National Defense Medical College Research Articles

A CASE OF ESOPHAGEAL CARCINOMA WITH A GIANT INTRAMURAL GASTRIC METASTASIS

A 60-year-old male was admitted with a 2-month history of dysphagia. Roentogenological and endoscopic examination revealed an esophageal carcinoma with a giant intramural gastric metastasis. The intramural gastric metastasis took the form of a giant 8.0×7.5×7.0cm submucosal tumor that invaded the diaphragm and left lobe of the liver. Distal esophagectomy and total gastrectomy via left thoracotomy and laparotomy were performed via continguous incisions, and esophagojejunostomy was performed through an anterior thoracic route after blunt resection of the proximal esophagus. Postoperatively, the patient was treated with 45 Gy of radiation to neck bilaterally, and mediastinum, in a “T”-shaped pattern. At 25 months after operation, he is well with no evidence of recurrence. It is rare for a metastatic lesion of esophageal cancer to the stomach to be markedly larger than the primary lesion, as in the present case. We also discuss 14 cases of esophageal carcinoma with intramural gastric metastasis encountered at the National Defense Medical College Hospital.

Immunohistochemical analysis of cathepsin B expression in human lung adenocarcinoma: The role in cancer progression : Ozeki Y, Takishima K, Takagi K, Aida S, Tamai S, Mamiya G et al. Department of Biochemistry, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama 359. Jpn J Cancer Res 1993;84:972–5

Immunohistochemical analysis of cathepsin B expression in human lung adenocarcinoma: The role in cancer progression : Ozeki Y, Takishima K, Takagi K, Aida S, Tamai S, Mamiya G et al. Department of Biochemistry, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama 359. Jpn J Cancer Res 1993;84:972–5

Expression of carbohydrate antigens in human pulmonary adenocarcinoma : Kawai T, Suzuki M, Kase K, Ozeki Y. Department of Pathology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359. Cancer 1993;72:1581–7

Expression of carbohydrate antigens in human pulmonary adenocarcinoma : Kawai T, Suzuki M, Kase K, Ozeki Y. Department of Pathology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359. Cancer 1993;72:1581–7

Pleuropneumonectomy for pleuritis carcinomatosa without pleural effusion in adenocarcinoma of lung : K. Takagi, I. Aoki, M. Watanabe, T. Ogata, K. Nagai ∗, T. Kodama ∗. Dept. of 2nd Surgery, National Defense Medical College (NDMC), Tokorozawa, ∗National Cancer Center Hospital (East) Chiba, Japan

Pleuropneumonectomy for pleuritis carcinomatosa without pleural effusion in adenocarcinoma of lung : K. Takagi, I. Aoki, M. Watanabe, T. Ogata, K. Nagai ∗, T. Kodama ∗. Dept. of 2nd Surgery, National Defense Medical College (NDMC), Tokorozawa, ∗National Cancer Center Hospital (East) Chiba, Japan

防衛医科大学校図書館の昨今

防衛医科大学校図書館の昨今

外来で行うレーザー手術

In four years from July 1988 to July 1992, surgical operation was performed in 261 patients, 306 cases at the laser outpatient clinic of the department of otolaryngology, National Defense Medical College. They are broken down to nasal disease 215 cases, oral cavity disease 68 cases, laryngo-tracheal disease 12 cases, pharyngeal disease 5 cases and 6 other cases. All the patients developed no such serious complications as requiring hospital admission, and laser operation was performed safely at outpatient clinic.It can be mentioned as the merit of laser surgery that hemorrhage during and after operation is very slight. With this surgery, intranasal tampon and special nasal treatment in rhinological surgery and suturing of the operative wound and extraction of stitches in oral surgery are no longer needed, which will make easy surgery at the outpatient clinic and expand the indications of such surgery.

Leiomyosarcoma of the uterus: ultrasonography and serum lactate dehydrogenase level.

Between January 1, 1979, and September 30, 1990, a total of 1,886 patients in the National Defense Medical College Hospital, a self-referred population, had a hysterectomy because of signs and symptoms presumably resulting from uterine myomas. After hysterectomy with presumed benign disease, a histologic diagnosis of leiomyosarcoma was made in 7 patients (0.37%). Preoperative diagnosis of leiomyosarcoma was not made in any of the 7 patients. However, serum lactate dehydrogenase levels were abnormally elevated in 3 of them, and degenerative changes were found within the tumor by ultrasonography in 5 of them. Furthermore, increased lactate dehydrogenase levels and degenerative changes within the tumor were found in 3 of the patients whose tumors had 10 or more mitoses per 10 high-power fields. The prognosis for the leiomyosarcomas with increased mitotic rates is very poor. Therefore, a degenerative change within the uterine mass and an increased lactate dehydrogenase level, when present, should suggest the diagnosis of leiomyosarcoma.

Effects of beta-1 selectivity and intrinsic sympathomimetic activity (ISA) of beta-blockers to beta-adrenocepter density (BAD) in spontaneously hypertensive rats (SHR): M.Akanuma, F.Ohsuzu, K.Katushika, S.Maie, N.Sakata, H.Nakamura Department of Internal Medicine I. National Defense Medical College, Saitama, Japan

Effects of beta-1 selectivity and intrinsic sympathomimetic activity (ISA) of beta-blockers to beta-adrenocepter density (BAD) in spontaneously hypertensive rats (SHR): M.Akanuma, F.Ohsuzu, K.Katushika, S.Maie, N.Sakata, H.Nakamura Department of Internal Medicine I. National Defense Medical College, Saitama, Japan

防衛医大皮膚科におけるＢｏｗｅｎ病１９例の統計的観察

昭和58年1月より昭和63年12月までの6年間に当教室で経験したBowen病19例について報告した。性別は男10例, 女9例, 発症年齢は42歳から91歳までで, 50歳以上の症例が19例中17例を占めた。多発例は2例に, 内臓悪性腫瘍の合併は1例に認めた。またDAKOB580を用いHuman papilloma virusの検索を行い1例で陽性所見を得た。

頭がい内進展を認めたし骨どう神経しょうしゅ症例

Neurinoma originating in the nasal cavity and paranasal sinuses is rare. We had a patient with a neurinoma arising from the ethmoid sinus and extending into the anterior cranial fossa. A 45-year-old woman was admitted to the Department of Otolaryngology of the National Defense Medical College with the chief complaint of right nasal obstruction. Anterior rhinoscopy showed a necrotic mass filling the anterior part of the nasal cavity. Biopsy from the surface of the mass revealed histological features suggestive of neurinoma. Under general anesthesia, Denker's operation was performed to extirpate the neoplasm. However, the tumor extended into the anterior cranial fossa and could not be removed because it was firmly adherent to the dura. The remainder of the neoplasm was removed completely through a frontal cranial approach and a lateral rhinotomy approach. The histological section of the tumor showed a typical neurinoma, demonstrating Antoni A and B types of cell pattern.

An Application of JOIS Service at the National Defense Medical College Library

An Application of JOIS Service at the National Defense Medical College Library