Bioefficacy of thiocyclam hydrogen oxalate 50 SP, a new molecule of nereistoxin group, was evaluated against three major pests of rice viz. stem borer, leaf folder and whorl maggot during Sali (Kharif) and Ahu (Rabi) seasons, 2016–2017 at Instructional Cum Research (ICR) farm of Assam Agricultural University, Jorhat. Cartap hydrochloride 50 EC and trizophos 40 EC were used as standard check along with three doses of thiocyclam hydrogen oxalate 50 SP viz., 200, 350 and 500 g ai ha−1. The result showed that thiocyclam hydrogen oxalate 50 SP @ 200 and 500 g ai ha−1 recorded the lowest dead heart (2.3 and 2.0%), white ear head (1.4 and 1.3%) and leaf folder infestation (3.0 and 2.8%) with highest yield (5069 and 5097 kg ha−1) in Sali (Kharif) season 2016. Similarly, in Ahu (Rabi) season of 2017, the thiocyclam hydrogen oxalate 50 SP @ 200 and 500 g ai ha−1 recorded the lowest dead heart (1.9 and 1.8%), white ear head (1.0 and 0.5%) and leaf damage by whorl maggot (2.2 and 2.1%) with highest yield (4691 and 4861 kg ha−1), respectively. Moreover, thiocyclam hydrogen oxalate did not show any deleterious effect on natural enemies population of rice ecosystem.