Objective To explore the role of rumor analysis of tumor specific growth factor(TSGF) and the detection of cancer cell in nasopharyneal smears for treatment of nasophyngeal carcinoma.Methods To analyze the relationship between the change of TSGF level before and after irradiation in 100 patients with nasopharyngeal carcinoma and detection result of cancer cell in nasopharyngeal smear after irradiation. Rusults The difference in level of TSGF before and after irradiation is obvious( P 0.05),the difference in level of TSGF for positive of nasopharyngeal smears and negative of nasopharyngeal smears is obvious ( P 0.05).Conclusion It can be judged whether cancer cells is remained after nasopharyneal carcinoma irradiation by analyzing the level of TSGF before and after irradiation combined the detecting cancer cell in nasopharyngeal smears.