National Cancer Database Analysis Research Articles

The impact of radiation therapy variables on pediatric high-grade glioma outcomes: A National Cancer Database analysis.

The purpose of this analysis is to report patterns of care for pediatric patients with high-grade glioma (pHGG) and evaluate the impact of radiotherapy (RT) variables on outcomes using the National Cancer Database (NCDB). Eligibility criteria included age<22 years, histologically diagnosed WHO grade III-IV gliomas treated with ≥50Gy and<76Gy RT between 2004 and 2013, and RT initiation within 90 days of diagnosis. RT variables including RT dose, RT timing, and RT modality were analyzed along with baseline demographic, tumor, and treatment variables to assess the impact on overall survival. A total of 498 pHGG patients were included. The median age was 15 years (range, 0-21), common diagnoses were astrocytoma (55%) and glioblastoma (30%), 73.5% underwent surgical resection and 90.2% received chemotherapy. The median RT dose was 59.4Gy (SD 2.9Gy) starting at a median of 4.4weeks from diagnosis (SD 2.5weeks). Fourteen patients were treated with proton therapy. Median follow-up was 19.6 months with 1- and 3-year overall survival of 78.4% and 40.4%, respectively. On multivariable analysis, female gender, older age, and RT delay of ≥6weeks were significantly associated with a lower rate of death; glioblastoma histology, no surgical resection/biopsy only, and earlier RT initiation<6weeks from diagnosis were associated with a higher rate of death. There was no relationship between RT dose or proton versus photon therapy and overall survival. Outcomes for pHGG are poor. There was no benefit to early RT timing when RT is initiated within 90 days of diagnosis or higher RT dose in this dataset.

Real-World Treatment Patterns and Outcomes of Solitary Plasmacytoma in the United States: A National Cancer Database (NCDB) Analysis of Years 2004-2020

Background: Solitary plasmacytoma, whether it affects the bone (P-Bone) or occurs as an extramedullary disease (P-EM), is typically treated with radiation therapy. Surgery, either combined with radiation or as a standalone option, is also recognized as a curative option, especially for P-EM. Prognosis depends on treatment and disease location. In this IRB approved retrospective analysis, the National Cancer Database (NCDB) was utilized to assess treatment patterns and overall survival (OS) among plasmacytoma patients treated at Commission on Cancer (CoC) accredited facilities across the USA. Methods: N=9,427 plasmacytoma patients from 2004 to 2020 were identified using the NCDB, excluding multiple myeloma patients. Descriptive statistics examined data and differences in primary site, radiation dosage, and treatment patterns. OS tables and Kaplan-Meier curves compared primary sites, radiation dose, and treatment outcomes. Multivariate Cox regression analysis identified independent survival factors. SAS version 9.4 was used to analyze the data. Results: P-Bone accounted for 73% while P-EM represented 27% of cases. Patients' characteristics are presented in Table 1. The median OS was significantly longer in P-EM patients with OS of 146 months compared to 106 months in P-Bone patients (p&amp;lt;0.0001). Radiation therapy alone was the most utilized modality in both P-Bone (58%) and P-EM (36%), followed by combination of radiation and surgery in 20% and 27% of cases, respectively. Notably, a small proportion of patients received surgery alone (8% in P-Bone and 23% in P-EM). Patients who underwent combined surgery and radiation exhibited the longest median OS of 181 months, compared to 137 months for surgery alone and 116 months for radiation alone (p&amp;lt;0.0001)(Fig 1). Median OS also varied significantly (p&amp;lt;0.0001) based on the radiation dose: &amp;lt;35Gy (46.62 months), 35-39.9Gy (80.66 months), 40-44.9Gy (125.31 months), 45-49.9Gy (151.52 months), and ≥50Gy (176.36 months). Primary P-Bone sites were categorized as follows: limb bones (n=932), skull and mandible (n=571), vertebral column (n=2,729), ribs/sternum/clavicle (n=861), and pelvis (n=991). The median OS varied significantly (p&amp;lt;0.0001) across the bone sites, with the longest median OS of 122.25 months observed in cases involving the skull and mandible (95% CI: 102.34-181.29) followed by vertebral column with OS of 110.88 months (95% CI: 102.87-120.90). Pelvis, ribs/sternum/clavicle, limb bones, and other bones demonstrated median OS values of 108.75 months (95% CI: 88.51-122.71), 105.49 months (95% CI: 88.87-124.42), 96.43 months (95% CI: 79.61-122.68), and 72.18 (95% CI: 60.65-93.01) respectively (p&amp;lt;0.0001). In most bone sites, the predominant radiation dose fell within the range of 45-49.9 Gy (21.67% for limb bones, 26.78% for skull and mandible, 32.28% for vertebral column). However, the ribs/sternum/clavicle and pelvis categories stood out, with the predominant radiation dose being equal to or exceeding 50 Gy (32.96% for ribs/sternum/clavicle, 29.9% for pelvis). Furthermore, radiation therapy alone emerged as the predominant treatment modality across all bone sites. Conclusion: This 16-year study to 2020 is the largest database to date in the USA that analyzes the real-world treatment patterns and OS of P-bone and P-EM. Long term median survival of greater than 9 years was observed for solitary plasmacytoma. Combined surgery and radiation therapy showed improved survival outcomes in solitary plasmacytoma, emphasizing the role for combined modality in selected sites, but optimal radiation dose is unclear. P-Bone, given the locations, are generally treated with radiation only. Therefore, evaluation of the radiation dose for curative modality is pertinent for management. This study suggests 45-50 Gy may confer better survival than lower dosage. Guidelines for radiation dose vary. Our study provides an additional 7-year data to a published database to 2013 (Ghiassi-Nejad et al.) with similar OS. We further stratified the outcome of P-bone, the bulk of solitary plasmacytoma by site of disease and radiation dose along with patient characteristics. Although higher doses have benefit for survival, modern techniques will hopefully decrease comorbidities that can occur locally and longitudinally. Our large dataset can provide reference to develop better guidelines for management of solitary plasmacytoma, especially P-bone.

EP07.01-13 Definitive Chemoradiation versus Radiation Alone for Stage II Non-Small Cell Lung Cancer. A National Cancer Database Analysis

EP07.01-13 Definitive Chemoradiation versus Radiation Alone for Stage II Non-Small Cell Lung Cancer. A National Cancer Database Analysis

Axillary management in breast cancer after neoadjuvant chemotherapy in the modern era: A national cancer database analysis

BackgroundAxillary management for node-positive breast cancer continues to evolve. Data further supporting targeted axillary dissection after neoadjuvant chemotherapy was published in 2016 and may have induced changes in practice. MethodsPatients included in the National Cancer Database from 2014 to 2017 with clinical T1 to T4 and node-positive disease who underwent neoadjuvant chemotherapy before surgical axillary management were evaluated. Patients were divided into the following 3 groups: selective axillary dissection, minimal axillary dissection, and maximal axillary dissection, according to surgical axillary management and pathological node status. ResultsPatients who underwent selective axillary dissection were younger (52.4 years ± 12.4, P < .0001) compared to maximal axillary dissection (55.1 ± 12.7) and minimal axillary dissection (54.6 ± 12.7). Patients with higher clinical stage more frequently underwent maximal axillary dissection, and those with lower tumor grade more frequently underwent minimal axillary dissection (P < .0001). Community cancer programs were more likely to perform maximal axillary dissection compared to all other types of programs and had the slowest rate of adoption of selective axillary dissection. Integrated Network Cancer Programs had the lowest proportion of maximal axillary dissection performed and the highest proportion of selective axillary dissection. Uninsured patients were more likely to receive maximal axillary dissection, and those with private insurance were more likely to undergo selective axillary dissection (P < .0001). Selective axillary dissection rates increased from 29.8% of procedures in 2016 to 41.5% in 2017, and MaxAD rates decreased from 62.4% in 2016 to 47.9% in 2017. ConclusionUtilization of selective axillary dissection has increased since 2016; however, discrepancies in surgical axillary management after neoadjuvant chemotherapy still exist.

Comparative real-world survival outcomes of muscle-invasive bladder cancer treated with bladder-only vs. whole-pelvis concurrent chemoradiation.

Elective pelvic nodal irradiation for patients with muscle-invasive bladder cancer (MIBC) undergoing trimodal therapy (TMT ) is controversial. In patients with node-negative (N0) MIBC, the benefit of elective whole-pelvis concurrent chemoradiation (WP-CCR) compared to bladder-only (BO )-CCR has not been demonstrated. Using real-world data from the National Cancer Database (NCDB ), we sought to compare the overall survival (OS ) between BO-CCR and WP-CCR for MIBC. Using the 2020 NCDB Participant User File, we identified cases of MIBC diagnosed between 2017 and 2019. We selected patients with clinical T2-T4aN0M0 disease receiving CCR as first-line treatment. CCR was defined as transurethral resection of bladder tumor followed by ≥40 Gy radiation to the bladder with concurrent single- or multiple-agent chemotherapy. Based on elective nodal irradiation status, patients were stratified as having received BO-CCR vs. WP-CCR. OS analysis was performed using summary three-month conditional landmark, inverse probability treatment weighting (IPTW)-adjusted Kaplan-Meier estimates, and Cox regression. A total of 604 patients receiving CCR for MIBC were identified: 367 (60.8%) BO-CCR and 237 (39.2%) WP-CCR. Before IPTW, the groups were imbalanced in terms of baseline characteristics. The median followup of the weighted population was 42.3 months (interquartile range 18.1-49.1 months). In IPTW-adjusted Cox proportional hazards regression analysis, WP-CCR was associated with a significant OS benefit compared to BO-CCR (adjusted hazard ratio 0.72, 95% confidence interval 0.54-0.96, p=0.026). In the setting of CCR for N0 MIBC, this retrospective NCDB analysis revealed that WP-CCR was associated with a benefit in OS compared to BO-CCR.

Defining the Oligometastatic State and Predicting Overall Survival in Uterine Cancers using a Recursive Partitioning Analysis: A National Cancer Database Analysis

Oligometastatic disease is an intermediate state between locoregional disease and widely metastatic disease. Studies have shown an overall survival advantage in oligometastatic patients treated aggressively in multiple cancers. However, few studies have explored this relationship in oligometastatic gynecological cancers. In this study, we sought to identify if an oligometastatic state with improved overall survival exists in uterine cancer and whether treatment patterns, or patient factors play a role in survival. The National Cancer Database was retrospectively analyzed in patients diagnosed with uterine cancer between 2004-2019. We excluded patients with non-metastatic disease at diagnosis, lack of metastatic sites listed, multiple primaries and missing survival data. Survival analyses were performed using Cox proportional hazards analyses and the Kaplan-Meier method and differences between groups were evaluated with log-rank tests. Recursive partitioning analysis (RPA) was performed using the rpart package in R. Amongst 641,276 women with uterine cancer, 17,343 were ultimately in our study population after exclusion who had a median age of 64 (range 18-90), median overall survival of 11.1 months, and a total of 24,337 metastases that represented the following metastatic sites: lung (35%), other (24%) (sites "other" than bone, brain liver or lung), liver (15%), bone (12%), distant lymph nodes (10%), brain (3%) and carcinomatosis (1%). Multivariate cox proportional hazards analysis identified the following variables as significantly associated with survival, which were then used for RPA: one metastatic site, treatment, grade, age, race, Charlson-Deyo score. The data was split 70/30% for training and validation, respectively. A survival model was built using RPA on the training data with 10-fold cross-validation and had accuracy of 76.25% (p = 3.393e-0.5). Survival prediction was performed on the internal validation data set with 76.69% accuracy (p = 0.004). RPA stratified 4 groups with the following median survivals: 5.9, 8.6, 29.5, and 43.8 months (log-rank test p<0.0001). The group with the best overall survival was defined by 1 metastatic site (carcinomatosis, distant lymph nodes and "other"), combination treatment with systemic therapy and radiation or surgery and low-grade histology. An oligometastatic state with involvement of one metastatic site does exist with improved survival in uterine cancer. The RPA defined groups may aid in identifying patients that are best suited for aggressive definitive combination therapy versus those that would be better suited for comfort care. Analysis is ongoing and will further delineate the relationship between specific treatment modalities and overall survival in patients with one metastatic site. This study may set the foundation for a prospective clinical trial.

Patterns of Care for Patients with Locally Advanced Rectal Cancer Treated with Total Neoadjuvant Therapy between 2016-2020: An NCDB Analysis

Treatment for locally advanced rectal cancer (LARC), defined as T3/4 or any T with N+ disease, typically requires multi-modality management consisting of radiation (RT), chemotherapy (CHT), and surgery. Despite emerging evidence that total neoadjuvant therapy (TNT) is the preferred treatment of LARC, it remains unknown what proportion of patients are receiving TNT in the United States. Our objective was to (1) determine the proportion of patients with LARC receiving TNT over time, (2) determine the most common method in which TNT is being delivered, and (3) determine what factors are associated with a lower likelihood of receiving TNT in the United States. Retrospective data was obtained from the National Cancer Database (NCDB) for patients diagnosed with rectal cancer between 2016-2020. Patients were excluded if they had M1 disease, T1-2 N0 disease, incomplete staging information, non-adenocarcinoma histology, received RT to a non-rectum site, or received a non-definitive RT dose. Patients were determined to have received TNT if they (1) received RT and multi-agent (MA)-CHT prior to surgery, (2) had an interval of >180 days from the onset of neoadjuvant therapy to surgery if they received long course (LC)-chemoradiation (CRT) (based on 35 days for LC-CRT + 112 days for 8 cycles of MA-CHT + 30 days to surgery), or (3) had an interval of >150 days from the onset of neoadjuvant therapy to surgery if they received short course (SC)-RT (based on 5 days for SC-RT + 112 days for 8 cycles of MA-CHT + 30 days to surgery). Data were analyzed using linear regression, Chi-square test, and binary logistic regression. Of the 26,375 patients included, the median age was 60 (range 21-90) years, with the majority of patients being <65 years old (65.6%), male (62.1%), and non-Hispanic white (77.0%). A total of 5,003 (19.0%) patients received TNT, and 21,372 (81.0%) patients received classical combined modality therapy (CMT). The proportion of patients receiving TNT increased significantly over time, from 6.1% in 2016, 9.0% in 2017, 15.3% in 2018, 25.8% in 2019, to 34.6% in 2020 (slope = 7.36, 95% CI 4.58-10.15, R2 = 0.96, p = 0.040). The most common TNT regimen was MA-CHT followed by LC-CRT (73.2% of cases from 2016-2020). The proportion of patients receiving SC-RT as part of TNT significantly increased from 2.8% in 2016, 1.7% in 2017, 4.6% in 2018, 7.3% in 2019, to 13.7% in 2020 (slope = 2.74, 95% CI 0.37-5.11, R2 = 0.82, p = 0.035). On multivariate analysis, factors associated with a lower likelihood of TNT use included age >65 (OR 0.66, 95% CI 0.61-0.71, p<0.001), female gender (OR 0.92, 95% CI 0.86-0.98, p = 0.014), Black race (OR 0.87, 95% CI 0.77-0.98, p = 0.024), and T3 N0 disease (OR 0.60, 95% CI 0.52-0.70, p<0.001). TNT utilization rates have significantly increased in recent years, from 6.1% in 2016 to 34.6% in 2020. The observed trend appears to be in line with the recent National Comprehensive Cancer Network (NCCN) guidelines recommending TNT as the preferred approach.

Three Decade Single-Institution Experience of Safety and Efficacy of Radiotherapy and Adjuvant Chemotherapy for Young Adult Patients with Medulloblastoma

The rarity of medulloblastoma in the adult population limits information on optimal treatment and clinical outcomes. Adjuvant chemoradiation has been correlated to improved overall survival (OS) in a recent National Cancer Database (NCDB) analysis. We performed a retrospective safety and efficacy analysis of radiation (RT) +/- adjuvant chemotherapy (aCTH) in young adult patients with medulloblastoma to better understand outcomes, prognostic factors, and possibly optimal treatment strategies. We conducted an IRB-approved retrospective chart review on young adult (age ≥18 - 39 years old) patients with medulloblastoma treated at our institution (1992-2018) with a minimum follow-up of 6 months from completion of therapy. We gathered data on patient and disease characteristics, treatment, and clinical outcomes, including OS, progression-free survival (PFS), local control (LC), and freedom from distant metastasis (FDM). We employed Cox regression model for univariable and multivariable analyses and Kaplan-Meier (KM) test methods for survival analyses, using JMP version 15.0 software. Thirty-one patients were treated with postoperative RT including craniospinal irradiation (median dose: 2340 cGy/13 fractions) followed by tumor bed/posterior fossa (median total dose: 5580 cGy/31 fractions) either alone (n = 9; 29%) or with adjuvant chemotherapy (aCTH: n = 22; 71%); mostly as per COG A9961 Regimen A: oral lomustine, intravenous cisplatin, and intravenous vincristine (n = 12). 54.6% (n = 12) were known to complete the full aCTH course. Common RT acute toxicities included G1-2 nausea and/or vomiting (N/V; n = 8) and G1-2 fatigue (n = 6). Common aCTH acute toxicities included G1-2 N/V (n = 7) and peripheral neuropathy: G1-2 (n = 6) and G3 (n = 3). Late adverse events were primarily G1-2 peripheral neuropathy and gait imbalance (22.6%), G1-2 hormonal disturbances (19.4%) and G1-2 neurocognitive impairment (16.1%). Male patients had worse OS, PFS, FDM, and LC. Age at diagnosis, tumor location (lateral vs. central), and completion of aCTH course were shown on uni- and multi-variable analysis to be significantly associated with OS; p<0.05. KM survival analysis revealed superior 10-year PFS and OS in patients who completed aCTH compared to those who received RT alone or did not complete aCTH: 72.9% vs 59.3% vs 42%, p = 0.461, and 74.1% vs 63.5% vs 40%, p = 0.033, respectively. A similar trend was noted for LC and FDM. Our series provides a report of acute and late side effects of treatment of young adult patients with medulloblastoma. Significant OS and PFS advantage are seen of aCTH completion in this patient population. Since optimal treatment of these patients is still an unmet need, prospective studies for this rare disease entity are needed.

Non-Operative Management of Rectal or Anal Canal Adenocarcinoma: National Cancer Database Analysis of the Impact of Disease, Treatment, and Social Determinants of Health on Overall Survival

For select patients with rectal or anal canal adenocarcinoma (RA-ACA), a non-operative management (NOM) strategy utilizing definitive radiotherapy (RT) has emerged as an option with the goal to improve quality of life compared with surgical management while maintaining similar oncologic outcomes. Disease and treatment characteristics as well as social determinants of health have been associated with access to care and health outcomes, and we hypothesized that such factors would impact overall survival (OS) amongst patients who received a NOM approach. The purpose of this study was to explore the influence of patient demographics, disease characteristics, and social determinants of health on OS amongst those receiving NOM utilizing the National Cancer Database (NCDB). We identified patients at least 18 of years of age diagnosed with clinical stage 1-3 RA-ACA from 2004-2018. The NOM cohort included patients who received RT and either refused surgery or surgery was not recommended in their treatment. Patients were excluded if receipt of chemotherapy or RT were unknown, received RT to a site outside of the pelvis, or received palliative-intent treatment. OS was estimated using the Kaplan-Meier method. Univariable and multivariable (MVA) Cox proportional hazards model was used to assess characteristics associated with OS. Analyses were performed using STATA (version 17, College Station, TX). A p<0.05 was considered statistically significant. A total of 12,409 patients were identified as the NOM cohort. The median OS was 48.8 months (95% CI: 46.8-50.6). On MVA, variables associated with poorer OS included age ≥ 70 vs 50-69, male sex, Charlson-Deyo Score ≥ 1 vs 0, insurance status (no insurance, Medicaid or Medicare vs. private), geographical region (South, Midwest or West vs. Northeast), rural urban density vs metro/urban, treatment in a community facility vs academic, year of diagnosis (2004-2011 vs. 2012-2018), clinical T4 vs T1, clinical N1 or N2 vs N0, and grade 3 vs 1 (all p<0.05). Treatment with a RT dose < 45 Gy vs. 45-54 Gy (HR: 2.24, 95% CI: 2.07-2.44), but not > 55 Gy vs. 45-54 Gy, and omission of chemotherapy (HR: 1.28, 95% CI: 1.16-1.43) were associated with poorer OS. Patient, disease, treatment, and social determinants of health may influence OS amongst patients with RA-ACA who receive a NOM approach. Further work is needed to determine if the influence on OS can be explained, in part, by patients' lack of access to the intense surveillance necessary and/or the potential need for subsequent surgical management. Heightened awareness of these differential outcomes is needed to assist in patient selection and to successfully address barriers in access to optimize outcomes for patients who receive NOM.

Estimating the overall survival benefit of adjuvant chemo-endocrine therapy in women over age 50 with pT1-2N0 early stage breast cancer and 21-gene recurrence score ≥26: A National Cancer Database analysis.

Validation studies of the 21-gene recurrence score (RS) previously demonstrated that adjuvant chemotherapy plus endocrine therapy (CET) was associated with a significant survival benefit in women with node negative breast cancer (BC) and RS >31. However, the TAILORx trial, did not quantify the benefit of adjuvant CET in older women with node negative hormone receptor positive (HR+) BC with RS ≥26. We hypothesized that CET would be associated with improved overall survival (OS) compared to endocrine therapy (ET) in women >50 with HR+/HER2-node negative BC and RS ≥26. The National Cancer Database (NCDB) was queried to identify women >50 with RS ≥26 ER+/HER2-BC pT1-2N0M0. Chi-square and logistic regression analysis determined the difference between ET and CET. OS was analyzed using a multivariable Cox model. We included 16,745 women-4740 (28.3%) received ET and 12,005 (71.7%) received CET. Women who received CET had: moderately (OR = 1.853, p < 0.001) or poorly/undifferentiated tumors (OR = 3.875, p < 0.001), pT2 (OR = 1.356, p < 0.001), or lymph-vascular invasion (OR = 1.206, p = 0.001). After accounting for demographic and oncologic factors, 5-year OS rates were significantly superior in women receiving CET vs. ET alone (95.4% vs. 92.0%, Hazard Ratio = 0.680, p < 0.001). We observed that CET was associated with a clinically and statistically significant higher OS compared to ET alone in women >50 years of age with RS ≥26 pT1 and pT2 N0M0 HR+/HER2-breast cancer, and which suggests that cytotoxic chemotherapy has an impact on reducing mortality that is independent of induction of premature ovarian failure.

Pathologic Nodal Staging Before SBRT for Early-stage NSCLC Does Not Impact Overall Survival: A Propensity Score-matched NCDB Analysis.

Stereotactic body radiation therapy (SBRT) for early-stage non-small cell carcinoma of the lung (NSCLC) is increasingly utilized. We sought to assess overall survival (OS) for early-stage NSCLC patients receiving SBRT depending on staging method. Early-stage NSCLC patients treated with definitive SBRT were identified in the National Cancer Database (NCDB), and OS was determined based on method of staging. Patient, disease, and treatment characteristics were also analyzed. A total of 12,106 patients were included; 865 (7%) received invasive staging (nodal sampling, NS) and 11,241 (93%) had no nodal sampling (NNS). From this larger dataset, a propensity score matching (1:1 without replacement) was performed, which yielded 839 patients for each group (NNS and NS). With a median follow-up time of 3.12 years, median survival for all patients included in the matched dataset was 2.75 years (95% CI: 2.55-2.93y), with 2- and 5-year OS estimated at 63.9% and 25.7%, respectively. In a multivariable analysis on matched data, there was no difference in mortality risk between the NNS and NS groups (hazard ratio=1.08, 95% CI: 0.94-1.24, P =0.25). Negative prognostic factors identified in the multivariable analysis of the matched data included: age more than 65, male sex, Charlson-Deyo Score ≥1, and tumor size ≥3cm. SBRT use in early-stage NSCLC steadily increased over the study period. Most patients proceeded to SBRT without nodal staging, conflicting with National Comprehensive Cancer Network (NCCN) guidelines which recommend pathologic mediastinal lymph node evaluation for all early-stage NSCLC cases, except stage IA. Our findings suggest similar OS in patients with early-stage NSCLC treated with SBRT irrespective of nodal staging. Furthermore, we highlight patient-related, disease-related, and treatment-related prognostic factors to consider when planning therapy for these patients.

Unmasking disparities in survival among Asian American and Pacific Islander women with cervical cancer: A national cancer database analysis from 2004 to 2015 (036)

Unmasking disparities in survival among Asian American and Pacific Islander women with cervical cancer: A national cancer database analysis from 2004 to 2015 (036)

Gynecologic cancer trends by disaggregated Asian American and Native Hawaiian/Pacific Islander groups: A national cancer database analysis (060)

Gynecologic cancer trends by disaggregated Asian American and Native Hawaiian/Pacific Islander groups: A national cancer database analysis (060)

Oncotype Dx Score, HER2 Low Expression, and Clinical Outcomes in Early-Stage Breast Cancer: A National Cancer Database Analysis.

The interaction between HER2-low expression, oncotype recurrence score (RS), and their influence on the prognosis of HR+/HER2- breast cancer (BC) is not very well studied. We conducted a retrospective cohort study of patients diagnosed with resectable HER2-low and HER2-zero BC from the National Cancer Database. The primary outcome was overall survival (OS), and the association of RS with the clinical outcomes in HR+/HER2- BC was analyzed as an exploratory endpoint. The distribution of RS was comparable between HER2-low and HER2-zero groups; however, the RSs of HER2-low tumors were more likely to be 16-25. Women with HER2-low tumors had longer 5-year OS than women with HER2-zero tumors in the HR-negative (84.3% vs. 83.9%; p < 0.001, HR: 0.87 (0.84-0.90), p < 0.001) but not in the HR-positive group (94.0% vs. 94.0%; p = 0.38, HR: 0.97 (0.95-0.99), p = 0.01). The survival advantage was observed in patients who received adjuvant/neoadjuvant chemotherapy (p-interaction (chemo vs. no chemo) < 0.001). Among those who received adjuvant chemotherapy in the group with higher RSs (26-100), those with HER2-low BC had higher 5-year OS than HER2-zero BC. Resectable HER2-low BC had a better prognosis than HER2-zero BC. Among those who received adjuvant chemotherapy in the higher oncotype RS group, those with HER2-low tumors had better survival.

Impact of travel burden on the treatment of stage I and II breast cancer: A National Cancer Database analysis

BackgroundAlthough historic studies of state registries have demonstrated decreased radiation therapy use for patients with breast cancer living further away from radiation facilities, the association between travel distance and breast cancer treatment in a modern national cohort remains unknown. MethodsFemale patients with estrogen receptor/progesterone receptor positive and human epidermal growth factor receptor 2 negative pathologic stages I to II breast cancer were identified from the National Cancer Database (2018–2020) and dichotomized by distance ≤20 miles or >20 miles (75th percentile) from the treatment facility. The association between travel distance and type of surgery and treatment administered was analyzed by univariate and multivariate logistic regression and after 1:1 propensity matching. ResultsOf the 293,318 patients identified for inclusion, the median age was 63 years, and most patients (n = 190,567, 65%) lived ≤20 miles of the treatment facility. Patients with a travel burden >20 miles were more likely to receive a mastectomy (≤20 miles 30.4% vs >20 miles 34.0%, P < .001; odds ratio 1.14, P = .016), and less likely to receive radiation (≤20 miles 63.3% vs >20% miles 60.1%, P < .001; odds ratio 0.81, P < .001). These findings persisted after propensity score matching (n = 33,544 per cohort), with patients living further being more likely to undergo a mastectomy (≤20 miles 30.3% vs >20 miles 35.3%, P < .001) and less likely to receive radiation (≤ 20 miles 65.4% vs. >20 miles 58.5%, P < .001). ConclusionPatients with hormone receptor-positive stage I to II breast cancer with a larger travel burden are more likely to receive a mastectomy and less likely to undergo radiation therapy to treat their disease.

Letter to the Editor Regarding “Chordoma of the Skull Base: A National Cancer Database Analysis of Current Practice Patterns and Outcomes”

Letter to the Editor Regarding “Chordoma of the Skull Base: A National Cancer Database Analysis of Current Practice Patterns and Outcomes”

A national cancer database analysis of the clinicopathologic characteristics and outcomes of appendiceal malignant mesenchymal tumors

The present study aimed to assess the characteristics and outcomes of appendiceal malignant mesenchymal tumors. This was a retrospective case-series study of patients with appendiceal malignant mesenchymal tumors in the national cancer database (2005–2019). The main outcomes were overall survival (OS) and short-term mortality. 53 patients (40 GISTs and 13 sarcomas) were included. 92.6% of GIST patients had stage I disease and 76.9% of GISTs were ≤2 cm. Most appendiceal GISTs were treated with appendectomy or partial colectomy whereas half of patients with appendiceal sarcoma underwent hemicolectomy or subtotal colectomy. Only one short-term mortality was recorded in the sarcoma group. One-third of patients with sarcoma had positive surgical margins versus 5.1% of patients with GISTs. GIST patients had longer median OS (117.1 vs 54.8 months) than sarcoma patients.

Immunochemotherapy or chemotherapy alone in primary central nervous system lymphoma: a National Cancer Database analysis

AbstractDebate remains over the role of rituximab, a large molecule with reduced central nervous system (CNS) penetration, in therapy for primary CNS lymphoma (PCNSL). Since 2013, the National Cancer Database has distinguished between chemotherapy and immunotherapy for frontline treatment. In this setting, rituximab would be the only standard frontline immunotherapy. We examined factors associated with the receipt of immunotherapy using a multivariate regression model for relative risk, with a random intercept to account for the hospital-specific treatment selection process. Patients were matched using a 1:1 propensity score to limit possible confounders, and overall survival (OS) was compared in the matched cohort. We identified 4691 patients with PCNSL diagnosed between 2013 and 2018. The use of immunotherapy has increased from 45% in 2013 to 76% in 2018. Immunotherapy use was associated with sociodemographic variables and local (hospital level) preference rather than clinical factors. The main factors associated with reduced use of immunotherapy included male sex, Black race or Hispanic ethnicity (compared with White non-Hispanic), HIV+ status, treatment in a lower-volume hospital, and earlier year of diagnosis. We matched 2830 patients for the survival analysis. Receipt of immunotherapy was associated with a significantly better OS (hazard ratio [HR], 0.75; 95% confidence interval [CI], 0.67-0.83). There was heterogeneity according to age, because the advantage of immunotherapy was more pronounced for patients aged ≤75 years (HR, 0.71; 95% CI, 0.63-0.80) than for those older than 75 years (HR, 0.87; 95% CI, 0.70-1.08). Overall, our findings support the current trend toward rituximab use, although a nuanced approach should be adopted when treating older patients.

Impact of Tumor Size and Management on Survival in Small Gastric Gastrointestinal Stromal Tumors

BackgroundSociety guidelines remain inconsistent on the role of endoscopic and radiographic surveillance as an alternative to surgical resection of small gastric gastrointestinal stromal tumors (GISTs). Herein, we aimed to assess survival among patients with gastric GISTs undergoing observation versus surgical resection, stratified by tumor size. MethodsThe National Cancer Database (NCDB) was queried for gastric GISTs < 2 cm diagnosed from 2010-2017. Patients were stratified by management strategy—observation vs surgical resection. The primary outcome, overall survival (OS), was examined with Kaplan-Meier and multivariable Cox proportional hazard methods. Subgroup analyses were conducted on tumors < 1 cm and 1–2 cm in size. ResultsAltogether, 1208 patients were identified: 439 (36.3%) undergoing observation and 769 (63.7%) receiving surgical resection. In the overall cohort, patients undergoing surgical resection demonstrated improved survival (93.6 vs. 88.8% 5-year OS, p=0.02). In multivariable analysis, upfront surgical resection was not associated with a reduction in mortality; however, there was a significant interaction with tumor size. For patients with tumors < 1 cm, there was no difference in survival based on management strategy. However, resection of tumors 1–2 cm was associated with improved survival relative to surveillance. ConclusionsWhile surgical resection and surveillance were associated with similar survival for patients with gastric GISTs < 1 cm, this NCDB analysis suggests that patients with tumor size ≥ 1 cm may benefit from upfront surgical resection. Prospective studies comparing these two approaches and their impact on recurrence-free and disease-specific survival are needed to better align consensus guidelines and recommendations.

P11 Guideline-concordant care for patients with locally advanced cervical cancer by disaggregated LatinX ethnicity and Asian American and Native Hawaiian/ Pacific Islander race: A National Cancer Database Analysis

P11 Guideline-concordant care for patients with locally advanced cervical cancer by disaggregated LatinX ethnicity and Asian American and Native Hawaiian/ Pacific Islander race: A National Cancer Database Analysis