<i>Background</i>: The implementation of an E-learning pedagogical model of education for Bachelor of Nursing Science students presents obstacles, including delayed assignment completion, insufficient class participation, low competency, and job loss. <i>Objective</i>: To explore nursing students’ challenges associated with open distance learning at the National University of Lesotho. <i>Methodology</i>: A quantitative cross-sectional survey design was used in this study. A structured questionnaire was used to collect data and was distributed to Participants online through google forms. The study was conducted for the period of three weeks in the month of May 2024. The data was analyzed descriptively using Statistical Package of Social Sciences. <i>Results</i>: A total of 58 students responded, out of which 93% experienced challenges during open distance learning while 7% did not. About 81% of Participants struggled with technology, while 71% complained about unreliable internet and personal issues that affected their study during open distance learning. Furthermore, environmental factors interrupted communications among learners and instructors. Issues of unreliable internet, impaired interaction, insufficient built-in support, institutional organization and personal factors that affected open distance learning were revealed. <i>Conclusion</i>: The research findings provide insight on the need to efficiently implement open distance learning for nursing students. Challenges experienced by nursing students that affected their learning include struggling with technology, requiring built-in support systems, and the need to secure an internet connection during open distance learning. Furthermore, prior planning for open distance learning is necessary for proper organization and management of personal issues affecting open distance learning.
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