Timely and accurate extraction of urban built-up areas is crucial to addressing environmental problems related to fast changes in urban land cover, which is fundamental for optimizing land use patterns and supporting global sustainable development. Nighttime light (NTL) from the Suomi National Polar-orbiting Partnership Visible Infrared Imaging Radiometer Suite (NPP-VIIRS) offer a new data source for extracting urban information. However, this kind of data suffer from drawbacks of blooming effects. To address this problem, in this study, the Enhanced Nighttime Light Urban Index (ENUI) approach, which involves the combination of NPP-VIIRS NTL with the Normalized Difference Vegetation Index (NDVI), Normalized Difference Water Index (NDWI), and Normalized Difference Built-up Index (NDBI), is proposed and tested. This approach was used to rapidly monitor the urban built-up areas in the Guangdong-Hong Kong-Macao Greater Bay Area in 2012, 2015, and 2018. The average overall accuracy and Map-level Image Classification Efficacy (MICE) for the extraction results are 93.56% and 0.77, respectively, while those of the Local-Optimized Thresholding (LOT) are 86.48% and 0.54, respectively; meanwhile, the average F-score values, user's accuracy and producer's accuracy for urban areas using the proposed approach increased by 9.98%, 10.90% and 8.67%, respectively, compared with the LOT. These findings suggest that this approach has a higher extraction accuracy than the LOT; this is primarily ascribed to the integration of NTL data with the NDVI, NDWI, and NDBI, which increases the variability of nighttime light in the urban core area and adequately alleviates the blooming effects of nighttime light brightness in water bodies and vegetated areas. The proposed approach shows great potentials to accurately and effectively monitor multi-temporal urban information and address environmental issues using NPP-VIIRS NTL data in global urban agglomerations.