The industry approach for natural montmorillonite clay has been reported. Modified clays have enhanced physicochemical properties with good acceptance characteristics for different types of industries, such as cement, pharmaceutical, paper, rubber, wood, and waste recycling processes. This innovative work deals with the promising behavior of mutated sodium bentonite concerning the elemental, thermal, structural, and morphological study. In this research, commercial sodium bentonite clay has been activated with 4M of sodium hydroxide. Characterization techniques of SEM/EDAX, FT-IR, XRD,TGA, and DTA/DSC have been reported to investigate mutated characteristics after the base activation. At atmospheric conditions, samples refluxed and calcined at 105ºC and 500ºC respectively for three hours. Anhydride, carboxylic acid, andalkyl halides have been removed after base treatment. The XRD data reveals that the crystallite size (average) is more than three times than the parental after mutation. The atomic and weight percentage of silicates have been improved respectively from 45.4% to 53.02% and 41.87% to 62.85%. Morphology shows an untreated sample has an unsymmetrical bed type layer that has been improved and a bunch of similar structure molecules has been found similar to the fibers. A sharp and smooth fall has been recorded due to perennial loss of hydroxyl groups and hydration water at 100ºC. The modified structure of the commercial sodium bentonite has a prominent behavior relevant to the different industrial aspects. The thermal analysis also satisfies that the different and useful micro structure is developed after base activation.