This study attempted to find safe and effective green insecticidal agents against Musca domestica L., which is a major public health pest in tropical and subtropical countries that have already developed resistance to synthetic pesticides. Plant essential oil-based insecticides are new, effective, and eco-friendly alternatives. Today, they are a housefly control method of choice. The study evaluated the insecticidal effect against M. domestica adults of essential oils (EOs) from Cymbopogon citratus (Stapf.), Illicium verum Hook. f., and Myristica fragrans (Houtt.) as well as their major active chemical constituents. Formulations of these individual and combined compounds were evaluated to see whether they were synergistic against M. domestica. Chemical compositions of these EOs were also analyzed by GC–MS. The major constituent of C. citratus was found to be geranial (45.4 %); that of I. verum was trans-anethole (94.0 %), and that of M. fragrans was α-pinene (21.6 %). Formulation CB3 (0.5 % I. verum EO + 0.5 % geranial) exhibited the highest synergistic effect (SI = 0.04), with 100 % knockdown and mortality rates, a 50 % knockdown time (KT50) of 4.0 min, and a 50 % lethal time (LT50) of 6.0 min. CB3 was more effective than 1% w/v cypermethrin, followed by CB5 (0.5 % M. fragrans EO + 0.5 % geranial), CB7 (0.5 % α-pinene + 0.5 % geranial), and CB8 (0.5 % geranial + 0.5 % trans-anethole). To conclude, some formulations of combined C. citratus, I. verum, and M. fragrans were strongly synergistic against M. domestica and more effective than cypermethrin. Moreover, since they have been long used as natural food ingredients and in traditional medicine, they are also safe for humans, non-target organisms, and the environment.