For the nation’s 215,000 children and adolescents with diabetes, major advances in diabetes management, medical research, and technology mean a brighter future. At the same time, young people with diabetes face unique and sometimes dangerous immediate challenges due to sometimes unpredictable glucose levels. As the number of students with diabetes increases, and diabetes care technologies change and require more intense diabetes management in school and at home, school nurses face new and ongoing challenges in providing care to students with diabetes. The updated 2010 edition of Helping the Student With Diabetes Succeed: A Guide for School Personnel, published by the National Diabetes Education Program (NDEP), is now available. The purpose of the guide is to educate school personnel about effective diabetes management. The guide also shares a framework and a set of practices, based on the school health team approach, that enable schools to ensure a safe learning environment for students with diabetes, particularly those who use insulin to control the disease (all students with type 1 and most with type 2 diabetes). In this article, we provide sample case studies and answers to frequently asked questions to help school nurses put the NDEP school guide information into practice in the school setting.