Traditional fossil fuelled power plants are commonly based on steam Rankine cycle or Brayton Joule cycle. Using water or air as working fluid is obviously the most obvious choice for the wide availability of these substances in nature. However, the scarcity of natural energy sources and the strong need of reducing environmental impact have necessarily drawn the research to new energy systems configurations operating with other working fluids, which are able to recover lower temperature sources, such as Sun or industrial wasted heat. The variety of new working fluids (refrigerants or organic fluids) widens the choice to a variety of configurations that can be tailored to the specific source characteristics and boundary constraints. It is not always easy or even possible to conceive the best configuration for given specifications with the mere experience of a common designer. To design a new system configuration, the designer normally uses some “non-codified rules” deriving from his knowledge of basic thermodynamics and energy engineering. This paper aims instead at showing a practical tool that is based on a new methodology, named SYNTHSEP, to generate new energy system configurations. This methodology starts from the simple thermodynamic cycles operated by a given fluid made up of the four fundamental processes (compression, heating, expansion and cooling) and uses a rigorous set of codified rules to build the final system configuration. The paper presents the basics of the new methodology and how it has been implemented in a practical tool that simply requires the information about the elementary cycles and their shared processes as input data.