You have accessJournal of UrologyInfections/Inflammation of the Genitourinary Tract: Prostate & Genitalia1 Apr 20131177 SIGNIFICANT BIOMARKER FOR LOWER URINARY TRACT SYMPTOMS OR PAIN FROM CHRONIC PROSTATITIS Fukashi Yamamichi, Minori Matsumoto, Katsumi Shigemura, Toshiro Shirakawa, Hideaki Miyake, Soichi Arakawa, Kazushi Tanaka, and Masato Fujisawa Fukashi YamamichiFukashi Yamamichi Kobe, Japan More articles by this author , Minori MatsumotoMinori Matsumoto Kobe, Japan More articles by this author , Katsumi ShigemuraKatsumi Shigemura Kobe, Japan More articles by this author , Toshiro ShirakawaToshiro Shirakawa Kobe, Japan More articles by this author , Hideaki MiyakeHideaki Miyake Kobe, Japan More articles by this author , Soichi ArakawaSoichi Arakawa Kobe, Japan More articles by this author , Kazushi TanakaKazushi Tanaka Kobe, Japan More articles by this author , and Masato FujisawaMasato Fujisawa Kobe, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.814AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We have previously presented the treatments and biomarker for chronic prostatitis (CP) patients and their symptoms; however, CP often has recurrent cases and the mechanism of diseases has not been fully established. This study intended to extend our study with more number of patients for detecting a significant inflammatory and immune system biomarker for CP and their symptoms relating not only urination but pain that can be used for researching molecular targeted therapy. METHODS We investigated the expressions of inflammatory and/or immune system-relating biomarkers such as transforming growth factor-β 1 (TGF-β1), Interleukin (IL)-6, CD-3 (as a T-lymphocyte marker), and CD-163 (as a macrophage marker) using prostate biopsy specimens with results of prostatic inflammation. We examined the correlation between these makers' expressions and symptoms scoring using National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) and lower urinary tract symptoms (LUTS) evaluated by International prostate symptom score (IPSS)/ quality of life (QOL), and Overactive bladder symptom score (OABSS). RESULTS Our statistical analyses of NIH-CPSI scores and IHC protein expressions of potentially significant biomarkers for high NIH-CPSI scores demonstrated a significant correlation between IL-6 expression and urinary symptoms (p=0.0162) and total scores (pain or discomfort, urination, impact of symptom, and QOL) (p=0.0467). The expressions the tested 2 potential biomarkers (CD-3 and CD-163) had significant correlation with pain or discomfort, and impact of symptom, respectively. Our statistical analyses of LUTS scores (IPSS/QOL and OABSS) and IHC protein expressions of potentially significant biomarkers for high LUTS scores demonstrated a significant correlation only between CD-3 expression and daytime frequency (p=0.0048) and storage symptom scores (incomplete emptying, daytime frequency, urgency, and nocturia frequency) (p=0.018) in IPSS/QOL. These results suggest that storage symptoms, but not voiding symptoms, and especially daytime frequency might correlate with inflammatory and immune factor T-lymphocytes. CONCLUSIONS This study showed IL-6, CD-3 and CD-163 significantly related to urination, pain or impact of symptom, and CD-3 significantly correlated with frequency and storage symptom in CP patients by the evaluation of NIH-CPSI scores and LUTS scores using IPSS/QOL. These results might contribute to the research for establishment of new molecular targeted therapy based on CP patients' symptoms. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e480-e481 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Fukashi Yamamichi Kobe, Japan More articles by this author Minori Matsumoto Kobe, Japan More articles by this author Katsumi Shigemura Kobe, Japan More articles by this author Toshiro Shirakawa Kobe, Japan More articles by this author Hideaki Miyake Kobe, Japan More articles by this author Soichi Arakawa Kobe, Japan More articles by this author Kazushi Tanaka Kobe, Japan More articles by this author Masato Fujisawa Kobe, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...