National Innovation Research Articles

Evolution of State Scientific and Technical Policy in USSR in Late 1960s

This study conducts a comparative analysis of the state of the scientific and technical complex of the USSR and leading Western countries in the 1960s based on declassified archival materials. It identifies the main trends in science and technology during this period and the factors that led to the lagging behind of the USSR. Previously unpublished archival documents are introduced into scholarly discourse. It is demonstrated that the data sent to the country’s leadership by leading specialists and scientists of the Academy of Sciences indicated the USSR’s lag in several crucial directions determining the pace of scientific and technical progress. Key hindering factors cited by experts included insufficient funding, lack of coordination among various agencies, absence of interaction between the defense and civilian sectors of science, and planning miscalculations. The conclusion is drawn that this list can be supplemented with reasons such as inadequate competence of some top-level government officials, departmental approach, shortage of specialists in key areas, and disregard for recommendations from leading scientists. Meanwhile, trends in the development of the scientific and technical sphere in the USA and other leading countries indicated the establishment of national innovation systems as highly effective mechanisms for accelerating scientific and technical progress.

Application of ChatGPT in soil science research and the perceptions of soil scientists in Indonesia

Since its arrival in late November 2022, ChatGPT-3.5 has rapidly gained popularity and significantly impacted how research is planned, conducted, and published using a generative artificial intelligence approach. ChatGPT-4 was released four months later and became more popular in November 2023. However, there is little study about the perception of scientists of these chatbots, especially in soil science. This article presents the new findings of a brief research investigating soil scientists' responses and perceptions towards chatbots in Indonesia. This artificial intelligence application facilitates conversation-based interactions in text format. The study evaluated ten ChatGPT answers to fundamental questions in soil science, which has developed into a normal science with a mutually agreed-upon paradigm. The evaluation was carried out by seven soil scientists recognized for their expertise in Indonesia, using a scale of 1–100. In addition, a questionnaire was distributed to soil scientists at the National Research and Innovation Agency of the Republic of Indonesia (BRIN), universities, and Indonesian Soil Science Society (HITI) members to gauge their perception of ChatGPT's presence in the research field. The study results indicate that the scores of ChatGPT answers range from 82.99 to 92.24. ChatGPT-4 is better than both the paid and free versions of ChatGPT-3.5. There is no significant difference between the English and Indonesian versions of ChatGPT-4.0. However, the perception of general soil scientists about the level of trust is only 55%. Furthermore, 80% of soil scientists believe that chatbots can only be used as digital tools to assist in soil science research and cannot be used without the involvement of soil scientists.

Analysis of national strategic innovation objectives using adapted Porter’s diamond model: a comparison of Romania and Türkiye

Purpose Nowadays, nations are rapidly changing and evolving, both because of global competitiveness and technological development. The fast change of the economies and the interconnected world has brought a more globalized world than ever. The purpose of this paper is to assess Romania (RO) and Türkiye (TR) by using a customized version of Porter’s diamond model (PDM), with an emphasis on identifying the key components of their innovation systems. Design/methodology/approach The paper uses a recognized model to unfold its structure. Based on the PDM, this paper tackles the topic of innovation systems both of RO and TR. Applying the model, a mapping of indicators representing components of the national innovation system is made possible. Besides the traditional four determinants (dimensions) of the model, the authors adapted it and added the technology conditions. Using the five dimensions, a comparison of strategical objectives is made between RO and TR. Findings The results show the potential for both countries to develop and embrace the innovation capacity, while there is still room for improvement in this regard. Another point is the map of innovation system components that were used for the comparison. The implications of innovation are analyzed at a strategical level, comparing the mapping with the national strategical objectives. Originality/value There are many studies using this model, however a few bring into the light the impact of innovation systems at national level. Hence, a new framework is provided to evaluate innovative systems using a selection of modern indicators. This study uses an existing model in literature, Porter’s model mapping indicators, which highlight the innovation capacity.

Strategi Inovasi Untuk Meningkatkan Pelayanan Perizinan Penelitian Asing

Indonesia's natural and cultural riches have attracted the attention of foreign researchers to conduct research in Indonesia. Indonesia is considered to be one of the largest biological laboratories in the world, so there are many objects that can be used for research by foreign researchers. To provide research licensing services for foreign researchers who wish to conduct research in Indonesia, a legal basis was issued, namely Law No. 11 of 2019 concerning the National System of Science and Technology which regulates research licensing for foreign researchers in Indonesia. As a supporter of Law no. 11 of 2019, BRIN Regulation no. 22 of 2022 concerning Ethical Clearance has been issued. To provide foreign research licensing services according to Law No. 11 of 2019, it is carried out by the Directorate of Research and Innovation Licensing and Scientific Governance of the National Research and Innovation Agency (BRIN). To make it easier to apply for research permits for foreign researchers, several service improvements were made, namely the first was the formation of an ethics commission team to replace the TKPIPA team to evaluate incoming proposals. Second, the number of files that foreign researchers need to prepare is less than before, namely from 14 documents to 7 documents. Third, creating an ethical clearance website to upload the required files in digital form which was previously done offline and submitting hard copy files. Fourth, the addition of financial reporting features to make it easier to check payments and send research progress reports by foreign researchers.

Investing in knowledge assets: a novel approach for measuring national intellectual capital index in emerging economies

PurposeThe aims of the current study were twofold: first, to rank the world’s emerging economies based on a novel National Intellectual Capital Index (NICI) and its components; and second, to examine the impact of NICI and its components on economic growth, measured in terms of real GDP per capita.Design/methodology/approachWe employed principal component analysis (PCA) to construct the novel NICI based on five key socio-economic indicators including (1) national human capital, (2) national structural capital, (3) national relational capital, (4) national informational capital and (5) national innovational capital. These indicators are publicly available for many countries. The index was generated by considering the most appropriate socio-economic indicators as precise measures of NIC from the Penn world table (version 10.0), the World Bank’s database of world governance and development indicators and the KOF globalization across the selected emerging economies.FindingsThe empirical findings revealed that national human capital is a significant driver of NIC, corresponding to higher economic growth. This is followed by national informational capital, national relational capital, national innovation capital and national structural capital. Furthermore, results indicate that the contribution of national structural capital is marginal compared to other critical strands of NIC.Practical implicationsNIC is generally considered the most valuable strategic resource for driving knowledge economies, especially in the Industry 5.0 revolution. Ranking emerging economies based on the NICI sheds light on the accumulated stock of NIC and how it contributes to and improves the economic growth of these economies. The stock of NIC is considered a critical success factor for measuring both current and future economic prosperity. Therefore, using the socio-economic indicators of KOFGI as accurate measures of NICI will assist policymakers in formulating and implementing relevant policies to enhance the accumulation of knowledge-based capital, which are critical components of NIC.Originality/valueTo the best of the authors' knowledge, this is the first study of its kind, both theoretically and empirically, to measure the National Intellectual Capital Index (NICI) using the most nascent socio-economic indicators of NIC. Moving forward, this study evaluates the impact of NICI and its components on economic growth, which is a relatively sparse area of research in the context of emerging knowledge economies.

Innovative public procurement policy failure: a case analysis from Poland

Objectives: The rising popularity of innovation public procurement (IPP) sets a question about conditions as an effective tool of transformative policies, including the governance level, coordination and strategic development. The purpose of the article is to explore the failure of governance in a Polish IPP to present how IPP guidelines are implemented empirically. The other contributions refer to merging DARPA’s approach and IPP. Research Design & Methods: The research article presents conclusions from the case study of first large-scale trial of public procurement procedure with respect to an innovative partnership in Poland. Findings: The case is a rarely analyzed example of policy failure and shows that ignoring stakeholders’ needs, timeline constrains and market capacity can result in policy failure. Program history highlights that proper risk analysis and adaptation to the market context can prevent program failure. Implications / Recommendations: The article opens up a field for considering what steps are crucial in formulating IPP. The analysis leads to the main conclusion that transformative policy frameworks using demand- pull tools need to be embedded in the market realities and capabilities of national innovation systems. Article classification: research article

CEO’s Financial Background and Corporate Green Innovation

Innovation is the primary driving force for development, and enterprises, as the main drivers of innovation, are an important part of implementing the national innovation strategy. This paper, combining the perspective of the enterprise lifecycle, thoroughly examines the differential impact of the CEO’s financial background on green innovation in enterprises at different stages of the lifecycle. This study finds that the CEO’s financial background has a significant inhibitory effect on green innovation in enterprises, and this conclusion holds true after multiple robustness tests. From the perspective of the lifecycle, it is found that when enterprises are in the mature stage, the CEO’s financial background has a strong inhibitory effect on innovation output. The impact of the CEO’s financial background on green innovation output in the growth stage is relatively weak, while there is no significant impact on green innovation in the declining period. Furthermore, based on the enterprise lifecycle, it is found that the CEO’s financial background has a stronger inhibitory effect on green innovation in non-state-owned enterprises and high-tech industries. The research findings of this paper have important theoretical value and practical significance for promoting green innovation in enterprises and implementing the national innovation strategy.

Industrial Robot Digital Twin Application Technology

This paper mainly discusses the core position of the course "Industrial robot Application Technology" in the national double high construction professional group and the innovation of teaching methods. The "task-driven, process" of production-teaching collaboration built through digital twin technology aims to cultivate students' design development. The importance of the course "Industrial Robot Application Technology" is introduced. Teachers' teaching innovation team, national production training base and national science and technology innovation service platform support the digital development of this technology in intelligent manufacturing to create a digital twin teaching platform. In the course material content-based teaching design and the docking of industrial needs, including and industrial robot operation certification. In addition, the action-oriented teaching concept, ideological and political materials are integrated into the teaching design, and the paper emphasizes the teaching material compilation method and three-dimensional teaching material design. At the same time, it also has a potential impact on the expected model innovation of the application and promotion of teaching materials and continuing education.

Navigating an emerging innovation ecosystem: a case study of fuel cell innovation in Taiwan

ABSTRACT The Taiwanese government has actively promoted and established policies for developing fuel cell research and industrial activities since the early 2000s. The activities, including those of Taiwanese policy actors, private firms, and research institutions, are part of a fuel cell innovation ecosystem. Through an embedded case study, this paper examines past national policies, sectoral-level developments, and how a firm has navigated the environment. The analysis is based on the notion of an innovation ecosystem, which analytically covers micro, meso, and macro levels and has more porous boundaries than a national innovation system. Hence, the contribution of this paper relates to creating a deeper understanding of what is happening under the surface of government policy and what path firms can take. Thus, it contributes to studies on latecomer strategies in technology sectors of the dynamic interaction between policy, sectoral development, and firm strategy.

Evaluation index system of science and technology innovation think tank talents based on competency model

As China’s economy progresses towards high-quality development, the construction of science and technology think tanks, with talent construction as the key, has become an important supporting force and occupies a unique position in the national innovation system. In recent years, with the rapid expansion of the number of think tank talents, how to evaluate and manage think tank talents has become a key factor in the development of think tank influence and competitiveness. Based on the experience of talent team construction at home and abroad, Taking the typical science and technology innovation think tanks of Henan Province as an example, this paper analyzes the current situation and status quo of science and technology innovation think tank talents, and finds problems in the talents, Summarize the factors that affect the talent construction and development of science and technology innovation think tanks, From the perspective of six dimensions of competency model, four first-level indicators of talent quantity, talent quality, talent ability and talent contribution of science and technology innovation think tank and 16 subordinate second-level indicators are constructed for talent evaluation of think tank. Ahp is adopted to set questionnaires and collect data with Likert5-level scale, and yaahp software is used to verify the weight verification evaluation effect. Invite experts in the field to score the evaluation indicators. The research results show that the talent evaluation index of science and technology innovation think tank based on competency model pays more attention to the standardization, integration and systematization of the talent evaluation of the think tank, and the system is scientific and reasonable. It can provide reference and reference for promoting the construction, evaluation and development management of scientific and technological innovation think tanks.

The Influence of Organizational Commitment, Non-Financial Compensation and Organizational Justice on Readiness to Change

This research aims to examine and analyze Organizational Commitment, Non-Financial Compensation and Organizational Justice on Readiness to Change. The population in this research were employees of the Deputy for Human Resources for Science and Technology, the National Research and Innovation Agency. The sample used was 114 people. The sampling method uses a quota sampling model. The data collection method used a survey method, with the research instrument being a questionnaire using a Likert scale as a questionnaire assessment tool. Methods of data analysis using SPSS 26. The results of this research indicate that organizational commitment has a positive effect on readiness to change, non-financial compensation has a positive effect on readiness to change and organizational justice has a positive effect on readiness to change.

INOVACIONI MAKROMENADŽMENT U EKONOMIJI ZNANJA

After explaining the key postulates of the knowledge economy paradigm, the paper looks at the importance of unifying national policies of scientific, technological and industrial development in the form of innovative macro-management. A review has been made on the instruments offers demands and protection using which the entrepreneurial state works on the promotion national innovation Authors represent the opinion that the main building block of innovation macro-management is the concept of the national innovation system (NIS), whereby the unification platform activities academic community economy state and society represent so called spiral models innovation Base these model makes learning communicating and cooperation as a fundamental social process, on the one hand, and the growing network of activities of all participants in the creation of new knowledge and especially in the commercial valorization of knowledge into innovations, on the other hand.

Strengthening Indonesia’s Strategic Trade Management Regulation Against Proliferation of Weapons of Mass Destruction

International law governing the control of WMD proliferation cannot solely focus on state actors but must also include non-state actors. To address the risks and combat the proliferation of WMD by non-state actors through the ordinary course of trade, the UNSC issued Resolution 1540, which contains the obligation to adopt domestic policies to prevent WMD proliferation. Indonesia has a legal obligation to comply with and implement this resolution under international law. This paper discusses the need assessment for Indonesia to enact a solid regulatory framework to implement Strategic Trade Management (STM). This paper questions how STM regulations are governed in the Indonesian context presently and how they should be regulated better to accommodate contemporary dynamics. This study is a legal and policy study involving literature review or desk research. Literature review involves gathering data and information such as literary texts, policy papers, legislative regulations, and other relevant documents. This study finds that even though Indonesia had already implemented some form of STM policy through export-import control and restriction (larangan dan pembatasan), it still left out the gap in properly regulating dual-use goods. Strategic goods regulation in Indonesian legislation is not intended in the context of dual-use goods, as export/import restrictions are designed to enhance Indonesia’s product competitiveness and market expansion, both domestically and internationally, increase the capabilities of exporters/importers, and enhance national product development and innovation. Implementation of STM policy One of the objectives that can be achieved is maintaining national security, especially in providing a sense of security for the Indonesian people and businesses. Implementing STM will also benefit businesses by reducing the risk of financial losses, such as being involved in export/import transactions prohibited by other countries or even by Indonesia. Moreover, by implementing STM, it is not unlikely that investment from countries with high technology will increase.

Body Position Dependent Participation of Abdominal and Thoracic Breathing Movements During the Breathing Cycle

Aims: Both abdominal and thoracic breathing movements play important roles in the mechanics of breathing, participating differently in various body positions with abdominal breathing having a greater role. Recent studies showed that an early proning position of awake, non-intubated patients during the COVID-19 pandemic, even during pregnancy (PMID: 32320506, PMID: 33309507, PMID: 34915799) significantly affected the ventilatory parameters and mortality of SARS-CoV-2 patients. Thus, we hypothesized that in different body positions the participation of abdominal (AB) and thoracic breathing (TB) during the complete respiratory cycle (CRC) is different. To test this, we measured the participation of AB and TB to the CRC in different body positions under resting conditions. Methods: In young participants (N=26) age between 18 and 24 (M=21.3±1.6), changes in abdominal and chest circumferences were measured using plethysmography respiratory belts, during inhalation and exhalation in standing (ST), sitting (SI), supine (SU), prone (PR), and all on fours (AF) body positions. Respiratory frequency was also measured. Results: In different positions, the contribution of AB and TB to CRC were significantly different (F(4,100)=4.999, p=0.004, η2p=0.17). AB was significantly higher than TB in all positions (p<0.001). More specifically, AB gradually increased, while TB gradually decreased in the following order: SU(AB/TB) = 74.8±12.9%/25.2%, ST = 69±16%/31%, PR = 66.8±20.2%/33.2%, SI = 65.5±14.8%/34.5%, AF = 61.1±15.1%/38.9%. A significantly higher value was measured in the SU position compared to AF (p<0.001) and SI (p=0.011) positions; PR and ST positions showed intermediate values, which were not significantly different from those yielded by either of the other positions. Respiratory frequency was similar in different body positions. Conclusions: These data show that different body positions significantly affect the participation of abdominal and thoracic breathing during resting condition, underscoring not only the importance of respiratory distress patients positioning during hospitalization, but its usefulness in developing a respiratory training plan for elite athletes to optimize their physical and mental performance in competitive sports. AK: Ministry of Innovation and Technology (MIT) of Hungary-NRDI TKP2020-NKA-17, TKP2021-EGA-37, and National Research, Development, and Innovation Offce (NKFIH) OTKA K 132596 K_19, and Hungarian Academy of Sciences, Post-Covid 2021-34, and HUN-REN-SU: 02068 of Hungary, JT: ÚNKP-22-4-II-SE-4 (JT), TKP2021-EGA-25. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Preface

Proceeding of the 11th International Conference on Sustainable Energy Engineering and Application 2024 (ICSEEA 2024) Dear Colleagues,It is with great pleasure and honor that we are delighted to present the Proceedings of the 11th International Conference on Sustainable Energy Engineering and Application 2024 (ICSEEA 2024). This esteemed conference provided a platform for experts, researchers, and industry leaders to exchange insights, innovations, and strategies. It took place at The Stones Hotel, Bali – Indonesia, from 28th to 29th February 2023, under the theme “Transforming Energy, Industry, and Transportation Technology Towards a Decarbonized Society.” This compilation of conference proceedings is published in the prestigious IOP Conference Series, Earth and Environmental Science (EES), signifying our commitment to disseminating the profound ideas of experts to accelerate progress and serve as a pivotal platform for exploring advancements in energy, industry, and transportation technologies, thereby shaping a cleaner and more sustainable future.The 11th ICSEEA 2024 was hosted by the Research Organization for Energy and Manufacture, a division of the National Research and Innovation Agency (BRIN), reflecting our commitment as a government agency to enhancing the quality of Indonesian research, technology, and innovation. The conference focused on key areas including new renewable energy, sustainable transportation, and green maritime technology.During this event, we were pleased to witness the participation of 105 presentations attended by 54 national and 24 international institutions. It featured keynote speakers from 4 different countries, enriching the discourse with diverse perspectives and insights. Additionally, the event served as a platform for major companies deeply committed to sustainable energy, including Pertamina, Paragon Corp, Geodipa Energy, PLN Engineering, Huawei Indonesia, and GMF Aero Asia, to share their industrial insights and contributions. In addition to the aforementioned companies, other companies also contributed as sponsors to this event, including PLN Nusantara Power Service, Mitratel, Eksperta Adi Manusa, and Bank BJB.Moreover, this event fostered collaboration among researchers from five research centres specializing in energy and manufacturing, National Research and Innovation Agency namely the Research Center for Energy Conversion and Conservation, Research Center for Transportation Technology, Research Center for Process and Manufacturing Industry Technology, Research Center for Structural Strength Technology, Research Center for Hydrodynamics Technology, Research Center for Testing Technology and Standards, and Research Center for Sustainable Production System and Life Cycle.The 11th ICSEEA 2024 has been a resounding success, reflecting our collective strong initiative to mitigate carbon emissions and foster sustainability. As we reflect on the achievements of this conference, we are filled with hope and determination to continue our journey towards a cleaner, greener future. With unwavering dedication and collaboration, we are confident that we can overcome obstacles and realize our vision of a decarbonized society for generations to come.Lastly, we extend our heartfelt gratitude to all participants, organizing committee members, and sponsors who have contributed to the success of this conference.We also express our appreciation to all the reviewers for generously dedicating their time and providing constructive comments or suggestions on the manuscripts.Furthermore, we would like to acknowledge the efforts of the Editorial members, especially those involved in the proceedings section, for their hard work and invaluable contributions to this publication.We look forward to seeing you at the next ICSEEA conference.List of Chairman, Editor are available in the pdf.

Molecular Basis of Different Flow-Induced Responses of Small Intra- and Extracranial Cerebral Arteries: Role of Arachidonic Acid and Nitric Oxide Pathways

Background / Objectives. Previous studies showed that increases in intraluminal flow elicit primarily dilations in isolated rat extracranial basilar arteries (BA), whereas constrictions in the intracranial middle cerebral arteries (MCA) (Koller A, Toth P. J Vasc. Res. 2012, PMID: 22739136). These responses are most likely due to the absence or presence of physical constraints (rigid cranium). Thus, we hypothesized that the underlying molecular pathways are also different, corresponding to the functional vasomotor responses. Material and Methods. Protein and gene expression of key AA-pathway enzymes and receptors, such as cyclooxygenase (COX1 and COX2) and thromboxane A2 receptor (TxA2R), and vasodilator enzymes, such as prostacyclin synthase (PGIS) were measured in isolated BA and MCA from male rats (3 months old, n=18). Results. By western blotting protein expression of vasoconstrictor metabolites COX1/2, Cyp4A and receptor TBXA2R were significantly higher whereas expression of dilator PGIS was significantly lower in MCA than in BA. Using qPCR we found that expression of genes coding vasoconstrictor enzymes COX1/2, Cyp4A and receptor TBXA2R was significantly higher, whereas gene coding dilator PGIS was significantly lower in intracranial compared to extracranial arteries. In addition, RNAseq analysis demonstrated that expression of multiple genes coding vasoconstrictor molecules is higher in intracranial compared to extracranial arteries. Conclusions. These findings provide mechanistic basis for the observed different functional, vasomotor responses of BA and MCA to increases in flow, by showing the different expression of enzymes (COX1/2, Cyp) producing constrictor prostanoids (such as 20-HETE), receptors (TxA2R) and dilator prostanoid (PGIS). In addition, these findings reinforce the importance of regional differences in the regulation of cerebral arterial resistance, thereby providing appropriate blood flow to the brain, and at the same time, autoregulation of cerebral blood flow. Ministry of Innovation and Technology (MIT) of Hungary-NRDI TKP2020-NKA-17, TKP2021-EGA-37, and National Research, Development, and Innovation Offce (NKFIH) OTKA K 132596 K_19, and Hungarian Academy of Sciences, Post-Covid 2021-34, and HUN-REN-SU: 02068 of Hungary. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Antihypertensive effect of chicken blood peptide hydrolysate in streptozotocin-induced diabetic rats

Chicken blood peptide hydrolysate (CBH) has been reported to exert antioxidant, angiotensin 1-converting enzyme (ACE) inhibitory, and cholesterol-lowering activities. Antihypertensive effect of the CBPH was also demonstrated in spontaneously hypertensive rats. This study aimed to assess the anti-diabetic and antihypertensive effect of the CBH in streptozotocin (STZ)-induced diabetic rats. CBH was prepared from fresh chicken blood collected from an industrial slaughterhouse in Nakhon Ratchasima, Thailand. Adult male Wistar rats were randomly divided into 2 main groups: normal and STZ-induced diabetes mellitus (DM) groups. Five subgroups of each main group were given distilled water, metformin (200 mg/kg), and CBH (300, 600, 1200 mg/kg) by oral gavage for 28 days (n=10 per each group). Fasting blood sugar level and OGTT were evaluated before and at the end of experiment. Each rat underwent monitoring of blood pressure using femoral artery. STZ-induced diabetic rats showed higher fasting blood glucose concentration and area under curve from OGTT than normal rats, which was not reduced by all treatments. STZ-induced diabetic rats showed higher mean arterial blood pressure than normal rats, which was significantly reduced by metformin and CBH (300 and 1200 mg/kg) (p<0.05). The blood pressure-lowering effect of CBH suggested the potential for the application of CBH in the management of diabetic hypertension. However, attention must be paid to concerns about bird flu in certain places and prohibition of the use of blood product. This work was supported by Suranaree University of Technology (SUT), Thailand Science Research and Innovation (TSRI), and National Science Research and Innovation Fund (NSRF) (FF1-111-65-12-30(08)). This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Antidiabetic activity of egg white protein hydrolysate in streptozotocin-induced diabetic rats

Egg white protein hydrolysate (EWH) has been reported to work as a cardiovascular protective agent. EWH exert antioxidant, vascular relaxing, anti-inflammatory properties and antihypertensive properties. This study aimed to assess the anti-diabetic and antihypertensive effect of the EWH in streptozotocin (STZ)-induced diabetic rats. Adult male Wistar rats were randomly divided into 2 main groups: normal and STZ-induced diabetes mellitus (DM) groups. Five subgroups of each main group were given distilled water, metformin (200 mg/kg), and EWH (300, 600, 1200 mg/kg) by oral gavage for 28 days (n=10 per each group). Fasting blood sugar level and OGTT were evaluated before and at the end of experiment. Each rat underwent monitoring of blood pressure using femoral artery. STZ-induced diabetic rats showed higher fasting blood glucose concentration and area under curve from OGTT than normal rats, which was significantly reduced by 600 mg/kg of EWH (p<0.05). STZ-induced diabetic rats showed higher mean arterial blood pressure than normal rats, which was significantly reduced by metformin (p<0.05). A decrease in hypertension in STZ-induced diabetic rats following EWH, but without significant difference, was observed. EWH may be useful in controlling the blood glucose level in diabetes mellitus and is therefore recommended for further studies. This work was supported by Suranaree University of Technology (SUT), Thailand Science Research and Innovation (TSRI), and National Science Research and Innovation Fund. (NSRF) (FF1-111-65-12-30(08)). This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Importance of both Hemidiaphragms in Maintaining Optimal Breathing Mechanics, Respiratory Rate, and Hemoglobin Oxygen Saturation: a Case Study

Background: The mechanical process of breathing consists of the abdominal breathing (AB) driven/generated by the diaphragm, and thoracic breathing (TB) generated by the intercostal muscles. The coordinated movements of the two portions of diaphragm account for 80% of the inspiration, although their exact roles are still investigated. While bilateral diaphragmatic paralysis causes severe shortness of breath, unilateral hemidiaphragm paralysis is asymptomatic at rest, making it challenging to diagnose. Objective: To measure and compare the amplitudes of abdominal and chest movements in different body positions between a healthy individual and an individual with unilateral diaphragmatic paralysis (phrenic nerve injury). Methods: Changes in the circumference of the abdomen and chest were measured during inhalation and exhalation with respiratory plethysmography belts (placed on standardized reproducible positions on the chest, and abdomen) in different body positions: sitting (SI), standing (ST), lying (SU) and prone (PR) in a healthy (H) individual and an individual with unilateral diaphragmatic paralysis. (Ph). Breathing frequency and other parameters were calculated from the measured signals. Furthermore, the blood oxygen saturation (SpO2) was measured with a pulse oximeter. Results: Percent (%) contribution of abdominal breathing H/Ph: SI: 29.6/16.0; ST: 72.8/50.3; SU: 90.6/-53.5; PR: 32.8/1.1. A negative sign shows paradoxical breathing. Respiratory rate (1/min) H/Ph: SI:18.7/19.4; ST: 19.0/15.0; SU: 15.9/37.5; PR: 16.6/35.9. Phase angle of abdominal and thoracic breathing curves (degrees) H/Ph: SI: 4.09/-5.73; ST: -20.82/-9.48; SU: 3.68/184.29; PR: 25.08/-26.51. In case of a negative sign, chest breathing precedes abdominal expansion, and vice versa in the case of a positive sign. A value around 180 degrees indicates paradoxical breathing, seen in Ph, when SpO2 significantly decreased: SI: 93% vs. SU: 82%. Conclusions: In different body positions, the amplitude changes of the abdomen and chest differed substantially during the complete respiratory cycle. Both portions of diaphragm are important because in unilateral phrenic nerve injury, abdominal breathing markedly decreased in most body positions compared to a healthy individual. Furthermore, paradoxical breathing occurred in a supine position, as indicated by a change in the phase angle. The lowest respiratory rate was measured in standing position (15/min), in which the participation of the abdomen/chest ratio was 50.3%, / 49.7%, while the highest value was obtained in supine position (38 breaths/min), which coincided by a decreased hemoglobin oxygen saturation / i.e. oxygen intake. In case of hemidiaphragm paralysis, the diminished mechanical breathing effciency requires a higher respiratory rate to sustain/maintain hemoglobin oxygen saturation. However, this elevated respiratory rate also increases energy consumption, potentially resulting in dyspnea during physical exertion / exercise. Ministry of Innovation and Technology (MIT) of Hungary-NRDI TKP2020-NKA-17, TKP2021-EGA-37, and National Research, Development, and Innovation Offce (NKFIH) OTKA K 132596 K_19, and Hungarian Academy of Sciences, Post-Covid 2021-34, and HUN-REN-SE: 02068 of Hungary. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Impact of national innovation capability on economic growth: Evidence from ASEAN countries through Global Innovation Index

Impact of national innovation capability on economic growth: Evidence from ASEAN countries through Global Innovation Index