The chapter reviews available data on the ability of keratinophilic fungi and include a variety of filamentous fungi mainly comprising Hyphomycetes and several other taxonomic groups. Hyphomycetes include dermatophytes and a great variety of dermatophytes filamentous fungi. Most of the latter occur as saprophytes in soil,and some are plant pathogens. Chrysosporium species are the commonest dermatophytes filamentous fungi and are predominantly recovered from soil and other natural substrata by hair baiting technique C. tropicum and C. panniocola have been frequently isolated from human and animal’s skin lesions but their etiological relationship has not been established. The criteria considered important for evaluating the role of dermatophytes filamentous fungi in skin infection are the demonstration of mycelial elements in direct microscopy of skin scrapings or biopsy compatible with those in culture repeated positive cultures from clinical material. The Oils plant has been reported to have antibacterial, antifungal, antiviral, antipurasitic and antidermatophytic properties. It is now considered as a valuable source of natural products for development of medicines against various diseases and also for development of Industrial products. In this review is a compilation of updated information on plant essential oils with antifungal properties.