Abstract The Pesticide Handlers Exposure Database has been developed to provide generic pesticide worker (i.e., applicator) exposure estimates. The dermal and inhalation exposure estimates generated by the system are based on actual field monitoring data, which are reported genetically (i.e., not chemical specific). The Pesticide Handlers Exposure Database provides a much larger number of observations than are available from a single exposure study when conducting exposure and risk assessments. The exposure data in the system have been reviewed for scientific integrity and are graded based on analytical quality assurance. The U.S. Environmental Protection Agency is currently using the Pesticide Handlers Exposure Database for the pesticide registration/reregistration process. The major limitation of the system is the insufficient amount of data. To increase the utility of the database, the Pesticide Handlers Exposure Database Task Force is currently updating the system with an additional 50 exposure studie...