcitrant sCOD. This study provides evidence of i) Basidiomycetes high affinity for cellulose-containing carriers that could favour fungi attachment in sterile and not-sterile conditions, t .and ii) the feasibility of a combined use of Ascomycetes and Basidiomycetes in bioremediation.

Self-Healing, Antibacterial, and 3D-Printable Polymerizable Deep Eutectic Solvents Derived from Tannic Acid

Polymerizable deep eutectic solvents (PDESs) have received great attention in the field of sustainable materials due to their green synthesis process and convenient designability. In this work, we developed a novel ternary PDES based on natural tannic acid (TA), choline chloride (ChCl), and hydroxyethyl methacrylate (HEMA). Density functional theory analysis indicated that hydrogen bonds and van der Waals forces are the main driving forces for the formation of the PDESs. The obtained TA-based PDESs not only showed high biobased content (40.13–52.96%) and superior thermal/mechanical properties (a Tg of 56.08–78.72 °C, tensile stress of 5.45–13.71 MPa, toughness of 13.40–23.29 MJ/m3, etc.), but also demonstrated excellent self-healing and antibacterial properties. Furthermore, the developed TA-based PDESs without any UV-photoblocker can be directly used in LCD 3D printing. The optimal PDES sample (ChCl/HEMA/TA20) showed a low penetration depth (0.192 mm); thus, different structures with high resolution were successfully printed using this sample. In general, the developed TA-based PDESs can be used as green and multifunctional materials for a high-resolution UV-curable 3D printing process.

Green Synthesis of De Novo Bioinspired Porous Iron-Tannate Microstructures with Amphoteric Surface Properties

Bioinspired porous microstructures of iron-tannate (Fe(III)-TA) coordination polymer framework were synthesized by catenating natural tannic acid with iron(II), using a scalable aqueous synthesis method in ambient conditions. The chemical composition, morphology, physiochemical properties, and colloidal stability of microstructures were elucidated. The surface area (SBET) and the desorption pore volume were measured to be 70.47 m2/g and 0. 44 cm3/g, respectively, and the porous structure was confirmed with an average pore dimension of ~27 nm. Microstructures were thermally stable up to 180 °C, with an initial weight loss of 13.7% at 180 °C. They exhibited high chemical stability with pH-responsive amphoteric properties in aqueous media at pH levels ranging from 2 to 12. Supporting their amphoteric sorption, microstructures exhibited rapid removal of Pb+2 from water, with 99% removal efficiency, yielding a maximum sorption capacity of 166.66 mg/g. Amphoteric microstructures of bioinspired metal–phenolate coordination polymers remain largely unexplored. Additionally, natural polyphenols have seldomly been used as polytopic linkers to construct both porous and pH-responsive amphoteric coordination polymer frameworks with a robust structure in both acidic and basic media. Thus, this de novo porous microstructure of Fe(III)-TA and its physiochemical surface properties have opened new avenues to design thermally and chemically stable, eco-friendly, low-cost amphoteric sorbents with multifunctionality for adsorption, ion exchange, separation, storage, and sensing of both anions and cations present in heterogeneous media.