National Institute Research Articles

Genotyping of Vanilla planifolia Jacks ex Andrews from the Totonacapan region using Inter-Simple Sequence Repeat markers

Vanilla is the only genus of plants in the Orchidaceae family used in the food industry, being the most widely used flavoring worldwide and the second most valuable economically. Cultivation is of great biocultural importance in the Totonacapan region, in the state of Veracruz, as this region is considered its center of origin and distribution. However, little is known regarding the number of genotypes present in this area, as well as the genetic diversity, which is vital for the improvement of this crop. Therefore, the objective of this study was to perform the genotyping of 60 Vanilla planifolia accessions from the Germplasm Bank of The National Institute of Forestry, Agriculture, and Livestock Research (Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias - INIFAP), Experimental Field Ixtacuaco, which were selected and collected in the Totonacapan region. For this purpose, the number of V. planifolia genotypes was determined based on ISSR (Inter-Simple Sequence Repeat) molecular markers. Three DNA extraction protocols from plants and fungi described in the literature were evaluated, and a fourth protocol was adapted with different procedures from the previous protocols, seeking to obtain a high concentration and good quality and integrity. Once quality DNA was obtained, fourteen ISSR primers were evaluated, of which three primers that showed the highest number of amplified bands were selected. Subsequently, the genotyping of the 60 accessions was carried out, resulting in nine genotypes with primer 808 and six genotypes with primers 812 and 856. These results allowed the genotyping of Vanilla planifolia accessions with ISSR markers, which will help evaluate the genetic diversity of this crop in the Totonacapan region in the future.

Identifying Socially Optimal Equilibria Using Combinatorial Properties of Nash Equilibria in Bimatrix Games

Nash equilibrium is arguably the most fundamental concept in game theory, which is used to analyze and predict the behavior of the players. In many games, there exist multiple equilibria, with different expected payoffs for the players, which in turn raises the question of equilibrium selection. In this paper, we study the [Formula: see text]-hard problem of identifying a socially optimal Nash equilibrium in two-player normal-form games (called bimatrix games), which may be represented by a mixed integer linear program (MILP). We characterize the properties of the equilibria and develop several classes of valid inequalities accordingly. We use these theoretical results to provide a decomposition-based reformulation of the MILP, which we solve by a branch-and-cut algorithm. Our extensive computational experiments demonstrate superiority of our approach over solving the MILP formulation through feeding it into a commercial solver or through the “traditional” Benders’ decomposition. Of note, our proposed approach can find provably optimal solutions for many instances. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms. Funding: This work was supported by the National Institute of Dental and Craniofacial Research [Grant R01DE028283]. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funding agreements ensured the authors’ independence in designing the study, interpreting the data, writing, and publishing the report. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.0072 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2022.0072 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .

Improving patients’ experiences of diagnosis and treatment of vertebral fracture: co-production of knowledge sharing resources

BackgroundOsteoporosis involves changes to bones that makes them prone to fracture. The most common osteoporotic fracture is vertebral, in which one or more spinal vertebrae collapse. People with vertebral fracture are at high risk of further fractures, however around two-thirds remain undiagnosed. The National Institute for Health and Care Excellence (NICE) recommends bone protection therapies to reduce this risk. This study aimed to co-produce a range of knowledge sharing resources, for healthcare professionals in primary care and patients, to improve access to timely diagnosis and treatment.MethodsThis study comprised three stages: 1. In-depth interviews with primary care healthcare professionals (n = 21) and patients with vertebral fractures (n = 24) to identify barriers and facilitators to diagnosis and treatment. 2. A taxonomy of barriers and facilitators to diagnosis were presented to three stakeholder groups (n = 18), who suggested ways of identifying, diagnosing and treating vertebral fractures. Fourteen recommendations were identified using the nominal group technique. 3. Two workshops were held with stakeholders to co-produce and refine the prototype knowledge sharing resources (n = 12).ResultsStage 1: Factors included lack of patient information about symptoms and risk factors, prioritisation of other conditions and use of self-management. Healthcare professionals felt vertebral fractures were harder to identify in lower risk groups and mistook them for other conditions. Difficulties in communication between primary and secondary care meant that patients were not always informed of their diagnosis, or did not start treatment promptly. Stage 2: 14 recommendations to improve management of vertebral fractures were identified, including for primary care healthcare professionals (n = 9) and patients (n = 5). Stage 3: The need for allied health professionals in primary care to be informed about vertebral fractures was highlighted, along with ensuring that resources appealed to under-represented groups. Prototype resources were developed. Changes included help-seeking guidance and clear explanations of medical language.ConclusionsThe study used robust qualitative methods to co-produce knowledge sharing resources to improve diagnosis. A co-production approach enabled a focus on areas stakeholders thought to be beneficial to timely and accurate diagnosis and treatment. Dissemination of these resources to a range of stakeholders provides potential for substantial reach and spread.

Ferroelectric 2D SnS2 Analog Synaptic FET.

In this study, the development and characterization of 2D ferroelectric field-effect transistor (2D FeFET) devices are presented, utilizing nanoscale ferroelectric HfZrO2 (HZO) and 2D semiconductors. The fabricated device demonstrated multi-level data storage capabilities. It successfully emulated essential biological characteristics, including excitatory/inhibitory postsynaptic currents (EPSC/IPSC), Pair-Pulse Facilitation (PPF), and Spike-Timing Dependent Plasticity (STDP). Extensive endurance tests ensured robust stability (107 switching cycles, 105 s (extrapolated to 10 years)), excellent linearity, and high Gmax /Gmin ratio (>105 ), all of which are essential for realizing multi-level data states (>7-bit operation). Beyond mimicking synaptic functionalities, the device achieved a pattern recognition accuracy of ≈94% on the Modified National Institute of Standards and Technology (MNIST) handwritten dataset when incorporated into a neural network, demonstrating its potential as an effective component in neuromorphic systems. The successful implementation of the 2D FeFET device paves the way for the development of high-efficiency, ultralow-power neuromorphic hardware which is in sub-femtojoule (48 aJ/spike) and fast response (1 µs), which is 104 folds faster than human synapse (≈10ms). The results of the research underline the potential of nanoscale ferroelectric and 2D materials in building the next generation of artificial intelligence technologies.

Nutrition interventions for body composition, physical function, cognition in hospitalized older adults: A systematic review of individuals 75 years and older.

Globally, the oldest old population is expected to triple by 2050. Hospitalization and malnutrition can result in progressive functional decline in older adults. Minimizing the impact of hospitalization on functional status in older adults has the potential to maintain independence, reduce health and social care costs, and maximize years in a healthy state. This study aimed to systematically review the literature to identify nutritional interventions that target physical function, body composition, and cognition in the older population (≥ 75 years). A systematic review was conducted to evaluate the efficacy of nutritional interventions on physical function, body composition, and cognition in adults aged ≥ 75 years or mean age ≥80 years. Searches of PubMed (National Institutes of Health, National Library of Medicine), Scopus (Elsevier), EMBASE (Elsevier), Cumulative Index to Nursing and Allied Health Literature (CINAHL) with Full Text (EBSCOhost), and PsycInfo (EBSCOhost) were conducted. Screening, data extraction, and quality assessment were performed in duplicate and independently (CRD42022355984; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=355984). Of 8311 citations identified, 2939 duplicates were excluded. From 5372 citations, 189 articles underwent full-text review leaving a total of 12 studies for inclusion. Interventions were food-based, protein-based, carbohydrate-based, personalized, or used parenteral nutrition. Ten studies monitored anthropometric or body composition changes with three showing maintenance or improvements in lean mass, body mass index, triceps skinfold, and mid-upper arm circumference compared with the control group. Six studies monitored physical function but only the largest study found a beneficial effect on activities of daily living. Two of three studies showed the beneficial effects of nutritional intervention on cognition. There are few, high-quality, nutrition-based interventions in older adults ≥75 years. Despite heterogeneity, our findings suggest that large, longer-term (>2 weeks) nutritional interventions have the potential to maintain body composition, physical function, and cognition in adults aged 75 years and older during hospitalization.

Radiation protection aspects in the design of a Boron Neutron Capture Therapy irradiation room

Boron Neutron Capture Therapy (BNCT) is a radiotherapy whose effect is due to the combination of low-energy neutron irradiation prior chemical targeting of tumour tissues with boron-10. The context of this work is the design of a clinical BNCT facility based on a Radio-Frequency Quadrupole proton accelerator, manufactured by the Italian National Institute of Nuclear Physics (INFN). Such a machine can provide a neutron beam suitable for the treatment of deep-seated tumours when coupled to a beryllium target and a Beam Shaping Assembly whose main constituent is densified lithiated aluminium fluoride. This paper refines the design of the facility, already addressed in preliminary studies, from the point of view of dosimetric quantities in the room and in the patient. The presented calculations have been performed with different Monte Carlo codes, and assess the time evolution of the dose due to the neutron activation of the irradiated materials. A comprehensive evaluation of the dose absorbed in the healthy organs of the patient is provided, with focus on the residual radioactivity of the patient urine, for three different treatment positions. Borated concrete is confirmed to be the best material for constructing the walls of the treatment room. A lead shielding at the beam-port is proposed to reduce the gamma dose at the irradiation position due to the activation of the Beam Shaping Assembly.

Typology of sheep farmers benefited by the Program for the Improvement of indigenous Production and Productivity

Objective: To identify the typology and describe the sheep farmers benefited by the Programa para el Mejoramiento de la Producción y Productividad Indígena (PROIN: Program for the Improvement of Indigenous Production and Productivity) of the Instituto Nacional de Pueblos Indígenas (INPI: National Institute for Indigenous Peoples), in Campeche. Design/Methodology/Approach: One-hundred ninety-nine sheep farmers registered as beneficiaries in the Program were interviewed. They belonged to 27 sheep farms (SF), located in seven municipalities. A questionnaire including socioeconomic and technical questions and 15 quantitative and qualitative variables was conducted. Variables were correlated and a principal components analysis was carried out to define types of farms. The variables that explained the highest variability in the data set were number of sheep, number of sheep sold per year, annual income from sheep sales, productive purpose of the sheep farming, and feeding system. These variables were then used to perform a cluster analysis in order to identify and cluster the sheep farms. Results: Three groups of farmers were identified: Conventional (C, 74%) with 70 sheep and annual sales for $10,109.00; Transitional (T, 15%) with 169 sheep and annual sales for $36,680.00; and those in business (B, 11%) with 142 sheep and annual sales for $48,443.00. All the producers (100%) carry out extensive grazing. The breeds used by C and T are Pelibuey × Black Belly (78%), while B uses Pelibuey × Kathadin (21.7%). Study Limitations/Implications: Implemented support strategies must differentiate according to the type of farm. Findings/Conclusions: Three types of sheep farmers were identified: Conventional, Transitional, and Enterprise. Farmer types were differentiated by the number of sheep, sales, income, sheep production system, and feeding system they use.

Retrospective review of maternal HIV viral load electronic gatekeeping codes in South Africa.

Maternal electronic gatekeeping (eGK) codes for HIV viral load (VL) testing of pregnant and breastfeeding women were developed to permit increased frequency of maternal HIV VL testing without automated gatekeeping cancellation, and to enable virological surveillance. This study describes the national uptake of maternal eGK codes and VL suppression (VLS) rates disaggregated by age during antenatal, delivery and postnatal periods in South Africa during 2022. HIV VL tests associated with C#PMTCT (used for antenatal and postnatal testing) and C#DELIVERY (used at delivery) eGK codes between 01 January and 31 December 2022, were extracted from the National Institute for Communicable Diseases Data Warehouse. Uptake of eGK codes was calculated using indicators from the District Health Information System as denominators while HIV VLS rates (< 1000 copies/mL) were calculated as monthly and annual percentages. Overall, national maternal eGK code uptake was 41.8%, 24.5% and 0.12% for the antenatal, delivery and postnatal periods, respectively. The monthly antenatal eGK uptake increased from 27.5% to 58.5% while delivery uptake increased from 17.3% to 30.0%. The overall annual maternal HIV VLS rate was 86.7% antenatally and 87.2% during delivery. The monthly average HIV VLS for adolescent girls and young women (AGYW) was 76.1% antenatally and 79.6% during delivery. Although overall national uptake of maternal HIV VL eGK codes was low, antenatal and delivery uptake improved over time, thereby facilitating use of eGK codes for programmatic monitoring of maternal VLS rates for the first time. Quality of care among pregnant AGYW requires urgent attention.

Addressing Participation in Adults With Postconcussive Symptoms Using Cognitive Strategy Training: A Feasibility Trial.

Some people experience persistent symptoms after a concussion that greatly affect occupational performance. To evaluate the feasibility and preliminary effect of metacognitive strategy training in a sample of adults with postconcussive symptoms. Single-group, prospective design. University research laboratory. Adults with persistent concussive symptoms affecting function (N = 14). Ten 45-min sessions of a metacognitive strategy training intervention, Cognitive Orientation to daily Occupational Performance (CO-OP). Assessed feasibility outcomes included recruitment, retention, and adherence rates, and intervention acceptability was evaluated with the Client Satisfaction Questionnaire-8. The preliminary effect was measured on occupational performance (Canadian Occupational Performance Measure), concussive symptoms (Neurobehavioral Symptom Inventory), sleep (Pittsburgh Sleep Quality Inventory), vision (College of Optometrists in Vision Development-Quality of Life Outcomes Assessment), and cognition outcomes (Dysexecutive Questionnaire, Weekly Calendar Planning Activity, and National Institutes of Health Toolbox Cognition Battery). Acceptable recruitment (32%), retention (93%), and adherence rates (100%) were observed, along with a high level of acceptability to participants. Large intervention effects were present for occupational performance, general concussive symptoms, and cognitive functioning. Findings suggest that the CO-OP is feasible to administer for adults with postconcussive symptoms and perceived as suitable for the needs of this population. Feasibility findings, coupled with improvements in occupational performance outcomes, provide the foundation for a future larger scale trial. Plain-Language Summary: The Cognitive Orientation to daily Occupational Performance intervention is practical to use to address the functional impact of persistent concussive symptoms in adults. Further research is needed to evaluate the efficacy of the CO-OP intervention with this population.

Comparison and analysis research on occupational exposure limits of coal dust between China and foreign countries

Objective: To study and compare the occupational exposure limits (OELs) of coal dust between China and foreign countries, understand the OEL of coal dust in China, and provide data and basis for revising the OEL of coal dust in China. Methods: In August 2023, by searching the official websites of limits setting institutions in relevant countries and regions at home and abroad, collecting and sorting out the OELs of coal dust issued by 10 limit setting institutions in 6 countries and the background information of the formulation, and conducting specific analysis on the classification, limit level and formulation principles of coal dust OEL in each country/institution. Results: In China and Japan, the total dust and respirable dust of coal dust OEL were established respectively, while in other countries, only the time-weighted average concentration (TWA) of respirable coal dust exposure was established. The TWA prescribed by China's Notional Health Commission, the United States Occupational Safety and Health Administration (OSHA) , the United States Mining Safety and Health Administration (MSHA) and the Australian Safety Work Bureau when the SiO(2) content was less than 5% were 5, 2.4, 2 and 3 mg/m(3) respectively. China GBZ 2.1-2019 sets the limit of 2.5 mg/m(3) for respirable coal dust with SiO(2) content less than 10%. The TWA set by the American Conference of Government Industrial Hygienists (ACGIH) and the South African Department of Mines and Energy (DME) for anthracite coal were 0.4 and 0.8 mg/m(3), respectively, and bituminous coal or lignite were 0.9 and 1.8 mg/m(3), respectively. The respirable coal dust TWA set by the National Institute for Occupational Safety and Health (NIOSH) in the United States was 1 mg/m(3), and the TWA set by the New Zealand Work Safety Authority was 3 mg/m(3). Conclusion: At present, the OEL of coal dust in China is at a relatively loose level, and it is suggested to further explore the possibility of revising coal dust OEL.

Multifunctional HfAlO thin film: Ferroelectric tunnel junction and resistive random access memory.

This study presents findings indicating that the ferroelectric tunnel junction (FTJ) or resistive random-access memory (RRAM) in one cell can be intentionally selected depending on the application. The HfAlO film annealed at 700 °C shows stable FTJ characteristics and can be converted into RRAM by forming a conductive filament inside the same cell, that is, the process of intentionally forming a conductive filament is the result of defect generation and redistribution, and applying compliance current prior to a hard breakdown event of the dielectric film enables subsequent RRAM operation. The converted RRAM demonstrated good memory performance. Through current-voltage fitting, it was confirmed that the two resistance states of the FTJ and RRAM had different transport mechanisms. In the RRAM, the 1/f noise power of the high-resistance state (HRS) was about ten times higher than that of the low-resistance state (LRS). This is because the noise components increase due to the additional current paths in the HRS. The 1/f noise power according to resistance states in the FTJ was exactly the opposite result from the case of the RRAM. This is because the noise component due to the Poole-Frenkel emission is added to the noise component due to the tunneling current in the LRS. In addition, we confirmed the potentiation and depression characteristics of the two devices and further evaluated the accuracy of pattern recognition through a simulation by considering a dataset from the Modified National Institute of Standards and Technology.

Using Conversation Analysis to explore assessments of decision-making capacity in a hospital setting.

Healthcare professionals (HCPs) have a responsibility to conduct assessments of decision-making capacity that comply with the Mental Capacity Act 2005 (MCA). Current best-practice guidance, such as the Mental Capacity Code of Practice and National Institute for Health and Care Excellence decision-making and mental capacity guidance, does not stipulate how to accomplish this in practice, for example, what questions should be asked, how options and information should be provided. In addition, HCPs struggle to assess the capacity of individuals with communication difficulties. This study was a service evaluation that aimed to objectively analyse, using Conversation Analysis (CA), how real-life capacity assessments were conducted in a hospital setting with patients with acquired brain injury (ABI)-related communication difficulties. A second aim was to establish the feasibility of using CA to advance knowledge of the conduct of capacity assessment. Four naturally occurring capacity assessments were video-recorded. Recordings involved speech and language therapists, occupational therapists, neuropsychologists and patients with communication difficulties as a result of ABI. The methods and findings of CA were used to investigate the interactional behaviours of HCPs and patients during assessments of decision-making capacity. The analysis was informed by our knowledge of the MCA best practice guidance. An overall structure of capacity assessment that enacted some of the best-practice MCA guidance was identified in one recording, consisting of six phases: (i) opening, (ii) preparation, (iii) option-listing, (iv) test, (v) decision, and (vi) close. The preparation phase consisted of two sub-components: information gathering and information giving. Variation from this structure was observed across the dataset, notably in the way in which options were (or were not) presented. CA is a feasible empirical method for exploring the structure and conduct of capacity assessments. CA identifies and provides ways of describing interactional behaviours that align with and diverge from best-practice MCA guidance. Future CA studies including a wider range of health and social care professionals and patients have the potential to inform evidence based training for HCPs who conduct assessments of decision-making capacity. What is already known on this subject The Mental Capacity Act (MCA) is poorly implemented in practice. Healthcare professionals (HCPs) find it challenging to assess the decision-making capacity of individuals with communication difficulties, and people with communication difficulties are often excluded from or insufficiently supported during capacity assessment. Research is limited to self-report methods. Observational studies of capacity assessment are required. What this study adds This is the first study to use Conversation Analysis (CA) to explore how capacity assessments are conducted in a hospital setting by HCPs with people with communication difficulties as a result of acquired brain injury. One video-recorded capacity assessment was structured in six phases that aligned with best practice MCA guidance. However, other capacity assessments deviated from this structure. One phase, option listing, varied in practice and options were not always presented. What are the clinical implications of this work? CA revealed interactional behaviours that align with and diverge from best-practice MCA guidance. Future CA studies are warranted to inform training for health and social care professionals who conduct capacity assessments.

Field Evaluation of Six Newly Introduced Soybean Varieties in the National Pulses Program Germplasm, Kongo Central Province

Aim: To evaluate the behavior of soybean varieties recently introduced in germplasm of National Pulses Program of National Institute for Agricultural Study and Research.&#x0D; Study Design: The study was conducted using a randomized complete block design (RCBD) with six treatments replicated three times.&#x0D; Place and Duration of the Study: The experiment was carried out at the Lieutenant-Colonel EBEYA Military Camp, precisely in the POUDRIERE site in LOMA district from April 14 to June 17, 2023. &#x0D; Methodology: The study was conducted with six soybean varieties replicated three times. Data collected concerned percentage of seedlings emerged, vegetative development and production parameters.&#x0D; Results: The emerged plants rate varies from 82.6 to 90%, collar diameter from 4.3 to 6.4mm, and plant height from 27.9 to 51.3 cm. The leaflet number per plant varies from 18.3 to 32, while their length and width varied from 6 to 9.4cm, and from 10.5 to 17.7cm, respectively. On each plant, the number of branches bearing pods varied from 3.6 to 5. The number of pods and seed per plant varied from 18 to 37, and from 34.3 to 68, respectively. Overall, soybean varieties flowered on 34.4 to 68 DAS. The 100-seed weight varied from 8 to 15.3g, and yield obtained from 572.9 to 2,203kg/ha. &#x0D; Conclusion: Overall, the results of this study indicate that vegetative development and production parameters vary among varieties. This variability in behavior results from the interactions between intrinsic properties of each soybean variety and agroenvironmental conditions of experimental field. The yields obtained were lower than the global average. However, variety TGM 0169 considered late, had high emerged plants rate (90%), and yielded more than 2t/ha, which is far higher than the average recorded in the majority of Sub-Saharan African countries. Ultimately, TGM 0162 appeared as elite variety whatever parameter considered.

Characterization of Fiber Metal Laminates for the Development of Subsea Housing

Fiber Metal Laminates (FML) are hybrid composites comprising metals and Fiber Reinforced Plastics (FRP). FMLs are the most widely used in aerospace, defence and automotive sectors due to their superior qualities like light weight, tensile, compression, flexural, excellent fatigue and impact resistance. The properties like strength-to-weight ratio, susceptibility to corrosion and good heat conduction of FML make it suitable for subsea applications. Commonly, FML with a combination of aluminium (Al), titanium (Ti), stainless steel (SS) alloys and FRP are widely used for ocean applications. Compared to other FML, the SS alloy-based FML is typically used in subsea applications as it has more creep and excellent corrosion resistance. In India, under the Ocean Acoustics programme of the National Institute of Ocean Technology (NIOT), an autonomous underwater Ambient Noise Measurement System (ANMS) has been developed and deployed in the shallow waters of Indian seas for the past 12 years to study the background noise prevailing in the sea. To accommodate electronics and power packs for the measurement of ambient noise at an ocean depth of 100 m, subsea housing with stainless steel 316L (SS316L) material for a pressure rating of 1 MPa has been developed. The objective of this study is to develop the FML with SS316L and FRP for reducing the weight of the housing. Based on the literature studies and Classical Laminate Theory (CLT), the FML has been fabricated as a 0.45 m (450 mm) panel with a sequence of SS316L as outer layers and E-glass fibre and carbon as the inner layers. The total thickness of the laminates is 0.006 m (6 mm). The developed FMLs are processed with water jet cutting machines to carry out various testing such as tensile, compression and flexural, which are relevant to the characterization of FML and the experimental results are described in the paper.

Development of a partnership between academia, community, and government in response to the 2022 mpox outbreak in Japan.

Objectives In response to the steady rise in the number of cases of mpox in nonendemic countries, starting with an outbreak in the United Kingdom in May 2022, the World Health Organization declared a public health emergency of international concern on July 23, 2022. As of November 13, 2022, seven cases of mpox have been reported in Japan.Methods A community engagement approach was applied to prevent the spread of mpox in Japan.Results A tripartite partnership between academia, community, and government (ACG) was established to promote multisectoral communication between vulnerable communities, medical personnel involved in diagnosis and treatment, public health specialists at public health centers, epidemiologists at the National Institute of Infectious Diseases (NIID), and government and public administration. Through information sharing, this ACG partnership can translate accurate information into effective infection control measures.Conclusion By developing and maintaining the ACG partnership, an environment will be created that allows an immediate response to future public health crises affecting vulnerable communities. This Practice Report describes the process of establishing an ACG partnership.

Representation of Women Authorship in the Top 5 Transplantation Journals in the United States.

In the United States, only 13% of transplant surgeons are women. We evaluated gender distribution and trends of American authorship over the past 10 y in high-impact solid organ transplantation journals to gain insight into the current status of women authorship in transplantation. Original articles from 2012 to 2021 from the 5 highest-impact solid organ transplantation journals were extracted from Scopus. First and last author's gender was predicted using Genderize.io. Data of first and last authors, article type and topic, location, citation, and funding metrics were analyzed. Chi-square, logistic regression, and trend tests were performed where appropriate. Statistical significance was set at <0.05. Women's first and last authorship increased over time among all journals. There was an increase in women first authors in the American Journal of Transplantation and in senior women authors in Liver Transplantation and Transplantation . Significant differences in gender authorship in lung, intestine, pancreas, general, and islet cell transplantation were found. Women's last authorship was associated with 1.69 higher odds of having a woman first author when adjusting for year and journal. There was an increase in the rate of women's first and last author collaborations over the years. Women last authors had 1.5 higher odds of being funded by the National Institutes of Health over the years. Despite an increase in women transplant surgeons and physicians, the gap in women authorship in transplantation persists. Women's last authorship was associated with higher odds of having a woman first author, pointing to the importance of mentorship for women joining the transplant academia.

Urinary tract infections in pediatric orthopedic surgical patients: a Single Institution National Surgical Quality Improvement Program Study.

Perioperative urinary tract infections (UTIs) are poorly studied among pediatric orthopedic surgical patients. We evaluated the incidence of and risk factors for UTI in a large volume of pediatric orthopedic surgical patients. Children <18 who underwent orthopedic surgery between March 2015 and December 2018 were analyzed using our institution's National Surgical Quality Improvement Program (NSQIP) data. Demographic, perioperative and outcome data of patients who developed a UTI within 30 days of surgery were compared to patients without UTI. NSQIP data were available for 520 surgeries (324 girls and 196 boys). Median age at surgery was 13.5 years. A Foley was placed in 301/520 cases (88/196 boys and 213/324 girls) in 264 children. Six cases of UTI occurred within 30 days of surgery (1.2% of surgeries). The UTI rate among patients with a Foley was 2.3%, and among girls with a Foley was 2.8%. No UTIs occurred without a Foley, nor any in boys. All six occurred in the American Society of Anesthesiologists Class 2 females, ages 7-15 undergoing elective surgery with Foley for over 48 h. Factors associated with an increased odds of developing UTI included: higher BMI [OR, 1.12 (CI, 1.01-1.22; P = 0.03)], developmental delay [OR, 7.82 (CI, 1.40-43.7; P = 0.02)], structural central nervous system abnormality [OR, 17.5 (CI, 3.89-90.4; P = 0.01)], longer duration with Foley [OR, 1.68 (CI, 1.22-2.32; P = 0.002)] and hospital readmission within 30 days [OR 14.2 (CI, 2.32-87.3; P = 0.004)]. Risk of UTI is low after pediatric orthopedic surgery. Girls with comorbidities including structural central nervous system abnormality, developmental delay and higher BMI with prolonged Foley catheterization may have higher postoperative UTI risk. Level of Evidence: II.

Survey to assess the feasibility of establishing an international network for evidence synthesis in occupational safety and health.

Evidence synthesis in the field of occupational safety and health (OSH) has been continuously growing over the last two decades. With over 100 systematic reviews now published, the Cochrane Work Review group has played an important role in this development and the Cochrane Thematic Group 'Work & Health & Social Security' was established recently to combine evidence from both the OSH and insurance medicine fields. Worldwide, many organizations produce and synthesize evidence in OSH that can complement and support each other. We believe that a global network including Cochrane and others can collaborate on methods development and in the production, synthesis, use and dissemination of different types of evidence even more effectively. To determine if establishing a global network for evidence synthesis in OSH is feasible. We conducted a survey of international and national institutions between November 2022 and January 2023 using LimeSurvey. Participants included representatives of affiliated and sustaining members of the International Commission on Occupational Health, national institutes for OSH, academia and other international organizations. From 151 invitations, we received responses from 57 representatives of 54 organizations. Representatives reported that their organization will contribute financially on an annual basis (n = 1) or provide in-kind support (n = 10), and will probably be able to provide financial or in-kind support (n = 25). The feasibility criterion was met and an international network is being established.

Transforming trash: strategies to develop waste into a feedstock for a circular bioeconomy

AbstractOrganic by‐product and waste streams generated from agriculture and food production are important future feedstocks for manufacturing chemicals, polymers, and other materials in a circular bioeconomy. These waste streams are currently underutilized and under‐explored in the context of biomanufacturing though much funding and infrastructure have been made available for their use in energy generation. The natural ability of microorganisms to utilize compounds in organic wastes, coupled with advances in engineering biology that enable scientists to manipulate biological systems to produce chemicals, polymers, and materials, and improve upon those processes, present a promising technological approach to the utilization of these waste streams as feedstocks. However, the characteristics of waste streams make them challenging to incorporate into biomanufacturing processes. These challenges can be addressed with additional advances in engineering biology research and thoughtful approaches to process development. Research and process development around the use of existing, localized waste streams present distinct benefits and raise interesting considerations, and are important undertakings. These activities will be as complex as the waste streams targeted; as such, coordination of efforts across relevant agencies and organizations, and collaborations between researchers, waste generators, customers, and other stakeholders will be critical to their success. To make meaningful and rapid contributions towards utilization of organic wastes as biomanufacturing feedstocks we recommend: (1) The National Institute of Food and Agriculture (NIFA) at the US Department of Agriculture should incorporate into existing programs the development of organic waste conversion into chemicals, polymers, and other materials using engineering biology and, if possible, establish new programs focused on this area; and (2) NIFA should oversee, coordinate, and publicize collaborative efforts that include federal agencies, state and regional agricultural research centers and cooperatives, and program‐related infrastructure.

Association of Hyperuricaemia with Angiographic Severity of Coronary Artery Disease in Patients of Acute Coronary Syndrome

Background: Coronary artery disease (CAD) is a major cause of death and a global health issue that has reached pandemic proportions in both industrialized and developing countries. Coronary artery disease is primarily caused by atherosclerosis of the epicardial coronary arteries. Aim of the study: The aim of our study was to investigate the relationship between hyperuricemia and the angiographic severity of coronary artery disease in patients who have recently been diagnosed with acute coronary syndrome. Methods: This cross-sectional analytical study was conducted in the department of Cardiology, National Institute of Cardiovascular Diseases and Hospital, Dhaka, Bangladesh, from December 2011 to November 2012. The study included 103 patients who were newly diagnosed as acute coronary syndrome. The individuals in this study were separated into two groups based on their serum uric acid levels. All acquired data was entered into a Microsoft Excel Work Sheet and analyzed using descriptive statistics in SPSS 11.5. Results: The study populations are mainly between 40 to 75 years (90.6% &amp; 92% remaining in group- I &amp; group- II respectively). It was found that majority of the study participants were male in both groups. Findings of the study shows that there is no statistically significant difference observed in respect smoking habit (p-0.86), hypertension (p-0.32), DM (p-0.53), dyslipidemia p-6.93) and family history of IHD (p-0.68) between two groups. The data of biochemical parameters reveals that HDL level is comparatively lower in group-II (38.72± 2.19) than group- I (39.64 ± 2.11) and it is statistically significant (p=0.03). This study findings reveals that the value of stenosis in Friesinger score in group-II (9.30± 3.96) is remarkably higher than that of group-I (0.77± 3.43) and it is statistically highly significant (p-0.001). Conclusion: This study reveals that hyperuricaemia may be an independent risk factor and predictor of the severity of coronary artery ......