Background and aim: Human norovirus are the leading cause of acute viral gastroenteritis worldwide. In China, the occurrence of norovirus outbreaks in different regions shows significant heterogeneity, while few study has focused on the spatial epidemiological characteristics of norovirus outbreaks. Thus, the aim of this study is to clarify the epidemiological characteristics and spatial distribution patterns of norovirus outbreaks. Methods: In China, according to the National Notifiable Disease Reporting System (NNDRS), 964 human norovirus outbreaks involving 50,548 cases in 26 provinces reported from 2012 to 2018 were analyzed in this study. Results: The outbreaks showed typical seasonality, with more outbreaks in winter and fewer in summer, and the total number of infected cases increased over time. The most common setting of norovirus outbreaks was school especially middle schools and primary schools with major transmission route of life-contact. More outbreaks occurred in southeast coastal areas of China and showed significant spatial aggregation. The highly clustered areas of norovirus outbreaks have expanded towards northeast over time. Conclusions: By identifying the epidemiological characteristics and high-risk areas of norovirus outbreaks, this study provides important scientific support for the development of preventive and control measures of norovirus outbreaks, which is conducive to the administrative management of high risk settings and reduction of disease burden in susceptible areas. Keywords: norovirus outbreak; epidemiological characteristics; spatio-temporal heterogeneity; spatio-temporal aggregation