HomeCirculationVol. 111, No. 17Issue Highlights Free AccessIn BriefPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessIn BriefPDF/EPUBIssue Highlights Originally published3 May 2005https://doi.org/10.1161/circ.111.17.2151Circulation. 2005;111:2151PERCUTANEOUS MITRAL VALVE REPAIR FOR CHRONIC ISCHEMIC MITRAL REGURGITATION: A REAL-TIME THREE-DIMENSIONAL ECHOCARDIOGRAPHIC STUDY IN AN OVINE MODEL, by Daimon et al.Ischemic mitral regurgitation is associated with adverse prognosis in patients with chronic heart failure as well as after myocardial infarction and coronary revascularization. There is great interest in surgical remodeling procedures and mitral valve reconstruction to correct the mitral regurgitation and potentially improve prognosis. One of the limitations to this approach has been the relatively high operative morbidity and even mortality associated with such surgical procedures. In this issue of Circulation, Daimon et al demonstrate the utility of percutaneous placement of an annuloplasty device in a sheep model of chronic ischemic mitral regurgitation. They demonstrate the benefit of this approach in reducing mitral regurgitation as well as beneficially improving mitral annular dimension and functional closure of the valve. This study supports the clinical potential of percutaneous nonsurgical approaches to treating patients with ischemic mitral regurgitation. See p 2183.INFLAMMATION AND CAROTID ARTERY—RISK FOR ATHEROSCLEROSIS STUDY (ICARAS), by Schillinger et al.Prior studies have demonstrated that inflammatory markers such as C-reactive protein (CRP) are related to prevalent and incident cardiovascular events. However, the temporality of the relations between inflammation and atherosclerosis has been less clear. Inflammation may predispose to atherosclerosis, but it is equally plausible that atherosclerosis predisposes to inflammation. In a prospective study of almost 1300 patients, Schillinger and colleagues examined the relation between CRP and serum amyloid A and ultrasound progression of carotid atherosclerosis. In adjusted analyses compared with the bottom quartile, individuals in the top quartiles of CRP and serum amyloid A, respectively, were about 4 and 2 times more likely to develop progression of carotid atherosclerosis. This study documents that inflammatory markers predict atherosclerosis progression. Although the authors cannot prove a causal relation, their study is consistent with the hypothesis that inflammation may contribute to atherosclerosis progression. See p 2203.DUAL ANTIPLATELET THERAPY WITH CLOPIDOGREL AND ASPIRIN IN SYMPTOMATIC CAROTID STENOSIS EVALUATED USING DOPPLER EMBOLIC SIGNAL DETECTION: THE CLOPIDOGREL AND ASPIRIN FOR REDUCTION OF EMBOLI IN SYMPTOMATIC CAROTID STENOSIS (CARESS) TRIAL, by Markus et al.Patients with symptomatic carotid stenosis are at high risk for stroke. Unlike coronary occlusion, cerebrovascular ischemia in such patients is rarely caused by carotid occlusion at the plaque but rather is due to platelet emboli arising from its ruptured surface. Indeed, asymptomatic microembolic signals can be detected by transcranial Doppler ultrasound in up to half of patients with symptomatic carotid stenosis. The role of platelets was for the first time convincingly clarified in the CARESS study, which randomized such patients to aspirin or aspirin and clopidogrel. Not only were microemboli more frequent in patients with events than in those without, dual platelet inhibition also was more effective in inhibiting platelet activity ex vivo and in reducing microemboli as detected by transcranial Doppler ultrasound. Thus, CARESS adds to the plausibility of dual antiplatelet therapy to prevent embolic stroke. See p 2233.Visit http://www.circ.ahajournals.org:Clinician UpdateControversies in Antiplatelet Therapy for Patients With Cardiovascular Disease. See p e267.Images in Cardiovascular MedicineTraumatic Coronary Artery Fistula in a Child. See p e272. Download figureDownload PowerPointCorrespondenceLetter Regarding Article by Rosenhek et al, “Statins but Not Angiotensin-Converting Enzyme Inhibitors Delay Progression of Aortic Stenosis.” See p e274.Letter Regarding Article by Masoudi et al, “National Patterns of Use and Effectiveness of Angiotensin-Converting Enzyme Inhibitors in Older Patients With Heart Failure and Left Ventricular Systolic Dysfunction.” See p e276.Letter Regarding Article by Kaufmann et al, “Systemic Inhibition of Nitric Oxide Synthase Unmasks Neural Constraint of Maximal Myocardial Blood Flow in Humans.” See p e278. Previous Back to top Next FiguresReferencesRelatedDetails May 3, 2005Vol 111, Issue 17 Advertisement Article InformationMetrics https://doi.org/10.1161/circ.111.17.2151 Originally publishedMay 3, 2005 PDF download Advertisement
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