Natural Agglutinin Research Articles

The occurrence of natural antibodies in rabbit sera in relation to the paracolon group of organisms.

1. Naturally occurring agglutinins to paracolon bacilli have been found in seven out of ten sera from non-immunized rabbits and in one anti-Salmonellaand two anti-paracolon immune rabbits' sera after complete absorption with the immunizing strain.2. The a antigen of Stamp & Stone, which is known to occur as a natural agglutinin, has been demonstrated in one out of nine paracolon bacilli.3. Rabbits which before immunization show agglutinins to the immunizing strain or to an α antigen should not be used for the preparation of diagnostic antisera for intestinal Gram-negative bacilli.

Natural Meningococcal Agglutinins and Lysins in Human Serum

ConclusionsOur data permit certain deductions regarding the nature and origin of the natural meningococcal agglutinin and lysin. It is clear that both antibodies increase in intensity and extensity with age and since conditions are generally favorable for the successive absorption from the nasopharynx of antigenic material belonging to the genus Neisseria one might be led to believe that both are due to occult immunization. However, as will appear below, it is more than likely that we are dealing with two separate entities.The natural meningococcal agglutinin, according to our data, possesses a well marked immunological specificity. This is suggested not only by the occurrence of type-specific agglutinins in a certain percentage of normal human sera but more particularly by the fact that such agglutinins can be exhausted only by absorption with the specific antigens. In this respect the natural agglutinin resembles the immune agglutinin. Our observation that natural agglutinins occurred more often again...