In-Vessel Retention (IVR) is one of the existing strategies of severe accident management of LWR, which intends to stabilize and isolate corium & fission products inside the reactor pressure vessel (RPV) and primary containment structure. Since it has become an important safety objective for nuclear reactors, it is therefore needed to model and evaluate relevant phenomena of IVR strategy in assessing safety of nuclear power reactors. One of the relevant phenomena during accident progression in the oxidic pool is non-uniform high heat generation occurring at large scale. Consequently, direct experimental studies at these scales are not possible. The role computer codes and models are therefore important in order to transpose experimental results to reactor safety applications. In this paper, the state-of-the-art ANSYS FLUENT CFD code is used to simulate Non-uniform heat generation in the lower plenum by the application of Cartridge heating under severe accident conditions to derive the basic accident scenario. However, very few studies have been performed to simulate non-uniform decay heat generation by Cartridge heaters in a pool corresponding lower plenum of power reactor. The current investigation focuses on non-uniform heating in the fluid domain by Cartridge heaters, which has been done using ANSYS FLUENT CFD code by K-epsilon model. The computed results are based on qualitative assessment in the form of temperature and velocity contour and quantitative assessment in terms of temperature and heat flux distribution to assess the impact of heating method on natural convective fluid flow and heat transfer.